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公开(公告)号：US10377062B2
公开(公告)日：2019-08-13
申请号：US13758872
申请日：2013-02-04
申请人： Transderm, Inc.
发明人： Roger L. Kaspar , Tycho Speaker
IPC分类号： A61M37/00 , B29C41/02 , B29C59/02 , B29L1/00 , A61B5/00 , A61K9/00 , B81C1/00 , B29C39/42 , B29C41/50 , B29C39/38 , B29L31/00
摘要： The present invention provides for transdermal delivery devices having microneedle arrays, as well as methods for their manufacture and use. In one embodiment, a transdermal delivery device is provided. The transdermal delivery device includes a polymer layer which has microneedles projecting from one of its surfaces. The microneedles are compositionally homogenous with the polymer base layer.
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公开(公告)号：US20220323049A1
公开(公告)日：2022-10-13
申请号：US17731193
申请日：2022-04-27
申请人： Transderm, Inc.
发明人： Roger L. Kaspar , Tycho Speaker
摘要： A moisture-responsive film can include a complexing substrate and an iodine layer applied to the complexing substrate to form the moisture-responsive film. The moisture-responsive film can include a test area formed on a testing surface of the moisture-responsive film.
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公开(公告)号：US20170209553A1
公开(公告)日：2017-07-27
申请号：US15331469
申请日：2016-10-21
申请人： Transderm, Inc.
发明人： Roger L. Kaspar , Tycho Speaker
CPC分类号： A61K38/4893 , A61K9/0014 , A61K9/0021 , A61K9/0024 , A61K47/32 , A61K47/36 , A61L31/048 , A61L31/148 , A61L31/16 , A61M37/0015 , A61M2037/0046 , A61M2037/0061 , C12Y304/24069
摘要： A therapeutic toxin dosage form for treating a disease, disorder, or condition in a subject can include a microneedle array and a therapeutically effective amount of a therapeutic toxin loaded to the microneedle array for administration to the subject. Additionally, a method of treating a disease, disorder, or condition in a subject can include administering a therapeutically effective amount of a therapeutic toxin to the subject via a microneedle array.
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4.发明申请METHODS OF TREATING PAIN AND/OR ITCH WITH SMALL MOLECULE INHIBITORS TARGETING AN mTOR PATHWAY 审中-公开使用小分子抑制剂治疗疼痛和/或其治疗方法公开(公告)号：US20160184279A1
公开(公告)日：2016-06-30
申请号：US14965839
申请日：2015-12-10
申请人： Transderm, Inc.
发明人： Roger L. Kaspar , Tycho Speaker
IPC分类号： A61K31/436 , A61K9/00
CPC分类号： A61K31/436 , A61K9/0014 , A61K47/10 , A61K47/12 , A61K47/32 , A61K47/44
摘要： Methods of treating pain and/or itch in a targeted region of a subject and compositions and dosage forms therefor are described herein. Such methods can include topically administering a therapeutically effective amount of an mTOR pathway inhibitor to the subject.
摘要翻译： 本文描述了治疗受试者的目标区域中的疼痛和/或瘙痒的方法及其组合物和剂型。 这样的方法可以包括向受试者局部施用治疗有效量的mTOR途径抑制剂。
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公开(公告)号：US20230278266A1
公开(公告)日：2023-09-07
申请号：US17983601
申请日：2022-11-09
申请人： TransDerm, Inc.
发明人： Roger L. KASPAR , Tycho Speaker
CPC分类号： B29C41/02 , A61B5/685 , A61K9/0021 , A61M37/0015 , B81C1/00111 , B29C39/42
摘要： An active agent can be administered transdermally to a patient by using a transdermal patch that has microneedles that are compositionally homogenous with a base layer. The transdermal patch can contain an active agent that can be delivered to a skin surface of a subject when the patch is applied.
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公开(公告)号：US20200330738A1
公开(公告)日：2020-10-22
申请号：US16917809
申请日：2020-06-30
申请人： TransDerm, Inc.
发明人： Roger L. Kaspar , Tycho Speaker
IPC分类号： A61M37/00
摘要： The present invention is drawn to a low-cost “meso” device that is able to effectively deliver functional self-delivery siRNA to subject and inhibit expression of a gene in the subject as well as related methods. In particular, a method of transdermally delivering nucleic acid material to a subject is provided. The method includes adapting a motorized meso machine for delivery of nucleic acid material; introducing nucleic acid material into a chamber of the motorized meso machine; and contacting the motorized meso machine to a skin surface of a subject for a period of time sufficient to deliver the nucleic acid material into the skin surface of the subject.
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公开(公告)号：US20230263868A1
公开(公告)日：2023-08-24
申请号：US17968740
申请日：2022-10-18
申请人： Transderm, Inc.
发明人： Roger L. Kaspar , Tycho Speaker
CPC分类号： A61K38/4893 , A61K9/0014 , A61L31/048 , A61L31/148 , A61L31/16 , C12Y304/24069 , A61K47/36
摘要： A therapeutic toxin dosage form for treating a disease, disorder, or condition in a subject can include a microneedle array and a therapeutically effective amount of a therapeutic toxin loaded to the microneedle array for administration to the subject. Additionally, a method of treating a disease, disorder, or condition in a subject can include administering a therapeutically effective amount of a therapeutic toxin to the subject via a microneedle array.
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公开(公告)号：US20210000455A1
公开(公告)日：2021-01-07
申请号：US17001610
申请日：2020-08-24
申请人： Transderm, Inc.
发明人： Roger L. Kaspar , Tycho Speaker
摘要： A moisture-responsive film can include a complexing substrate and an iodine layer applied to the complexing substrate to form the moisture-responsive film. The moisture-responsive film can include a test area formed on a testing surface of the moisture-responsive film.
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公开(公告)号：US20190337197A1
公开(公告)日：2019-11-07
申请号：US16510815
申请日：2019-07-12
申请人： TransDerm, Inc.
发明人： Roger L. KASPAR , Tycho Speaker
摘要： An active agent can be administered transdermally to a patient by using a transdermal patch that has microneedles that are compositionally homogenous with a base layer. The transdermal patch can contain an active agent that can be delivered to a skin surface of a subject when the patch is applied.
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公开(公告)号：US10751032B2
公开(公告)日：2020-08-25
申请号：US15939207
申请日：2018-03-28
申请人： Transderm, Inc.
发明人： Roger L. Kaspar , Tycho Speaker
摘要： A moisture-responsive film can include a complexing substrate and an iodine layer applied to the complexing substrate to form the moisture-responsive film. The moisture-responsive film can include a test area formed on a testing surface of the moisture-responsive film.
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