公开(公告)号：US20090261822A1

公开(公告)日：2009-10-22

申请号：US11918853

申请日：2006-03-25

申请人： Stephan Appelt ,  Wolfgang Haesing ,  Ulrich Sieling ,  Holger Kuehn

发明人： Stephan Appelt ,  Wolfgang Haesing ,  Ulrich Sieling ,  Holger Kuehn

IPC分类号： G01R33/26

CPC分类号： G01R33/282

摘要： The invention concerns a method for hyperpolarizing lithium atoms in a mixture by optically pumping, in a sampling cell, atoms of a first type or alkali metal and by spin exchange between the optically pumped electron of the alkali metal and the lithium atom electron. The lithium atoms are preferably oxidized into Li+ ions and accumulated. The nuclear spin polarization of the Li+ ions can be transmitted to a nuclear spin of an anion. The invention also concerns a method for producing substances with nuclear spin polarization in general. In accordance with said method, lithium atoms are optically pumped from atoms of a first type of alkali metal in a sampling cell and hyperpolarized by spin exchange between the optical pumped electron of the alkali metal and the lithium atom electron, the lithium atoms being then oxidized into Li+ ions. Then, the nuclear spin polarization of the Li+ ions is transmitted to another nucleus of an anion. Thus it is possible to obtain hyperpolarized nuclei such as, for example, 13C, 31P or 29Si in solid or liquid phase, in large amounts and at high polarizing levels.

摘要翻译： 本发明涉及一种通过在采样单元中光学泵浦第一类型或碱金属原子并通过碱性金属的光泵浦电子与锂原子电子之间的自旋交换来超极化混合物中的锂原子的方法。 锂原子优选被氧化成Li +离子并累积。 Li +离子的核自旋极化可以传递到阴离子的核自旋。 本发明还涉及通常产生具有核自旋极化的物质的方法。 根据所述方法，锂原子在取样室中从第一种碱金属的原子被光泵浦，并通过碱金属的光泵浦电子与锂原子电子之间的自旋交换进行超极化，然后锂原子被氧化 进入Li +离子。 然后，Li +离子的核自旋极化被传递到阴离子的另一个核。 因此，可以在固相或液相中以大量和高极化水平获得超极化核，例如13C，31P或29Si。

公开(公告)号：US20070229072A1

公开(公告)日：2007-10-04

申请号：US11571372

申请日：2005-06-01

申请人： Stephan Appelt ,  Daniel Gembris ,  Horst Halling ,  Richard Patzak ,  Friedrich-Wolfgang Haesing ,  Ulrich Sieling

发明人： Stephan Appelt ,  Daniel Gembris ,  Horst Halling ,  Richard Patzak ,  Friedrich-Wolfgang Haesing ,  Ulrich Sieling

IPC分类号： G01V3/14

CPC分类号： G01R33/46 ,  G01N24/08 ,  G01R33/24

摘要： The present invention relates to a method as well as a device for analyzing a sample, in particular by MR spectroscopy in weak magnetic fields. The method according to the invention for analyzing a sample provides that a hyperpolarized medium is added to a sample and that the chemical shift is determined. The hyperpolarization causes a greater extent of alignment of the nuclei, thus improving the signal-to-noise-ratio in the measurement of the chemical shift. Thus, the sample is exposed to an alternating electromagnetic field and a static magnetic field B0, and the nuclear magnetic resonance is measured. Due to the hyperpolarization, comparatively weak static magnetic fields suffice for determining the chemical shift. Weak magnetic fields within the sense of the invention are fields having a strength of less than 200 G. For example, they are very weak fields in the range of under B0=0.001, T=10 G. The advantage of the determination of the chemical shift in weak fields is that appropriate devices can be manufactured and maintained at comparatively low cost.

摘要翻译： 本发明涉及一种方法以及特别是通过弱磁场中的MR光谱分析样品的装置。 根据本发明的用于分析样品的方法提供了将超极化介质添加到样品中并确定化学位移。 超极化导致核的更大程度的对准，从而提高化学位移测量中的信噪比。 因此，样品暴露于交变电磁场和静磁场B 0 0，并且测量核磁共振。 由于超极化，相对较弱的静磁场足以确定化学位移。 在本发明意义上的弱磁场是具有小于200G的强度的场。例如，它们是在B 0 0 = 0.001，T = 10G的范围内的非常弱的磁场。 确定弱磁场中的化学位移的优点是可以以相对较低的成本制造和维持适当的装置。

公开(公告)号：US20070080684A1

公开(公告)日：2007-04-12

申请号：US10586000

申请日：2005-01-13

申请人： Stephan Appelt ,  Friedrich Hasing ,  Giovanni D'Orsaneo ,  Ulrich Sieling

发明人： Stephan Appelt ,  Friedrich Hasing ,  Giovanni D'Orsaneo ,  Ulrich Sieling

IPC分类号： G01V3/00 ,  A61B5/055

CPC分类号： G01R33/282 ,  A61K49/1815

摘要： The invention relates to a method for the hyperpolarisation of atomic nuclei by means of optical pumps in a sample cell. Polarisation of an electron spin of an optically pumpable species, which is produced by means of laser light, is transferred to the nucleus spin of an atom which is to be hyperpolarisied. According to the invention, components of the mixture and/or other inert compounds for hyperpolarisation are guided in the sample cell such that the mixture does not come into contact with the inner wall of the sample cell, or does to a small degree. A device for carrying out said method comprises at least one means which guides the components of the mixture of non-optical pumpable species and nuclei which are to be hyperpolarisied, and/or other inert compounds for hyperpolarisation, into the sample cell (5) such that the mixture does not come into contact with the inner wall of the sample cell (5), or does to small degree. As a result, the wall can be prevented from sagging.

摘要翻译： 本发明涉及通过样品池中的光泵对原子核进行超极化的方法。 通过激光产生的可光泵浦物质的电子自旋的极化被转移到要超极化的原子的核心旋转。 根据本发明，用于超极化的混合物和/或其它惰性化合物的组分在样品池中引导，使得混合物不与样品池的内壁接触，或者在很小程度上。 用于执行所述方法的装置包括至少一个装置，其将非光可泵送物质的混合物的组分和要超极化的核的组分和/或用于超极化的其它惰性化合物引导到样品池（5）中， 混合物不与样品池（5）的内壁接触，或者具有很小的程度。 结果，可以防止墙下垂。

公开(公告)号：US07541806B2

公开(公告)日：2009-06-02

申请号：US11681331

申请日：2007-03-02

申请人： Stephan Appelt ,  Holger Kuhn ,  Ulrich Sieling ,  Friedrich-Wolfgang Hasing

发明人： Stephan Appelt ,  Holger Kuhn ,  Ulrich Sieling ,  Friedrich-Wolfgang Hasing

IPC分类号： G01V3/00

CPC分类号： G01R33/4608 ,  G01N24/087 ,  G01R33/383 ,  G01R33/445 ,  G01R33/4633 ,  G01R33/465 ,  G01R33/5605

摘要： The invention relates to a method and a device for examining molecules by means of NMR spectroscopy. It is the object of the invention to be able to characterize a sample with a high resolution and comprehensively. The object is solved by a method and an associated device for examining a sample by means of nuclear magnetic spectroscopy by measuring heteronuclear and homonuclear J-couplings in a small magnetic field and by using the measured heteronuclear and homonuclear J-couplings for characterizing the sample.

摘要翻译： 本发明涉及通过NMR光谱检测分子的方法和装置。 本发明的目的是能够以高分辨率和全面地表征样品。 该目的通过一种方法和相关设备来解决，用于通过在小磁场中测量异核和同核J耦合并通过使用测量的异核和同核J耦合来表征样品，通过核磁谱检查样品。

公开(公告)号：US07495435B2

公开(公告)日：2009-02-24

申请号：US10586000

申请日：2005-01-13

申请人： Stephan Appelt ,  Friedrich Wolfgang Häsing ,  Giovanni D'Orsaneo ,  Ulrich Sieling

发明人： Stephan Appelt ,  Friedrich Wolfgang Häsing ,  Giovanni D'Orsaneo ,  Ulrich Sieling

IPC分类号： G01V3/00

CPC分类号： G01R33/282 ,  A61K49/1815

摘要： An apparatus for hyperpolarizing atomic nuclei through optical pumping has a cylindrical optical pumping cell having an inlet and an outlet spaced therefrom. A supply of a mixture of optically pumpable species and hyperpolarizable nuclei is connected to the inlet of the cell. A nozzle at an inlet of the optical pumping cell forms and injects a jet flow of the mixture into the optical pumping cell. It is then drawn out through the outlet such that the mixture touches the inner walls of the optical pumping cell only adjacent the outlet.

摘要翻译： 通过光泵浦使原子核超极化的装置具有圆柱形的光泵浦单元，其具有与其间隔开的入口和出口。 供应光泵浦物质和超极化核的混合物连接到电池入口。 在光泵浦单元的入口处的喷嘴形成并将混合物的喷射流注入到光泵浦单元中。 然后通过出口将其抽出，使得混合物仅在出口附近接触光泵浦单元的内壁。

公开(公告)号：US20070296412A1

公开(公告)日：2007-12-27

申请号：US11681331

申请日：2007-03-02

申请人： Stephan Appelt ,  Holger Kuhn ,  Ulrich Sieling ,  Friedrich-Wolfgang Hasing

发明人： Stephan Appelt ,  Holger Kuhn ,  Ulrich Sieling ,  Friedrich-Wolfgang Hasing

IPC分类号： G01V3/14

CPC分类号： G01R33/4608 ,  G01N24/087 ,  G01R33/383 ,  G01R33/445 ,  G01R33/4633 ,  G01R33/465 ,  G01R33/5605

摘要： The invention relates to a method and a device for examining molecules by means of NMR spectroscopy. It is the object of the invention to be able to characterize a sample with a high resolution and comprehensively. The object is solved by a method and an associated device for examining a sample by means of nuclear magnetic spectroscopy by measuring heteronuclear and homonuclear J-couplings in a small magnetic field and by using the measured heteronuclear and homonuclear J-couplings for characterizing the sample.

摘要翻译： 本发明涉及通过NMR光谱检测分子的方法和装置。 本发明的目的是能够以高分辨率和全面地表征样品。 该目的通过一种方法和相关设备来解决，用于通过在小磁场中测量异核和同核J耦合并通过使用测量的异核和同核J耦合来表征样品，通过核磁谱检查样品。

公开(公告)号：US08248068B2

公开(公告)日：2012-08-21

申请号：US11918853

申请日：2006-03-25

申请人： Stephan Appelt ,  Wolfgang Häsing ,  Ulrich Sieling ,  Holger Kühn

发明人： Stephan Appelt ,  Wolfgang Häsing ,  Ulrich Sieling ,  Holger Kühn

IPC分类号： G01V3/00

CPC分类号： G01R33/282

摘要： The invention concerns a method for hyperpolarizing lithium atoms in a mixture by optically pumping, in a sampling cell, atoms of a first type or alkali metal and by spin exchange between the optically pumped electron of the alkali metal and the lithium atom electron. The lithium atoms are preferably oxidized into Li+ ions and accumulated. The nuclear spin polarization of the Li+ ions can be transmitted to a nuclear spin of an anion. The invention also concerns a method for producing substances with nuclear spin polarization in general. In accordance with said method, lithium atoms are optically pumped from atoms of a first type of alkali metal in a sampling cell and hyperpolarized by spin exchange between the optical pumped electron of the alkali metal and the lithium atom electron, the lithium atoms being then oxidized into Li+ ions. Then, the nuclear spin polarization of the Li+ ions is transmitted to another nucleus of an anion. Thus it is possible to obtain hyperpolarized nuclei such as, for example, 13C, 31P or 29Si in solid or liquid phase, in large amounts and at high polarizing levels.

摘要翻译： 本发明涉及一种通过在采样单元中光学泵浦第一类型或碱金属原子并通过碱性金属的光泵浦电子与锂原子电子之间的自旋交换来超极化混合物中的锂原子的方法。 锂原子优选被氧化成Li +离子并累积。 Li +离子的核自旋极化可以传递到阴离子的核自旋。 本发明还涉及通常产生具有核自旋极化的物质的方法。 根据所述方法，锂原子在取样室中从第一种碱金属的原子被光泵浦，并通过碱金属的光泵浦电子与锂原子电子之间的自旋交换进行超极化，然后锂原子被氧化 进入Li +离子。 然后，Li +离子的核自旋极化被传递到阴离子的另一个核。 因此，可以在固相或液相中以大量和高极化水平获得超极化核，例如13C，31P或29Si。