-
公开(公告)号：US11867780B2
公开(公告)日：2024-01-09
申请号：US17056278
申请日：2019-05-22
CPC分类号： G01R33/34023 , A61B5/0042 , A61B5/055 , A61B5/70 , G01R33/3804
摘要： An asymmetric magnet for use in performing MRI of a patient's head. The magnet has a patient end. The magnet provides an offset imaging volume (35) in a recess with an isocentre that is positioned closer to the patient end than an opposite end. The magnet has at least three groups of coils (44, 45, 46) in a generally tapering arrangement. The magnet also has an additional group of coils (47). A first group of coils (44) overlaps the additional group of coils (47), such that a bottom portion (47″) of the additional group of coils (47) is positioned closer to the patient end of the magnet than a top portion (44′) of the first group of coils (44).
-
公开(公告)号：US20230346760A1
公开(公告)日：2023-11-02
申请号：US17997889
申请日：2021-05-06
IPC分类号： A61K31/445 , A61K45/06 , A61P31/04
CPC分类号： A61K31/445 , A61K45/06 , A61P31/04
摘要： Methods for treating or preventing diseases and conditions associated with Clostridium difficile infection are provided. The methods effectively inhibit bacterial pathogens induced UDP-glucose hydrolysis activity with minimized damage to host tissue.
-
公开(公告)号：US20220348934A1
公开(公告)日：2022-11-03
申请号：US17642492
申请日：2020-09-11
发明人： David ACKERLEY , Mark CALCOTT
摘要： The present invention encompasses non-ribosomal peptides and non-ribosomal peptide synthetases, and the preparation and use thereof. Specifically encompassed are methods for preparing non-ribosomal peptide synthetases, methods for preparing non-ribosomal peptides from these enzymes, as well as polynucleotides used for producing these enzymes, libraries comprising these polynucleotides, and microbial strains comprising these polynucleotides.
-
公开(公告)号：US11055830B2
公开(公告)日：2021-07-06
申请号：US16345927
申请日：2016-11-22
摘要： A rendering process and system that may be used to composite virtual objects in panoramic video to provide a virtual reality and augmented reality experience. The process includes receiving low dynamic range (LDR) video data, e.g. 360° video; generating radiance maps, such as diffuse and specular maps, from the LDR data; inverse tone mapping the LDR data of the maps to generate high dynamic range (HDR) data for the maps; and receiving at least one virtual object and applying image based lighting (IBL) to the virtual object using the HDR data of the maps. A perceptually based threshold is also applied to radiance maps to detect prominent pixels, and using the prominent pixels as salient lights for image based shadowing (IBS) associated the virtual object. Objects are composited 360° video in real time using IBL and IBS without precomputation allowing user interaction with the objects.
-
公开(公告)号：US20210139338A1
公开(公告)日：2021-05-13
申请号：US16628214
申请日：2018-07-02
IPC分类号： C01C1/04
摘要： The present invention concerns an ammonia production method comprising the steps of: providing at least one rare earth nitride material or layer in a chamber; creating a vacuum or an inert atmosphere in the chamber; and providing hydrogen H2 to react with nitrogen N released at an external surface of the at least one rare earth nitride material or layer to produce ammonia.
-
公开(公告)号：US20210032635A1
公开(公告)日：2021-02-04
申请号：US16651043
申请日：2018-09-28
摘要： A modular and hierarchical DNA assembly platform for synthetic biology is described. This enabling technology, termed MIDAS (for Modular Idempotent DNA Assembly System), can precisely assemble multiple DNA fragments in a single reaction using a standardised assembly design. It can be used to build genes from libraries of sequence-verified, reusable parts and to assemble multiple genes in a single vector. We describe the design and use of MIDAS, and its application in the reconstruction of the metabolic pathway for production of paspaline, a key intermediate in the biosynthesis of a range of indole diterpenes—a class of economically important secondary metabolites produced by several species of filamentous fungi.
-
公开(公告)号：US20200333684A1
公开(公告)日：2020-10-22
申请号：US16769554
申请日：2018-11-29
发明人： Shyamal Kush Kanchan Prasad , Nicholas Richard Monahan , Karen Elisabeth Thorn , Kai Chen , Justin Mark Hodgkiss
摘要： An optical system for narrowing the bandwidth of a beam of incident radiation includes an optical mixing unit configured to receive a first beam of radiation and a second beam of radiation. The first and second beams are spatially chirped and the first beam is inverted relative to the second beam. The optical mixing unit includes an optical mixing member, which includes a nonlinear optical medium to mix the first and second beams into an output beam having a narrower bandwidth than the beam of incident radiation.
-
公开(公告)号：US20190272626A1
公开(公告)日：2019-09-05
申请号：US16345927
申请日：2016-11-22
摘要： A rendering process and system that may be used to composite virtual objects in panoramic video to provide a virtual reality and augmented reality experience. The process includes receiving low dynamic range (LDR) video data, e.g. 360° video; generating radiance maps, such as diffuse and specular maps, from the LDR data; inverse tone mapping the LDR data of the maps to generate high dynamic range (HDR) data for the maps; and receiving at least one virtual object and applying image based lighting (IBL) to the virtual object using the HDR data of the maps. A perceptually based threshold is also applied to radiance maps to detect prominent pixels, and using the prominent pixels as salient lights for image based shadowing (IBS) associated the virtual object. Objects are composited 360° video in real time using IBL and IBS without precomputation allowing user interaction with the objects.
-
9.发明申请公开(公告)号：US20190257745A1
公开(公告)日：2019-08-22
申请号：US16340550
申请日：2017-10-11
发明人： Brendan Liam DARBY , Eric LE RU , Matthias MEYER
摘要： A spectrometer apparatus (1) is provided for measuring spectra of a liquid sample, such as a beverage such as wine. The apparatus (1) comprises an integrating cavity (3) comprising a reflective inner wall or walls (5), configured to receive a cuvette (7) containing the liquid sample within the integrating cavity (5). A combination of light inlet ports P1, P2 and light outlet ports P3, P4 are provided to receive light from at least one light source (9) and to deliver light to a spectrometer (11). A light path adjuster (13, 13B) is configured to selectively adjust a light path through the integrating cavity (5) such that at least two distinct light paths are provided; wherein when the light path adjuster (13, 13B) is in a first configuration, the apparatus (1) is in a transmission mode in which light from the light source follows a first light path (15) from the or one of the light inlet port(s) to the liquid sample such that the light from the light source irradiates the liquid sample directly before the light transmitted by the sample is transmitted through the or one of the light outlet port(s) and received by the spectrometer (11) for wavelength analysis of the light to provide an extinction spectrum of the liquid sample; and when the light path adjuster (13, 13B) is in a second configuration, the apparatus is in a diffusely reflecting mode in which light from the light source follows a second light path (17) from the or one of the inlet port(s) into the integrating cavity, is incident onto the reflective inner wall or walls of the integrating cavity and is diffusely reflected within the integrating cavity, such that the light from the light source irradiates the liquid sample before being transmitted through the or one of the light outlet port(s) and received by the spectrometer (11) for wavelength analysis of the light to provide an absorbance spectrum of the liquid sample contained in the liquid sample.
-
![Salt and polymorphic forms of (3R,4S)-L-((4-amino-5H-pyrrolo[3,2,-D]pyrimidin-7-yl)methyl)-4(methylthiomethyl)pyrodin-3-ol(MTDIA)](/abs-image/US/2019/03/12/US10227351B2/abs.jpg.150x150.jpg)
公开(公告)号：US10227351B2
公开(公告)日：2019-03-12
申请号：US15993669
申请日：2018-05-31
IPC分类号： C07D207/50 , C07D487/04 , C07D207/44 , C07D207/12 , C07D207/34 , C07C55/07 , C07C53/06 , C07C269/04 , A61K31/519 , A61P35/00 , A61P35/02
摘要： The invention relates to salt forms of (3R,4S)-1-((4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl)-4-(methyl-thiomethyl)pyrrolidin-3-ol, as well as polymorphic forms of the salts. The invention further relates to processes for preparing the salt forms and to the use of the salt forms in the treatment of diseases and disorders where it is desirable to inhibit 5′-methylthioadenosine phosphorylase (MTAP).
-
-
-
-
-
-
-
-
-
搜索结果
96 条记录 (耗时 0.03 秒)
