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    DRUG DELIVERY SYSTEMS AND METHODS COMPRISING POLYSIALIC ACID AND/OR OTHER POLYMERS
    2.
    发明申请
    DRUG DELIVERY SYSTEMS AND METHODS COMPRISING POLYSIALIC ACID AND/OR OTHER POLYMERS 有权

    公开(公告)号：US20220071917A9

    公开(公告)日：2022-03-10

    申请号：US16760527

    申请日：2018-11-02

    申请人： Universidade de Santiago de Compostela

    发明人： María José Alonso Fernandez ,  Desireé Teijeiro Osorio ,  Carmen María Teijeiro Valiño ,  Ana Cadete Pires

    IPC分类号： A61K9/51 ,  C07K16/22 ,  A61K39/395 ,  A61K47/62 ,  A61K47/69

    摘要： The present invention generally relates to particles, including nanocapsules or other nanoentities, comprising a polymer such as polysialic acid. The particles are able to access the interior of the cells, and/or to procure the intracellular release of the associated drugs. In 5 one aspect, the present invention is directed to nanocapsules or other entities having an exterior or surface comprising a polymer such as polysialic acid. In some cases, targeting moieties such as Lyp-1 or tLyp-1 peptide are bonded to the polymer, e.g., using aminoalkyl (C1-C4) succinimide or other linkers. These may be created, for example, by reacting a carboxylate moiety on a polymer with an aminoalkyl maleimide (C1-C4) or an aminoalkyl 10 (C1-C4) methacrylamide, and reacting the resulting aminoalkyl (C1-C4) maleimide or the aminoalkyl (C1-C4) methacrylamide to a cysteine or other sulfur group. Targeting moieties are bonded to the polymer, for example, by reacting a carboxylate moiety on a polymer with a N-hydroxysuccinimide or a carbodiimide, and reacting the intermediate formed with a lysine or arginine group on a targeting peptide to produce polymer-amide-peptide. Other 15 aspects of the invention are generally directed to methods of making or using such compositions, kits including such compositions, or the like.

    Nanoparticles with protected interiors, and methods of use thereof
    7.
    发明授权
    Nanoparticles with protected interiors, and methods of use thereof 有权

    公开(公告)号：US10471020B2

    公开(公告)日：2019-11-12

    申请号：US15350653

    申请日：2016-11-14

    申请人： Universidade de Santiago de Compostela

    发明人： Maria Josefa Alonso Fernandez ,  Zhigao Niu ,  Manuel Jesus Santander Ortega

    IPC分类号： A61K9/51 ,  A61K31/7088 ,  A61K38/28

    摘要： The present invention generally relates to particles, including nanoparticles, for example, for drug delivery or other applications. Certain aspects of the present invention are generally directed to particles, such as nanoparticles, comprising an inner portion and a coating. The inner portion may contain insulin or other therapeutic molecules for delivery to a living organism. In some cases, the molecules may be electrostatically complexed with an oppositely-charged peptide, such as an oligoarginine, or other species. The therapeutic molecules may also be water soluble. In some cases, the peptide may be conjugated to a hydrophobic portion, such as cholesterol, lauric acid, or a fatty acid chain. This hydrophobic modification may facilitate complex formation with the therapeutic molecule and the stability of the resulting complex. The complex typically is surrounded by a coating, which may protect the complex. For example, the coating may include polymers such as poly(glutamic acid) and poly(ethylene glycol). In some cases, the coated complex may also facilitate transport across cells, e.g., within the gastrointestinal tract. Other aspects of the invention are generally directed to methods of making or using such compositions, kits including such compositions, or the like.