公开(公告)号：US20060084608A1

公开(公告)日：2006-04-20

申请号：US11232439

申请日：2005-09-20

申请人： James Beltzer ,  M. Potter ,  Tony Fleming ,  Craig Rosen ,  Marilou Potter

发明人： James Beltzer ,  M. Potter ,  Tony Fleming ,  Craig Rosen ,  Marilou Potter

IPC分类号： A61K38/10

CPC分类号： C07K7/08 ,  A61K38/00 ,  A61K39/00 ,  C07K14/70578 ,  C07K14/7151 ,  C07K2319/00

摘要： Binding polypeptides that specifically bind BLyS protein or BLyS-like polypeptides can be used in methods of the invention for detecting, diagnosing, or prognosing a disease or disorder associated with aberrant BLyS or BLyS receptor expression or inappropriate function of BLyS or BLyS receptor, comprising BLyS binding polypeptides or fragments or variants thereof, that specifically bind to BLyS. The present invention further relates to methods and compositions for preventing, treating or ameliorating a disease or disorder associated with aberrant BLyS or BLyS receptor expression or inappropriate BLyS function or BLyS receptor function, comprising administering to an animal, preferably a human, an effective amount of one or more BLyS binding polypeptides or fragments or variants thereof, that specifically bind to BLyS.

公开(公告)号：US20070293434A9

公开(公告)日：2007-12-20

申请号：US11232439

申请日：2005-09-20

申请人： James Beltzer ,  M. Potter ,  Tony Fleming ,  Craig Rosen ,  Marilou Potter

发明人： James Beltzer ,  M. Potter ,  Tony Fleming ,  Craig Rosen ,  Marilou Potter

IPC分类号： A61K38/10

CPC分类号： C07K7/08 ,  A61K38/00 ,  A61K39/00 ,  C07K14/70578 ,  C07K14/7151 ,  C07K2319/00

摘要： Binding polypeptides that specifically bind BLyS protein or BLyS-like polypeptides can be used in methods of the invention for detecting, diagnosing, or prognosing a disease or disorder associated with aberrant BLyS or BLyS receptor expression or inappropriate function of BLyS or BLyS receptor, comprising BLyS binding polypeptides or fragments or variants thereof, that specifically bind to BLyS. The present invention further relates to methods and compositions for preventing, treating or ameliorating a disease or disorder associated with aberrant BLyS or BLyS receptor expression or inappropriate BLyS function or BLyS receptor function, comprising administering to an animal, preferably a human, an effective amount of one or more BLyS binding polypeptides or fragments or variants thereof, that specifically bind to BLyS.

摘要翻译： 特异性结合BLyS蛋白或BLyS样多肽的结合多肽可用于本发明的检测，诊断或预后与异常的BLyS或BLyS受体表达或与BLyS或BLyS受体不相适应的功能相关的疾病或病症的方法，其包括BLyS 特异性结合BLyS的结合多肽或其片段或变体。 本发明还涉及用于预防，治疗或改善与异常BLyS或BLyS受体表达或不适当的BLyS功能或BLyS受体功能相关的疾病或病症的方法和组合物，其包括向动物，优选人类施用有效量的 一种或多种与BLyS特异性结合的BLyS结合多肽或其片段或变体。

公开(公告)号：US20060193829A1

公开(公告)日：2006-08-31

申请号：US11345031

申请日：2006-01-31

申请人： Jinan Yu ,  M. Potter ,  Brian Kelley ,  Jeffrey Deetz ,  James Booth ,  Marilous Potter

发明人： Jinan Yu ,  M. Potter ,  Brian Kelley ,  Jeffrey Deetz ,  James Booth ,  Marilous Potter

IPC分类号： C07K7/06

CPC分类号： C07K7/06 ,  C07K7/08 ,  C07K14/00 ,  C07K14/755

摘要： It is an object of the present invention to provide novel binding molecules for factor VIII and factor VIII-like proteins. Preferred binding molecules of the present invention exhibit not only distinct characteristics for binding of the target factor VIII polypeptides but also specific and desirable characteristics for release (elution) of the target polypeptides. Especially preferred binding molecules according to the invention are short polypeptide sequences, characterized by a stable loop structure.