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公开(公告)号：US07785814B2
公开(公告)日：2010-08-31
申请号：US11575732
申请日：2005-09-21
IPC分类号： G01N33/574
CPC分类号： G01N33/57407
摘要： The invention provides a method of detecting a proliferative disease, such as a disease associated with the abnormal expression of BORIS, in a mammal comprising detecting antibodies to BORIS in a sample obtained from the mammal. The invention also provides BORIS polypeptides as well as compositions and kits comprising the BORIS polypeptides and methods of using the same. The invention further provides a method of inducing an immune response in a mammal using BORIS polypeptides.
摘要翻译： 本发明提供了一种检测哺乳动物中增殖性疾病，例如与BORIS异常表达相关的疾病的方法，包括在从哺乳动物获得的样品中检测BORIS抗体。 本发明还提供BORIS多肽以及包含BORIS多肽的组合物和试剂盒及其使用方法。 本发明还提供了使用BORIS多肽在哺乳动物中诱导免疫应答的方法。
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公开(公告)号：US20120237520A1
公开(公告)日：2012-09-20
申请号：US13478779
申请日：2012-05-23
IPC分类号： A61K39/395 , C12Q1/68 , G01N33/574 , A61P35/00 , C12N5/071 , C07K14/47 , C07K16/18
CPC分类号： G01N33/574
摘要： A method of detecting a proliferative disease, such as a disease associated with the abnormal expression of BORIS, in a mammal comprising testing for the expression of a BORIS isoform in the tissue of a mammal that does not express BORIS in the absence of disease, as well as a method of treating or preventing such a disease, isolated or purified BORIS isoform polypeptides and nucleic acids, and kits and arrays comprising same.
摘要翻译： 一种在哺乳动物中检测增殖性疾病，例如与异常表达BORIS有关的疾病的方法，包括在不存在疾病的情况下在不表达BORIS的哺乳动物的组织中测试BORIS同种型的表达，所述方法如 以及治疗或预防这种疾病，分离或纯化的BORIS同种型多肽和核酸的方法，以及包含其的试剂盒和阵列。
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公开(公告)号：US08440415B2
公开(公告)日：2013-05-14
申请号：US13478779
申请日：2012-05-23
IPC分类号： G01N33/53
CPC分类号： G01N33/574
摘要： A method of detecting a proliferative disease, such as a disease associated with the abnormal expression of BORIS, in a mammal comprising testing for the expression of a BORIS isoform in the tissue of a mammal that does not express BORIS in the absence of disease, as well as a method of treating or preventing such a disease, isolated or purified BORIS isoform polypeptides and nucleic acids, and kits and arrays comprising same.
摘要翻译： 一种在哺乳动物中检测增殖性疾病，例如与异常表达BORIS有关的疾病的方法，包括在不存在疾病的情况下在不表达BORIS的哺乳动物的组织中测试BORIS同种型的表达，所述方法如 以及治疗或预防这种疾病，分离或纯化的BORIS同种型多肽和核酸的方法，以及包含其的试剂盒和阵列。
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公开(公告)号：US07375206B2
公开(公告)日：2008-05-20
申请号：US10505377
申请日：2003-02-21
CPC分类号： C07K14/47 , C07K14/4702 , C12Q1/6886 , C12Q2600/106 , G01N33/57484
摘要： An isolated or purified nucleic acid molecule consisting essentially of a nucleotide sequence encoding a human or a non-human BORIS, or a fragment of either of the foregoing; an isolated or purified nucleic acid molecule consisting essentially of a nucleotide sequence that is complementary to a nucleotide sequence encoding a human or a non-human BORIS, or a fragment of either of the foregoing; a vector comprising such an isolated or purified nucleic acid molecule; a cell comprising such a vector; an isolated or purified polypeptide molecule consisting essentially of an amino acid sequence encoding a human or a non-human BORIS, or a fragment of either of the foregoing; a cell line that produces a monoclonal antibody that is specific for an aforementioned isolated or purified polypeptide molecule; and the monoclonal antibody produced by the cell line; methods of diagnosing a cancer or a predisposition to a cancer in a male or female mammal; a method of prognosticating a cancer in a mammal; a method of assessing the effectiveness of treatment of a cancer in a mammal; a method of treating a mammal prophylactically or therapeutically for a cancer, and a composition comprising a carrier and an inhibitor of BORIS.
摘要翻译： 分离或纯化的核酸分子，主要由编码人或非人BORIS的核苷酸序列或前述任一种的片段组成; 基本上由与编码人或非人BORIS的核苷酸序列互补的核苷酸序列或前述任一种的片段组成的分离或纯化的核酸分子; 包含这种分离或纯化的核酸分子的载体; 包含这种载体的细胞; 基本上由编码人或非人BORIS的氨基酸序列或前述任一种的片段组成的分离或纯化的多肽分子; 产生对上述分离或纯化的多肽分子特异性的单克隆抗体的细胞系; 和由细胞系产生的单克隆抗体; 在男性或女性哺乳动物中诊断癌症或倾向于癌症的方法; 预测哺乳动物癌症的方法; 一种评估哺乳动物癌症治疗有效性的方法; 用于预防或治疗癌症的哺乳动物的方法，以及包含载体和BORIS抑制剂的组合物。
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公开(公告)号：US08206933B2
公开(公告)日：2012-06-26
申请号：US12439063
申请日：2007-08-30
IPC分类号： G01N33/53
CPC分类号： G01N33/574
摘要： A method of detecting a proliferative disease, such as a disease associated with the abnormal expression of BORIS, in a mammal comprising testing for the expression of a BORIS isoform in the tissue of a mammal that does not express BORIS in the absence of disease, as well as a method of treating or preventing such a disease, isolated or purified BORIS isoform polypeptides and nucleic acids, and kits and arrays comprising same.
摘要翻译： 一种在哺乳动物中检测增殖性疾病，例如与异常表达BORIS有关的疾病的方法，包括在不存在疾病的情况下在不表达BORIS的哺乳动物的组织中测试BORIS同种型的表达，所述方法如 以及治疗或预防这种疾病，分离或纯化的BORIS同种型多肽和核酸的方法，以及包含其的试剂盒和阵列。
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公开(公告)号：US20100021465A1
公开(公告)日：2010-01-28
申请号：US12439063
申请日：2007-08-30
IPC分类号： A61K39/395 , G01N33/53 , C12Q1/68 , C07H21/04 , C12N15/63 , C12N5/00 , C07K16/00 , A61K38/16 , A61K31/7088 , C40B40/06 , A61K39/00 , C07K14/00
CPC分类号： G01N33/574
摘要： A method of detecting a proliferative disease, such as a disease associated with the abnormal expression of BORIS, in a mammal comprising testing for the expression of a BORIS isoform in the tissue of a mammal that does not express BORIS in the absence of disease, as well as a method of treating or preventing such a disease, isolated or purified BORIS isoform polypeptides and nucleic acids, and kits and arrays comprising same.
摘要翻译： 一种在哺乳动物中检测增殖性疾病，例如与异常表达BORIS有关的疾病的方法，包括在不存在疾病的情况下在不表达BORIS的哺乳动物的组织中测试BORIS同种型的表达，所述方法如 以及治疗或预防这种疾病，分离或纯化的BORIS同种型多肽和核酸的方法，以及包含其的试剂盒和阵列。
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