公开(公告)号：US10377062B2

公开(公告)日：2019-08-13

申请号：US13758872

申请日：2013-02-04

申请人： Transderm, Inc.

发明人： Roger L. Kaspar ,  Tycho Speaker

IPC分类号： A61M37/00 ,  B29C41/02 ,  B29C59/02 ,  B29L1/00 ,  A61B5/00 ,  A61K9/00 ,  B81C1/00 ,  B29C39/42 ,  B29C41/50 ,  B29C39/38 ,  B29L31/00

摘要： The present invention provides for transdermal delivery devices having microneedle arrays, as well as methods for their manufacture and use. In one embodiment, a transdermal delivery device is provided. The transdermal delivery device includes a polymer layer which has microneedles projecting from one of its surfaces. The microneedles are compositionally homogenous with the polymer base layer.

公开(公告)号：US20200330738A1

公开(公告)日：2020-10-22

申请号：US16917809

申请日：2020-06-30

申请人： TransDerm, Inc.

发明人： Roger L. Kaspar ,  Tycho Speaker

IPC分类号： A61M37/00

摘要： The present invention is drawn to a low-cost “meso” device that is able to effectively deliver functional self-delivery siRNA to subject and inhibit expression of a gene in the subject as well as related methods. In particular, a method of transdermally delivering nucleic acid material to a subject is provided. The method includes adapting a motorized meso machine for delivery of nucleic acid material; introducing nucleic acid material into a chamber of the motorized meso machine; and contacting the motorized meso machine to a skin surface of a subject for a period of time sufficient to deliver the nucleic acid material into the skin surface of the subject.

公开(公告)号：US20220323049A1

公开(公告)日：2022-10-13

申请号：US17731193

申请日：2022-04-27

申请人： Transderm, Inc.

发明人： Roger L. Kaspar ,  Tycho Speaker

IPC分类号： A61B10/00 ,  A61B5/00 ,  G01N33/52

摘要： A moisture-responsive film can include a complexing substrate and an iodine layer applied to the complexing substrate to form the moisture-responsive film. The moisture-responsive film can include a test area formed on a testing surface of the moisture-responsive film.

公开(公告)号：US20170209553A1

公开(公告)日：2017-07-27

申请号：US15331469

申请日：2016-10-21

申请人： Transderm, Inc.

发明人： Roger L. Kaspar ,  Tycho Speaker

IPC分类号： A61K38/48 ,  A61L31/14 ,  A61L31/16 ,  A61K9/00 ,  A61L31/04

CPC分类号： A61K38/4893 ,  A61K9/0014 ,  A61K9/0021 ,  A61K9/0024 ,  A61K47/32 ,  A61K47/36 ,  A61L31/048 ,  A61L31/148 ,  A61L31/16 ,  A61M37/0015 ,  A61M2037/0046 ,  A61M2037/0061 ,  C12Y304/24069

摘要： A therapeutic toxin dosage form for treating a disease, disorder, or condition in a subject can include a microneedle array and a therapeutically effective amount of a therapeutic toxin loaded to the microneedle array for administration to the subject. Additionally, a method of treating a disease, disorder, or condition in a subject can include administering a therapeutically effective amount of a therapeutic toxin to the subject via a microneedle array.

公开(公告)号：US20160184279A1

公开(公告)日：2016-06-30

申请号：US14965839

申请日：2015-12-10

申请人： Transderm, Inc.

发明人： Roger L. Kaspar ,  Tycho Speaker

IPC分类号： A61K31/436 ,  A61K9/00

CPC分类号： A61K31/436 ,  A61K9/0014 ,  A61K47/10 ,  A61K47/12 ,  A61K47/32 ,  A61K47/44

摘要： Methods of treating pain and/or itch in a targeted region of a subject and compositions and dosage forms therefor are described herein. Such methods can include topically administering a therapeutically effective amount of an mTOR pathway inhibitor to the subject.

摘要翻译： 本文描述了治疗受试者的目标区域中的疼痛和/或瘙痒的方法及其组合物和剂型。 这样的方法可以包括向受试者局部施用治疗有效量的mTOR途径抑制剂。

公开(公告)号：US20230263868A1

公开(公告)日：2023-08-24

申请号：US17968740

申请日：2022-10-18

申请人： Transderm, Inc.

发明人： Roger L. Kaspar ,  Tycho Speaker

IPC分类号： A61K38/48 ,  A61K9/00 ,  A61L31/04 ,  A61L31/14 ,  A61L31/16

CPC分类号： A61K38/4893 ,  A61K9/0014 ,  A61L31/048 ,  A61L31/148 ,  A61L31/16 ,  C12Y304/24069 ,  A61K47/36

摘要： A therapeutic toxin dosage form for treating a disease, disorder, or condition in a subject can include a microneedle array and a therapeutically effective amount of a therapeutic toxin loaded to the microneedle array for administration to the subject. Additionally, a method of treating a disease, disorder, or condition in a subject can include administering a therapeutically effective amount of a therapeutic toxin to the subject via a microneedle array.

公开(公告)号：US20210000455A1

公开(公告)日：2021-01-07

申请号：US17001610

申请日：2020-08-24

申请人： Transderm, Inc.

发明人： Roger L. Kaspar ,  Tycho Speaker

IPC分类号： A61B10/00 ,  A61B5/00 ,  G01N33/52

摘要： A moisture-responsive film can include a complexing substrate and an iodine layer applied to the complexing substrate to form the moisture-responsive film. The moisture-responsive film can include a test area formed on a testing surface of the moisture-responsive film.

公开(公告)号：US10751032B2

公开(公告)日：2020-08-25

申请号：US15939207

申请日：2018-03-28

申请人： Transderm, Inc.

发明人： Roger L. Kaspar ,  Tycho Speaker

IPC分类号： A61B10/00 ,  A61B5/00 ,  G01N33/52

摘要： A moisture-responsive film can include a complexing substrate and an iodine layer applied to the complexing substrate to form the moisture-responsive film. The moisture-responsive film can include a test area formed on a testing surface of the moisture-responsive film.

公开(公告)号：US10695548B1

公开(公告)日：2020-06-30

申请号：US15668606

申请日：2017-08-03

申请人： Transderm Inc.

发明人： Roger L. Kaspar ,  Tycho Speaker

IPC分类号： A61M37/00

摘要： The present invention is drawn to a low-cost “meso” device that is able to effectively deliver functional self-delivery siRNA to subject and inhibit expression of a gene in the subject as well as related methods. In particular, a method of transdermally delivering nucleic acid material to a subject is provided. The method includes adapting a motorized meso machine for delivery of nucleic acid material; introducing nucleic acid material into a chamber of the motorized meso machine; and contacting the motorized meso machine to a skin surface of a subject for a period of time sufficient to deliver the nucleic acid material into the skin surface of the subject.

公开(公告)号：US20180345627A1

公开(公告)日：2018-12-06

申请号：US15939207

申请日：2018-03-28

申请人： Transderm, Inc.

发明人： Roger L. Kaspar ,  Tycho Speaker

IPC分类号： B32B9/02 ,  B32B27/30 ,  B32B27/34 ,  B32B27/36 ,  B32B27/40 ,  B32B33/00 ,  G01N33/52 ,  G01N21/81

摘要： A moisture-responsive film can include a complexing substrate and an iodine layer applied to the complexing substrate to form the moisture-responsive film. The moisture-responsive film can include a test area formed on a testing surface of the moisture-responsive film.