公开(公告)号：US07202040B2

公开(公告)日：2007-04-10

申请号：US10499172

申请日：2002-12-13

申请人： Masaaki Mori ,  Tomoko Chikatsu ,  Shuji Sato ,  Toshimi Nagi ,  Tsukasa Sugo

发明人： Masaaki Mori ,  Tomoko Chikatsu ,  Shuji Sato ,  Toshimi Nagi ,  Tsukasa Sugo

IPC分类号： G01N33/53 ,  G01N33/00 ,  C12Q1/68 ,  C12N15/00 ,  A61K38/02 ,  A61K38/16

CPC分类号： C07K14/705 ,  A61K31/00 ,  G01N2500/02 ,  Y10S435/975

摘要： The present invention relates to a screening method/screening kit for screening a compound or its salt that changes the binding properties of (a) a protein containing the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 1 or SEQ ID NO: 19, its partial peptides, or salts thereof, and (b) a ligand capable of binding specifically to the protein; compounds obtained by the screening or salts thereof; pharmaceuticals comprising the compounds or salts thereof; a protein containing the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 19; etc. The compounds obtained by the screening of the present invention are useful as agents for the prevention/treatment of, for example, neurodegenerative diseases, immunological diseases, edema, acid indigestion, etc.

摘要翻译： 本发明涉及一种用于筛选化合物或其盐的筛选方法/筛选试剂盒，其改变（a）含有与SEQ ID NO：1所示的氨基酸序列相同或基本相同的氨基酸序列的蛋白质的结合特性。 1或SEQ ID NO：19，其部分肽或其盐，和（b）能够特异性结合蛋白质的配体; 通过筛选获得的化合物或其盐; 包含其化合物或其盐的药物; 含有与SEQ ID NO：19所示的氨基酸序列相同或基本相同的氨基酸序列的蛋白质; 通过本发明的筛选获得的化合物可用作预防/治疗例如神经变性疾病，免疫疾病，水肿，酸消化不良等的试剂。

公开(公告)号：US20050048605A1

公开(公告)日：2005-03-03

申请号：US10489537

申请日：2002-09-13

申请人： Masaaki Mori ,  Kozo Hayashi ,  Hiroyuki Miya ,  Shuji Sato ,  Chieko Kitada ,  Hirokazu Matsumoto ,  Toshimi Nagi ,  Yukio Shimomura

发明人： Masaaki Mori ,  Kozo Hayashi ,  Hiroyuki Miya ,  Shuji Sato ,  Chieko Kitada ,  Hirokazu Matsumoto ,  Toshimi Nagi ,  Yukio Shimomura

IPC分类号： A61K38/00 ,  A61K48/00 ,  C07K14/705 ,  C12N15/12 ,  C12P21/08 ,  C07H21/04 ,  C07K14/47

CPC分类号： C07K14/705 ,  A61K38/00 ,  A61K48/00

摘要： The present invention aims at providing a novel polypeptide, a receptor, a DNA thereof, and the like. Specifically, the present invention provides a polypeptide having a binding ability to the protein represented by SEQ ID NO: 1 or SEQ ID NO: 3, or its amide, its ester or its salt, a polynucleotide encoding the polypeptide, an antisense polynucleotide or an antibody to the polypeptide, a screening of agent for prevention and/or treatment of cancer, obesity, etc., which comprises using the above, and the like. The polypeptide, receptor, polynucleotide, antisense polynucleotide, antibody and the like are useful for an agent of prevention and/or treatment of cancer, obesity and the like. Further, they are useful for a screening of an agent for prevention and/or treatment of cancer, obesity and the like.

摘要翻译： 本发明的目的在于提供新的多肽，受体及其DNA等。 具体地说，本发明提供了具有与SEQ ID NO：1或SEQ ID NO：3所代表的蛋白结合能力的多肽或其酰胺，其酯或其盐，编码多肽的多核苷酸，反义多核苷酸或 对多肽的抗体，筛选用于预防和/或治疗癌症，肥胖症等的药剂，其包括使用上述方法等。 多肽，受体，多核苷酸，反义多核苷酸，抗体等可用于预防和/或治疗癌症，肥胖症等。 此外，它们可用于筛选用于预防和/或治疗癌症，肥胖症等的药剂。

公开(公告)号：US07323541B2

公开(公告)日：2008-01-29

申请号：US10489537

申请日：2002-09-13

申请人： Masaaki Mori ,  Kozo Hayashi ,  Hiroyuki Miya ,  Shuji Sato ,  Chieko Kitada ,  Hirokazu Matsumoto ,  Toshimi Nagi ,  Yukio Shimomura

发明人： Masaaki Mori ,  Kozo Hayashi ,  Hiroyuki Miya ,  Shuji Sato ,  Chieko Kitada ,  Hirokazu Matsumoto ,  Toshimi Nagi ,  Yukio Shimomura

IPC分类号： A61K38/04

CPC分类号： C07K14/705 ,  A61K38/00 ,  A61K48/00

摘要： The present invention aims at providing a novel polypeptide, a receptor, a DNA thereof, and the like. Specifically, the present invention provides a polypeptide having a binding ability to the protein represented by SEQ ID NO: 1 or SEQ ID NO: 3, or its amide, its ester or its salt, a polynucleotide encoding the polypeptide, an antisense polynucleotide or an antibody to the polypeptide, a screening of agent for prevention and/or treatment of cancer, obesity, etc., which comprises using the above, and the like.The polypeptide, receptor, polynucleotide, antisense polynucleotide, antibody and the like are useful for an agent of prevention and/or treatment of cancer, obesity and the like. Further, they are useful for a screening of an agent for prevention and/or treatment of cancer, obesity and the like.

摘要翻译： 本发明的目的在于提供新的多肽，受体及其DNA等。 具体地说，本发明提供了具有与SEQ ID NO：1或SEQ ID NO：3所代表的蛋白结合能力的多肽或其酰胺，其酯或其盐，编码多肽的多核苷酸，反义多核苷酸或 对多肽的抗体，筛选用于预防和/或治疗癌症，肥胖症等的药剂，其包括使用上述方法等。 多肽，受体，多核苷酸，反义多核苷酸，抗体等可用于预防和/或治疗癌症，肥胖症等。 此外，它们可用于筛选用于预防和/或治疗癌症，肥胖症等的药剂。

公开(公告)号：US20050154190A1

公开(公告)日：2005-07-14

申请号：US10499172

申请日：2002-12-13

申请人： Masaaki Mori ,  Tomoko Chikatsu ,  Shuji Sato ,  Toshimi Nagi ,  Tsukasa Sugo

发明人： Masaaki Mori ,  Tomoko Chikatsu ,  Shuji Sato ,  Toshimi Nagi ,  Tsukasa Sugo

IPC分类号： A61K31/00 ,  A61P25/00 ,  A61P29/00 ,  A61P37/00 ,  A61P43/00 ,  C07K14/705 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N15/12 ,  G01N33/53 ,  A01K67/00 ,  C07F9/10 ,  C07H21/04 ,  G01N33/567

CPC分类号： C07K14/705 ,  A61K31/00 ,  G01N2500/02 ,  Y10S435/975

摘要： The present invention relates to a screening method/screening kit for screening a compound or its salt that changes the binding properties of (a) a protein containing the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 1 or SEQ ID NO: 19, its partial peptides, or salts thereof, and (b) a ligand capable of binding specifically to the protein; compounds obtained by the screening or salts thereof; pharmaceuticals comprising the compounds or salts thereof; a protein containing the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 19; etc. The compounds obtained by the screening of the present invention are useful as agents for the prevention/treatment of, for example, neurodegenerative diseases, immunological diseases, edema, acid indigestion, etc.

摘要翻译： 本发明涉及一种用于筛选化合物或其盐的筛选方法/筛选试剂盒，其改变（a）含有与SEQ ID NO：1所示的氨基酸序列相同或基本相同的氨基酸序列的蛋白质的结合特性。 1或SEQ ID NO：19，其部分肽或其盐，和（b）能够特异性结合蛋白质的配体; 通过筛选获得的化合物或其盐; 包含其化合物或其盐的药物; 含有与SEQ ID NO：19所示的氨基酸序列相同或基本相同的氨基酸序列的蛋白质; 通过本发明的筛选获得的化合物可用作预防/治疗例如神经变性疾病，免疫疾病，水肿，酸消化不良等的试剂。