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    Screening method
    1.
    发明申请
    Screening method 失效
    筛选方法

    公开(公告)号：US20050154190A1

    公开(公告)日：2005-07-14

    申请号：US10499172

    申请日：2002-12-13

    申请人： Masaaki Mori ,  Tomoko Chikatsu ,  Shuji Sato ,  Toshimi Nagi ,  Tsukasa Sugo

    发明人： Masaaki Mori ,  Tomoko Chikatsu ,  Shuji Sato ,  Toshimi Nagi ,  Tsukasa Sugo

    IPC分类号： A61K31/00 ,  A61P25/00 ,  A61P29/00 ,  A61P37/00 ,  A61P43/00 ,  C07K14/705 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N15/12 ,  G01N33/53 ,  A01K67/00 ,  C07F9/10 ,  C07H21/04 ,  G01N33/567

    CPC分类号： C07K14/705 ,  A61K31/00 ,  G01N2500/02 ,  Y10S435/975

    摘要： The present invention relates to a screening method/screening kit for screening a compound or its salt that changes the binding properties of (a) a protein containing the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 1 or SEQ ID NO: 19, its partial peptides, or salts thereof, and (b) a ligand capable of binding specifically to the protein; compounds obtained by the screening or salts thereof; pharmaceuticals comprising the compounds or salts thereof; a protein containing the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 19; etc. The compounds obtained by the screening of the present invention are useful as agents for the prevention/treatment of, for example, neurodegenerative diseases, immunological diseases, edema, acid indigestion, etc.

    摘要翻译： 本发明涉及一种用于筛选化合物或其盐的筛选方法/筛选试剂盒，其改变（a）含有与SEQ ID NO：1所示的氨基酸序列相同或基本相同的氨基酸序列的蛋白质的结合特性。 1或SEQ ID NO：19，其部分肽或其盐，和（b）能够特异性结合蛋白质的配体; 通过筛选获得的化合物或其盐; 包含其化合物或其盐的药物; 含有与SEQ ID NO：19所示的氨基酸序列相同或基本相同的氨基酸序列的蛋白质; 通过本发明的筛选获得的化合物可用作预防/治疗例如神经变性疾病，免疫疾病，水肿，酸消化不良等的试剂。

    Method for screening compounds which change the binding properties of a protein with a ligand
    2.
    发明授权
    Method for screening compounds which change the binding properties of a protein with a ligand 失效
    筛选用配体改变蛋白质的结合特性的化合物的方法

    公开(公告)号：US07202040B2

    公开(公告)日：2007-04-10

    申请号：US10499172

    申请日：2002-12-13

    申请人： Masaaki Mori ,  Tomoko Chikatsu ,  Shuji Sato ,  Toshimi Nagi ,  Tsukasa Sugo

    发明人： Masaaki Mori ,  Tomoko Chikatsu ,  Shuji Sato ,  Toshimi Nagi ,  Tsukasa Sugo

    IPC分类号： G01N33/53 ,  G01N33/00 ,  C12Q1/68 ,  C12N15/00 ,  A61K38/02 ,  A61K38/16

    CPC分类号： C07K14/705 ,  A61K31/00 ,  G01N2500/02 ,  Y10S435/975

    摘要： The present invention relates to a screening method/screening kit for screening a compound or its salt that changes the binding properties of (a) a protein containing the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 1 or SEQ ID NO: 19, its partial peptides, or salts thereof, and (b) a ligand capable of binding specifically to the protein; compounds obtained by the screening or salts thereof; pharmaceuticals comprising the compounds or salts thereof; a protein containing the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 19; etc. The compounds obtained by the screening of the present invention are useful as agents for the prevention/treatment of, for example, neurodegenerative diseases, immunological diseases, edema, acid indigestion, etc.

    摘要翻译： 本发明涉及一种用于筛选化合物或其盐的筛选方法/筛选试剂盒，其改变（a）含有与SEQ ID NO：1所示的氨基酸序列相同或基本相同的氨基酸序列的蛋白质的结合特性。 1或SEQ ID NO：19，其部分肽或其盐，和（b）能够特异性结合蛋白质的配体; 通过筛选获得的化合物或其盐; 包含其化合物或其盐的药物; 含有与SEQ ID NO：19所示的氨基酸序列相同或基本相同的氨基酸序列的蛋白质; 通过本发明的筛选获得的化合物可用作预防/治疗例如神经变性疾病，免疫疾病，水肿，酸消化不良等的试剂。

    Method for screening MCH receptor antagonist/agonist
    3.
    发明授权
    Method for screening MCH receptor antagonist/agonist 失效
    筛选MCH受体拮抗剂/激动剂的方法

    公开(公告)号：US07273710B2

    公开(公告)日：2007-09-25

    申请号：US10332082

    申请日：2001-07-04

    申请人： Masaaki Mori ,  Yukio Shimomura ,  Mioko Harada ,  Tsukasa Sugo ,  Yasushi Shintani

    发明人： Masaaki Mori ,  Yukio Shimomura ,  Mioko Harada ,  Tsukasa Sugo ,  Yasushi Shintani

    IPC分类号： C07K11/02 ,  C07K14/705 ,  G01N33/566

    CPC分类号： G01N33/566 ,  A61K38/00 ,  G01N33/74 ,  G01N2333/726

    摘要： The present invention relates to a screening method for a compound or a salt thereof that alters the binding property of MCH or a salt thereof to SLT or a salt thereof, or a partial peptide thereof, an amide or an ester thereof, or a salt thereof, characterized by using MCH, a derivative or a salt thereof and SLT or a salt thereof, or a partial peptide thereof, an amide or an ester thereof, or a salt thereof. The screening method of the present invention is useful for screening an SLT agonist, which can be used as an agent for promoting appetite (eating), and an SLT antagonist, which can be used as a prophylactic and/or therapeutic agent for obesity.

    摘要翻译： 本发明涉及一种化合物或其盐的筛选方法，其改变MCH或其盐与SLT或其盐或其部分肽，酰胺或其酯或其盐的结合性 其特征在于使用MCH，其衍生物或其盐，SLT或其盐或其部分肽，酰胺或其酯或其盐。 本发明的筛选方法可用于筛选可用作促进食欲的药物（进食）的SLT激动剂和可用作肥胖症的预防和/或治疗剂的SLT拮抗剂。

    Humanin-like peptide and use thereof
    4.
    发明授权
    Humanin-like peptide and use thereof 失效
    人类样肽及其用途

    公开(公告)号：US07053053B2

    公开(公告)日：2006-05-30

    申请号：US10481044

    申请日：2002-06-14

    申请人： Tsukasa Sugo ,  Masaaki Mori

    发明人： Tsukasa Sugo ,  Masaaki Mori

    IPC分类号： A61K38/17 ,  C07K14/47 ,  G01N33/50

    CPC分类号： C07K14/47 ,  A01K2217/05 ,  A61K38/00

    摘要： A novel polypeptide having a cell death inhibitory activity and use thereof is provided. The polypeptide and the polynucleotide encoding it can be used as a diagnostic, therapeutic or prophylactic agent for various diseases and disorders. Certain suitable diseases and disorders which may be diagnosed, treated, or prevented with the polypeptide and the polynucleotide encoding it are selected from neurodegenerative diseases, brain dysfunctions, cancers, immunological disease, infections, gastrointestinal diseases, circulatory diseases, and endocrine diseases. The polypeptide and the polynucleotide encoding it can be used as a cell death inhibitor.

    摘要翻译： 提供了具有细胞死亡抑制活性的新型多肽及其用途。 多肽和编码它的多核苷酸可以用作各种疾病和病症的诊断，治疗或预防剂。 可以用多肽和编码它的多核苷酸诊断，治疗或预防的某些合适的疾病和病症选自神经变性疾病，脑功能障碍，癌症，免疫疾病，感染，胃肠道疾病，循环系统疾病和内分泌疾病。 多肽和编码它的多核苷酸可以用作细胞死亡抑制剂。

    Antiobestic agents methods for screening antiobestic agents and kits comprising same
    5.
    发明授权
    Antiobestic agents methods for screening antiobestic agents and kits comprising same 失效
    用于筛选抗生物剂的抗生物剂方法和包含其的试剂盒

    公开(公告)号：US06991908B1

    公开(公告)日：2006-01-31

    申请号：US09869540

    申请日：1999-12-27

    申请人： Masaaki Mori ,  Yukio Shimomura ,  Shiro Takekawa ,  Tsukasa Sugo ,  Yoshihiro Ishibashi ,  Chieko Kitada ,  Nobuhiro Suzuki

    发明人： Masaaki Mori ,  Yukio Shimomura ,  Shiro Takekawa ,  Tsukasa Sugo ,  Yoshihiro Ishibashi ,  Chieko Kitada ,  Nobuhiro Suzuki

    IPC分类号： G01N33/53

    CPC分类号： C07K7/08 ,  A61K38/10 ,  G01N33/74 ,  G01N2333/575 ,  G01N2333/726 ,  G01N2500/00 ,  G01N2500/02 ,  Y10S436/808

    摘要： The present invention provides a method for screening a compound or its salt that alters the binding property between MCH or its salt and SLC-1 or its salt, characterized by using MCH or its derivative or a salt thereof and SLC-1 or its salt is useful for screening an SLC-1 agonist which can be used not only as an appetite (eating) promoting agent but also as a prophylactic/therapeutic agent for weak pains, atonic bleeding, before and after expulsion, subinvolution of uterus, cesarean section, induced abortion, galactostasis, and the like, and an SLC-1 antagonist which can be used not only as an antiobestic agents (drug), an appetite (eating) modulator, and the like, but also as a prophylactic/therapeutic agent for hyperstimulation, ankylosing uterine contractions, fetal distress, uterine rupture, cervical laceration, preterm delivery, Prader-Wili syndrome and the like.

    摘要翻译： 本发明提供一种筛选化合物或其盐的方法，其改变MCH或其盐与SLC-1或其盐之间的结合性质，其特征在于使用MCH或其衍生物或其盐，SLC-1或其盐是 可用于筛选SLC-1激动剂，其不仅可以用作食欲（进食）促进剂，而且可用作弱疼痛，无症状出血，驱除前后，子宫切除，剖宫产，诱导 流产，半乳糖淀粉酶等，以及不仅可以用作抗生素（药物），食欲调节剂等的SLC-1拮抗剂，而且可以用作过度刺激的预防/治疗剂， 强直性子宫收缩，胎儿窘迫，子宫破裂，子宫颈撕裂，早产，Prader-Wili综合征等。