摘要:
The present teachings relate to compounds of Formula (I): and pharmaceutically acceptable salts, hydrates, esters, and prodrugs thereof, wherein R1, R2, R3, R4, R5, ring A, and Z are as defined herein. The present teachings also provide methods of preparing compounds of Formula (I) and methods of use compounds of Formula (I) in treating pathologic conditions or disorders mediated wholly or in part by deacetylases.
摘要:
A skin engaging member for use with a hair removal device, said skin engaging member comprising: a carrier comprising a pair of opposing sidewalls forming a channel; and at least one skin conditioning composition at least partially contained within said channel, wherein said skin conditioning composition comprising: at least one of a lipid, an emollient hydrocarbon, a lipophilic skin active, and a mixture thereof; and a block polymer selected from the group consisting of: a di-block copolymer, a tri-block copolymer, a multi-block copolymer, a radial block copolymer, a random block copolymer, and mixtures thereof.
摘要:
Personal cleansing compositions comprising a thickening system consisting essentially of hydrophobically modified water-soluble associative polymer and polar oil having a required HLB of at least 12, a nonionic polyhydroxy fatty acid amide surfactant, a water-soluble surfactant other than the polyhydroxy fatty acid amide surfactant, and water, wherein the polar oil has an average carbon chain length of from about 12 to about 16 carbon atoms and wherein the water-soluble surfactants have an average carbon chain of from about 10 to about 18 carbon atoms. These compositions may also comprise a perfume or cosmetic oil, or a hydrotrope. The compositions of the present invention deliver excellent product thickening and rheological attributes, in storage, in dispensing and in use, in combination with good efficacy benefits such as excellent rinsibility, mildness, skin conditioning, skin moisturizing, product stability, cleansing and lathering.
摘要:
Personal cleansing compositions comprise a thickening system consisting essentially of associative polymer which is a hydrophobically modified water-soluble associative polymer and polar oil having a required HLB of at least 12, a water-soluble surfactant, optionally a cationic polymeric skin conditioning agent, and water, wherein the polar oil has an average carbon chain length of from about 12 to about 16 carbon atoms and wherein the water-soluble surfactants have an average carbon chain of from about 10 to about 18 carbon atoms. These compositions may also comprise a hydrotrope. These compositions may optionally comprise a perfume or cosmetic oil. These compositions deliver excellent product thickening and rheological attributes, in storage, in dispensing and in use, in combination with good efficacy benefits such as mildness, a moisturized skin feel, rinsibility, skin conditioning, product stability and lather attributes.
摘要:
In a digital television signal processing system, a special codeword, a Packet Alignment Flag (PAF), is inserted into an MPEG codeword bitstream to signify the presence of a Group of Pictures (GOP). The PAF immediately precedes a Picture Start codeword for an "I" frame, which initiates a GOP. A data packet under construction when a PAF appears is terminated since a GOP is intended to begin at a packet boundary. Such termination may result in an abbreviated packet of less than a prescribed number of codewords needed to complete a data packet. The last word of each packet is designated as such to facilitate the subsequent combining of data packets with respective headers. An incomplete data packet is filled with null (zeroed bits) words to make up a complete data packet with a prescribed number of words.
摘要:
Samples of lubrication fluid are taken at relatively long sampling periods. Upon the derived rate of change of the amount of an inspected constituent differing by more than an acceptable value the lubrication fluid is changed and two further samples are taken over a relatively short sampling period. The rate of change in the amount of inspected constituent and the relatively short sampling period gives an indication of the operational condition of the mechanical equipment.
摘要:
The disclosed compounds relate to treatments and therapies for protein kinase-associated disorders. There is also a need for compounds useful in the treatment or prevention or amelioration of one or more symptoms of cancer, transplant rejections, and autoimmune diseases. Furthermore, there is a need for methods for modulating the activity of protein kinases, such as CDK1, CDK2, CDK4, CDK5, CDK6, CDK7, CDK8 and CDK9, using the compounds provided herein.
摘要:
The invention relates to modified Factor IX polypeptides such as Factor IX polypeptides with one or more amino acid substitutions. The invention also relates to methods of making modified Factor IX polypeptides, and methods of using modified Factor IX polypeptides, for example, to treat patients afflicted with hemophilia B.
摘要:
A method and apparatus to mount a uniform force hydrostatic bolster plate to a substrate. One embodiment of the invention involves a method to assemble a uniform force hydrostatic bolster plate on a substrate. A second embodiment of the invention involves a method to fabricate a uniform force hydrostatic bolster plate. A third embodiment of the invention involves an assembled substrate with a uniform force hydrostatic bolster plate on the opposite side of the assembled substrate, under an electrical contact area of a component on the assembled substrate.
摘要:
An apparatus in one example comprises a first card guide base portion and a card guide end portion. The first card guide base portion is connected with a second card guide base portion in a side-by-side relationship. The card guide end portion is employable with the first card guide base portion to comprise one or more portions of a card guide path. The card guide end portion comprises a face of a color that is different from a color of the first card guide base portion.