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公开(公告)号:US08216567B2
公开(公告)日:2012-07-10
申请号:US13231050
申请日:2011-09-13
申请人: Tony Klink , John Kink , Laura Strong
发明人: Tony Klink , John Kink , Laura Strong
CPC分类号: A61K38/465 , A61K38/00 , C12N9/22 , C12Y301/2601 , C12Y301/27005
摘要: The present invention relates to the use of ribonucleases (RNases) in the treatment or prevention of disease.
摘要翻译: 本发明涉及核糖核酸酶(RNA酶)在治疗或预防疾病中的用途。
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公开(公告)号:US08628768B2
公开(公告)日:2014-01-14
申请号:US13545387
申请日:2012-07-10
申请人: Tony Klink , John Kink , Laura Strong
发明人: Tony Klink , John Kink , Laura Strong
IPC分类号: A61K36/46
CPC分类号: A61K38/465 , A61K38/00 , C12N9/22 , C12Y301/2601 , C12Y301/27005
摘要: The present invention relates to the use of ribonucleases (RNases) in the treatment or prevention of disease.
摘要翻译: 本发明涉及核糖核酸酶(RNA酶)在治疗或预防疾病中的用途。
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公开(公告)号:US20120276077A1
公开(公告)日:2012-11-01
申请号:US13545387
申请日:2012-07-10
申请人: Tony Klink , John Kink , Laura Strong
发明人: Tony Klink , John Kink , Laura Strong
CPC分类号: A61K38/465 , A61K38/00 , C12N9/22 , C12Y301/2601 , C12Y301/27005
摘要: The present invention relates to the use of ribonucleases (RNases) in the treatment or prevention of disease.
摘要翻译: 本发明涉及核糖核酸酶(RNA酶)在治疗或预防疾病中的用途。
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公开(公告)号:US20100080789A1
公开(公告)日:2010-04-01
申请号:US12572016
申请日:2009-10-01
申请人: Tony Klink , John Kink , Laura Strong
发明人: Tony Klink , John Kink , Laura Strong
CPC分类号: A61K38/465 , A61K38/00 , C12N9/22 , C12Y301/2601 , C12Y301/27005
摘要: The present invention relates to the use of ribonucleases (RNases) in the treatment or prevention of disease.
摘要翻译: 本发明涉及核糖核酸酶(RNA酶)在治疗或预防疾病中的用途。
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公开(公告)号:US08487078B2
公开(公告)日:2013-07-16
申请号:US13252679
申请日:2011-10-04
申请人: Tony Klink , Jane Beebe , David Lasky , Karen Kleman-Leyer , Richard Somberg
发明人: Tony Klink , Jane Beebe , David Lasky , Karen Kleman-Leyer , Richard Somberg
CPC分类号: C12Q1/42 , A61K38/00 , C07K7/06 , C07K7/08 , C12Q1/485 , G01N33/573 , G01N2333/81 , G01N2333/9121
摘要: Compositions, methods, and kits for detecting and monitoring kinase, phosphatase and protein post-translational modification activity are described. The compositions typically include a peptide, a detectable moiety, and a protease cleavage site. Modification of a peptide by a kinase, phosphatase or other protein post-translational modification alters the proteolytic sensitivity of the peptide, resulting in a change of a detectable property of the composition. Panel assays for determining substrates or modulators of kinase, phosphatase or other protein post-translational modification activity are also described.
摘要翻译: 描述了用于检测和监测激酶,磷酸酶和蛋白质翻译后修饰活性的组合物,方法和试剂盒。 组合物通常包括肽,可检测部分和蛋白酶切割位点。 通过激酶,磷酸酶或其他蛋白质翻译后修饰来修饰肽改变了肽的蛋白水解敏感性,导致组合物的可检测性质的变化。 还描述了用于确定激酶,磷酸酶或其他蛋白质翻译后修饰活性的底物或调节剂的面板测定法。
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公开(公告)号:US20120083427A1
公开(公告)日:2012-04-05
申请号:US13252679
申请日:2011-10-04
CPC分类号: C12Q1/42 , A61K38/00 , C07K7/06 , C07K7/08 , C12Q1/485 , G01N33/573 , G01N2333/81 , G01N2333/9121
摘要: Compositions, methods, and kits for detecting and monitoring kinase, phosphatase and protein post-translational modification activity are described. The compositions typically include a peptide, a detectable moiety, and a protease cleavage site. Modification of a peptide by a kinase, phosphatase or other protein post-translational modification alters the proteolytic sensitivity of the peptide, resulting in a change of a detectable property of the composition. Panel assays for determining substrates or modulators of kinase, phosphatase or other protein post-translational modification activity are also described.
摘要翻译: 描述了用于检测和监测激酶,磷酸酶和蛋白质翻译后修饰活性的组合物,方法和试剂盒。 组合物通常包括肽,可检测部分和蛋白酶切割位点。 通过激酶,磷酸酶或其他蛋白质翻译后修饰来修饰肽改变了肽的蛋白水解敏感性,导致组合物的可检测性质的改变。 还描述了用于确定激酶,磷酸酶或其他蛋白质翻译后修饰活性的底物或调节剂的面板测定法。
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公开(公告)号:US20120003150A1
公开(公告)日:2012-01-05
申请号:US13231050
申请日:2011-09-13
申请人: Tony Klink , John Kink , Laura Strong
发明人: Tony Klink , John Kink , Laura Strong
IPC分类号: A61K51/10 , A61K39/395 , A61P35/04 , A61P35/00 , A61P35/02
CPC分类号: A61K38/465 , A61K38/00 , C12N9/22 , C12Y301/2601 , C12Y301/27005
摘要: The present invention relates to the use of ribonucleases (RNases) in the treatment or prevention of disease.
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公开(公告)号:US08067536B2
公开(公告)日:2011-11-29
申请号:US12728926
申请日:2010-03-22
申请人: Tony Klink , Jane Beebe , David Lasky , Karen Kleman-Leyer , Richard Somberg
发明人: Tony Klink , Jane Beebe , David Lasky , Karen Kleman-Leyer , Richard Somberg
CPC分类号: C12Q1/42 , A61K38/00 , C07K7/06 , C07K7/08 , C12Q1/485 , G01N33/573 , G01N2333/81 , G01N2333/9121
摘要: Compositions, methods, and kits for detecting and monitoring kinase, phosphatase and protein post-translational modification activity are described. The compositions typically include a peptide, a detectable moiety, and a protease cleavage site. Modification of a peptide by a kinase, phosphatase or other protein post-translational modification alters the proteolytic sensitivity of the peptide, resulting in a change of a detectable property of the composition. Panel assays for determining substrates or modulators of kinase, phosphatase or other protein post-translational modification activity are also described.
摘要翻译: 描述了用于检测和监测激酶,磷酸酶和蛋白质翻译后修饰活性的组合物,方法和试剂盒。 组合物通常包括肽,可检测部分和蛋白酶切割位点。 通过激酶,磷酸酶或其他蛋白质翻译后修饰来修饰肽改变了肽的蛋白水解敏感性,导致组合物的可检测性质的变化。 还描述了用于确定激酶,磷酸酶或其他蛋白质翻译后修饰活性的底物或调节剂的面板测定法。
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公开(公告)号:US08029782B2
公开(公告)日:2011-10-04
申请号:US12572016
申请日:2009-10-01
申请人: Tony Klink , John Kink , Laura Strong
发明人: Tony Klink , John Kink , Laura Strong
CPC分类号: A61K38/465 , A61K38/00 , C12N9/22 , C12Y301/2601 , C12Y301/27005
摘要: The present invention relates to the use of ribonucleases (RNases) in the treatment or prevention of disease.
摘要翻译: 本发明涉及核糖核酸酶(RNA酶)在治疗或预防疾病中的用途。
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公开(公告)号:US20070059787A1
公开(公告)日:2007-03-15
申请号:US11485957
申请日:2006-07-14
申请人: Tony Klink , Jane Beebe , David Lasky , Karen Kleman-Leyer , Richard Somberg
发明人: Tony Klink , Jane Beebe , David Lasky , Karen Kleman-Leyer , Richard Somberg
CPC分类号: C12Q1/42 , A61K38/00 , C07K7/06 , C07K7/08 , C12Q1/485 , G01N33/573 , G01N2333/81 , G01N2333/9121
摘要: Compositions, methods, and kits for detecting and monitoring kinase, phosphatase and protein post-translational modification activity are described. The compositions typically include a peptide, a detectable moiety, and a protease cleavage site. Modification of a peptide by a kinase, phosphatase or other protein post-translational modification alters the proteolytic sensitivity of the peptide, resulting in a change of a detectable property of the composition. Panel assays for determining substrates or modulators of kinase, phosphatase or other protein post-translational modification activity are also described.
摘要翻译: 描述了用于检测和监测激酶,磷酸酶和蛋白质翻译后修饰活性的组合物,方法和试剂盒。 组合物通常包括肽,可检测部分和蛋白酶切割位点。 通过激酶,磷酸酶或其他蛋白质翻译后修饰来修饰肽改变了肽的蛋白水解敏感性,导致组合物的可检测性质的变化。 还描述了用于确定激酶,磷酸酶或其他蛋白质翻译后修饰活性的底物或调节剂的面板测定法。
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