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11 条记录 (耗时 0.048 秒)

    Streptomyces anulatus microorganism and a process for producing the substance GM-95
    3.
    发明授权
    Streptomyces anulatus microorganism and a process for producing the substance GM-95 失效
    链霉菌属微生物和生产物质GM-95的方法

    公开(公告)号：US07192763B2

    公开(公告)日：2007-03-20

    申请号：US10401589

    申请日：2003-03-31

    申请人： Haruo Seto ,  Kazuo Shin-Ya ,  Konstanty Wierzba

    发明人： Haruo Seto ,  Kazuo Shin-Ya ,  Konstanty Wierzba

    IPC分类号： C12N1/20 ,  C12P17/18

    CPC分类号： C12P17/185 ,  C07D513/00 ,  C07D513/22

    摘要： A compound which has the following formula (1), a process for its production, a pharmaceutical composition comprising the compound as an active ingredient, a method of treating tumor which comprises administering the compound, use of the compound as a medicine, and a microorganism capable of producing the compound. The compound of the present invention is a novel compound which has antitumor action and is useful as a medicine.

    摘要翻译： 具有下式（1）的化合物，其制备方法，包含该化合物作为活性成分的药物组合物，治疗肿瘤的方法，其包括给予化合物，使用该化合物作为药物和微生物 能够生产化合物。 本发明化合物是具有抗肿瘤作用的新化合物，可用作药物。

    Alpha-glucosidase activity inhibitor
    4.
    发明申请
    Alpha-glucosidase activity inhibitor 审中-公开
    α-葡糖苷酶活性抑制剂

    公开(公告)号：US20070036872A1

    公开(公告)日：2007-02-15

    申请号：US10577612

    申请日：2004-11-04

    申请人： Hiroshi Tsuboi ,  Shuji Ikegami ,  Zai-si Ji ,  Hiroyuki Itou ,  Munehiro Oda ,  Kazuo Shin

    发明人： Hiroshi Tsuboi ,  Shuji Ikegami ,  Zai-si Ji ,  Hiroyuki Itou ,  Munehiro Oda ,  Kazuo Shin

    IPC分类号： A61K36/185

    CPC分类号： A61K36/65 ,  A23L33/105 ,  A23V2002/00 ,  A23V2200/328

    摘要： The present inventors focused on the lotus plant and prepared lotus extracts. When α-glucosidase and its substrate sucrose were reacted with the lotus extracts to examine the effect of adding the extracts on the enzymatic reaction, the lotus extracts were found to have α-glucosidase inhibitory activity. Furthermore, when the lotus extract and sucrose were administered to mice and their blood glucose levels were measured, the lotus extracts were found to suppress blood glucose levels. More specifically, the present inventors discovered that the lotus extracts have α-glucosidase inhibitory activity and can be used to control blood glucose levels.

    摘要翻译： 本发明人专注于莲花植物和制备的莲花提取物。 当α-葡萄糖苷酶及其底物蔗糖与莲花提取物反应以检查添加提取物对酶反应的作用时，发现莲藕提取物具有α-葡糖苷酶抑制活性。 此外，当向小鼠施用荷叶提取物和蔗糖并测量其血糖水平时，发现莲藕提取物抑制血糖水平。 更具体地，本发明人发现莲藕提取物具有α-葡糖苷酶抑制活性，可用于控制血糖水平。

    Substance GM-95, process for producing the same and utilization thereof
    5.
    发明授权
    Substance GM-95, process for producing the same and utilization thereof 失效
    物质GM-95，其制备方法及其应用

    公开(公告)号：US06613759B1

    公开(公告)日：2003-09-02

    申请号：US09806475

    申请日：2001-04-09

    申请人： Haruo Seto ,  Kazuo Shin-Ya ,  Konstanty Wierzba

    发明人： Haruo Seto ,  Kazuo Shin-Ya ,  Konstanty Wierzba

    IPC分类号： A61K3133

    CPC分类号： C12P17/185 ,  C07D513/00 ,  C07D513/22

    摘要： A compound which has the following formula (1), a process for its production, a pharmaceutical composition comprising the compound as an active ingredient, a method of treating tumor which comprises administering the compound, use of the compound as a medicine, and a microorganism capable of producing the compound. The compound of the present invention is a novel compound which has antitumor action and is useful as a medicine.

    摘要翻译： 具有下式（1）的化合物，其制备方法，包含该化合物作为活性成分的药物组合物，治疗肿瘤的方法，其包括给予化合物，使用该化合物作为药物和微生物 能够生产化合物。 本发明化合物是具有抗肿瘤作用的新化合物，可用作药物。

    Composition improving lipid metabolism
    6.
    发明授权
    Composition improving lipid metabolism 失效
    组合物改善脂质代谢

    公开(公告)号：US06355279B1

    公开(公告)日：2002-03-12

    申请号：US09215258

    申请日：1998-12-18

    申请人： Zai-Si Ji ,  Kazuo Shin ,  Hiroyuki Ito ,  Masako Tsunematsu

    发明人： Zai-Si Ji ,  Kazuo Shin ,  Hiroyuki Ito ,  Masako Tsunematsu

    IPC分类号： A01N6500

    CPC分类号： A61K36/16 ,  A61K36/9066 ,  A61K2300/00

    摘要： Extract of at least one selected from GAJUTSU (zedoariae rhizoma), KYOUOU (curcumae rhizoma) and ICHO leaves (ginko leaves) obtained using polar solvent, and composition containing the extract are disclosed; since the extract has an excellent effect on lowering the level of blood triglyceride, is derived from natural material and has an excellent level of safety, the extract and the composition can be used as or in drink, food or medicine.

    摘要翻译： 公开了从极性溶剂获得的GAJUTSU（zedoariae rhizoma），KYOUOU（curcumae rhizoma）和ICHO叶（银杏叶）中提取的至少一种提取物，以及含有该提取物的组合物。 由于提取物对降低血液甘油三酯水平具有优异的效果，因天然物质而具有优良的安全性，所以提取物和组合物可以作为饮料，食品或药物使用。

    Physiologically active substance PF1191 and process for producing the same
    9.
    发明授权
    Physiologically active substance PF1191 and process for producing the same 失效
    生理活性物质PF1191及其生产方法

    公开(公告)号：US06171829B2

    公开(公告)日：2001-01-09

    申请号：US09380823

    申请日：1999-09-10

    申请人： Haruo Seto ,  Kazuo Shin-Ya ,  Takashi Yaguchi ,  Toru Sasaki

    发明人： Haruo Seto ,  Kazuo Shin-Ya ,  Takashi Yaguchi ,  Toru Sasaki

    IPC分类号： C07D20712

    CPC分类号： C12P17/10

    摘要： A substance PF1191 having an inhibitory activity to kainic acid toxicity represented by the following formula (I) which is obtained by incubating a fungus belonging to the genus Eupenicillium and isolating the product thus produced from the culture by solvent extraction, adsorption column chromatography, gel filtration, etc.

    摘要翻译： 具有下述式（I）表示的对红藻氨酸毒性具有抑制活性的物质PF1191，其通过温育属于Eupenicillium属的真菌并通过溶剂萃取，吸附柱色谱法，凝胶过滤分离由培养物产生的产物 等等

    Dihydrophenazinecarboxylic acid derivatives
    10.
    发明授权
    Dihydrophenazinecarboxylic acid derivatives 失效
    二氢吩嗪酮羧酸衍生物

    公开(公告)号：US6150363A

    公开(公告)日：2000-11-21

    申请号：US319285

    申请日：1999-06-02

    申请人： Toshihiro Takahashi ,  Yutaka Nomura ,  Haruo Seto ,  Kazuo Shin-ya

    发明人： Toshihiro Takahashi ,  Yutaka Nomura ,  Haruo Seto ,  Kazuo Shin-ya

    IPC分类号： C07D241/48 ,  A61K31/495 ,  C07D241/46

    CPC分类号： C07D241/48

    摘要： Dihydrophenazinecarboxylic acid derivatives of the formula (I) wherein R.sup.1 represents hydrogen, linear or branched alkyl, etc., each of R.sup.2 and R.sup.3 represents hydrogen, 3-methyl-2-butenyl, etc., and each of R.sup.4 and R.sup.5 represents hydrogen, alkyl, alkenyl, aralkyl, aryl, hydroxyl, alkoxy, aryloxy, aralkyloxy, halogen, nitro, cyano, alkylsulfonyl, arylsulfonyl, alkylcarbonyl, arylcarbonyl, etc., provided that there is no case that both of R.sup.4 and R.sup.5 are hydrogen. The dihydrophenazinecarboxylic acid derivatives are excellent in the inhibition of glutamic acid toxicity. ##STR1##

    摘要翻译： PCT No.PCT / JP97 / 03674。 371日期1999年6月2日 102（e）1999年6月2日PCT 1997年10月14日提交PCT公布。 出版物WO98 / 24772 日期：1998年6月11日其中R 1表示氢，直链或支链烷基等的式（I）的二氢吩嗪嗪羧酸衍生物，R 2和R 3各自表示氢，3-甲基-2-丁烯基等，R 4 并且R 5表示氢，烷基，烯基，芳烷基，芳基，羟基，烷氧基，芳氧基，芳烷氧基，卤素，硝基，氰基，烷基磺酰基，芳基磺酰基，烷基羰基，芳基羰基等。 是氢。 二氢吩嗪酮羧酸衍生物对谷氨酸毒性的抑制是优异的。