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公开(公告)号:US20130230886A1
公开(公告)日:2013-09-05
申请号:US13799650
申请日:2013-03-13
申请人: Christian Votsmeier , Uwe Gritzan , Kornelia Kirchner , Michael Strerath , Kerstin Baral , Ulrich Haupts , Wayne M. Coco , Susanne Steinig , Andreas Scheidig , Klaus Pellengahr , Simone Brückner , Hanna Plittersdorf , Peter Scholz , Jan Tebbe
发明人: Christian Votsmeier , Uwe Gritzan , Kornelia Kirchner , Michael Strerath , Kerstin Baral , Ulrich Haupts , Wayne M. Coco , Susanne Steinig , Andreas Scheidig , Klaus Pellengahr , Simone Brückner , Hanna Plittersdorf , Peter Scholz , Jan Tebbe
IPC分类号: C07K16/24
CPC分类号: C07K16/241 , C07K2317/14 , C07K2317/24 , C07K2317/55 , C07K2317/56 , C07K2317/64 , C07K2317/76 , C07K2317/90 , C07K2317/92
摘要: Provided herein are antibodies, antigen binding portions, and derivatives thereof that are capable of binding tumor necrosis factor alpha (TNFα); nucleic acids encoding the antibodies, antigen binding portions, and derivatives thereof, including complementary nucleic acids; vectors; and host cells containing the nucleic acids.
摘要翻译: 本文提供能够结合肿瘤坏死因子α(TNFalpha)的抗体,抗原结合部分及其衍生物; 编码抗体的核酸,抗原结合部分及其衍生物,包括互补核酸; 向量 和含有核酸的宿主细胞。
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公开(公告)号:US20160024222A1
公开(公告)日:2016-01-28
申请号:US14770222
申请日:2014-03-14
申请人: Ye JIN , John E. MURPHY , Terry HERMISTON , Frank DITTMER , Michael STRERATH , Uwe GRITZAN , Timothy MYLES
发明人: Ye Jin , John E. Murphy , Terry Hermiston , Timothy Myles , Frank Dittmer , Michael Strerath , Uwe Gritzan
IPC分类号: C07K16/36
CPC分类号: C07K16/36 , A61K38/4846 , A61K45/06 , C07K16/18 , C07K16/38 , C07K2317/21 , C07K2317/32 , C07K2317/33 , C07K2317/55 , C07K2317/565
摘要: This patent document relates to antibodies, antigen-binding antibody fragments (Fabs), and other protein scaffolds, directed against human antithrombin β complexed with heparin and/or heparin-like structure (ATβH). These ATβH binding proteins can block the anti-coagulant activity of ATβ to induce coagulation. Therapeutic uses of these antibodies and binders are described herein as are methods of panning and screening specific antibodies.
摘要翻译: 该专利文献涉及针对人抗凝血酶的抗体,抗原结合抗体片段(Fabs)和其它蛋白质支架; 与肝素和/或肝素样结构复合(AT& H)。 这些AT&Bgr H结合蛋白可以阻断AT&Bgr的抗凝血活性; 诱导凝血。 这些抗体和结合物的治疗用途在本文中描述为淘选和筛选特异性抗体的方法。
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公开(公告)号:US08399627B2
公开(公告)日:2013-03-19
申请号:US12808608
申请日:2008-12-24
申请人: Christian Votsmeier , Uwe Gritzan , Kornelia Kirchner , Michael Strerath , Kerstin Baral , Ulrich Haupts , Wayne M. Coco , Susanne Steinig , Andreas Scheidig , Klaus Pellengahr , Simone Brückner , Hanna Plittersdorf , Peter Scholz , Jan Tebbe
发明人: Christian Votsmeier , Uwe Gritzan , Kornelia Kirchner , Michael Strerath , Kerstin Baral , Ulrich Haupts , Wayne M. Coco , Susanne Steinig , Andreas Scheidig , Klaus Pellengahr , Simone Brückner , Hanna Plittersdorf , Peter Scholz , Jan Tebbe
CPC分类号: C07K16/241 , C07K2317/14 , C07K2317/24 , C07K2317/55 , C07K2317/56 , C07K2317/64 , C07K2317/76 , C07K2317/90 , C07K2317/92
摘要: Provided herein are antibodies, antigen binding portions, and derivatives thereof that are capable of binding tumor necrosis factor alpha (TNFα); nucleic acids encoding the antibodies, antigen binding portions, and derivatives thereof, including complementary nucleic acids; vectors; and host cells containing the nucleic acids.
摘要翻译: 本文提供能够结合肿瘤坏死因子α(TNFα)的抗体,抗原结合部分及其衍生物; 编码抗体的核酸,抗原结合部分及其衍生物,包括互补核酸; 向量 和含有核酸的宿主细胞。
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公开(公告)号:US20120164130A1
公开(公告)日:2012-06-28
申请号:US13388288
申请日:2010-08-02
申请人: Alan Brooks , Chandra Patel , Xiaoqiao Jiang , Uwe Gritzan , Heiner Apeler , Jun Wang
发明人: Alan Brooks , Chandra Patel , Xiaoqiao Jiang , Uwe Gritzan , Heiner Apeler , Jun Wang
CPC分类号: C12N9/644 , A61K38/00 , C12Y304/21022
摘要: The invention relates to modified Factor IX polypeptides such as Factor IX polypeptides with one or more amino acid substitutions. The invention also relates to methods of making modified Factor IX polypeptides, and methods of using modified Factor IX polypeptides, for example, to treat patients afflicted with hemophilia B.
摘要翻译: 本发明涉及修饰的因子IX多肽,例如具有一个或多个氨基酸取代的因子IX多肽。 本发明还涉及制备修饰的因子IX多肽的方法,以及使用修饰的因子IX多肽的方法,例如治疗患有血友病B的患者。
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公开(公告)号:US20100297700A1
公开(公告)日:2010-11-25
申请号:US12808608
申请日:2008-12-24
申请人: Christian Votsmeier , Uwe Gritzan , Kornelia Kirchner , Michael Strerath , Kerstin Baral , Ulrich Haupts , Wayne Coco , Susanne Steinig , Andreas Scheidig , Klaus Pellengahr , Simone Brückner , Hanna Plittersdorf , Peter Scholz , Jan Tebbe
发明人: Christian Votsmeier , Uwe Gritzan , Kornelia Kirchner , Michael Strerath , Kerstin Baral , Ulrich Haupts , Wayne Coco , Susanne Steinig , Andreas Scheidig , Klaus Pellengahr , Simone Brückner , Hanna Plittersdorf , Peter Scholz , Jan Tebbe
CPC分类号: C07K16/241 , C07K2317/14 , C07K2317/24 , C07K2317/55 , C07K2317/56 , C07K2317/64 , C07K2317/76 , C07K2317/90 , C07K2317/92
摘要: Provided herein are antibodies, antigen binding portions, and derivatives thereof that are capable of binding tumor necrosis factor alpha (TNFα); nucleic acids encoding the antibodies, antigen binding portions, and derivatives thereof, including complementary nucleic acids; vectors; and host cells containing the nucleic acids.
摘要翻译: 本文提供能够结合肿瘤坏死因子α(TNFα)的抗体,抗原结合部分及其衍生物; 编码抗体的核酸,抗原结合部分及其衍生物,包括互补核酸; 向量 和含有核酸的宿主细胞。
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