-
1.发明授权Amide-substituted 8-N-benzimidazoles, method for the production thereof, and use of the same as medicaments 有权酰胺取代的8-N-苯并咪唑，其制备方法及其用途公开(公告)号：US08163774B2
公开(公告)日：2012-04-24
申请号：US11854578
申请日：2007-09-13
申请人： Elisabeth DeFossa , Karl Schoenafinger , Gerhard Jaehne , Christian Buning , Georg Tschank , Ulrich Werner
发明人： Elisabeth DeFossa , Karl Schoenafinger , Gerhard Jaehne , Christian Buning , Georg Tschank , Ulrich Werner
IPC分类号： A61K31/445 , C07D401/00
CPC分类号： C07D401/04 , C07D401/14
摘要： The present invention comprises the use of amino-substituted 8-N-benzimidazoles compounds of formula I wherein R3, R4-R5, R11 and R20-R21 are hereinafter defined which display a therapeutically utilizable blood sugar-lowering action. These compounds are intended to be particularly suitable in the treatment of diabetes.
摘要翻译： 本发明包括使用式I的氨基取代的8-N-苯并咪唑化合物，其中R3，R4-R5，R11和R20-R21在下文中定义，其显示出治疗上可用的降血糖作用。 这些化合物特别适用于治疗糖尿病。
-
2.发明授权Amino-substituted 8-N-benzimidazoles and methods for their use in blood sugar disorders 有权氨基取代的8-N-苯并咪唑及其用于血糖障碍的方法公开(公告)号：US08003668B2
公开(公告)日：2011-08-23
申请号：US11855231
申请日：2007-09-14
申请人： Elisabeth Defossa , Karl Schoenafinger , Gerhard Jaehne , Christian Buning , Georg Tschank , Ulrich Werner
发明人： Elisabeth Defossa , Karl Schoenafinger , Gerhard Jaehne , Christian Buning , Georg Tschank , Ulrich Werner
IPC分类号： A61K31/445 , C07D401/00
CPC分类号： C07D401/04 , A61K31/454
摘要： The present invention comprises the use of amino-substituted 8-N-benzimidazoles compounds of formula I wherein R3, R4-R5, R11 and R20-R21 are hereinafter defined which display a therapeutically utilizable blood sugar-lowering action. These compounds are intended to be particularly suitable in the treatment of diabetes.
摘要翻译： 本发明包括使用式I的氨基取代的8-N-苯并咪唑化合物，其中R3，R4-R5，R11和R20-R21在下文中定义，其显示出治疗上可用的降血糖作用。 这些化合物特别适用于治疗糖尿病。
-
3.发明授权Substituted 8-aminoalkoxy-xanthine compounds and compositions useful in the treatment of hyperlipidemia and diabetes 有权取代的8-氨基烷氧基 - 黄嘌呤化合物和可用于治疗高脂血症和糖尿病的组合物公开(公告)号：US07879864B2
公开(公告)日：2011-02-01
申请号：US11674261
申请日：2007-02-13
申请人： Karl Schoenafinger , Gerhard Jaehne , Elisabeth Defossa , Christian Buning , Georg Tschank , Ulrich Werner
发明人： Karl Schoenafinger , Gerhard Jaehne , Elisabeth Defossa , Christian Buning , Georg Tschank , Ulrich Werner
IPC分类号： C07D473/02 , A61K31/522 , A61P3/10 , A61P3/06
CPC分类号： C07D473/04
摘要： Compounds for the treatment of elevated blood glucose levels and the physiological and metabolic disorders arising therefrom are disclosed which are inhibitors of the enzyme dipeptidyl peptidase IV (DDP-IV) and comprise novel substituted bicyclic 8-pyrrolidinoxanthines of formula I and their derivatives: wherein the various R-groups are defined herein. These compounds may be combined with other secondary active compounds which also are effective in the treatment of said disorders and the disease states or physiological manifestations arising therefrom.
摘要翻译： 公开了用于治疗升高的血糖水平的化合物和由此产生的生理和代谢紊乱，其是酶二肽基肽酶IV（DDP-IV）的抑制剂，并且包含式I的新型取代的双环8-吡咯烷基亚基黄嘌呤及其衍生物：其中 本文定义了各种R基团。 这些化合物可以与其它二级活性化合物组合，其也可有效治疗所述疾病以及由此产生的疾病状态或生理表现。
-
4.发明授权Substituted bicyclic 8-pyrrolidinoxanthines, methods for their production, pharmaceutical formulations and their use 有权取代的双环8-吡咯烷子基黄嘌呤，其生产方法，药物制剂及其用途公开(公告)号：US07838528B2
公开(公告)日：2010-11-23
申请号：US11623770
申请日：2007-01-17
申请人： Karl Schoenafinger , Gerhard Jaehne , Elisabeth Defossa , Lothar Schwink , Holger Wagner , Christian Buning , Georg Tschank , Ulrich Werner
发明人： Karl Schoenafinger , Gerhard Jaehne , Elisabeth Defossa , Lothar Schwink , Holger Wagner , Christian Buning , Georg Tschank , Ulrich Werner
IPC分类号： C07D473/06 , C07D473/04 , A61K31/522 , A61P3/10 , C07D487/04 , A61P3/06
CPC分类号： C07D519/00
摘要： Compounds for the treatment of elevated blood glucose levels and the physiological and metabolic disorders arising therefrom are disclosed and comprise novel substituted bicyclic 8-pyrrolidinoxanthines and their derivatives of formula I: wherein the various R groups are hereinafter defined. The present invention also comprises pharmaceutical compositions comprising them as well as processes for the preparation of these compounds. Particular blood glucose disorders treatable thereby include type-2 diabetes, insulin resistance, hyperglycemia, arteriosclerotic diseases and the like.
摘要翻译： 公开了用于治疗升高的血糖水平的化合物和由其引起的生理和代谢紊乱，并且包含新颖的取代的双环8-吡咯烷基亚基黄嘌呤及其式I的衍生物：其中各种R基团在下文中定义。 本发明还包括包含它们的药物组合物以及这些化合物的制备方法。 因此可治疗的特定血糖障碍包括2型糖尿病，胰岛素抵抗，高血糖症，动脉硬化疾病等。
-
公开(公告)号：US5556856A
公开(公告)日：1996-09-17
申请号：US416467
申请日：1995-04-04
申请人： Jurgen Engel , Bernhard Kutscher , Ilona Fleischhauer , Stefan Szelenyi , Peter Metzenauer , Ulrich Werner
发明人： Jurgen Engel , Bernhard Kutscher , Ilona Fleischhauer , Stefan Szelenyi , Peter Metzenauer , Ulrich Werner
IPC分类号： A61K31/502 , A61K31/50 , A61K31/55 , A61P9/06 , A61P25/04 , A61P29/00 , A61P35/00 , A61P43/00 , C07D401/04 , C07D403/04 , C07D453/02 , A61K31/495
摘要： Phthalazinone derivatives and their optical isomers are used as medications to combat heart rhythm disturbances, to combat pain and to break through multi-drug resistance.
摘要翻译： 使用酞嗪酮衍生物及其旋光异构体作为抗心律失常药物，抵抗疼痛，突破多药耐药。
-
公开(公告)号：US08633156B2
公开(公告)日：2014-01-21
申请号：US12820727
申请日：2010-06-22
申请人： Paul Habermann , Gerhard Seipke , Roland Kurrle , Gunter Muller , Mark Sommerfeld , Norbert Tennagels , Georg Tschank , Ulrich Werner
发明人： Paul Habermann , Gerhard Seipke , Roland Kurrle , Gunter Muller , Mark Sommerfeld , Norbert Tennagels , Georg Tschank , Ulrich Werner
CPC分类号： C07K14/62
摘要： The invention relates to novel insulin analogs having a basal time-action profile, which are characterized by the addition and/or substitution of negatively and positively charged amino acid residues and by an amidation of the C-terminal carboxy group of the B chain and histidine in position 8 of the insulin A chain. The invention also relates to the production and use thereof.
摘要翻译： 本发明涉及具有基础时间作用特征的新型胰岛素类似物，其特征在于负和带正电荷的氨基酸残基的添加和/或取代以及B链和组氨酸的C端羧基的酰胺化 在胰岛素A链的位置8。 本发明还涉及其生产和使用。
-
7.发明授权Substituted 8-aminoalkylthioxanthines, and their use as inhibitors of dipeptidyl peptidase IV 有权取代的8-氨基烷基噻吨苷，并且它们用作二肽基肽酶IV的抑制剂公开(公告)号：US08236810B2
公开(公告)日：2012-08-07
申请号：US11622029
申请日：2007-01-11
申请人： Karl Schoenafinger , Gerhard Jaehne , Elisabeth Defossa , Guenter Billen , Christian Buning , Georg Tschank , Ulrich Werner
发明人： Karl Schoenafinger , Gerhard Jaehne , Elisabeth Defossa , Guenter Billen , Christian Buning , Georg Tschank , Ulrich Werner
IPC分类号： C07D473/04 , C07D473/06 , A61K31/522 , A61P31/10 , A61P19/02 , A61P3/06
CPC分类号： C07D473/12 , C07D473/04 , C07D473/06 , C07D473/08 , C07D473/10
摘要： The invention 8-aminothioxanthines and the derivatives of formula I wherein the various R groups and substituents are comprised of a number of different (C1-C10)-alkyl, cycloalkyl, aryl, alkene, alkyne, etc. groups and derivatives thereof which are hereinafter more specifically defined for the treatment of metabolic disorders such as type-2 diabetes, hyperglycemia, arteriosclerotic diseases and the like.
摘要翻译： 本发明8-氨基噻吨苷和式I的衍生物，其中各种R基团和取代基由许多不同的（C 1 -C 10） - 烷基，环烷基，芳基，烯烃，炔等基团及其衍生物组成，其在下文中 更具体地定义用于治疗代谢性疾病如2型糖尿病，高血糖症，动脉硬化疾病等。
-
公开(公告)号：US20120122774A1
公开(公告)日：2012-05-17
申请号：US13310118
申请日：2011-12-02
申请人： Reinhard Becker , Annke Frick , Peter Boderke , Christiane Fürst , Werner Müller , Katrin Tertsch , Ulrich Werner , Petra Loos , Isabell Schöttle
发明人： Reinhard Becker , Annke Frick , Peter Boderke , Christiane Fürst , Werner Müller , Katrin Tertsch , Ulrich Werner , Petra Loos , Isabell Schöttle
CPC分类号： A61K38/28 , A61K9/0019 , A61K9/08 , A61K38/2278 , A61K38/26 , A61K47/02 , A61K47/10 , A61K47/26
摘要： The application relates to an aqueous pharmaceutical formulation comprising 200-1000 U/mL [equimolar to 200-1000 IU human insulin] of insulin glargine.
摘要翻译： 本申请涉及包含200-1000U / mL [等摩尔至200-1000IU人胰岛素]甘精胰岛素的水性药物制剂。
-
公开(公告)号：US20110301081A1
公开(公告)日：2011-12-08
申请号：US13110568
申请日：2011-05-18
申请人： Reinhard Becker , Annke Frick , Peter Boderke , Christiane Fürst , Werner Müller , Katrin Tertsch , Ulrich Werner , Petra Loos , Isabell Schöttle
发明人： Reinhard Becker , Annke Frick , Peter Boderke , Christiane Fürst , Werner Müller , Katrin Tertsch , Ulrich Werner , Petra Loos , Isabell Schöttle
CPC分类号： A61K38/28 , A61K9/0019 , A61K9/08 , A61K38/2278 , A61K38/26 , A61K47/02 , A61K47/10 , A61K47/26
摘要： The application relates to an aqueous pharmaceutical formulation comprising 200-1000 U/mL [equimolar to 200-1000 IU human insulin] of insulin glargine.
摘要翻译： 本申请涉及包含200-1000U / mL [等摩尔至200-1000IU人胰岛素]甘精胰岛素的水性药物制剂。
-
10.发明授权Substituted, bicyclic 8-pyrrolidinoxanthines, and methods for their use as inhibitors of dipeptidyl peptidase 有权取代的双环8-吡咯烷基亚基黄嘌呤及其作为二肽基肽酶抑制剂的方法公开(公告)号：US07888343B2
公开(公告)日：2011-02-15
申请号：US11624511
申请日：2007-01-18
申请人： Karl Schoenafinger , Gerhard Jaehne , Elisabeth Defossa , Lothar Schwink , Holger Wagner , Christian Buning , Georg Tschank , Ulrich Werner
发明人： Karl Schoenafinger , Gerhard Jaehne , Elisabeth Defossa , Lothar Schwink , Holger Wagner , Christian Buning , Georg Tschank , Ulrich Werner
IPC分类号： C07D519/00 , A61K31/522 , A61P3/06 , A61P3/10 , C07D471/04 , C07D487/04
CPC分类号： C07D519/00
摘要： The present invention involves substituted bicyclic 8-pyrrolidinoxanthines and their derivatives of formula I: wherein the various R groups are defined herein. The present invention also comprises pharmaceutical compositions comprising them as well as processes for the preparation of these compounds and methods for the treatment of metabolic disorders such as type-2 diabetes, insulin resistance, hyperglycemia, arteriosclerosis diseases and the like through the administration of said compositions.
摘要翻译： 本发明涉及取代的双环8-吡咯烷基亚基黄嘌呤及其式I的衍生物：其中各种R基团在本文中定义。 本发明还包括包含它们的药物组合物以及这些化合物的制备方法和通过施用所述组合物治疗代谢紊乱如2型糖尿病，胰岛素抵抗，高血糖症，动脉硬化疾病等的方法 。
-
-
-
-
-
-
-
-
-
搜索结果
36 条记录 (耗时 0.03 秒)
