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公开(公告)号：US20110009491A1
公开(公告)日：2011-01-13
申请号：US12877471
申请日：2010-09-08
申请人： Yoshio SATO , Seiya Makino , Nobuo Yoda , Kakuhei Isawa , Tomonori Kamiyama , Kenichi Hojo , Mizue Saito , Naoki Taketomo , Keisuke Furuichi , Shuji Ikegami
发明人： Yoshio SATO , Seiya Makino , Nobuo Yoda , Kakuhei Isawa , Tomonori Kamiyama , Kenichi Hojo , Mizue Saito , Naoki Taketomo , Keisuke Furuichi , Shuji Ikegami
IPC分类号： A61K31/192 , A61P1/00
CPC分类号： C12P7/42 , A23L33/10 , A61K31/192
摘要： A composition containing 1,4-dihydroxy-2-naphthoic acid at a high concentration is obtained by intracellularly and extracellularly producing 1,4-dihydroxy-2-naphthoic acid using a bacterium belonging to the genus Propionibacterium and collecting it. This composition is efficacious in improving intestinal flora, alleviating abdominal ailments in association with the intake of milk, and preventing metabolic bone diseases.
摘要翻译： 通过使用属于丙酸杆菌属的细菌并通过细胞内和细胞外产生1,4-二羟基-2-萘甲酸，得到高浓度的含有1,4-二羟基-2-萘甲酸的组合物。 该组合物有效改善肠道菌群，减轻与摄入牛奶相关的腹部疾病，并预防代谢性骨病。
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公开(公告)号：US20090312425A1
公开(公告)日：2009-12-17
申请号：US12543814
申请日：2009-08-19
申请人： Yoshio Sato , Seiya Makino , Nobuo Yoda , Kakuhei Isawa , Tomonori Kamiyama , Kenichi Hojo , Mizue Saito , Naoki Taketomo , Keisuke Furuichi , Shuji Ikegami
发明人： Yoshio Sato , Seiya Makino , Nobuo Yoda , Kakuhei Isawa , Tomonori Kamiyama , Kenichi Hojo , Mizue Saito , Naoki Taketomo , Keisuke Furuichi , Shuji Ikegami
IPC分类号： A61K31/192 , C12P7/42
CPC分类号： C12P7/42 , A23L33/10 , A61K31/192
摘要： A composition containing 1,4-dihydroxy-2-naphthoic acid at a high concentration is obtained by intracellularly and extracellularly producing 1,4-dihydroxy-2-naphthoic acid using a bacterium belonging to the genus Propionibacterium and collecting it. This composition is efficacious in improving intestinal flora, alleviating abdominal ailments in association with the intake of milk, and preventing metabolic bone diseases.
摘要翻译： 通过使用属于丙酸杆菌属的细菌并通过细胞内和细胞外产生1,4-二羟基-2-萘甲酸，得到高浓度的含有1,4-二羟基-2-萘甲酸的组合物。 该组合物有效改善肠道菌群，减轻与摄入牛奶相关的腹部疾病，并预防代谢性骨病。
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公开(公告)号：US20080146657A1
公开(公告)日：2008-06-19
申请号：US10578015
申请日：2004-11-04
申请人： Hiroshi Tsuboi , Shuji Ikegami , Tomonori Kamiyama , Zai-si Ji , Yukio Asami , Hiroyuki Itou , Munehiro Oda , Kazuo Shin
发明人： Hiroshi Tsuboi , Shuji Ikegami , Tomonori Kamiyama , Zai-si Ji , Yukio Asami , Hiroyuki Itou , Munehiro Oda , Kazuo Shin
IPC分类号： A61K31/352 , A61P3/04 , A61P3/10 , C07D311/30
CPC分类号： A61K31/7048 , A23L33/105 , A61K31/352 , A61K36/62 , C07D311/30
摘要： The present inventors produced lotus leaf extracts, and discovered that quercetin is one of the active ingredients. As a result of treating β3-adrenergic receptor-expressing cells and feeding diabetes model mice with quercetin and evaluating its effects, the present inventors discovered specifically that quercetin produces obesity-improving effects and antidiabetic effects by acting as a β3-adrenergic receptor agonist.
摘要翻译： 本发明人发明了莲叶提取物，发现槲皮素是活性成分之一。 作为治疗β3 - 肾上腺素能受体表达细胞并用槲皮素喂养糖尿病模型小鼠并评价其效果的结果，本发明人特别发现槲皮素通过作为 β3 - 肾上腺素能受体激动剂。
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公开(公告)号：US07834061B2
公开(公告)日：2010-11-16
申请号：US12543814
申请日：2009-08-19
申请人： Yoshio Sato , Seiya Makino , Nobuo Yoda , Kakuhei Isawa , Tomonori Kamiyama , Kenichi Hojo , Mizue Saito , Naoki Taketomo , Keisuke Furuichi , Shuji Ikegami
发明人： Yoshio Sato , Seiya Makino , Nobuo Yoda , Kakuhei Isawa , Tomonori Kamiyama , Kenichi Hojo , Mizue Saito , Naoki Taketomo , Keisuke Furuichi , Shuji Ikegami
CPC分类号： C12P7/42 , A23L33/10 , A61K31/192
摘要： A composition containing 1,4-dihydroxy-2-naphthoic acid at a high concentration is obtained by intracellularly and extracellularly producing 1,4-dihydroxy-2-naphthoic acid using a bacterium belonging to the genus Propionibacterium and collecting it. This composition is efficacious in improving intestinal flora, alleviating abdominal ailments in association with the intake of milk, and preventing metabolic bone diseases.
摘要翻译： 通过使用属于丙酸杆菌属的细菌并通过细胞内和细胞外产生1,4-二羟基-2-萘甲酸，得到高浓度的含有1,4-二羟基-2-萘甲酸的组合物。 该组合物有效改善肠道菌群，减轻与摄入牛奶相关的腹部疾病，并预防代谢性骨病。
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公开(公告)号：US07629155B2
公开(公告)日：2009-12-08
申请号：US12100075
申请日：2008-04-09
申请人： Yoshio Sato , Seiya Makino , Nobuo Yoda , Kakuhei Isawa , Tomonori Kamiyama , Kenichi Hojo , Mizue Saito , Naoki Taketomo , Keisuke Furuichi , Shuji Ikegami
发明人： Yoshio Sato , Seiya Makino , Nobuo Yoda , Kakuhei Isawa , Tomonori Kamiyama , Kenichi Hojo , Mizue Saito , Naoki Taketomo , Keisuke Furuichi , Shuji Ikegami
CPC分类号： C12P7/42 , A23L33/10 , A61K31/192
摘要： A composition containing 1,4-dihydroxy-2-naphthoic acid at a high concentration is obtained by intracellularly and extracellularly producing 1,4-dihydroxy-2-naphthoic acid using a bacterium belonging to the genus Propionibacterium and collecting it. This composition is efficacious in improving intestinal flora, alleviating abdominal ailments in association with the intake of milk, and preventing metabolic bone diseases.
摘要翻译： 通过使用属于丙酸杆菌属的细菌并通过细胞内和细胞外产生1,4-二羟基-2-萘甲酸，得到高浓度的含有1,4-二羟基-2-萘甲酸的组合物。 该组合物有效改善肠道菌群，减轻与摄入牛奶相关的腹部疾病，并预防代谢性骨病。
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公开(公告)号：US08110607B2
公开(公告)日：2012-02-07
申请号：US12877471
申请日：2010-09-08
申请人： Yoshio Sato , Seiya Makino , Nobuo Yoda , Kakuhei Isawa , Tomonori Kamiyama , Kenichi Hojo , Mizue Saito , Naoki Taketomo , Keisuke Furuichi , Shuji Ikegami
发明人： Yoshio Sato , Seiya Makino , Nobuo Yoda , Kakuhei Isawa , Tomonori Kamiyama , Kenichi Hojo , Mizue Saito , Naoki Taketomo , Keisuke Furuichi , Shuji Ikegami
CPC分类号： C12P7/42 , A23L33/10 , A61K31/192
摘要： A composition containing 1,4-dihydroxy-2-naphthoic acid at a high concentration is obtained by intracellularly and extracellularly producing 1,4-dihydroxy-2-naphthoic acid using a bacterium belonging to the genus Propionibacterium and collecting it. This composition is efficacious in improving intestinal flora, alleviating abdominal ailments in association with the intake of milk, and preventing metabolic bone diseases.
摘要翻译： 通过使用属于丙酸杆菌属的细菌并通过细胞内和细胞外产生1,4-二羟基-2-萘甲酸，得到高浓度的含有1,4-二羟基-2-萘甲酸的组合物。 该组合物有效改善肠道菌群，减轻与摄入牛奶相关的腹部疾病，并预防代谢性骨病。
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公开(公告)号：US20080194688A1
公开(公告)日：2008-08-14
申请号：US12100075
申请日：2008-04-09
申请人： Yoshio SATO , Seiya MAKINO , Nobuo YODA , Kakuhei ISAWA , Tomonori KAMIYAMA , Kenichi HOJO , Mizue SAITO , Naoki TAKETOMO , Keisuke FURUICHI , Shuji IKEGAMI
发明人： Yoshio SATO , Seiya MAKINO , Nobuo YODA , Kakuhei ISAWA , Tomonori KAMIYAMA , Kenichi HOJO , Mizue SAITO , Naoki TAKETOMO , Keisuke FURUICHI , Shuji IKEGAMI
IPC分类号： A61K31/192 , A61P1/00 , A61P19/08
CPC分类号： C12P7/42 , A23L33/10 , A61K31/192
摘要： A composition containing 1,4-dihydroxy-2-naphthoic acid at a high concentration is obtained by intracellularly and extracellularly producing 1,4-dihydroxy-2-naphthoic acid using a bacterium belonging to the genus Propionibacterium and collecting it. This composition is efficacious in improving intestinal flora, alleviating abdominal ailments in association with the intake of milk, and preventing metabolic bone diseases.
摘要翻译： 通过使用属于丙酸杆菌属的细菌并通过细胞内和细胞外产生1,4-二羟基-2-萘甲酸，得到高浓度的含有1,4-二羟基-2-萘甲酸的组合物。 该组合物有效改善肠道菌群，减轻与摄入牛奶相关的腹部疾病，并预防代谢性骨病。
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公开(公告)号：US07374915B2
公开(公告)日：2008-05-20
申请号：US10486421
申请日：2002-08-06
申请人： Yoshio Sato , Seiya Makino , Nobuo Yoda , Kakuhei Isawa , Tomonori Kamiyama , Kenichi Hojo , Mizue Saito , Naoki Taketomo , Keisuke Furuichi , Shuji Ikegami
发明人： Yoshio Sato , Seiya Makino , Nobuo Yoda , Kakuhei Isawa , Tomonori Kamiyama , Kenichi Hojo , Mizue Saito , Naoki Taketomo , Keisuke Furuichi , Shuji Ikegami
CPC分类号： C12P7/42 , A23L33/10 , A61K31/192
摘要： A composition containing 1,4-dihydroxy-2-naphthoic acid at a high concentration is obtained by intracellularly and extracellularly producing 1,4-dihydroxy-2-naphthoic acid using a bacterium belonging to the genus Propionibacterium and collecting it. This composition is efficacious in improving intestinal flora, alleviating abdominal ailments in association with the intake of milk, and preventing metabolic bone diseases.
摘要翻译： 通过使用属于丙酸杆菌属的细菌并通过细胞内和细胞外产生1,4-二羟基-2-萘甲酸，得到高浓度的含有1,4-二羟基-2-萘甲酸的组合物。 该组合物有效改善肠道菌群，减轻与摄入牛奶相关的腹部疾病，并预防代谢性骨病。
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