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公开(公告)号：US20070054925A1
公开(公告)日：2007-03-08
申请号：US11396079
申请日：2006-03-31
申请人： Timothy Guzi , Kamil Paruch , Michael Dwyer , Ronald Doll , Viyyoor Girijavallabhan , Alan Mallams , Carmen Alvarez , Kartik Keertikar , Jocelyn Rivera , Tin-Yau Chan , Vincent Madison , Thierry Fischmann , Lawrence Dillard , Vinh Tran , Zhen He , Ray James , Haengsoon Park , Vidyadhar Paradkar , Douglas Hobbs
发明人： Timothy Guzi , Kamil Paruch , Michael Dwyer , Ronald Doll , Viyyoor Girijavallabhan , Alan Mallams , Carmen Alvarez , Kartik Keertikar , Jocelyn Rivera , Tin-Yau Chan , Vincent Madison , Thierry Fischmann , Lawrence Dillard , Vinh Tran , Zhen He , Ray James , Haengsoon Park , Vidyadhar Paradkar , Douglas Hobbs
IPC分类号： A61K31/519 , C07D487/04
CPC分类号： C07D487/04 , A61K31/495
摘要： In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.
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公开(公告)号：US20070054906A1
公开(公告)日：2007-03-08
申请号：US11396001
申请日：2006-03-31
申请人： Timothy Guzi , Kamil Paruch , Michael Dwyer , Ronald Doll , Viyyoor Girijavallabhan , Alan Mallams , Carmen Alvarez , Kartik Keertikar , Jocelyn Rivera , Tin-Yau Chan , Vincent Madison , Thierry Fischmann , Lawrence Dillard , Vinh Tran , Zhen He , Ray James , Haengsoon Park , Vidyadhar Paradkar , Douglas Hobbs
发明人： Timothy Guzi , Kamil Paruch , Michael Dwyer , Ronald Doll , Viyyoor Girijavallabhan , Alan Mallams , Carmen Alvarez , Kartik Keertikar , Jocelyn Rivera , Tin-Yau Chan , Vincent Madison , Thierry Fischmann , Lawrence Dillard , Vinh Tran , Zhen He , Ray James , Haengsoon Park , Vidyadhar Paradkar , Douglas Hobbs
IPC分类号： A61K31/5377 , A61K31/519 , C07D487/04
CPC分类号： C07D487/04
摘要： In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.
摘要翻译： 在其许多实施方案中，本发明提供了一类新颖的吡唑并[1,5-a]嘧啶化合物作为细胞周期蛋白依赖性激酶的抑制剂，制备此类化合物的方法，含有一种或多种此类化合物的药物组合物，制备药物制剂的方法 包括一种或多种这样的化合物，以及使用这些化合物或药物组合物治疗，预防，抑制或改善与CDK相关的一种或多种疾病的方法。
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3.发明授权6-substituted 2-(benzimidazolyl)purine and purinone derivatives for immunosuppression 有权6-取代的2-（苯并咪唑基）嘌呤和嘌呤酮衍生物用于免疫抑制公开(公告)号：US07919490B2
公开(公告)日：2011-04-05
申请号：US11867562
申请日：2007-10-04
申请人： Irina Neagu , David Diller , Celia Kingsbury , Adolph C. Bohnstedt , Michael J. Ohlmeyer , Vidyadhar Paradkar , Nasrin Ansari
发明人： Irina Neagu , David Diller , Celia Kingsbury , Adolph C. Bohnstedt , Michael J. Ohlmeyer , Vidyadhar Paradkar , Nasrin Ansari
IPC分类号： C07D473/32 , C07D473/18 , A61K31/52 , A61K31/522 , A61P37/06 , A61P11/06 , A61P35/02 , C07D239/48 , C07D239/50 , C07D405/12 , C07D405/14
CPC分类号： C07D473/32 , C07D473/16 , C07D473/18 , C07D473/40
摘要： The present invention provides novel purinones and purines useful for the prevention and treatment of autoimmune diseases, inflammatory disease, mast cell mediated disease and transplant rejection. The compounds are of the general formulae I and II shown below, in which Q is selected from the group consisting of CX and nitrogen; and A is chosen from the group consisting of H, (C1-C6) alkyl, heteroaryl, and aryl:
摘要翻译： 本发明提供了可用于预防和治疗自身免疫性疾病，炎性疾病，肥大细胞介导的疾病和移植排斥的新型嘌呤酮和嘌呤。 该化合物具有下列通式I和II，其中Q选自CX和氮; 并且A选自H，（C 1 -C 6）烷基，杂芳基和芳基：
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4.发明授权8-substituted 2-(benzimidazolyl)purine derivatives for immunosuppression 失效8-取代的2-（苯并咪唑基）嘌呤衍生物用于免疫抑制公开(公告)号：US07915268B2
公开(公告)日：2011-03-29
申请号：US11867397
申请日：2007-10-04
IPC分类号： C07D473/32 , A61K31/52 , A61P35/02 , A61P35/00 , A61P11/06 , A61P17/06 , A61P19/02 , C07D405/12 , C07D405/14 , C07D403/04
CPC分类号： C07D473/32
摘要： The present invention provides novel purines useful for the prevention and treatment of autoimmune diseases, inflammatory diseases, mast cell mediated disease and transplant rejection. The compounds of the general formula I shown below, in which Q is selected from the group consisting of CX and nitrogen; and A is chosen from the group consisting of alkyl, heterocyclyl, aryl, substituted alkyl, substituted heterocyclyl, substituted aryl, and halogen:
摘要翻译： 本发明提供了可用于预防和治疗自身免疫疾病，炎性疾病，肥大细胞介导的疾病和移植排斥的新型嘌呤。 下述通式I的化合物，其中Q选自CX和氮; 并且A选自烷基，杂环基，芳基，取代的烷基，取代的杂环基，取代的芳基和卤素：
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公开(公告)号：US07902187B2
公开(公告)日：2011-03-08
申请号：US12196516
申请日：2008-08-22
申请人： Irina Neagu , David Diller , Celia Kingsbury , Adolph C. Bohnstedt , Michael J. Ohlmeyer , Vidyadhar Paradkar , Nasrin Ansari
发明人： Irina Neagu , David Diller , Celia Kingsbury , Adolph C. Bohnstedt , Michael J. Ohlmeyer , Vidyadhar Paradkar , Nasrin Ansari
IPC分类号： C07D473/32 , C07D473/18 , A61K31/52 , A61K31/522 , A61P37/06 , A61P11/06 , A61P35/02 , C07D239/48 , C07D239/50 , C07D405/12 , C07D405/14
CPC分类号： C07D473/16 , C07D473/18 , C07D473/32 , C07D473/40
摘要： The present invention provides novel purinones and purines useful for the prevention and treatment of autoimmune diseases, inflammatory disease, mast cell mediated disease and transplant rejection. The compounds are of the general formulae I and II shown below, in which Q is selected from the group consisting of CX and nitrogen; and A is chosen from the group consisting of H, (C1-C6) alkyl, heteroaryl, and aryl:
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6.发明申请6-SUBSTITUTED 2-(BENZIMIDAZOLYL)PURINE AND PURINONE DERIVATIVES FOR IMMUNOSUPPRESSION 有权6-取代的2-（苯并咪唑）嘌呤和嘌呤衍生物用于免疫抑制公开(公告)号：US20080214580A1
公开(公告)日：2008-09-04
申请号：US11867562
申请日：2007-10-04
申请人： Irina Neagu , David Diller , Celia Kingsbury , Adolph C. Bohnstedt , Michael J. Ohlmeyer , Vidyadhar Paradkar , Nasrin Ansari
发明人： Irina Neagu , David Diller , Celia Kingsbury , Adolph C. Bohnstedt , Michael J. Ohlmeyer , Vidyadhar Paradkar , Nasrin Ansari
IPC分类号： A61K31/522 , C07D473/16
CPC分类号： C07D473/32 , C07D473/16 , C07D473/18 , C07D473/40
摘要： The present invention provides novel purinones and purines useful for the prevention and treatment of autoimmune diseases, inflammatory disease, mast cell mediated disease and transplant rejection. The compounds are of the general formulae I and II:
摘要翻译： 本发明提供了可用于预防和治疗自身免疫性疾病，炎性疾病，肥大细胞介导的疾病和移植排斥的新型嘌呤酮和嘌呤。 该化合物具有通式I和II：
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7.发明申请8-SUBSTITUTED 2-(BENZIMIDAZOLYL)PURINE DERIVATIVES FOR IMMUNOSUPPRESSION 失效8-取代的2-（苯并咪唑）嘌呤衍生物用于免疫抑制公开(公告)号：US20080085898A1
公开(公告)日：2008-04-10
申请号：US11867397
申请日：2007-10-04
IPC分类号： A61K31/52 , A61K31/5377 , A61P29/00 , A61P35/00 , A61P37/00 , A61P9/00 , C07D487/04
CPC分类号： C07D473/32
摘要： The present invention provides novel purines useful for the prevention and treatment of autoimmune diseases, inflammatory disease, mast cell mediated disease and transplant rejection. The compounds are of the general formula I:
摘要翻译： 本发明提供了可用于预防和治疗自身免疫性疾病，炎性疾病，肥大细胞介导的疾病和移植排斥的新型嘌呤。 该化合物具有通式I：
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公开(公告)号：US20080050384A1
公开(公告)日：2008-02-28
申请号：US11788847
申请日：2007-04-20
申请人： Timothy Guzi , Kamil Paruch , Michael Dwyer , Ronald Doll , Viyyoor Girijavallabhan , Alan Mallams , Carmen Alvarez , Kartik Keertikar , Jocelyn Rivera , Tin-Yau Chan , Vincent Madison , Thierry Fischmann , Lawrence Dillard , Vinh Tran , Zhenmin He , Ray James , Haengsoon Park , Vidyadhar Paradkar , Douglas Hobbs , Paul Kirschmeier , Rajat Bannerji
发明人： Timothy Guzi , Kamil Paruch , Michael Dwyer , Ronald Doll , Viyyoor Girijavallabhan , Alan Mallams , Carmen Alvarez , Kartik Keertikar , Jocelyn Rivera , Tin-Yau Chan , Vincent Madison , Thierry Fischmann , Lawrence Dillard , Vinh Tran , Zhenmin He , Ray James , Haengsoon Park , Vidyadhar Paradkar , Douglas Hobbs , Paul Kirschmeier , Rajat Bannerji
IPC分类号： A61K31/519 , A61K31/33 , A61K31/4965 , A61K31/56 , A61K31/675 , A61K33/24 , A61K38/46 , A61P19/02 , A61P35/00 , A61P43/00 , A61P29/00 , A61K39/395 , A61K33/36 , A61K31/7004 , A61K31/655 , A61K31/535 , A61K31/497
CPC分类号： A61K31/33 , A61K31/4965 , A61K31/497 , A61K31/519 , A61K31/535 , A61K31/555 , A61K31/56 , A61K31/655 , A61K31/675 , A61K31/7004 , A61K33/24 , A61K45/06 , A61K2300/00
摘要： In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.
摘要翻译： 在其许多实施方案中，本发明提供了一类新颖的吡唑并[1,5-a]嘧啶化合物作为细胞周期蛋白依赖性激酶的抑制剂，制备此类化合物的方法，含有一种或多种此类化合物的药物组合物，制备药物制剂的方法 包括一种或多种这样的化合物，以及使用这些化合物或药物组合物治疗，预防，抑制或改善与CDK相关的一种或多种疾病的方法。
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9.发明申请6-SUBSTITUTED 2-(BENZIMIDAZOLYL)PURINE AND PURINONE DERIVATIVES FOR IMMUNOSUPPRESSION 有权6-取代的2-（苯并咪唑）嘌呤和嘌呤衍生物用于免疫抑制公开(公告)号：US20090069289A1
公开(公告)日：2009-03-12
申请号：US12196516
申请日：2008-08-22
申请人： Irina Neagu , David Diller , Celia Kingsbury , Adolph C. Bohnstedt , Michael J. Ohlmeyer , Vidyadhar Paradkar , Ansari Nasrin
发明人： Irina Neagu , David Diller , Celia Kingsbury , Adolph C. Bohnstedt , Michael J. Ohlmeyer , Vidyadhar Paradkar , Ansari Nasrin
IPC分类号： C07D473/28 , A61K31/522 , A61K31/497 , A61K31/5377 , A61K31/551
CPC分类号： C07D473/16 , C07D473/18 , C07D473/32 , C07D473/40
摘要： The present invention provides novel purinones and purines useful for the prevention and treatment of autoimmune diseases, inflammatory disease, mast cell mediated disease and transplant rejection. The compounds are of the general formulae I and II:
摘要翻译： 本发明提供了可用于预防和治疗自身免疫性疾病，炎性疾病，肥大细胞介导的疾病和移植排斥的新型嘌呤酮和嘌呤。 该化合物具有通式I和II：
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公开(公告)号：US20070037824A1
公开(公告)日：2007-02-15
申请号：US10654546
申请日：2003-09-03
申请人： Timothy Guzi , Kamil Paruch , Michael Dwyer , Ronald Doll , Viyyoor Girijavallabhan , Alan Mallams , Carmen Alvarez , Kartik Keertikar , Jocelyn Rivera , Tin-Yau Chan , Vincent Madison , Thierry Fischmann , Lawrence Dillard , Vinh Tran , Zhen He , Ray James , Haengsoon Park , Vidyadhar Paradkar , Douglas Hobbs
发明人： Timothy Guzi , Kamil Paruch , Michael Dwyer , Ronald Doll , Viyyoor Girijavallabhan , Alan Mallams , Carmen Alvarez , Kartik Keertikar , Jocelyn Rivera , Tin-Yau Chan , Vincent Madison , Thierry Fischmann , Lawrence Dillard , Vinh Tran , Zhen He , Ray James , Haengsoon Park , Vidyadhar Paradkar , Douglas Hobbs
IPC分类号： A61K31/519 , C07D487/02
CPC分类号： C07D487/04
摘要： In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.
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