公开(公告)号：US5973000A

公开(公告)日：1999-10-26

申请号：US867823

申请日：1997-06-03

申请人： Tsunao Magara ,  Yoshiharu Tsuji ,  Chika Hamada ,  Yosuke Nakazawa ,  Eriko Takeoka ,  Masahiro Tajima ,  Masazumi Watanabe

发明人： Tsunao Magara ,  Yoshiharu Tsuji ,  Chika Hamada ,  Yosuke Nakazawa ,  Eriko Takeoka ,  Masahiro Tajima ,  Masazumi Watanabe

IPC分类号： A61K8/42 ,  A61Q7/00 ,  A61K31/27

CPC分类号： A61Q7/00 ,  A61K8/42 ,  A61Q5/006 ,  A61Q5/02 ,  Y10S514/88

摘要： The invention relates to a hair revitalizing tonic composition containing, as an active ingredient, at least one lipid derivative of the general formula ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4 and Y are as defined in the specification, and a and b are 0 or 1, as well as its use. Thus, there is provided a hair revitalizing tonic composition having an excellent hair loss prevention and hair revitalizing effect and, moreover, an excellent dandruff and itchy scalp prevention effect.

摘要翻译： 本发明涉及含有作为活性成分的至少一种通式如下的脂质衍生物的头发活力补品组合物，其中R1，R2，R3，R4和Y如说明书中所定义，a和b为0或1 ，以及其使用。 因此，提供了具有优异的脱发预防和头发复兴效果的头发复兴滋补组合物，此外，还具有优异的头皮屑和瘙痒的头皮防止效果。

公开(公告)号：US06177067B1

公开(公告)日：2001-01-23

申请号：US09169940

申请日：1998-10-13

申请人： Tsunao Magara ,  Yoshiharu Tsuji ,  Masahiro Tajima ,  Koji Kobayashi ,  Hirotada Fukunishi ,  Masazumi Watanabe

发明人： Tsunao Magara ,  Yoshiharu Tsuji ,  Masahiro Tajima ,  Koji Kobayashi ,  Hirotada Fukunishi ,  Masazumi Watanabe

IPC分类号： A61K706

CPC分类号： A61K8/44 ,  A61K8/49 ,  A61K8/4926 ,  A61K8/494 ,  A61Q5/00 ,  A61Q5/006 ,  A61Q5/02 ,  A61Q7/00 ,  Y10S514/88

摘要： Disclosed is a hair revitalizing tonic composition containing a dimethylpropanediol derivative of the formula: wherein R1 and R2 are each independently a C1-30 hydrocarbon group which may be substituted, or a five- or six-membered heterocyclic group which contains 1 to 4 heteroatoms selected from oxygen, sulfur and nitrogen atoms and which may be substituted, R3 is hydrogen atom, an alkyl group which may be substituted, an acyl group, an alkoxycarbonyl group, a phenoxycarbonyl group, or a carbamoyl group which may be substituted, and a and b are each 0 or 1, as well as a method for effecting hair growth promotion, hair growth stimulation, or hair loss prevention in mammals by using such a hair revitalizing tonic composition. Also disclosed is the use of a compound of formula (I) in the preparation of a hair revitalizing tonic composition. Thus, this invention can provide an excellent means of hair revitalization or hair loss prevention in mammals.

摘要翻译： 本发明公开了一种含有下式的二甲基丙二醇衍生物的头发活力补品组合物：其中R 1和R 2各自独立地为可被取代的C 1-30烃基或选自含有1至4个杂原子的五元或六元杂环基 可以被氧，硫和氮原子取代，可以被取代，R3是氢原子，可被取代的烷基，酰基，烷氧基羰基，苯氧基羰基或可被取代的氨基甲酰基，以及 b各自为0或1，以及通过使用这种头发活化的滋补组合物来实现哺乳动物的头发生长促进，毛发生长刺激或脱发防止的方法。 还公开了式（I）化合物在制备头发活化滋补组合物中的用途。 因此，本发明可以提供哺乳动物的头发复兴或脱发预防的优良手段。

公开(公告)号：US06174885B1

公开(公告)日：2001-01-16

申请号：US09257940

申请日：1999-02-26

申请人： Hirotada Fukunishi ,  Tsunao Magara ,  Koji Kobayashi

发明人： Hirotada Fukunishi ,  Tsunao Magara ,  Koji Kobayashi

IPC分类号： A61K31535

CPC分类号： C07D295/205 ,  A61K8/44 ,  A61Q7/00 ,  C07C271/20 ,  C07C2601/16 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D295/13

摘要： A [6-(substituted-methyl)-3-cyclohexenyl]formamide derivative or a salt thereof expressed by the following Formula (I): wherein one of A and B is a hydrocarbon group of C10-30 expressed by R1 and the other is—(CH2)n-NR2R3; Z is —O—, —OCO—, —OCONR6— or —NR6—; R2 and R3 individually represent a hydrogen, lower alkyl, phenyl or benzyl group, or together represent a heterocycle having 3-7 members; —NR5—(CH2)n-NR2R3 or —NR6—(CH2)n-NR2R3 may be Group W, and —OCONR6—(CH2)n-NR2R3 may be —OCO—W, wherein W is a formula of: wherein ring E is a heterocycle of 6 or 7 members including two nitrogen atoms and R2 is a hydrogen, lower alkyl, phenyl or benzyl group; R4 is a halogen, lower alkyl, lower acyl, nitro, cyano, lower alkoxycarbonyl, carbamoyl, lower alkylcarbamoyl, lower alkylamino, lower acylamino, lower alkoxy or lower acyloxy group; each of R5 and R6 is a hydrogen, lower alkyl, lower acyl, lower alkylcarbamoyl group, or a part of said Group W; m is an integer of 0-2; and n is an integer of 0-5. The [6-(substituted-methyl)-3-cyclohexenyl]formamide derivative or the salt thereof has excellent hair growth and regrowth promoting effects, which are useful for care, improvement or prevention of hair loss in mammals and, in particular, in human.

摘要翻译： 由下式（I）表示的[6-（取代甲基）-3-环己烯基]甲酰胺衍生物或其盐：其中A和B中的一个是由R 1表示的C 10-30的烃基，另一个是 - （CH 2）n -NR 2 R 3; Z是-O - ， - OCO - ， - OCONR 6 - 或-NR 6 - ; R2和R3各自表示氢，低级烷基，苯基或苄基，或一起表示具有3-7个成员的杂环; -NR 5 - （CH 2）n -NR 2 R 3或-NR 6 - （CH 2）n -NR 2 R 3可以是W组，-OCONR 6 - （CH 2）n -NR 2 R 3可以是-OCO-W，其中W是下式的化合物：其中环 E是6或7个成员的杂环，包括两个氮原子，R 2是氢，低级烷基，苯基或苄基; R4是卤素，低级烷基，低级酰基，硝基，氰基，低级烷氧基羰基，氨基甲酰基，低级烷基氨基甲酰基，低级烷基氨基，低级酰基氨基，低级烷氧基或低级酰氧基。 R5和R6各自为氢，低级烷基，低级酰基，低级烷基氨基甲酰基或所述W组的一部分; m是0-2的整数; n为0-5的整数。 [6-（取代甲基）-3-环己烯基]甲酰胺衍生物或其盐具有优异的毛发生长和再生长促进作用，其可用于哺乳动物，特别是人的护理，改善或预防脱发 。

公开(公告)号：US5972929A

公开(公告)日：1999-10-26

申请号：US137148

申请日：1998-08-20

申请人： Koji Kobayashi ,  Hirotada Fukunishi ,  Tsunao Magara

发明人： Koji Kobayashi ,  Hirotada Fukunishi ,  Tsunao Magara

IPC分类号： A61K8/49 ,  A61Q7/00 ,  C07D239/90 ,  A61K31/495

CPC分类号： C07D239/90 ,  A61K8/4953 ,  A61Q7/00

摘要： A quinazolinone derivative or a salt thereof expressed by the following Formula (I); ##STR1## wherein each of A and B is R.sup.1 or --(CH.sub.2).sub.n -NR.sup.2 R.sup.3 ; wherein R.sup.1 represents a hydrocarbon group of C.sub.10-30 ; wherein R.sup.2 and R.sup.3 individually represent a hydrogen atom, a lower alkyl group, a phenyl group, or a benzyl group, or together represent a heterocyclic ring having 3-7 members; and n represents an integer of 1-5; wherein when A is R.sup.1, B is --(CH.sub.2).sub.n -NR.sup.2 R.sup.3 and when A is --(CH.sub.2).sub.n -NR.sup.2 R.sup.3, B is R.sup.1 ; and wherein R.sup.4 is selected from the group consisting of a hydrogen atom, a halogen atom, a lower alkyl group, a lower acyl group, a nitro group, a cyano group, an amino group, a lower alkoxycarbonyl group, a lower alkylamino group, a lower alkoxy group, a lower acyloxy group, a carbamoyl group, a lower alkylcarbamoyl group, and a lower acylamino group. The quinazolinone derivative or the salt thereof has excellent hair growth and regrowth promoting effects, which are useful for care, improvement or prevention of hair loss in mammals and, in particular, in humans.

摘要翻译： 由下式（I）表示的喹唑啉酮衍生物或其盐; 其中A和B各自为R 1或 - （CH 2）n -NR 2 R 3; 其中R1表示C10-30的烃基; 其中R2和R3各自表示氢原子，低级烷基，苯基或苄基，或一起表示具有3-7个成员的杂环; n表示1-5的整数， 其中当A为R1时，B为 - （CH2）n-NR2R3，当A为 - （CH2）n-NR2R3时，B为R1; 并且其中R 4选自氢原子，卤素原子，低级烷基，低级酰基，硝基，氰基，氨基，低级烷氧基羰基，低级烷基氨基， 低级烷氧基，低级酰氧基，氨基甲酰基，低级烷基氨基甲酰基和低级酰氨基。 喹唑啉酮衍生物或其盐具有优异的毛发生长和再生长促进作用，其可用于哺乳动物，特别是人类的护发，改善或预防脱发。

公开(公告)号：US4666929A

公开(公告)日：1987-05-19

申请号：US847783

申请日：1986-04-03

申请人： Yoshihisa Sato ,  Tetsuji Hirao ,  Tsunao Magara ,  Kohya Shiratori

发明人： Yoshihisa Sato ,  Tetsuji Hirao ,  Tsunao Magara ,  Kohya Shiratori

IPC分类号： C07D213/30 ,  C07D307/42 ,  C07D213/55 ,  A61K31/34 ,  A61K31/44 ,  C07D307/54

CPC分类号： C07D213/30 ,  C07D307/42

摘要： Anthranilic acid ester derivatives having the general formula (I): ##STR1## wherein R represents as alkyl group having 1 to 3 carbon atoms substituted with a pyridyl group or a furanmethyl group. These anthranilic acid ester derivatives have a remarkable antiinflammatory and analygetic effect and a high endermic permeability and, therefore, is suitable for use as an antiinflammatory and analgetic agent.

摘要翻译： 具有通式（I）的邻氨基苯甲酸酯衍生物：其中R表示作为被吡啶基或呋喃甲基取代的具有1至3个碳原子的烷基。 这些邻氨基苯甲酸酯衍生物具有显着的抗炎和分析效果和高的皮肤渗透性，因此适合用作抗炎和止痛剂。