公开(公告)号：US20060269538A1

公开(公告)日：2006-11-30

申请号：US11441635

申请日：2006-05-26

Applicant: Andre Koltermann ,  Ulrich Kettling ,  Ulrich Haupts ,  Wayne Coco ,  Jan Tebbe ,  Christian Votsmeier ,  Andreas Scheidig

Inventor： Andre Koltermann ,  Ulrich Kettling ,  Ulrich Haupts ,  Wayne Coco ,  Jan Tebbe ,  Christian Votsmeier ,  Andreas Scheidig

IPC: A61K38/48 ,  C07H21/04 ,  C12P21/06 ,  C12N9/64 ,  C40B40/10 ,  C40B50/06

CPC classification number: C12Q1/37 ,  A61K38/00 ,  C12N9/64 ,  G01N2500/00

Abstract: The present invention provides variants of serine proteases of the S1 class with altered sensitivity to one or more activity-modulating substances. A method for the generation of such proteases is disclosed, comprising the provision of a protease library encoding polynucleotide sequences, expression of the enzymes, screening of the library in the presence of one or several activity-modulating substances, selection of variants with altered sensitivity to one or several activity-modulating substances and isolation of those polynucleotide sequences that encode for the selected variants.

Abstract translation: 本发明提供对一种或多种活性调节物质敏感性改变的S1类丝氨酸蛋白酶的变体。 公开了产生这种蛋白酶的方法，包括提供编码多核苷酸序列的蛋白酶文库，酶的表达，在一种或几种活性调节物质存在下筛选文库，选择对 一种或几种活性调节物质以及编码所选变体的那些多核苷酸序列的分离。

公开(公告)号：US20100297700A1

公开(公告)日：2010-11-25

申请号：US12808608

申请日：2008-12-24

Applicant: Christian Votsmeier ,  Uwe Gritzan ,  Kornelia Kirchner ,  Michael Strerath ,  Kerstin Baral ,  Ulrich Haupts ,  Wayne Coco ,  Susanne Steinig ,  Andreas Scheidig ,  Klaus Pellengahr ,  Simone Brückner ,  Hanna Plittersdorf ,  Peter Scholz ,  Jan Tebbe

Inventor： Christian Votsmeier ,  Uwe Gritzan ,  Kornelia Kirchner ,  Michael Strerath ,  Kerstin Baral ,  Ulrich Haupts ,  Wayne Coco ,  Susanne Steinig ,  Andreas Scheidig ,  Klaus Pellengahr ,  Simone Brückner ,  Hanna Plittersdorf ,  Peter Scholz ,  Jan Tebbe

IPC: C12P21/02 ,  C07K16/24 ,  C07H21/00 ,  C12N15/63 ,  C12N5/10

CPC classification number: C07K16/241 ,  C07K2317/14 ,  C07K2317/24 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/64 ,  C07K2317/76 ,  C07K2317/90 ,  C07K2317/92

Abstract: Provided herein are antibodies, antigen binding portions, and derivatives thereof that are capable of binding tumor necrosis factor alpha (TNFα); nucleic acids encoding the antibodies, antigen binding portions, and derivatives thereof, including complementary nucleic acids; vectors; and host cells containing the nucleic acids.

Abstract translation: 本文提供能够结合肿瘤坏死因子α（TNFα）的抗体，抗原结合部分及其衍生物; 编码抗体的核酸，抗原结合部分及其衍生物，包括互补核酸; 向量 和含有核酸的宿主细胞。

公开(公告)号：US20080064064A1

公开(公告)日：2008-03-13

申请号：US11778690

申请日：2007-07-17

Applicant: Oliver Kensch ,  Wayne Coco ,  Andreas Scheidig ,  Ute Beister ,  Birgitta Leuthner ,  Nadine Koch ,  Markus Rarbach ,  Ulrich Kettling ,  Ulrich Haupts

Inventor： Oliver Kensch ,  Wayne Coco ,  Andreas Scheidig ,  Ute Beister ,  Birgitta Leuthner ,  Nadine Koch ,  Markus Rarbach ,  Ulrich Kettling ,  Ulrich Haupts

IPC: C12P21/04 ,  A23F5/24 ,  A23K1/14 ,  C07H21/04 ,  C09K8/60 ,  C11D7/42 ,  C12N15/00 ,  C12N5/06 ,  C12N9/48

CPC classification number: C11D3/38636 ,  A23F5/246 ,  A23K20/189 ,  A23L29/06 ,  C09K8/68 ,  C12N9/2494 ,  C12Y302/01078

Abstract: The present invention provides an insertion, deletion and/or substitution mutein of wild-type Trichoderma reesei β-mannanase having enhanced thermostability, proteolytic stability, specific activity and/or stability at low pH, a nucleic acid molecule encoding said mannanase mutein, a composition comprising said mannanase mutein; a method for its preparation, and its use for food and feed processing, for coffee extraction and the processing of coffee waste, as a supplement to food and feed, for enzyme aided bleaching of paper pulps, as bleaching and/or desizing agent in textile industry, for oil and gas well stimulation by hydraulic fracturing, as detergent, for removal of biofilms and in delivery systems, or for the processing of renewable resources intended for the production of biological fuels.

Abstract translation: 本发明提供了具有增强的热稳定性，蛋白水解稳定性，比较活性和/或低pH稳定性的野生型里氏木霉β-甘露聚糖酶的插入，缺失和/或取代突变蛋白，编码所述甘露聚糖酶突变蛋白的核酸分子，组合物 包含所述甘露聚糖酶突变蛋白; 其制备方法及其用于食品和饲料加工的咖啡提取和咖啡废弃物的加工，作为食品和饲料的补充，用于纸浆的酶辅助漂白，作为纺织品中的漂白和/或脱浆剂 工业，通过水力压裂的油气井刺激，作为洗涤剂，用于去除生物膜和输送系统，或用于处理用于生产生物燃料的可再生资源。

公开(公告)号：US20050175581A1

公开(公告)日：2005-08-11

申请号：US11021951

申请日：2004-12-22

Applicant: Ulrich Haupts ,  Andre Koltermann ,  Andreas Scheidig ,  Christian Votsmeier ,  Ulrich Kettling ,  Wayne Coco

Inventor： Ulrich Haupts ,  Andre Koltermann ,  Andreas Scheidig ,  Christian Votsmeier ,  Ulrich Kettling ,  Wayne Coco

IPC: A61K38/19 ,  A61K38/21 ,  A61K38/48 ,  C12N9/64 ,  C12N9/76 ,  C12P21/06 ,  C12Q1/37

CPC classification number: C12N9/6427 ,  A61K38/482 ,  A61K38/4826 ,  A61K38/486 ,  A61K38/4873 ,  A61K38/488 ,  C12P21/06 ,  C12Q1/37

Abstract: The present invention provides method for the treatment of a disease by applying a medicament comprising a protease with a defined specificity is capable to hydrolyze specific peptide bonds within a target substrate related to such disease. The proteases with such a defined specificity can further be used for related therapeutic or diagnostic purposes.

Abstract translation: 本发明提供了通过应用包含具有确定的特异性的蛋白酶的药物能够水解与这种疾病相关的靶基质内的特异性肽键来治疗疾病的方法。 具有这种确定的特异性的蛋白酶可进一步用于相关的治疗或诊断目的。

公开(公告)号：US20050032162A1

公开(公告)日：2005-02-10

申请号：US10820640

申请日：2004-04-08

Applicant: Wayne Coco ,  Philip Pienkos ,  A. Loomis

Inventor： Wayne Coco ,  Philip Pienkos ,  A. Loomis

IPC: C07K14/485 ,  C07H21/04

CPC classification number: C07K14/485

Abstract: The present invention features polypeptides that have at least 90% amino acid identity to wild-type epidermal growth factor, and also have epidermal growth factor biological activity that is greater than the biological activity of wild-type epidermal growth factor.

Abstract translation: 本发明具有与野生型表皮生长因子具有至少90％氨基酸同一性的多肽，并且还具有比野生型表皮生长因子的生物活性更大的表皮生长因子生物活性。