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    Ketamine flow synthesis
    2.
    发明授权
    Ketamine flow synthesis 有权

    公开(公告)号：US11718578B2

    公开(公告)日：2023-08-08

    申请号：US17581578

    申请日：2022-01-21

    Applicant: Université de Liège

    Inventor： Thomas Toupy ,  Romaric Gerardy ,  Jean-Christophe Monbaliu ,  Diego Collin ,  Victor-Emmanuel Kassin

    IPC: C07C209/80 ,  C07C209/86

    CPC classification number: C07C209/80 ,  C07C209/86

    Abstract: The invention provides a method for synthesizing a compound of formula




    wherein each R independently represents an optionally substituted aryl, heteroaryl, alkyl, perfluoroalkyl, cycloalkyl, alkoxy, aryloxy, acyl, carboxyl, hydroxyl, halogen, amino, nitro, cyano, sulfo or sulfhydryl group, in ortho, meta or para position to the cycloalkylamine moiety; R1 and R2 each independently represents a hydrogen atom, a lower alkyl group or a cycloalkyl group; R3 represents a hydrogen group, substituted aryl, heteroaryl, alkyl, perfluoroalkyl, cycloalkyl, alkoxy, aryloxy group; Y represents an oxygen atom, a sulfur atom, a NH group, a NR4 group or a CH2 group;

    R4 represents a hydrogen atom or an alkyl, aryl or a heteroaryl group; and n and m each independently represents an integer from 1 to 5; or a pharmaceutically acceptable salt thereof; or a precursor thereof; wherein the method comprises one or more of the following steps: (a) reacting a compound of formula (II)





    wherein R, R3, Y, n and m are as defined above in relation to the compound of formula (I) with an oxygenating agent, a first additive and a second additive in a solvent in a fluidic network or in a batch process under thermal and/or photochemical conditions to form a compound of formula (III):





    wherein R, R3, Y, n and m are as defined above in relation to the compound of formula (I), (b) reacting a compound of formula (III) with a nitrogen containing nucleophile in the presence of a third additive and/or a solvent in the fluidic network or in a batch process under thermal conditions to form a compound of formula (IV):





    wherein R, R1, R2, R3, Y, n and m are as defined above in relation to the compound of formula (I); and/or

    (c) reacting a compound of formula (IV) in a fluidic network or in a batch process, optionally in the presence of a fourth additive, under thermal conditions to form a compound of formula (I); wherein one or more of steps (a), (b) and/or (c) is carried out in a fluidic network that comprises micro- and/or meso-channels having an internal dimension of from 100 μm to 2000 μm.

    Flexible thin-films for battery electrodes
    3.
    发明授权
    Flexible thin-films for battery electrodes 有权

    公开(公告)号：US11631837B2

    公开(公告)日：2023-04-18

    申请号：US16482570

    申请日：2018-01-29

    Applicant: UNIVERSITÉ DE LIÈGE

    Inventor： Frédéric Boschini ,  Caroline Piffet ,  Rudi Cloots

    IPC: H01M4/04 ,  H01M4/62 ,  H01M10/052 ,  H01M8/0223 ,  H01M10/05 ,  H01M4/13 ,  H01M4/02

    Abstract: A composition comprises: an at least partially hydrolysed polyvinyl acetate component having an hydrolysation degree of at least 5%; a polyalkylene glycol component having a number average molecular mass Mn lower than 9000 g/mol and consisting of one or more substances selected from the group consisting of polyethylene glycol, polypropylene glycol, copolymers of ethylene glycol and propylene glycol, and their derivatives; a positive or negative electrode active component; and a conductive component; wherein the mass ratio between the at least partially hydrolysed polyvinyl acetate component and the positive or negative electrode active component equals at least 0.12 and at most 0.30, and wherein the mass ratio between the polyalkylene glycol component and the positive or negative electrode active component equals at least 0.012 and at most 0.10.

    Osteomodulin and osteomodulin fragments as biomarkers for osteoarthritis and use thereof
    5.
    发明授权
    Osteomodulin and osteomodulin fragments as biomarkers for osteoarthritis and use thereof 有权

    公开(公告)号：US11255862B2

    公开(公告)日：2022-02-22

    申请号：US16140851

    申请日：2018-09-25

    Applicant: Université de Liège

    Inventor： Yves Henrotin ,  Christelle Sanchez ,  Edwin De Pauw ,  Gabriel Mazzucchelli

    IPC: G01N33/68 ,  C07K16/28

    Abstract: The present invention refers to osteomodulin (OMD) protein or fragment of osteomodulin (OMD) protein for use in the prognosis and/or diagnosis of osteoarthritis and/or subchondral bone sclerosis of mammals, preferably human individuals. The present invention further refers to a method for prognosis and/or diagnosis of osteoarthritis and/or subchondral bone sclerosis, comprising the following steps: i) measuring osteomodulin (OMD) protein or a fragment or fragments of osteomodulin (OMD) protein in samples of body fluids of mammalian individuals, preferably human serum samples; ii) judging that decreased levels of osteomodulin (OMD) protein or of said fragment(s) compared to levels in body fluids, preferably serum, of healthy individuals indicate onset of osteoarthritis and/or subchondral bone sclerosis. The present invention also provides an immunological binding partner specifically binding to osteomodulin (OMD) protein or fragment of osteomodulin (OMD) protein for use in the prognosis and/or diagnosis of osteoarthritis and/or subchondral bone sclerosis of mammals, preferably human individuals and a kit comprising said immunological binding partner.

    Method and system for determining the thermal power line rating
    7.
    发明授权
    Method and system for determining the thermal power line rating 有权

    公开(公告)号：US10197610B2

    公开(公告)日：2019-02-05

    申请号：US14579792

    申请日：2014-12-22

    Applicant: Université de Liège, Interface Entreprises-Université ,  Ampacimon S.A.

    Inventor： Jean-Louis Lilien ,  Huu-Minh Nguyen ,  Bertrand Godard

    IPC: G01R31/02 ,  G01R19/00 ,  G01N25/00 ,  H02G7/02 ,  H02J3/00 ,  G01C5/00

    Abstract: Method for measuring the power line thermal rating or maximum allowable current rating of an overhead power line with respect to a suspended/anchored cable span (2), comprising at least the following steps of: monitoring a motion of at least one point P of said suspended/anchored cable span (2) over a time interval; monitoring actual line current I, in A, over said time interval; determining an actual sag of said suspended/anchored cable, as a variable of actual line current; measuring or determining the effective wind speed of said suspended/anchored cable span (2) over said time interval; determining a sag reserve DF, in m, for thermal rating, which is the distance between the actual sag and a maximum allowable sag; determining the rate of change, tan(α), in m/A2, of the actual sag versus the square of the line current for the effective wind speed; and determining the power line thermal rating of the overhead power line, or ampacity, linked to a corresponding safety clearance, at measured or determined effective wind speed, by adding the square of actual current I to the ratio of the sag reserve DF by the sag rate of change, tan(α), at the effective wind speed, and taking the square root of that addition, i.e. Ampacity = I 2 + DF tan ⁡ ( α ) , wherein ampacity is in amperes.

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