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公开(公告)号：US07834061B2
公开(公告)日：2010-11-16
申请号：US12543814
申请日：2009-08-19
申请人： Yoshio Sato , Seiya Makino , Nobuo Yoda , Kakuhei Isawa , Tomonori Kamiyama , Kenichi Hojo , Mizue Saito , Naoki Taketomo , Keisuke Furuichi , Shuji Ikegami
发明人： Yoshio Sato , Seiya Makino , Nobuo Yoda , Kakuhei Isawa , Tomonori Kamiyama , Kenichi Hojo , Mizue Saito , Naoki Taketomo , Keisuke Furuichi , Shuji Ikegami
CPC分类号： C12P7/42 , A23L33/10 , A61K31/192
摘要： A composition containing 1,4-dihydroxy-2-naphthoic acid at a high concentration is obtained by intracellularly and extracellularly producing 1,4-dihydroxy-2-naphthoic acid using a bacterium belonging to the genus Propionibacterium and collecting it. This composition is efficacious in improving intestinal flora, alleviating abdominal ailments in association with the intake of milk, and preventing metabolic bone diseases.
摘要翻译： 通过使用属于丙酸杆菌属的细菌并通过细胞内和细胞外产生1,4-二羟基-2-萘甲酸，得到高浓度的含有1,4-二羟基-2-萘甲酸的组合物。 该组合物有效改善肠道菌群，减轻与摄入牛奶相关的腹部疾病，并预防代谢性骨病。
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公开(公告)号：US07629155B2
公开(公告)日：2009-12-08
申请号：US12100075
申请日：2008-04-09
申请人： Yoshio Sato , Seiya Makino , Nobuo Yoda , Kakuhei Isawa , Tomonori Kamiyama , Kenichi Hojo , Mizue Saito , Naoki Taketomo , Keisuke Furuichi , Shuji Ikegami
发明人： Yoshio Sato , Seiya Makino , Nobuo Yoda , Kakuhei Isawa , Tomonori Kamiyama , Kenichi Hojo , Mizue Saito , Naoki Taketomo , Keisuke Furuichi , Shuji Ikegami
CPC分类号： C12P7/42 , A23L33/10 , A61K31/192
摘要： A composition containing 1,4-dihydroxy-2-naphthoic acid at a high concentration is obtained by intracellularly and extracellularly producing 1,4-dihydroxy-2-naphthoic acid using a bacterium belonging to the genus Propionibacterium and collecting it. This composition is efficacious in improving intestinal flora, alleviating abdominal ailments in association with the intake of milk, and preventing metabolic bone diseases.
摘要翻译： 通过使用属于丙酸杆菌属的细菌并通过细胞内和细胞外产生1,4-二羟基-2-萘甲酸，得到高浓度的含有1,4-二羟基-2-萘甲酸的组合物。 该组合物有效改善肠道菌群，减轻与摄入牛奶相关的腹部疾病，并预防代谢性骨病。
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公开(公告)号：US08110607B2
公开(公告)日：2012-02-07
申请号：US12877471
申请日：2010-09-08
申请人： Yoshio Sato , Seiya Makino , Nobuo Yoda , Kakuhei Isawa , Tomonori Kamiyama , Kenichi Hojo , Mizue Saito , Naoki Taketomo , Keisuke Furuichi , Shuji Ikegami
发明人： Yoshio Sato , Seiya Makino , Nobuo Yoda , Kakuhei Isawa , Tomonori Kamiyama , Kenichi Hojo , Mizue Saito , Naoki Taketomo , Keisuke Furuichi , Shuji Ikegami
CPC分类号： C12P7/42 , A23L33/10 , A61K31/192
摘要： A composition containing 1,4-dihydroxy-2-naphthoic acid at a high concentration is obtained by intracellularly and extracellularly producing 1,4-dihydroxy-2-naphthoic acid using a bacterium belonging to the genus Propionibacterium and collecting it. This composition is efficacious in improving intestinal flora, alleviating abdominal ailments in association with the intake of milk, and preventing metabolic bone diseases.
摘要翻译： 通过使用属于丙酸杆菌属的细菌并通过细胞内和细胞外产生1,4-二羟基-2-萘甲酸，得到高浓度的含有1,4-二羟基-2-萘甲酸的组合物。 该组合物有效改善肠道菌群，减轻与摄入牛奶相关的腹部疾病，并预防代谢性骨病。
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公开(公告)号：US07374915B2
公开(公告)日：2008-05-20
申请号：US10486421
申请日：2002-08-06
申请人： Yoshio Sato , Seiya Makino , Nobuo Yoda , Kakuhei Isawa , Tomonori Kamiyama , Kenichi Hojo , Mizue Saito , Naoki Taketomo , Keisuke Furuichi , Shuji Ikegami
发明人： Yoshio Sato , Seiya Makino , Nobuo Yoda , Kakuhei Isawa , Tomonori Kamiyama , Kenichi Hojo , Mizue Saito , Naoki Taketomo , Keisuke Furuichi , Shuji Ikegami
CPC分类号： C12P7/42 , A23L33/10 , A61K31/192
摘要： A composition containing 1,4-dihydroxy-2-naphthoic acid at a high concentration is obtained by intracellularly and extracellularly producing 1,4-dihydroxy-2-naphthoic acid using a bacterium belonging to the genus Propionibacterium and collecting it. This composition is efficacious in improving intestinal flora, alleviating abdominal ailments in association with the intake of milk, and preventing metabolic bone diseases.
摘要翻译： 通过使用属于丙酸杆菌属的细菌并通过细胞内和细胞外产生1,4-二羟基-2-萘甲酸，得到高浓度的含有1,4-二羟基-2-萘甲酸的组合物。 该组合物有效改善肠道菌群，减轻与摄入牛奶相关的腹部疾病，并预防代谢性骨病。
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公开(公告)号：US20110009491A1
公开(公告)日：2011-01-13
申请号：US12877471
申请日：2010-09-08
申请人： Yoshio SATO , Seiya Makino , Nobuo Yoda , Kakuhei Isawa , Tomonori Kamiyama , Kenichi Hojo , Mizue Saito , Naoki Taketomo , Keisuke Furuichi , Shuji Ikegami
发明人： Yoshio SATO , Seiya Makino , Nobuo Yoda , Kakuhei Isawa , Tomonori Kamiyama , Kenichi Hojo , Mizue Saito , Naoki Taketomo , Keisuke Furuichi , Shuji Ikegami
IPC分类号： A61K31/192 , A61P1/00
CPC分类号： C12P7/42 , A23L33/10 , A61K31/192
摘要： A composition containing 1,4-dihydroxy-2-naphthoic acid at a high concentration is obtained by intracellularly and extracellularly producing 1,4-dihydroxy-2-naphthoic acid using a bacterium belonging to the genus Propionibacterium and collecting it. This composition is efficacious in improving intestinal flora, alleviating abdominal ailments in association with the intake of milk, and preventing metabolic bone diseases.
摘要翻译： 通过使用属于丙酸杆菌属的细菌并通过细胞内和细胞外产生1,4-二羟基-2-萘甲酸，得到高浓度的含有1,4-二羟基-2-萘甲酸的组合物。 该组合物有效改善肠道菌群，减轻与摄入牛奶相关的腹部疾病，并预防代谢性骨病。
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公开(公告)号：US20090312425A1
公开(公告)日：2009-12-17
申请号：US12543814
申请日：2009-08-19
申请人： Yoshio Sato , Seiya Makino , Nobuo Yoda , Kakuhei Isawa , Tomonori Kamiyama , Kenichi Hojo , Mizue Saito , Naoki Taketomo , Keisuke Furuichi , Shuji Ikegami
发明人： Yoshio Sato , Seiya Makino , Nobuo Yoda , Kakuhei Isawa , Tomonori Kamiyama , Kenichi Hojo , Mizue Saito , Naoki Taketomo , Keisuke Furuichi , Shuji Ikegami
IPC分类号： A61K31/192 , C12P7/42
CPC分类号： C12P7/42 , A23L33/10 , A61K31/192
摘要： A composition containing 1,4-dihydroxy-2-naphthoic acid at a high concentration is obtained by intracellularly and extracellularly producing 1,4-dihydroxy-2-naphthoic acid using a bacterium belonging to the genus Propionibacterium and collecting it. This composition is efficacious in improving intestinal flora, alleviating abdominal ailments in association with the intake of milk, and preventing metabolic bone diseases.
摘要翻译： 通过使用属于丙酸杆菌属的细菌并通过细胞内和细胞外产生1,4-二羟基-2-萘甲酸，得到高浓度的含有1,4-二羟基-2-萘甲酸的组合物。 该组合物有效改善肠道菌群，减轻与摄入牛奶相关的腹部疾病，并预防代谢性骨病。
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公开(公告)号：US09095604B2
公开(公告)日：2015-08-04
申请号：US13821284
申请日：2011-09-08
IPC分类号： A61K35/747 , A23L1/30 , A61K35/741 , C12N1/20 , C12R1/225 , A23K1/00 , A61K31/192 , A61K35/745 , A23C9/123 , C12Q1/02 , C12Q1/68
CPC分类号： A61K35/747 , A23C9/1238 , A23K10/18 , A23L33/135 , A23V2002/00 , A23V2200/3204 , A23Y2220/15 , A23Y2220/29 , A23Y2240/75 , A61K31/192 , A61K35/741 , A61K35/745 , C12N1/20 , C12Q1/02 , C12Q1/6897 , C12R1/225 , G01N2500/10 , G01N2800/06
摘要： The purpose of the present invention is to provide a probiotic(s) which can activate an aromatic hydrocarbon receptor (AhR) and can consequently prevent inflammatory damage in the digestive tract. The present invention relates to; a probiotic(s) capable of activating an AhR; an anti-inflammatory agent comprising the probiotic(s); an orally ingestible composition containing the anti-inflammatory agent; and a method for screening for the probiotic(s).
摘要翻译： 本发明的目的是提供可以活化芳族烃受体（AhR）并因此可以预防消化道炎症损伤的益生菌。 本发明涉及 能够激活AhR的益生菌; 包含益生菌的抗炎剂; 含有抗炎剂的口服摄取组合物; 以及筛选益生菌的方法。
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公开(公告)号：US20130302844A1
公开(公告)日：2013-11-14
申请号：US13821284
申请日：2011-09-08
CPC分类号： A61K35/747 , A23C9/1238 , A23K10/18 , A23L33/135 , A23V2002/00 , A23V2200/3204 , A23Y2220/15 , A23Y2220/29 , A23Y2240/75 , A61K31/192 , A61K35/741 , A61K35/745 , C12N1/20 , C12Q1/02 , C12Q1/6897 , C12R1/225 , G01N2500/10 , G01N2800/06
摘要： The purpose of the present invention is to provide a probiotic(s) which can activate an aromatic hydrocarbon receptor (AhR) and can consequently prevent inflammatory damage in the digestive tract. The present invention relates to; a probiotic(s) capable of activating an AhR; an anti-inflammatory agent comprising the probiotic(s); an orally ingestible composition containing the anti-inflammatory agent; and a method for screening for the probiotic(s).
摘要翻译： 本发明的目的是提供可以活化芳族烃受体（AhR）并因此可以预防消化道炎症损伤的益生菌。 本发明涉及 能够激活AhR的益生菌; 包含益生菌的抗炎剂; 含有抗炎剂的口服摄取组合物; 以及筛选益生菌的方法。
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