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公开(公告)号:US20070054925A1
公开(公告)日:2007-03-08
申请号:US11396079
申请日:2006-03-31
申请人: Timothy Guzi , Kamil Paruch , Michael Dwyer , Ronald Doll , Viyyoor Girijavallabhan , Alan Mallams , Carmen Alvarez , Kartik Keertikar , Jocelyn Rivera , Tin-Yau Chan , Vincent Madison , Thierry Fischmann , Lawrence Dillard , Vinh Tran , Zhen He , Ray James , Haengsoon Park , Vidyadhar Paradkar , Douglas Hobbs
发明人: Timothy Guzi , Kamil Paruch , Michael Dwyer , Ronald Doll , Viyyoor Girijavallabhan , Alan Mallams , Carmen Alvarez , Kartik Keertikar , Jocelyn Rivera , Tin-Yau Chan , Vincent Madison , Thierry Fischmann , Lawrence Dillard , Vinh Tran , Zhen He , Ray James , Haengsoon Park , Vidyadhar Paradkar , Douglas Hobbs
IPC分类号: A61K31/519 , C07D487/04
CPC分类号: C07D487/04 , A61K31/495
摘要: In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.
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2.
公开(公告)号:US20070054906A1
公开(公告)日:2007-03-08
申请号:US11396001
申请日:2006-03-31
申请人: Timothy Guzi , Kamil Paruch , Michael Dwyer , Ronald Doll , Viyyoor Girijavallabhan , Alan Mallams , Carmen Alvarez , Kartik Keertikar , Jocelyn Rivera , Tin-Yau Chan , Vincent Madison , Thierry Fischmann , Lawrence Dillard , Vinh Tran , Zhen He , Ray James , Haengsoon Park , Vidyadhar Paradkar , Douglas Hobbs
发明人: Timothy Guzi , Kamil Paruch , Michael Dwyer , Ronald Doll , Viyyoor Girijavallabhan , Alan Mallams , Carmen Alvarez , Kartik Keertikar , Jocelyn Rivera , Tin-Yau Chan , Vincent Madison , Thierry Fischmann , Lawrence Dillard , Vinh Tran , Zhen He , Ray James , Haengsoon Park , Vidyadhar Paradkar , Douglas Hobbs
IPC分类号: A61K31/5377 , A61K31/519 , C07D487/04
CPC分类号: C07D487/04
摘要: In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.
摘要翻译: 在其许多实施方案中,本发明提供了一类新颖的吡唑并[1,5-a]嘧啶化合物作为细胞周期蛋白依赖性激酶的抑制剂,制备此类化合物的方法,含有一种或多种此类化合物的药物组合物,制备药物制剂的方法 包括一种或多种这样的化合物,以及使用这些化合物或药物组合物治疗,预防,抑制或改善与CDK相关的一种或多种疾病的方法。
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公开(公告)号:US20070037824A1
公开(公告)日:2007-02-15
申请号:US10654546
申请日:2003-09-03
申请人: Timothy Guzi , Kamil Paruch , Michael Dwyer , Ronald Doll , Viyyoor Girijavallabhan , Alan Mallams , Carmen Alvarez , Kartik Keertikar , Jocelyn Rivera , Tin-Yau Chan , Vincent Madison , Thierry Fischmann , Lawrence Dillard , Vinh Tran , Zhen He , Ray James , Haengsoon Park , Vidyadhar Paradkar , Douglas Hobbs
发明人: Timothy Guzi , Kamil Paruch , Michael Dwyer , Ronald Doll , Viyyoor Girijavallabhan , Alan Mallams , Carmen Alvarez , Kartik Keertikar , Jocelyn Rivera , Tin-Yau Chan , Vincent Madison , Thierry Fischmann , Lawrence Dillard , Vinh Tran , Zhen He , Ray James , Haengsoon Park , Vidyadhar Paradkar , Douglas Hobbs
IPC分类号: A61K31/519 , C07D487/02
CPC分类号: C07D487/04
摘要: In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.
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公开(公告)号:US20060178371A1
公开(公告)日:2006-08-10
申请号:US11395676
申请日:2006-03-31
申请人: Timothy Guzi , Kamil Paruch , Michael Dwyer , Ronald Doll , Viyyoor Girijavallabhan , Carmen Alvarez , Tin-Yau Chan , Chad Knutson , Vincent Madison , Thierry Fischmann , Lawrence Dillard , Vinh Tran , Zhen He , Ray James , Haengsoon Park
发明人: Timothy Guzi , Kamil Paruch , Michael Dwyer , Ronald Doll , Viyyoor Girijavallabhan , Carmen Alvarez , Tin-Yau Chan , Chad Knutson , Vincent Madison , Thierry Fischmann , Lawrence Dillard , Vinh Tran , Zhen He , Ray James , Haengsoon Park
IPC分类号: A61K31/519 , A61K31/7048 , A61K31/704 , A61K31/525 , A61K31/66 , C07D487/04
CPC分类号: C07D487/04
摘要: In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.
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公开(公告)号:US20060173016A1
公开(公告)日:2006-08-03
申请号:US11395824
申请日:2006-03-31
申请人: Timothy Guzi , Kamil Paruch , Michael Dwyer , Ronald Doll , Viyyoor Girijavallabhan , Lawrence Dillard , Vinh Tran , Zhen He , Ray James , Haengsoon Park
发明人: Timothy Guzi , Kamil Paruch , Michael Dwyer , Ronald Doll , Viyyoor Girijavallabhan , Lawrence Dillard , Vinh Tran , Zhen He , Ray James , Haengsoon Park
IPC分类号: A61K31/517 , C07D487/04
CPC分类号: C07D487/04 , A61K31/519 , A61K31/52 , A61K31/704 , A61K31/7072 , A61K45/06 , A61K2300/00
摘要: In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.
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公开(公告)号:US20060235025A1
公开(公告)日:2006-10-19
申请号:US11395974
申请日:2006-03-31
申请人: Timothy Guzi , Kamil Paruch , Michael Dwyer , Ronald Doll , Viyyoor Girijavallabhan , Lawrence Dillard , Vinh Tran , Zhen He , Ray James , Haengsoon Park
发明人: Timothy Guzi , Kamil Paruch , Michael Dwyer , Ronald Doll , Viyyoor Girijavallabhan , Lawrence Dillard , Vinh Tran , Zhen He , Ray James , Haengsoon Park
IPC分类号: A61K31/519 , C07D487/04
CPC分类号: C07D487/04
摘要: In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.
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7.
公开(公告)号:US08294964B2
公开(公告)日:2012-10-23
申请号:US12420490
申请日:2009-04-08
申请人: Zhen He
发明人: Zhen He
摘要: What is disclosed is a novel system and method for performing a CMYK to CMYKKpRGB color transform which helps reduce engine-specific halftone artifacts in diverse printing devices capable of dot-on-dot printing. The present method lends adaptive color overlapping control to local color regions depending on the engine behaviors and imaging artifacts to be addressed. With such a transform, an added degree of flexibility is provided to a variety of halftoning algorithms to reduce engine-specific halftone artifacts. Advantageously, increased halftone image quality is effectuated for different engine behaviors in a computationally efficient manner. Various embodiments have been disclosed.
摘要翻译: 所公开的是用于执行CMYK到CMYKKpRGB颜色变换的新颖的系统和方法,其有助于在能够进行点对点打印的各种打印设备中减少引擎特定的半色调伪影。 本方法根据要解决的发动机行为和成像伪像,对局部颜色区域进行自适应颜色重叠控制。 通过这种变换,为各种半色调算法提供了增加的灵活性,以减少引擎特定的半色调伪像。 有利地,以计算上有效的方式对不同的发动机行为实现增加的半色调图像质量。 已经公开了各种实施例。
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公开(公告)号:US20110183159A1
公开(公告)日:2011-07-28
申请号:US12464689
申请日:2009-05-12
申请人: Zhen He , Kenneth H. Nealson , Florian Mansfeld
发明人: Zhen He , Kenneth H. Nealson , Florian Mansfeld
CPC分类号: H01M8/16 , C02F1/46104 , C02F3/301 , C02F3/302 , C02F3/341 , C02F2001/46123 , C02F2101/16 , C02F2101/163 , C02F2101/166 , Y02E60/527
摘要: A microbial fuel cell for generating electricity. The microbial fuel cell includes an anode and a cathode electrically coupled to the anode. The anode is in contact with a first fluid including microorganisms capable of catalyzing the oxidation of ammonium. The anode is in contact with a second fluid including microorganisms capable of catalyzing the reduction of nitrite. The anode and the cathode may be housed in a single compartment, and the cathode may rotate with respect to the anode. The microbial fuel cell can be used to remove ammonium from wastewater, to generate electricity, or both.
摘要翻译: 用于发电的微生物燃料电池。 微生物燃料电池包括电耦合到阳极的阳极和阴极。 阳极与包含能够催化铵氧化的微生物的第一流体接触。 阳极与包含能够催化还原亚硝酸盐的微生物的第二流体接触。 阳极和阴极可以容纳在单个隔室中,并且阴极可以相对于阳极旋转。 微生物燃料电池可用于从废水中除去铵,产生电力,或两者兼而有之。
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公开(公告)号:US07898705B2
公开(公告)日:2011-03-01
申请号:US11537032
申请日:2006-09-29
申请人: Zhen He
发明人: Zhen He
CPC分类号: H04N1/642
摘要: A method to determine the color status of a scanned original segments a binary halftone image into a predetermined number of local windows and converts each local window to a device-independent color space. The method then determines a color space parameter for each local window and compares the color space parameters for the local windows to at least one threshold to determine the color status of the scanned original. An apparatus having a scanner creates a scanned image of an original and has at least one processor to create a binary halftone image from the scanned image, segment the binary halftone image into a predetermined number of local windows, convert each local window to a device-independent color space, determine a color space parameter for each local window, and compare the color space parameter for each local window to at least one threshold to determine the color status for the scanned original.
摘要翻译: 确定扫描的原稿的颜色状态的方法将二进制半色调图像分割成预定数量的本地窗口,并将每个本地窗口转换为与设备无关的色彩空间。 该方法然后确定每个本地窗口的颜色空间参数,并将本地窗口的颜色空间参数与至少一个阈值进行比较,以确定扫描的原稿的颜色状态。 具有扫描器的装置产生原稿的扫描图像,并且具有至少一个处理器,用于从扫描图像创建二进制半色调图像,将二进制半色调图像分割成预定数量的本地窗口,将每个本地窗口转换为设备 - 独立颜色空间,确定每个本地窗口的颜色空间参数,并将每个本地窗口的颜色空间参数与至少一个阈值进行比较,以确定扫描原稿的颜色状态。
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公开(公告)号:US07715044B2
公开(公告)日:2010-05-11
申请号:US11093352
申请日:2005-03-29
申请人: Zhen He
发明人: Zhen He
CPC分类号: H04N1/6022 , H04N1/62
摘要: A method of gray component replacement receives a current pixel color value. A highlight likelihood and color neutrality is determined for the current pixel color value. An output pixel color value depending upon the color neutrality and the highlight likelihood is generated. The input pixel color value is obtained from an image acquisition system and the output color pixel value is used by an output engine to render the pixel.
摘要翻译: 灰色分量替换的方法接收当前像素颜色值。 确定当前像素颜色值的高光似然性和色彩中性。 产生取决于颜色中性和高光似然性的输出像素颜色值。 从图像获取系统获得输入像素颜色值,输出引擎使用输出彩色像素值来渲染像素。
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