公开(公告)号：US07397029B2

公开(公告)日：2008-07-08

申请号：US11620504

申请日：2007-01-05

Applicant: Vadym D. Berkout ,  Vladimir M. Doroshenko

Inventor： Vadym D. Berkout ,  Vladimir M. Doroshenko

IPC: B01D59/44

CPC classification number: H01J49/0045

Abstract: An apparatus for mass analyzing molecules includes a mass spectrometer configured to select precursor ions having a mass to charge ratio range, a metastable species generator configured to generate a metastable species for introduction into the mass spectrometer, and a mass detector configured to detect a mass of the product ions. The apparatus also includes interaction region in the mass spectrometer where the precursor ions are converted into product ions via interaction of the precursor ions with the metastable species. The mass spectrometer includes at least one of a three-dimensional ion trap, a linear ion trap, or an ion guide. The interaction region is located inside the three-dimensional ion trap, the linear trap, or the ion guide; and at least one of the precursor ions or at least one of the product ions are excited by an alternating electric field or collisionally activated to produce additional product ions.

Abstract translation: 用于质量分析分子的装置包括：质谱仪，其被配置为选择具有质荷比范围的前体离子;构造成产生用于引入质谱仪的亚稳态物质的亚稳态物质发生器;以及质量检测器， 产品离子。 该装置还包括质谱仪中的相互作用区域，其中前体离子通过前体离子与亚稳态物质的相互作用转化成产物离子。 质谱仪包括三维离子阱，线性离子阱或离子导体中的至少一种。 相互作用区域位于三维离子阱，线性阱或离子导向器内; 并且至少一种前体离子或至少一种产物离子被交变电场激发或者被碰撞激活以产生另外的产物离子。

公开(公告)号：US08440964B2

公开(公告)日：2013-05-14

申请号：US13213787

申请日：2011-08-19

Applicant: Vadym D Berkout ,  Vladimir M. Doroshenko

Inventor： Vadym D Berkout ,  Vladimir M. Doroshenko

IPC: G21K1/08 ,  H01J49/42 ,  H01J49/00

CPC classification number: H01J49/063 ,  H01J49/24

Abstract: A device and method for transporting ions along a longitudinal direction in an elevated gas pressure region. The device includes a multipole ion guide having a set of rods positioned along the longitudinal direction on an inscribed diameter equal to or less than 3.5 mm, a voltage source which provides alternating voltages to at least a subset of the rods to create a trapping field in a transverse direction, and a conductance limit having an opening d and placed at the exit of the multipole ion guide. At the end of this configuration near the opening of the conductance limit, a converging continuum gas flow through the conductance limit is provided that transfers the ions collimating near a center of the ion guide into a low gas pressure region. The method injects ions into the elevated gas pressure region of the ion guide, and transports the ions in the converging continuum gas flow into the low gas pressure region.

Abstract translation: 一种用于在升高的气体压力区域沿着纵向输送离子的装置和方法。 该装置包括多极离子导向器，其具有沿着纵向方向定位在一个等于或小于3.5mm的内接直径上的一组杆，电压源，其向至少一个棒的子集提供交流电压，以产生捕获场 横向和具有开口d并放置在多极离子导向器的出口处的电导极限。 在接近开路导通极限的结束时，提供通过电导限制的会聚连续气体流，其将在离子导向器的中心附近准直的离子转移到低气压区域。 该方法将离子注入离子导向器的升高的气体压力区域，并将会聚的连续气流中的离子输送到低气体压力区域。

公开(公告)号：US06858840B2

公开(公告)日：2005-02-22

申请号：US10441004

申请日：2003-05-20

Applicant: Vadym D. Berkout ,  Vladimir M. Doroshenko

Inventor： Vadym D. Berkout ,  Vladimir M. Doroshenko

IPC: B01D59/44 ,  H01J49/00 ,  H01J49/26 ,  H01J49/40 ,  H01J49/42

CPC classification number: H01J49/063 ,  H01J49/0054

Abstract: A system and method for mass analysis of an ion beam. The system includes a mass selector, at least one multipole ion guide, and a mass analyzer. In the system and method, precursor ions are selected with a desired mass to charge ratio. Electrons are injected into the multipole ion guide. The precursor ions are fragmented into product ions via electron capture dissociation from the injected electrons. The product ions are passed to a mass analyzer for a mass analysis.

Abstract translation: 一种用于离子束质量分析的系统和方法。 该系统包括质量选择器，至少一个多极离子导向器和质量分析器。 在该系统和方法中，以期望的质荷比选择前体离子。 电子注入到多极离子导向器中。 通过从注入的电子的电子俘获解离，前体离子被分裂成产物离子。 将产物离子通过质谱仪进行质量分析。

公开(公告)号：US20130043382A1

公开(公告)日：2013-02-21

申请号：US13213787

申请日：2011-08-19

Applicant: Vadym D. BERKOUT ,  Vladimir M. Doroshenko

Inventor： Vadym D. BERKOUT ,  Vladimir M. Doroshenko

IPC: H01J49/26

CPC classification number: H01J49/063 ,  H01J49/24

Abstract: A device and method for transporting ions along a longitudinal direction in an elevated gas pressure region. The device includes a multipole ion guide having a set of rods positioned along the longitudinal direction on an inscribed diameter equal to or less than 3.5 mm, a voltage source which provides alternating voltages to at least a subset of the rods to create a trapping field in a transverse direction, and a conductance limit having an opening d and placed at the exit of the multipole ion guide. At the end of this configuration near the opening of the conductance limit, a converging continuum gas flow through the conductance limit is provided that transfers the ions collimating near a center of the ion guide into a low gas pressure region. The method injects ions into the elevated gas pressure region of the ion guide, and transports the ions in the converging continuum gas flow into the low gas pressure region.

Abstract translation: 一种用于在升高的气体压力区域沿着纵向输送离子的装置和方法。 该装置包括多极离子导向器，其具有沿着纵向方向定位在一个等于或小于3.5mm的内接直径上的一组杆，电压源，其向至少一个棒的子集提供交流电压，以产生捕获场 横向和具有开口d并放置在多极离子导向器的出口处的电导极限。 在接近开路导通极限的结束时，提供通过电导限制的会聚连续气体流，其将在离子导向器的中心附近准直的离子转移到低气压区域。 该方法将离子注入离子导向器的升高的气体压力区域，并将会聚的连续气流中的离子输送到低气体压力区域。

公开(公告)号：US07365315B2

公开(公告)日：2008-04-29

申请号：US11144666

申请日：2005-06-06

Applicant: Vadym D. Berkout ,  Vladimir M. Doroshenko

Inventor： Vadym D. Berkout ,  Vladimir M. Doroshenko

IPC: B01D59/44 ,  H01J49/00

CPC classification number: H01J49/164

Abstract: An apparatus for analyzing a sample material includes a desorption mechanism configured to desorb molecules from the sample material, a metastable generator separate from the desorption mechanism and configured to generate a metastable species, and an interaction region configured for metastable species ionization of the desorbed molecules so as to produce gas-phase ions of the sample material.

Abstract translation: 用于分析样品材料的装置包括解吸机制，其被配置为从样品材料解吸分子，与解吸机构分离并构造成产生亚稳态物质的亚稳态发生体，以及被配置用于解吸分子的亚稳态物质离子化的相互作用区域 以产生样品材料的气相离子。

公开(公告)号：US07161146B2

公开(公告)日：2007-01-09

申请号：US11039842

申请日：2005-01-24

Applicant: Vladimir M. Doroshenko ,  Vadym D. Berkout

Inventor： Vladimir M. Doroshenko ,  Vadym D. Berkout

IPC: H01J49/40

CPC classification number: H01J49/063

Abstract: A method and system for producing an ion beam from an ion guide. In the method, ions are introduced into the ion guide, a radio frequency trapping field is generated in the ion guide to confine ions in a direction transverse to a longitudinal axis of the ion guide, a DC potential is generated along the longitudinal axis to direct ion motion along the longitudinal axis, a strength of the radio frequency trapping field is reduced toward an ion guide exit of the ion guide, and the ions are transmitted from the ion guide exit to form the ion beam. In the system, an ion guide is configured to transmit ions in a longitudinal axis of the ion guide and configured to trap ions in a direction transverse to the longitudinal axis via a radio frequency trapping field. The ion guide includes a segmented set of electrodes spaced along the longitudinal axis and an ion guide exit at the last of the segmented set of electrodes. A radio frequency device is configured to supply the radio frequency trapping field such that a strength of the radio frequency trapping field is reduced toward the ion guide exit.

Abstract translation: 一种用于从离子导向器制造离子束的方法和系统。 在该方法中，将离子引入离子导向器中，在离子导向器中产生射频捕获场，以将离子限制在与离子导向件的纵向轴线相垂直的方向上，沿着纵向轴线产生直流电势以引导 沿着纵轴的离子运动，离子导管的离子引导出口减小了射频捕获场的强度，离子从离子导出口传递，形成离子束。 在该系统中，离子导向器被配置为在离子导向件的纵向轴线上传输离子，并且被配置为通过射频捕获场在垂直于纵向轴线的方向上捕获离子。 离子导向器包括沿着纵向轴线间隔开的分段的电极组和在分段的电极组的最后一个处的离子引导出口。 射频装置被配置为提供射频捕获场，使得射频捕获场的强度朝离子引导出口减小。

公开(公告)号：US08188423B2

公开(公告)日：2012-05-29

申请号：US12784532

申请日：2010-05-21

Applicant: Vladimir M. Doroshenko ,  Vadym D. Berkout ,  Andrey Vilkov

Inventor： Vladimir M. Doroshenko ,  Vadym D. Berkout ,  Andrey Vilkov

IPC: H01J49/00 ,  B01D59/44

CPC classification number: H01J49/0045

Abstract: A method for fragmentation of analyte ions for mass spectroscopy and a system for mass spectroscopy. The method produces gas-phase analyte ions, produces gas-phase odd-electron containing species separately from the analyte ions, and mixes the gas-phase analyte ions and the odd-electron containing species at substantially atmospheric pressure conditions to produce fragment ions prior to introduction into a mass spectrometer. The system includes a gas-phase analyte ion source, a gas-phase odd-electron containing species source separate from the gas-phase analyte ion source, a mixing region where the gas-phase analyte ions and the odd-electron containing species are mixed at substantially atmospheric pressure to produce fragment ions of the analyte ions, a mass spectrometer having an entrance where at least a portion of the fragment ions are introduced into a vacuum of the mass spectrometer, and a detector in the mass spectrometer which determines a mass to charge ratio analysis of the fragment ions.

Abstract translation: 用于质谱分析的分析物离子的碎裂方法和用于质谱的系统。 该方法产生气相分析物离子，与分析物离子分开产生含气相奇异电子物质，并在基本大气压条件下将气相分析离子和含奇异电子的物质混合，以在 引入质谱仪。 该系统包括气相分析物离子源，与气相分析物离子源分离的气相奇电子物质源，气相分析物离子和含奇异电子的物质混合的混合区域 在基本上大气压下产生分析物离子的碎片离子，质谱仪具有入口，其中至少一部分碎片离子被引入质谱仪的真空中，以及质谱仪中的检测器， 电荷比分析碎片离子。

公开(公告)号：US20100288920A1

公开(公告)日：2010-11-18

申请号：US12784532

申请日：2010-05-21

Applicant: Vladimir M. Doroshenko ,  Vadym D. Berkout ,  Andrey Vilkov

Inventor： Vladimir M. Doroshenko ,  Vadym D. Berkout ,  Andrey Vilkov

IPC: H01J49/00 ,  B01D59/44

CPC classification number: H01J49/0045

Abstract: A method for fragmentation of analyte ions for mass spectroscopy and a system for mass spectroscopy. The method produces gas-phase analyte ions, produces gas-phase odd-electron containing species separately from the analyte ions, and mixes the gas-phase analyte ions and the odd-electron containing species at substantially atmospheric pressure conditions to produce fragment ions prior to introduction into a mass spectrometer. The system includes a gas-phase analyte ion source, a gas-phase odd-electron containing species source separate from the gas-phase analyte ion source, a mixing region where the gas-phase analyte ions and the odd-electron containing species are mixed at substantially atmospheric pressure to produce fragment ions of the analyte ions, a mass spectrometer having an entrance where at least a portion of the fragment ions are introduced into a vacuum of the mass spectrometer, and a detector in the mass spectrometer which determines a mass to charge ratio analysis of the fragment ions.

Abstract translation: 用于质谱分析的分析物离子的碎裂方法和用于质谱的系统。 该方法产生气相分析物离子，与分析物离子分开产生含气相奇异电子物质，并在基本大气压条件下将气相分析离子和含奇异电子的物质混合，以在 引入质谱仪。 该系统包括气相分析物离子源，与气相分析物离子源分离的气相奇电子物质源，气相分析物离子和含奇异电子的物质混合的混合区域 在基本上大气压下产生分析物离子的碎片离子，质谱仪具有入口，其中至少一部分碎片离子被引入质谱仪的真空中，以及质谱仪中的检测器， 电荷比分析碎片离子。

公开(公告)号：US07170051B2

公开(公告)日：2007-01-30

申请号：US11126215

申请日：2005-05-11

Applicant: Vadym D. Berkout ,  Vladimir M. Doroshenko

Inventor： Vadym D. Berkout ,  Vladimir M. Doroshenko

IPC: B01D59/44 ,  H01J49/00

CPC classification number: H01J49/0045

Abstract: An apparatus for mass analyzing molecules includes a mass spectrometer configured to select precursor ions having a mass to charge ratio range, a metastable species generator configured to generate a metastable species for introduction into the mass spectrometer, and a mass detector configured to detect a mass of the product ions. The apparatus also includes interaction region in the mass spectrometer where the precursor ions fragment into product ions via interaction of the precursor ions with the metastable species.

Abstract translation: 用于质量分析分子的装置包括：质谱仪，被配置为选择具有质荷比范围的前体离子;构造成产生用于引入质谱仪的亚稳态物质的亚稳态物质发生器;以及质量检测器， 产品离子。 该装置还包括质谱仪中的相互作用区域，其中前体离子通过前体离子与亚稳态物质的相互作用而分裂成产物离子。