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    Method of modulating cell survival and reagents useful for same
    2.
    发明申请
    Method of modulating cell survival and reagents useful for same 有权
    调节细胞存活的方法和对其有用的试剂

    公开(公告)号：US20050090442A1

    公开(公告)日：2005-04-28

    申请号：US10921065

    申请日：2004-08-18

    申请人： Perry Bartlett ,  Elizabeth Coulson ,  Katrina Fieldew ,  Manuel Baca ,  Trevor Kilpatrick ,  Cheema Surindar

    发明人： Perry Bartlett ,  Elizabeth Coulson ,  Katrina Fieldew ,  Manuel Baca ,  Trevor Kilpatrick ,  Cheema Surindar

    IPC分类号： A61K38/00 ,  A61K48/00 ,  C07K14/705 ,  C12N15/12 ,  A61K38/17 ,  C12N5/00

    CPC分类号： C07K14/70571 ,  A61K38/00 ,  A61K48/00

    摘要： The present invention relates generally to a method for modulating cell survival. Modulation of cell survival includes inducing, enhancing or otherwise promoting cell survival such as the survival of neural cells as well as facilitating cell death such as the death of targeted cancer cells. The modulation of cell survival is mediated by a region identified on the p75 neurotrophin receptor (p75NTR) required for death signalling. The present invention further provides genetic molecules which encode the death signalling region of p75NTR which are useful in antagonising death signal function as well as promoting cell death when expressed in targeted cells. The present invention also contemplates recombinant peptides, polypeptides and proteins s well as chemical equivalents, derivatives and homologues thereof which comprise the death signalling portion of p75NTR. Particularly useful molecules of the present invention comprise peptides corresponding to soluble forms of the death signalling portion of p75NTR. These molecules antagonise p75NTR-mediated cell death.

    摘要翻译： 本发明一般涉及调节细胞存活的方法。 细胞存活的调节包括诱导，增强或以其他方式促进细胞存活，例如神经细胞的存活以及促进细胞死亡，例如靶向癌细胞的死亡。 细胞存活的调节由死亡信号传导所需的p75神经营养因子受体（p75 NTR）鉴定的区域介导。 本发明进一步提供编码p75 NTR的死亡信号传导区的遗传分子，其可用于拮抗死亡信号功能以及当在靶细胞中表达时促进细胞死亡。 本发明还考虑重组肽，多肽和蛋白质以及其包含p75 NTR的死亡信号传导部分的化学等同物，衍生物和同系物。 本发明特别有用的分子包含对应于p75 NTR的死亡信号传导部分的可溶形式的肽。 这些分子拮抗p75 NTR介导的细胞死亡。

    Method of modulating cell survival and reagents useful for same
    3.
    发明授权
    Method of modulating cell survival and reagents useful for same 有权
    调节细胞存活的方法和对其有用的试剂

    公开(公告)号：US07919471B2

    公开(公告)日：2011-04-05

    申请号：US10921065

    申请日：2004-08-18

    申请人： Perry Francis Bartlett ,  Elizabeth Jane Coulson ,  Katrina Fieldew ,  Manuel Baca ,  Trevor Kilpatrick ,  Cheema Surindar

    发明人： Perry Francis Bartlett ,  Elizabeth Jane Coulson ,  Katrina Fieldew ,  Manuel Baca ,  Trevor Kilpatrick ,  Cheema Surindar

    IPC分类号： A61K48/00

    CPC分类号： C07K14/70571 ,  A61K38/00 ,  A61K48/00

    摘要： The present invention relates generally to a method for modulating cell survival. Modulation of cell survival includes inducing, enhancing or otherwise promoting cell survival such as the survival of neural cells as well as facilitating cell death such as the death of targeted cancer cells. The modulation of cell survival is mediated by a region identified on the p75 neurotrophin receptor (p75NTR) required for death signalling. The present invention further provides genetic molecules which encode the death signalling region of p75NTR which are useful in antagonising death signal function as well as promoting cell death when expressed in targeted cells. The present invention also contemplates recombinant peptides, polypeptides and proteins s well as chemical equivalents, derivatives and homologues thereof which comprise the death signalling portion of p75NTR. Particularly useful molecules of the present invention comprise peptides corresponding to soluble forms of the death signalling portion of p75NTR. These molecules antagonise p75NTR-mediated cell death.

    摘要翻译： 本发明一般涉及调节细胞存活的方法。 细胞存活的调节包括诱导，增强或以其他方式促进细胞存活，例如神经细胞的存活以及促进细胞死亡，例如靶向癌细胞的死亡。 细胞存活的调节由死亡信号传导所需的p75神经营养因子受体（p75NTR）鉴定的区域介导。 本发明还提供编码p75NTR的死亡信号传导区的遗传分子，其可用于拮抗死亡信号功能以及当在靶细胞中表达时促进细胞死亡。 本发明还考虑重组肽，多肽和蛋白质以及其包含p75NTR的死亡信号传导部分的化学等同物，衍生物和同系物。 本发明特别有用的分子包含对应于p75NTR的死亡信号传导部分的可溶形式的肽。 这些分子拮抗p75NTR介导的细胞死亡。

    Methods for the treatment and prophylaxis of demeyelinating disease
    4.
    发明申请
    Methods for the treatment and prophylaxis of demeyelinating disease 审中-公开
    治疗和预防脱髓鞘疾病的方法

    公开(公告)号：US20070212372A1

    公开(公告)日：2007-09-13

    申请号：US11799862

    申请日：2007-05-03

    申请人： Kylie Shipham ,  Tamara Bucci ,  Helmut Butzkueven ,  Trevor Kilpatrick ,  Perry Bartlett ,  Merja Soilu-Hanninen

    发明人： Kylie Shipham ,  Tamara Bucci ,  Helmut Butzkueven ,  Trevor Kilpatrick ,  Perry Bartlett ,  Merja Soilu-Hanninen

    IPC分类号： A61K39/00

    CPC分类号： C07K14/4703 ,  A61K38/2093

    摘要： The present invention relates to a method for the treatment and/or prophylaxis of a nervous system disease, demyelinating disease and/or an inflammatory disease of either the central or peripheral nervous system such as but not limited to an encephalopathic condition and even more particularly an encephalomyelopathic condition. The present invention further provides the use of leukemia inhibitory factor or derivatives, homologues or analogues thereof in the treatment and/or prophylaxis of a nervous system disease, demyelinating disease and/or an inflammatory disease of either the central or peripheral nervous system. Leukemia inhibitory factor may be used alone or in combination with one or more other therapeutic molecules.

    摘要翻译： 本发明涉及用于治疗和/或预防神经系统疾病，脱髓鞘疾病和/或中枢神经系统或周围神经系统的炎性疾病的方法，例如但不限于脑病，甚至更特别地， 脑炎病情。 本发明还提供了白血病抑制因子或其衍生物，同系物或类似物在治疗和/或预防神经系统疾病，脱髓鞘疾病和/或中枢神经系统或周围神经系统的炎性疾病中的用途。 白血病抑制因子可以单独使用或与一种或多种其它治疗分子组合使用。

    TAM receptors and TAM receptor ligands in detection and modulation of neuropathological disease
    5.
    发明授权
    TAM receptors and TAM receptor ligands in detection and modulation of neuropathological disease 有权
    TAM受体和TAM受体配体在神经病理学疾病的检测和调节中的应用

    公开(公告)号：US09139879B2

    公开(公告)日：2015-09-22

    申请号：US13817131

    申请日：2011-08-19

    申请人： Victoria Mary Perreau ,  Judith Field ,  Michele D Binder ,  Trevor Kilpatrick

    发明人： Victoria Mary Perreau ,  Judith Field ,  Michele D Binder ,  Trevor Kilpatrick

    IPC分类号： A61K39/39 ,  C12Q1/68 ,  G01N33/68 ,  A61K39/395 ,  C07K16/28

    CPC分类号： C12Q1/6883 ,  A61K39/3955 ,  C07K16/2863 ,  C12Q2600/158 ,  G01N33/6896 ,  G01N2333/91215 ,  G01N2800/285 ,  G01N2800/56

    摘要： Methods, compositions and kits based on TAM receptors, or TAM receptor ligands or agonists are for detection of neuropathological diseases or determination of their progression. The neural diseases include multiple sclerosis or other inflammatory neural disorders that are characterized by demyelination, oligodendrocyte cytotoxicity and microglial activation. These methods include screening cells of a subject where identification of an elevation of expression of a TAM receptor or a change in expression of a TAM receptor ligand indicates the presence of the disease presence or progression. In addition, subjects with such neuropathological diseases can be treated by administering TAM receptor ligands (such as GAS 6 or Protein S) or by administering agonists such as antibodies specific for the TAM receptors; Axl, Mer or Tyro3.

    摘要翻译： 基于TAM受体或TAM受体配体或激动剂的方法，组合物和试剂盒用于检测神经病理学疾病或其进展的确定。 神经疾病包括以脱髓鞘，少突胶质细胞毒素和小胶质细胞活化为特征的多发性硬化症或其它炎性神经障碍。 这些方法包括筛选受试者的细胞，其中鉴定TAM受体的表达升高或TAM受体配体的表达变化表明存在疾病存在或进展。 此外，可以通过施用TAM受体配体（例如GAS 6或蛋白S）或通过施用激动剂例如对TAM受体特异的抗体来治疗具有这种神经病理学疾病的受试者; Axl，Mer或Tyro3。

    TAM RECEPTOR LIGANDS, METABOLITES AND PRECURSORS THEREOF IN THE DETECTION AND MODULATION OF INFLAMMATORY NEUROPATHOLOGICAL DISEASE
    6.
    发明申请
    TAM RECEPTOR LIGANDS, METABOLITES AND PRECURSORS THEREOF IN THE DETECTION AND MODULATION OF INFLAMMATORY NEUROPATHOLOGICAL DISEASE 审中-公开
    TAM受体配体，代谢物和前体在炎症性神经病变的检测和调节中的作用

    公开(公告)号：US20140193364A1

    公开(公告)日：2014-07-10

    申请号：US14110685

    申请日：2012-04-04

    申请人： Trevor Kilpatrick ,  Michele Denise Binder ,  Zhi-Ming Gerry Ma

    发明人： Trevor Kilpatrick ,  Michele Denise Binder ,  Zhi-Ming Gerry Ma

    IPC分类号： G01N33/566

    CPC分类号： G01N33/566 ,  A61K38/215 ,  G01N33/6863 ,  G01N33/86 ,  G01N2333/745 ,  G01N2800/28 ,  G01N2800/285 ,  G01N2800/2871 ,  G01N2800/50 ,  G01N2800/52

    摘要： The present disclosure relates to the use of TAM receptor ligands, metabolites, precursor and binding partners thereof in the field of inflammatory neuropathology. This includes the early diagnosis and monitoring of an inflammatory neuropathology as well as screening for medicaments used in the treatment and prophylaxis of such a condition. The method comprises screening blood fluid from a subject for a TAM receptor ligand, or metabolite, or precursor thereof wherein an altered level of the ligand or its metabolite or precursor relative to a control is indicative of the presence of an inflammatory neuropathological disease or condition or a likelihood of developing the same. Diagnostic kits, high throughput screening assays and therapeutic compositions for inflammatory neuropathies are also taught herein.

    摘要翻译： 本公开涉及在炎症性神经病理学领域中使用TAM受体配体，其代谢物，前体和结合配偶体。 这包括早期诊断和监测炎症性神经病理学以及筛选用于治疗和预防这种病症的药物。 该方法包括筛选TAM受体配体或代谢物或其前体的来自受试者的血液，其中配体或其代谢物或前体相对于对照的改变水平指示存在炎症性神经病理学疾病或病症或 发展同样的可能性。 本文还介绍了诊断试剂盒，高通量筛选测定法和炎性神经病变治疗组合物。

    Method of modulating cell survival and reagents useful for same
    7.
    发明授权
    Method of modulating cell survival and reagents useful for same 有权
    调节细胞存活的方法和对其有用的试剂

    公开(公告)号：US08299027B2

    公开(公告)日：2012-10-30

    申请号：US12885194

    申请日：2010-09-17

    申请人： Perry Francis Bartlett ,  Elizabeth Jane Coulson ,  Katrina Fieldew ,  Manuel Baca ,  Trevor Kilpatrick ,  Cheema Surindar

    发明人： Perry Francis Bartlett ,  Elizabeth Jane Coulson ,  Katrina Fieldew ,  Manuel Baca ,  Trevor Kilpatrick ,  Cheema Surindar

    IPC分类号： A61K38/18

    CPC分类号： C07K14/70571 ,  A61K38/00 ,  A61K48/00

    摘要： The present invention relates generally to a method for modulating cell survival. Modulation of cell survival includes inducing, enhancing or otherwise promoting cell survival such as the survival of neural cells as well as facilitating cell death such as the death of targeted cancer cells. The modulation of cell survival is mediated by a region identified on the p75 neurotrophin receptor (p75NTR) required for death signalling. The present invention further provides genetic molecules which encode the death signalling region of p75NTR which are useful in antagonising death signal function as well as promoting cell death when expressed in targeted cells. The present invention also contemplates recombinant peptides, polypeptides and proteins as well as chemical equivalents, derivatives and homologues thereof which comprise the death signalling portion of p75NTR. Particularly useful molecules of the present invention comprise peptides corresponding to soluble forms of the death signalling portion of p75NTR. These molecules antagonise p75NTR-mediated cell death.

    摘要翻译： 本发明一般涉及调节细胞存活的方法。 细胞存活的调节包括诱导，增强或以其他方式促进细胞存活，例如神经细胞的存活以及促进细胞死亡，例如靶向癌细胞的死亡。 细胞存活的调节由死亡信号传导所需的p75神经营养因子受体（p75NTR）鉴定的区域介导。 本发明还提供编码p75NTR的死亡信号传导区的遗传分子，其可用于拮抗死亡信号功能以及当在靶细胞中表达时促进细胞死亡。 本发明还考虑了重组肽，多肽和蛋白质以及其包含p75NTR的死亡信号传导部分的化学等同物，衍生物和同系物。 本发明特别有用的分子包含对应于p75NTR的死亡信号传导部分的可溶形式的肽。 这些分子拮抗p75NTR介导的细胞死亡。

    METHOD OF MODULATING CELL SURVIVAL AND REAGENTS USEFUL FOR SAME
    8.
    发明申请
    METHOD OF MODULATING CELL SURVIVAL AND REAGENTS USEFUL FOR SAME 有权
    调节细胞存活的方法和有用的试剂

    公开(公告)号：US20110172143A1

    公开(公告)日：2011-07-14

    申请号：US12885194

    申请日：2010-09-17

    申请人： Perry Francis Bartlett ,  Elizabeth Jane Coulson ,  Katrina Fieldew ,  Manuel Baca ,  Trevor Kilpatrick ,  Cheema Surindar

    发明人： Perry Francis Bartlett ,  Elizabeth Jane Coulson ,  Katrina Fieldew ,  Manuel Baca ,  Trevor Kilpatrick ,  Cheema Surindar

    IPC分类号： A61K38/00 ,  A61K38/16 ,  A61P25/28 ,  A61P25/00 ,  A61P25/02 ,  A61P13/12 ,  A61P31/22 ,  A61P25/16 ,  A61P35/00 ,  A61P31/12 ,  A61P31/18

    CPC分类号： C07K14/70571 ,  A61K38/00 ,  A61K48/00

    摘要： The present invention relates generally to a method for modulating cell survival. Modulation of cell survival includes inducing, enhancing or otherwise promoting cell survival such as the survival of neural cells as well as facilitating cell death such as the death of targeted cancer cells. The modulation of cell survival is mediated by a region identified on the p75 neurotrophin receptor (p75NTR) required for death signalling. The present invention further provides genetic molecules which encode the death signalling region of p75NTR which are useful in antagonising death signal function as well as promoting cell death when expressed in targeted cells. The present invention also contemplates recombinant peptides, polypeptides and proteins as well as chemical equivalents, derivatives and homologues thereof which comprise the death signalling portion of p75NTR. Particularly useful molecules of the present invention comprise peptides corresponding to soluble forms of the death signalling portion of p75NTR. These molecules antagonise p75NTR-mediated cell death.

    摘要翻译： 本发明一般涉及调节细胞存活的方法。 细胞存活的调节包括诱导，增强或以其他方式促进细胞存活，例如神经细胞的存活以及促进细胞死亡，例如靶向癌细胞的死亡。 细胞存活的调节由死亡信号传导所需的p75神经营养因子受体（p75NTR）鉴定的区域介导。 本发明还提供编码p75NTR的死亡信号传导区的遗传分子，其可用于拮抗死亡信号功能以及当在靶细胞中表达时促进细胞死亡。 本发明还考虑了重组肽，多肽和蛋白质以及其包含p75NTR的死亡信号传导部分的化学等同物，衍生物和同系物。 本发明特别有用的分子包含对应于p75NTR的死亡信号传导部分的可溶形式的肽。 这些分子拮抗p75NTR介导的细胞死亡。