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1.发明申请公开(公告)号：US20170327572A1
公开(公告)日：2017-11-16
申请号：US15525799
申请日：2015-11-23
申请人： INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) , INSTITUT PASTEUR DE LILLE , UNIVERSITE DE LILLE 1 SCIENCES ET TECHNOLOGIES , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , UNIVERSITE DE DROIT ET DE LA SANTE DE LILLE 2
CPC分类号： C07K16/244 , A61K39/00 , A61K2039/505 , C07K16/2866 , C07K16/2887 , C07K2317/76
摘要： The present invention relates to methods and pharmaceutical compositions for the treatment of acute exacerbation of chronic obstructive pulmonary disease. In particular, the present invention relates to a method of treating acute exacerbation of chronic obstructive pulmonary disease in a subject in need thereof comprising administering the subject with a therapeutically effective amount of an antagonist of IL-20 cytokines.
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公开(公告)号：US20180186939A1
公开(公告)日：2018-07-05
申请号：US15740414
申请日：2016-07-01
申请人： UNIVERSITE DE LILLE 1, SCIENCES ET TECHNOLOGIES , UNIVERSITE LILLE 2 DROIT ET SANTE , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE , CENTRE HOSPITALIER REGIONAL UNIVERSITAIRE DE LILLE
发明人： Nicolas BLANCHEMAIN , Bernard MARTEL , Claudia FLORES , Frédéric CAZAUX , Feng CHAI , Nicolas TABARY , Marco LOPEZ HEREDIA
CPC分类号： C08J3/075 , A61L26/008 , A61L27/52 , A61M3/005 , B01J13/0056 , B01J13/0069 , C08J3/05 , C08J9/0066 , C08J9/28 , C08J2205/022 , C08J2305/08 , C08J2305/16 , C08J2405/08 , C08J2405/16
摘要： The present invention concerns a method for producing a hydrogel comprising the following steps in succession: a first step (i) of providing at least one powder of an anionic polymer (A) and at least one chitosan powder (B) comprising amine functions (—NH2); a second step (ii) consisting in dry mixing at least the powders (A) and (B) from the first step in order to form a mixture of powders; a third step (iii) of suspending the mixture of powders obtained from the second step in an aqueous medium having a pH that can enable the anionic polymer (A) to be dissolved without dissolving the chitosan (B); a fourth step (iv) of adding an acid to the suspension obtained from the third step in order to form the hydrogel; or the third (iii) and fourth (iv) steps are replaced by a mixing fifth step (v), comprising mixing an acidified aqueous medium including at least one compound (C) comprising at least one unit of a hexose or a unit derived from a hexose, and/or at least one phosphate of said compound (C), with said mixture comprising at least the powders (A) and (B) obtained from the second step (ii).
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3.发明申请公开(公告)号：US20190330330A1
公开(公告)日：2019-10-31
申请号：US16507126
申请日：2019-07-10
申请人： INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) , INSTITUT PASTEUR DE LILLE , UNIVERSITE DE LILLE 1 SCIENCES ET TECHNOLOGIES , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , UNIVERSITE DE DROIT ET DE LA SANTE DE LILLE 2
摘要： The present invention relates to methods and pharmaceutical compositions for the treatment of acute exacerbation of chronic obstructive pulmonary disease. In particular, the present invention relates to a method of treating acme exacerbation of chronic obstructive pulmonary disease in a subject in need thereof comprising administering the subject with a therapeutically effective amount of an antagonist of IL-20 cytokines.
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公开(公告)号：US09919029B2
公开(公告)日：2018-03-20
申请号：US14906747
申请日：2014-07-25
申请人： INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) , UNIVERSITE DE DROIT ET DE LA SANTE DE LILLE 2 , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , INSTITUT PASTEUR DE LILLE , UNIVERSITE DE LILLE 1 SCIENCES ET TECHNOLOGIES , ETH ZURICH , UNIVERSIDAD DE LA REPUBLICA
发明人： Wolf-Dietrich Hardt , Patrick Kaiser , Jean-Claude Sirard , Christophe Carnoy , Delphine Fougeron , Jose Alejandro Chabalgoity , Natalia Munoz
IPC分类号： A61K38/16 , A61K31/505 , A61K31/42 , A61K31/43 , A61K45/06 , A61K31/635
CPC分类号： A61K38/164 , A61K31/42 , A61K31/43 , A61K31/505 , A61K31/635 , A61K45/06 , Y02A50/402 , Y02A50/475 , Y02A50/481 , A61K2300/00
摘要： The present invention relates to methods and pharmaceutical compositions for the treatment of bacterial infections. In particular, the present invention relates to a Toll-like receptor (TLR) agonist for use in a method for the treatment of a bacterial infection in a subject in need thereof wherein the TLR agonist is administered to the subject in combination with at least one antibiotic.
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