公开(公告)号：US20220396631A1

公开(公告)日：2022-12-15

申请号：US17595637

申请日：2020-05-19

申请人： Lu HUANG ,  Brian GRANDA ,  John BLANKENSHIP ,  Aida ABUJOUB ,  Tony FLEMING ,  Haihui LU ,  Connie HONG ,  Brian HOLMBERG ,  Novartis AG

发明人： Brian Walter Granda ,  John Blankenship ,  Aida Abujoub ,  Tony Fleming ,  Lu Huang ,  Connie Hong ,  Brian Holmberg ,  Haihui Lu

IPC分类号： C07K16/28

摘要： The present disclosure provides multispecific binding molecules that specifically bind to BCMA, a component of a human T-cell receptor complex and either CD2 or a tumor associated antigen, conjugates comprising the multispecific binding molecules, and pharmaceutical compositions comprising the multispecific binding molecules and the conjugates The disclosure further provides methods of using the multispecific binding molecules to treat disease and disorders associated with expression of BCMA. The disclosure yet further provides recombinant host cells engineered to express the multispecific binding molecules and methods of producing the multispecific binding molecules by culturing the host cells under conditions in which the multispecific binding molecules are expressed.

公开(公告)号：US07026283B2

公开(公告)日：2006-04-11

申请号：US10004562

申请日：2001-12-05

申请人： Tony Fleming ,  Jean-Pierre Kinet

发明人： Tony Fleming ,  Jean-Pierre Kinet

IPC分类号： A61K39/395 ,  A61K39/00 ,  C12N15/00

CPC分类号： C07K16/2896 ,  A61K38/00 ,  C07K14/70596

摘要： Calcium independent CD81 inhibition of IgE-mediated degranulation in mast cells, particularly through the FcγRIII and FcεRI receptors, is described, as well as methods of inhibiting allergic processes.

摘要翻译： 描述了通过FcgammaRIII和FcepsilonRI受体对肥大细胞中IgE介导的脱粒的钙依赖性CD81抑制，以及抑制过敏过程的方法。

公开(公告)号：US20060084608A1

公开(公告)日：2006-04-20

申请号：US11232439

申请日：2005-09-20

申请人： James Beltzer ,  M. Potter ,  Tony Fleming ,  Craig Rosen ,  Marilou Potter

发明人： James Beltzer ,  M. Potter ,  Tony Fleming ,  Craig Rosen ,  Marilou Potter

IPC分类号： A61K38/10

CPC分类号： C07K7/08 ,  A61K38/00 ,  A61K39/00 ,  C07K14/70578 ,  C07K14/7151 ,  C07K2319/00

摘要： Binding polypeptides that specifically bind BLyS protein or BLyS-like polypeptides can be used in methods of the invention for detecting, diagnosing, or prognosing a disease or disorder associated with aberrant BLyS or BLyS receptor expression or inappropriate function of BLyS or BLyS receptor, comprising BLyS binding polypeptides or fragments or variants thereof, that specifically bind to BLyS. The present invention further relates to methods and compositions for preventing, treating or ameliorating a disease or disorder associated with aberrant BLyS or BLyS receptor expression or inappropriate BLyS function or BLyS receptor function, comprising administering to an animal, preferably a human, an effective amount of one or more BLyS binding polypeptides or fragments or variants thereof, that specifically bind to BLyS.

公开(公告)号：US06423501B2

公开(公告)日：2002-07-23

申请号：US08954279

申请日：1997-10-20

申请人： Tony Fleming ,  Jean-Pierre Kinet

发明人： Tony Fleming ,  Jean-Pierre Kinet

IPC分类号： G01N3353

CPC分类号： C07K16/2896 ,  A61K38/00 ,  C07K14/70596

摘要： Calcium independent CD81 inhibition of IgE-mediated degranulation in mast cells, particularly through the Fc&ggr;RIII and FC&egr;RI receptors, is described, as well as methods of inhibiting allergic processes.

摘要翻译： 描述了通过FcgammaRIII和FCepsiRI受体对肥大细胞中IgE介导的脱粒的钙依赖CD81抑制，以及抑制过敏过程的方法。

公开(公告)号：US20140134179A1

公开(公告)日：2014-05-15

申请号：US14126372

申请日：2012-06-13

申请人： Brad St. Croix ,  Tony Fleming ,  Amit Chaudhary ,  Saurabh Saha ,  Xiaoyan Michelle Zhang ,  Rou-fun Kwong

发明人： Brad St. Croix ,  Tony Fleming ,  Amit Chaudhary ,  Saurabh Saha ,  Xiaoyan Michelle Zhang ,  Rou-fun Kwong

IPC分类号： C07K16/28

CPC分类号： C07K16/28 ,  A61K2039/505 ,  A61K2039/507 ,  C07K16/2863 ,  C07K16/30 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/55 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/76

摘要： Antibodies that specifically bind TEM8 protein, and conjugates thereof, are disclosed herein. In some examples the conjugates and antibodies are useful for methods of detecting and treating pathogenic angiogenesis. In other examples the conjugates and antibodies are useful for methods of detecting and treating cancer. In additional examples, the conjugates and antibodies are useful for methods of decreasing binding of Anthrax protective antigen to a cell.

摘要翻译： 本文公开了特异性结合TEM8蛋白的抗体及其缀合物。 在一些实例中，缀合物和抗体可用于检测和治疗病原性血管发生的方法。 在其它实例中，缀合物和抗体可用于检测和治疗癌症的方法。 在另外的实例中，缀合物和抗体可用于减少炭疽保护性抗原与细胞结合的方法。

公开(公告)号：US20100233177A1

公开(公告)日：2010-09-16

申请号：US12595538

申请日：2008-04-11

申请人： David Langdon Yowe ,  Dmitri Mikhailov ,  Tony Fleming

发明人： David Langdon Yowe ,  Dmitri Mikhailov ,  Tony Fleming

IPC分类号： A61K39/395 ,  C07K16/40 ,  C12N5/02 ,  A61P9/00

CPC分类号： C07K16/40 ,  A61K38/00 ,  C07K2317/21 ,  C07K2317/55 ,  C07K2317/92 ,  C12N9/6421 ,  C12N9/6472

摘要： Epitopes of Proprotein convertase subtilisin/kexin type 9 (PCSK9), compositions that bind to PCSK9 and PCSK9 epitopes, and methods of using the compositions are described herein.

摘要翻译： 前体蛋白转化酶枯草杆菌蛋白酶/ kexin 9型（PCSK9）的表位，结合PCSK9和PCSK9表位的组合物以及使用该组合物的方法在本文中描述。

公开(公告)号：US20070293434A9

公开(公告)日：2007-12-20

申请号：US11232439

申请日：2005-09-20

申请人： James Beltzer ,  M. Potter ,  Tony Fleming ,  Craig Rosen ,  Marilou Potter

发明人： James Beltzer ,  M. Potter ,  Tony Fleming ,  Craig Rosen ,  Marilou Potter

IPC分类号： A61K38/10

CPC分类号： C07K7/08 ,  A61K38/00 ,  A61K39/00 ,  C07K14/70578 ,  C07K14/7151 ,  C07K2319/00

摘要： Binding polypeptides that specifically bind BLyS protein or BLyS-like polypeptides can be used in methods of the invention for detecting, diagnosing, or prognosing a disease or disorder associated with aberrant BLyS or BLyS receptor expression or inappropriate function of BLyS or BLyS receptor, comprising BLyS binding polypeptides or fragments or variants thereof, that specifically bind to BLyS. The present invention further relates to methods and compositions for preventing, treating or ameliorating a disease or disorder associated with aberrant BLyS or BLyS receptor expression or inappropriate BLyS function or BLyS receptor function, comprising administering to an animal, preferably a human, an effective amount of one or more BLyS binding polypeptides or fragments or variants thereof, that specifically bind to BLyS.

摘要翻译： 特异性结合BLyS蛋白或BLyS样多肽的结合多肽可用于本发明的检测，诊断或预后与异常的BLyS或BLyS受体表达或与BLyS或BLyS受体不相适应的功能相关的疾病或病症的方法，其包括BLyS 特异性结合BLyS的结合多肽或其片段或变体。 本发明还涉及用于预防，治疗或改善与异常BLyS或BLyS受体表达或不适当的BLyS功能或BLyS受体功能相关的疾病或病症的方法和组合物，其包括向动物，优选人类施用有效量的 一种或多种与BLyS特异性结合的BLyS结合多肽或其片段或变体。

公开(公告)号：US09181340B2

公开(公告)日：2015-11-10

申请号：US14126372

申请日：2012-06-13

申请人： Brad St. Croix ,  Tony Fleming ,  Amit Chaudhary ,  Saurabh Saha ,  Xiaoyan Michelle Zhang ,  Rou-fun Kwong ,  Mary Beth Hilton

发明人： Brad St. Croix ,  Tony Fleming ,  Amit Chaudhary ,  Saurabh Saha ,  Xiaoyan Michelle Zhang ,  Rou-fun Kwong ,  Mary Beth Hilton

IPC分类号： C07K16/30 ,  C07K16/28 ,  A61K39/00

CPC分类号： C07K16/28 ,  A61K2039/505 ,  A61K2039/507 ,  C07K16/2863 ,  C07K16/30 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/55 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/76

摘要： Antibodies that specifically bind TEM8 protein, and conjugates thereof, are disclosed herein. In some examples the conjugates and antibodies are useful for methods of detecting and treating pathogenic angiogenesis. In other examples the conjugates and antibodies are useful for methods of detecting and treating cancer. In additional examples, the conjugates and antibodies are useful for methods of decreasing binding of Anthrax protective antigen to a cell.

摘要翻译： 本文公开了特异性结合TEM8蛋白的抗体及其缀合物。 在一些实例中，缀合物和抗体可用于检测和治疗病原性血管发生的方法。 在其它实例中，缀合物和抗体可用于检测和治疗癌症的方法。 在另外的实例中，缀合物和抗体可用于减少炭疽保护性抗原与细胞结合的方法。