METHOD FOR CANCER DETECTION, DIAGNOSIS AND PROGNOSIS
    1.
    发明申请
    METHOD FOR CANCER DETECTION, DIAGNOSIS AND PROGNOSIS 有权
    癌症检测,诊断和预防方法

    公开(公告)号:US20110053152A1

    公开(公告)日:2011-03-03

    申请号:US12784446

    申请日:2010-05-20

    摘要: The present invention provides a method for diagnosing cancer, predicting a disease outcome or response to therapy in a patient sample. The method involves isolating a circulating tumor cell (CTC), for example, a viable CTC, from a sample using a parylene microfilter device comprising a membrane filter having or consisting of a parylene substrate, which has an array of holes with a predetermined shape and size; and detecting and quantifying telomerase activity in blood circulating tumor cells. The invention further provides methods of using cells live-captured in various applications.

    摘要翻译: 本发明提供一种用于诊断癌症的方法,预测患者样品中的疾病结果或对治疗的反应。 该方法包括使用聚对二甲苯微型过滤器装置从样品中分离循环肿瘤细胞(CTC),例如可行的CTC,所述聚对二甲苯微型过滤器包括具有具有预定形状的孔阵列的具有聚对二甲苯衬底或由聚对二甲苯衬底组成的膜过滤器, 尺寸; 并检测和定量血液循环肿瘤细胞中的端粒酶活性。 本发明还提供了使用在各种应用中实时捕获的细胞的方法。

    Method of making antitussive medicine and relieving cough
    2.
    发明授权
    Method of making antitussive medicine and relieving cough 有权
    制止咳药和缓解咳嗽的方法

    公开(公告)号:US07867998B2

    公开(公告)日:2011-01-11

    申请号:US11224165

    申请日:2005-09-12

    IPC分类号: A61K31/55

    CPC分类号: A61K31/55

    摘要: Method for relieving cough using an effective antitussive chemical compound belonging to stemoamide or tuberostemospironine and method for manufacturing pharmaceutical compositions for treating or relieving cough in human and animal subjects which including a stemoamide or tuberostemospironine compound. In addition, the antitussive property of the compounds provides a method for assessing the quality of herbs traditionally used in treating cough by analyzing the content of the effective chemical ingredient, i.e., compounds of stemoamide type and/or tuterostemospironine type. It further provides a method for identifying medicinal herbs which may be used for relieving cough by phytochemical determination of the existence of compounds that are of stemoamide or tuterostemospironine type.

    摘要翻译: 使用有效的镇痛化学化合物,即属于干酰胺或tuberostemospiron的缓解咳嗽的方法以及制备用于治疗或缓解人和动物受试者的咳嗽的药物组合物的方法,所述药物组合物包括硫酰胺或前列萘星宁化合物。 此外,化合物的镇咳性质提供了一种通过分析有效化学成分的含量,即硫代酰胺型和/或硫卓孕酮类型的化合物来评估传统上用于治疗咳嗽的药材质量的方法。 它还提供了一种用于鉴定药草的方法,该方法可用于通过植物化学测定来缓解咳嗽,所述化学物质确定是含有酰胺或硫代胸苷类的化合物。

    Valency platform molecules comprising aminooxy groups
    3.
    发明申请
    Valency platform molecules comprising aminooxy groups 审中-公开
    价值平台分子包含氨氧基

    公开(公告)号:US20060141597A1

    公开(公告)日:2006-06-29

    申请号:US11303591

    申请日:2005-12-16

    摘要: Molecules comprising aminooxy groups are provided, wherein the aminooxy groups provide attachment sites for the covalent attachment of other molecules. In one embodiment, polyoxyethylene molecules comprising aminooxy groups are provided that can be conjugated to wide variety of biologically active molecules including poly(amino acids). In another embodiment, valency platform molecules comprising aminooxy groups are provided. The aminooxy groups can be used to form covalent bonds with biological molecules such as poly(amino acids). The aminooxy groups can, for example, react with poly(amino acids) modified to contain carbonyl groups, such as glyoxyl groups, to form a conjugate of the valency platform molecule and the biologically active molecule via an oxime bond. The valency platform molecules comprising aminooxy groups are advantageously reactive in the formation of conjugates, and they also can be readily synthesized to form a composition with very low polydispersity.

    摘要翻译: 提供包含氨基氧基的分子,其中氨基氧基为其它分子的共价连接提供附着位点。 在一个实施方案中,提供了包含氨基氧基的聚氧乙烯分子,其可与多种生物活性分子(包括聚(氨基酸))缀合。 在另一个实施方案中,提供了包含氨基氧基的化合物平台分子。 氨基氧基可用于与生物分子如聚(氨基酸)形成共价键。 例如,氨基氧基可以与经修饰以含有羰基(例如乙醛基)的聚(氨基酸)反应,以通过肟键形成价态平台分子和生物活性分子的缀合物。 包含氨基氧基的价态平台分子在缀合物的形成中有利地是反应性的,并且它们也可以容易地合成以形成具有非常低的多分散性的组合物。

    MULTIPLE ANISOTROPIC PARAMETER INVERSION FOR A TTI EARTH MODEL USING WELL DATA
    4.
    发明申请
    MULTIPLE ANISOTROPIC PARAMETER INVERSION FOR A TTI EARTH MODEL USING WELL DATA 失效
    使用良好数据的TTI地球模型的多个ANISOTROPIC参数反演

    公开(公告)号:US20120185171A1

    公开(公告)日:2012-07-19

    申请号:US13368134

    申请日:2012-02-07

    IPC分类号: G06F19/00

    CPC分类号: G01V1/303

    摘要: A method for determining values of anisotropic model parameters of a Tilted Transversely Isotropic (TTI) Earth model, the method including obtaining an initial TTI earth model that substantially flattens common-imaging-point gathers and substantially ties seismic data to well data; inputting checkshot data and/or VSP data to determine updated values of Vp0 near the well locations; determining an incremental improvement Δδ; extrapolating the relative change Δδ from near-well locations to the entire three dimensional TTI earth model; determining updated values of Vp0=Vp0 (1−Δδ); inputting near-to-mid-offset/angle and mid-to-far-offset/angle residual moveout information; and providing updated values of δ and η.

    摘要翻译: 一种用于确定倾斜横向各向同性(TTI)地球模型的各向异性模型参数值的方法,该方法包括获得基本平坦的共同成像点集合并且将地震数据实质上与井数据相关联的初始TTI地球模型; 输入检查数据和/或VSP数据以确定井位置附近的Vp0的更新值; 确定渐进式改进; 将相对变化&Dgr;δ从近井位推导到整个三维TTI地球模型; 确定Vp0 = Vp0(1-&Dgr;δ)的更新值; 输入近中偏移/角度和中到远偏移/角度剩余移动信息; 并提供δ和eegr的更新值。

    Method of making antitussive medicine and relieving cough
    5.
    发明申请
    Method of making antitussive medicine and relieving cough 有权
    制止咳药和缓解咳嗽的方法

    公开(公告)号:US20070060564A1

    公开(公告)日:2007-03-15

    申请号:US11224165

    申请日:2005-09-12

    IPC分类号: A61K31/55

    CPC分类号: A61K31/55

    摘要: Method for relieving cough using an effective antitussive chemical compound belonging to stemoamide or tuberostemospironine and method for manufacturing pharmaceutical compositions for treating or relieving cough in human and animal subjects which including a stemoamide or tuberostemospironine compound. In addition, the antitussive property of the compounds provides a method for assessing the quality of herbs traditionally used in treating cough by analyzing the content of the effective chemical ingredient, i.e., compounds of stemoamide type and/or tuterostemospironine type. It further provides a method for identifying medicinal herbs which may be used for relieving cough by phytochemical determination of the existence of compounds that are of stemoamide or tuterostemospironine type.

    摘要翻译: 使用有效的镇痛化学化合物,即属于干酰胺或tuberostemospiron的缓解咳嗽的方法以及制备用于治疗或缓解人和动物受试者的咳嗽的药物组合物的方法,所述药物组合物包括硫酰胺或前列萘星宁化合物。 此外,化合物的镇咳性质提供了一种通过分析有效化学成分的含量,即硫代酰胺型和/或硫卓孕酮类型的化合物来评估传统上用于治疗咳嗽的药材质量的方法。 它还提供了一种用于鉴定药草的方法,该方法可用于通过植物化学测定来缓解咳嗽,所述化学物质确定是含有酰胺或硫代胸苷类的化合物。

    High density terminal block
    6.
    发明授权
    High density terminal block 有权
    高密度接线端子

    公开(公告)号:US09240637B2

    公开(公告)日:2016-01-19

    申请号:US14366765

    申请日:2011-12-23

    摘要: A module of a terminal block (100) comprises a body (104) having an input configured to be coupled to an input wire and an output configured to be coupled to a plurality of output wires, a conductive element disposed within the input, and a plurality of terminals, each terminal having a first portion and a second portion configured to be coupled to an output wire, wherein the first portions of the plurality of terminals are nested together to achieve a single conductive structure, and wherein the conductive element is configured to engage and compress the input wire against the single conductive structure.

    摘要翻译: 端子块(100)的模块包括主体(104),其具有被配置为耦合到输入线的输入端和被配置为耦合到多个输出线的输出,设置在输入内的导电元件,以及 多个端子,每个端子具有第一部分和第二部分,被配置为耦合到输出导线,其中多个端子的第一部分嵌套在一起以实现单个导电结构,并且其中导电元件被配置为 将输入线接合并压缩抵抗单个导电结构。

    METHODS AND APPARATUS FOR ASSOCIATING INTEREST TAGS WITH MEDIA ITEMS BASED ON SOCIAL DIFFUSIONS AMONG USERS
    7.
    发明申请
    METHODS AND APPARATUS FOR ASSOCIATING INTEREST TAGS WITH MEDIA ITEMS BASED ON SOCIAL DIFFUSIONS AMONG USERS 审中-公开
    基于用户社会差距的媒体项目相关标签的方法和装置

    公开(公告)号:US20150149469A1

    公开(公告)日:2015-05-28

    申请号:US14400943

    申请日:2012-06-14

    IPC分类号: G06F17/30 H04L29/06

    摘要: An approach is provided for associating interest tags with media items based on social diffusions among users. The media tagging platform processes and/or facilitates a processing of one or more user profiles to determine one or more interest tags relating to one or more users, captured at one or more user devices to determine one or more frequencies of the one or more signals. Next, the media tagging platform determines one or more social diffusions of the one or more media items among the one or more users. Then, the media tagging platform causes, at least in part, an association of the one or more media items with the one or more interest tags based, at least in part, on the one or more social diffusions.

    摘要翻译: 提供了一种用于将兴趣标签与基于用户之间的社会扩散的媒体项目相关联的方法。 媒体标签平台处理和/或促进一个或多个用户简档的处理以确定在一个或多个用户设备处捕获的与一个或多个用户相关的一个或多个兴趣标签,以确定一个或多个信号的一个或多个频率 。 接下来,媒体标签平台确定一个或多个用户中的一个或多个媒体项目的一个或多个社会扩散。 然后,媒体标签平台至少部分地至少部分地使一个或多个媒体项目与一个或多个兴趣标签的关联,至少部分地基于一个或多个社会扩散。

    HIGH DENSITY TERMINAL BLOCK
    8.
    发明申请
    HIGH DENSITY TERMINAL BLOCK 有权
    高密度端子块

    公开(公告)号:US20140335740A1

    公开(公告)日:2014-11-13

    申请号:US14366765

    申请日:2011-12-23

    摘要: A module of a terminal block (100) comprises a body (104) having an input configured to be coupled to an input wire and an output configured to be coupled to a plurality of output wires, a conductive element disposed within the input, and a plurality of terminals, each terminal having a first portion and a second portion configured to be coupled to an output wire, wherein the first portions of the plurality of terminals are nested together to achieve a single conductive structure, and wherein the conductive element is configured to engage and compress the input wire against the single conductive structure.

    摘要翻译: 端子块(100)的模块包括主体(104),其具有被配置为耦合到输入线的输入端和被配置为耦合到多个输出线的输出,设置在输入内的导电元件,以及 多个端子,每个端子具有第一部分和第二部分,被配置为耦合到输出导线,其中多个端子的第一部分嵌套在一起以实现单个导电结构,并且其中导电元件被配置为 将输入线接合并压缩抵抗单个导电结构。

    Multiple anisotropic parameter inversion for a TTI earth model using well data
    9.
    发明授权
    Multiple anisotropic parameter inversion for a TTI earth model using well data 失效
    使用井数据的TTI地球模型的多个各向异性参数反演

    公开(公告)号:US08666668B2

    公开(公告)日:2014-03-04

    申请号:US13368134

    申请日:2012-02-07

    IPC分类号: G01V1/00

    CPC分类号: G01V1/303

    摘要: A method for determining values of anisotropic model parameters of a Tilted Transversely Isotropic (TTI) Earth model, the method including obtaining an initial TTI earth model that substantially flattens common-imaging-point gathers and substantially ties seismic data to well data; inputting checkshot data and/or VSP data to determine updated values of Vp0 near the well locations; determining an incremental improvement Δδ; extrapolating the relative change Δδ from near-well locations to the entire three dimensional TTI earth model; determining updated values of Vp0=Vp0 (1−Δδ); inputting near-to-mid-offset/angle and mid-to-far-offset/angle residual moveout information; and providing updated values of δ and η.

    摘要翻译: 一种用于确定倾斜横向各向同性(TTI)地球模型的各向异性模型参数值的方法,该方法包括获得基本平坦的共同成像点集合并且将地震数据实质上与井数据相关联的初始TTI地球模型; 输入检查数据和/或VSP数据以确定井位置附近的Vp0的更新值; 确定增量改进Deltadelta; 将相对变化Deltadelta从近井位推广到整个三维TTI地球模型; 确定Vp0 = Vp0(1-Deltadelta)的更新值; 输入近中偏移/角度和中到远偏移/角度剩余移动信息; 并提供delta和eta的更新值。