公开(公告)号：US10377062B2

公开(公告)日：2019-08-13

申请号：US13758872

申请日：2013-02-04

申请人： Transderm, Inc.

发明人： Roger L. Kaspar ,  Tycho Speaker

IPC分类号： A61M37/00 ,  B29C41/02 ,  B29C59/02 ,  B29L1/00 ,  A61B5/00 ,  A61K9/00 ,  B81C1/00 ,  B29C39/42 ,  B29C41/50 ,  B29C39/38 ,  B29L31/00

摘要： The present invention provides for transdermal delivery devices having microneedle arrays, as well as methods for their manufacture and use. In one embodiment, a transdermal delivery device is provided. The transdermal delivery device includes a polymer layer which has microneedles projecting from one of its surfaces. The microneedles are compositionally homogenous with the polymer base layer.

公开(公告)号：US20200330738A1

公开(公告)日：2020-10-22

申请号：US16917809

申请日：2020-06-30

申请人： TransDerm, Inc.

发明人： Roger L. Kaspar ,  Tycho Speaker

IPC分类号： A61M37/00

摘要： The present invention is drawn to a low-cost “meso” device that is able to effectively deliver functional self-delivery siRNA to subject and inhibit expression of a gene in the subject as well as related methods. In particular, a method of transdermally delivering nucleic acid material to a subject is provided. The method includes adapting a motorized meso machine for delivery of nucleic acid material; introducing nucleic acid material into a chamber of the motorized meso machine; and contacting the motorized meso machine to a skin surface of a subject for a period of time sufficient to deliver the nucleic acid material into the skin surface of the subject.

公开(公告)号：US20140243765A1

公开(公告)日：2014-08-28

申请号：US14346031

申请日：2012-09-21

申请人： SAMYANG BIOPHARMACEUTICALS CORPORATION ,  TRANSDERM INC.

发明人： Hyun-Suk Yu ,  Young-Moo Lee ,  Hyun-Woo Kim ,  Hee-Sook Kim

IPC分类号： A61K9/70 ,  A61K31/4535 ,  A61K47/16 ,  A61K47/10 ,  A61K47/14 ,  A61K31/4468 ,  A61K47/22

CPC分类号： A61K9/7038 ,  A61K9/70 ,  A61K9/7061 ,  A61K31/4468 ,  A61K31/4535 ,  A61K47/10 ,  A61K47/14 ,  A61K47/16 ,  A61K47/22

摘要： Disclosed is a transdermal preparation, comprising sequentially-stacked layers of a backing layer, a barrier layer, a drug adhesive layer and a release layer, wherein the drug adhesive layer contains a drug selected from the group consisting of fentanyl, an analogue thereof and a pharmaceutically-acceptable salt thereof, a skin permeation enhancer of the drug, and a polyacrylate adhesive, which shows a high skin permeation with a low drug dosage, equivalent to one with high drug dosage, by increasing the skin permeation rate of drug.

摘要翻译： 公开了一种透皮制剂，其包括背衬层，阻挡层，药物粘合剂层和释放层的顺序层叠的层，其中药物粘合剂层含有选自芬太尼，其类似物和 其药学上可接受的盐，药物的皮肤渗透促进剂和聚丙烯酸酯粘合剂，其通过增加药物的皮肤渗透速率显示出具有相当于药物剂量高的药物用量的低皮肤渗透性。

公开(公告)号：US20220323049A1

公开(公告)日：2022-10-13

申请号：US17731193

申请日：2022-04-27

申请人： Transderm, Inc.

发明人： Roger L. Kaspar ,  Tycho Speaker

IPC分类号： A61B10/00 ,  A61B5/00 ,  G01N33/52

摘要： A moisture-responsive film can include a complexing substrate and an iodine layer applied to the complexing substrate to form the moisture-responsive film. The moisture-responsive film can include a test area formed on a testing surface of the moisture-responsive film.

公开(公告)号：US20170209553A1

公开(公告)日：2017-07-27

申请号：US15331469

申请日：2016-10-21

申请人： Transderm, Inc.

发明人： Roger L. Kaspar ,  Tycho Speaker

IPC分类号： A61K38/48 ,  A61L31/14 ,  A61L31/16 ,  A61K9/00 ,  A61L31/04

CPC分类号： A61K38/4893 ,  A61K9/0014 ,  A61K9/0021 ,  A61K9/0024 ,  A61K47/32 ,  A61K47/36 ,  A61L31/048 ,  A61L31/148 ,  A61L31/16 ,  A61M37/0015 ,  A61M2037/0046 ,  A61M2037/0061 ,  C12Y304/24069

摘要： A therapeutic toxin dosage form for treating a disease, disorder, or condition in a subject can include a microneedle array and a therapeutically effective amount of a therapeutic toxin loaded to the microneedle array for administration to the subject. Additionally, a method of treating a disease, disorder, or condition in a subject can include administering a therapeutically effective amount of a therapeutic toxin to the subject via a microneedle array.

公开(公告)号：US20160256443A1

公开(公告)日：2016-09-08

申请号：US14963137

申请日：2015-12-08

申请人： Transderm, Inc.

发明人： Roger Louis Kaspar ,  Robyn Patricia Hickerson

IPC分类号： A61K31/436 ,  A61K9/00

CPC分类号： A61K31/436 ,  A61K9/0014 ,  A61K9/0019 ,  A61K9/0053 ,  A61K31/4745

摘要： A method of treating or preventing keratin hyperproliferation skin disorders is set forth. The method includes the administration of an mTOR inhibitor to a subject afflicted with the hyperproliferation disorder. The mTOR inhibitor can be administered to the subject via any means known in the art including oral, topical, and transdermal administration.

摘要翻译： 阐述了治疗或预防角蛋白过度增生皮肤病的方法。 该方法包括向受到过度增生病症的受试者施用mTOR抑制剂。 可以通过本领域已知的任何方式将mTOR抑制剂施用于受试者，包括口服，局部和经皮给药。

公开(公告)号：US20160184279A1

公开(公告)日：2016-06-30

申请号：US14965839

申请日：2015-12-10

申请人： Transderm, Inc.

发明人： Roger L. Kaspar ,  Tycho Speaker

IPC分类号： A61K31/436 ,  A61K9/00

CPC分类号： A61K31/436 ,  A61K9/0014 ,  A61K47/10 ,  A61K47/12 ,  A61K47/32 ,  A61K47/44

摘要： Methods of treating pain and/or itch in a targeted region of a subject and compositions and dosage forms therefor are described herein. Such methods can include topically administering a therapeutically effective amount of an mTOR pathway inhibitor to the subject.

摘要翻译： 本文描述了治疗受试者的目标区域中的疼痛和/或瘙痒的方法及其组合物和剂型。 这样的方法可以包括向受试者局部施用治疗有效量的mTOR途径抑制剂。

公开(公告)号：US20210162682A1

公开(公告)日：2021-06-03

申请号：US17111439

申请日：2020-12-03

申请人： TransDerm, Inc.

发明人： Tycho J. SPEAKER ,  Manuel A. FLORES ,  Novejot K. SINGH ,  Abigail L. LAMBRETTI ,  Anna C. Henderson ,  Tyler A. STEWART ,  Andrea S. BURGON

IPC分类号： B29C67/00 ,  C08L29/04 ,  C08L5/00 ,  C08J5/18 ,  A61M37/00 ,  B29C69/00

摘要： Microstructure manufacturing apparatuses and methods are disclosed herein that enable the production of microstructures in an efficient, cost-effective manner that produces precise, high-quality microstructure products. In the manufacturing process for a microneedle array, for example, a template can be contacted against a surface of a continuous layer of a viscous polymer and separated from the surface to form a plurality of projections. The projections can then be solidified and later cut at a predetermined distance from the surface to form the microstructure.

公开(公告)号：US20210000455A1

公开(公告)日：2021-01-07

申请号：US17001610

申请日：2020-08-24

申请人： Transderm, Inc.

发明人： Roger L. Kaspar ,  Tycho Speaker

IPC分类号： A61B10/00 ,  A61B5/00 ,  G01N33/52

摘要： A moisture-responsive film can include a complexing substrate and an iodine layer applied to the complexing substrate to form the moisture-responsive film. The moisture-responsive film can include a test area formed on a testing surface of the moisture-responsive film.

公开(公告)号：US20190337197A1

公开(公告)日：2019-11-07

申请号：US16510815

申请日：2019-07-12

申请人： TransDerm, Inc.

发明人： Roger L. KASPAR ,  Tycho Speaker

IPC分类号： B29C41/02 ,  B81C1/00 ,  A61M37/00 ,  A61B5/00 ,  A61K9/00

摘要： An active agent can be administered transdermally to a patient by using a transdermal patch that has microneedles that are compositionally homogenous with a base layer. The transdermal patch can contain an active agent that can be delivered to a skin surface of a subject when the patch is applied.