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1.发明授权Detection of colon or breast cancer by measuring TTK polynucleotide expression 失效通过测量TTK多核苷酸表达检测结肠癌或乳腺癌公开(公告)号：US07501242B2
公开(公告)日：2009-03-10
申请号：US10951389
申请日：2004-09-27
Applicant: Christoph Reinhard , Anne B. Jefferson , Vivien W. Chan
Inventor： Christoph Reinhard , Anne B. Jefferson , Vivien W. Chan
CPC classification number: G01N33/68 , A61K38/00 , A61K2039/505 , C12N9/1205 , C12Q1/6886 , C12Q2600/106 , C12Q2600/136 , C12Q2600/142 , C12Q2600/158 , C12Y207/01037 , G01N33/5005 , G01N33/5008 , G01N33/5011 , G01N33/5044 , G01N33/57415 , G01N33/57419 , G01N33/57496 , G01N33/6842 , G01N2500/00
Abstract: The present invention provides methods for identification of cancerous cells by detection of expression levels of TTK, as well as diagnostic, prognostic and therapeutic methods that take advantage of the differential expression of these genes in mammalian cancer. Such methods can be useful in determining the ability of a subject to respond to a particular therapy, e.g., as the basis of rational therapy. In addition, the invention provides assays for identifying pharmaceuticals that modulate activity of these genes in cancers in which these genes are involved, as well as methods of inhibiting tumor growth by inhibiting activity of TTK.
Abstract translation: 本发明提供通过检测TTK的表达水平来鉴定癌细胞的方法，以及利用哺乳动物癌症中这些基因的差异表达的诊断，预后和治疗方法。 这样的方法可用于确定受试者对特定疗法的反应能力，例如作为理性治疗的基础。 此外，本发明提供了用于鉴定调节这些基因在其中涉及这些基因的癌症中这些基因的活性的药物的测定法，以及通过抑制TTK活性来抑制肿瘤生长的方法。
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公开(公告)号：US07700359B2
公开(公告)日：2010-04-20
申请号：US10948737
申请日：2004-09-22
Applicant: Vivien W. Chan , Jaime Escobedo , Pablo Dominguez Garcia , Rhonda Hansen , Joerg Kaufmann , Giulia C. Kennedy , George Lamson , Edward J. Moler , Filippo Randazzo , Christoph Reinhard , Julie Sudduth-Klinger
Inventor： Vivien W. Chan , Jaime Escobedo , Pablo Dominguez Garcia , Rhonda Hansen , Joerg Kaufmann , Giulia C. Kennedy , George Lamson , Edward J. Moler , Filippo Randazzo , Christoph Reinhard , Julie Sudduth-Klinger
CPC classification number: C12Q1/6886 , A61K48/00 , C12Q2600/112 , C12Q2600/136
Abstract: The present invention provides polynucleotides, as well as polypeptides encoded thereby, that are differentially expressed in cancer cells. These polynucleotides are useful in a variety of diagnostic and therapeutic methods. The present invention further provides methods of reducing growth of cancer cells. These methods are useful for treating cancer.
Abstract translation: 本发明提供在癌细胞中差异表达的多核苷酸以及由此编码的多肽。 这些多核苷酸可用于各种诊断和治疗方法。 本发明还提供减少癌细胞生长的方法。 这些方法可用于治疗癌症。
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3.发明授权Determining prognosis of colon or breast cancer by measuring TTK expression 失效通过测量TTK表达来确定结肠癌或乳腺癌的预后公开(公告)号：US07501244B2
公开(公告)日：2009-03-10
申请号：US10951477
申请日：2004-09-27
Applicant: Christoph Reinhard , Anne B. Jefferson , Vivien W. Chan
Inventor： Christoph Reinhard , Anne B. Jefferson , Vivien W. Chan
CPC classification number: G01N33/6842 , A61K38/00 , A61K2039/505 , C12N9/1205 , C12Q1/6886 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158 , C12Y207/01037 , G01N33/57415 , G01N33/57419 , G01N33/57496 , G01N33/68 , G01N2500/00
Abstract: The present invention provides methods for identification of cancerous cells by detection of expression levels of TTK, as well as diagnostic, prognostic and therapeutic methods that take advantage of the differential expression of these genes in mammalian cancer. Such methods can be useful in determining the ability of a subject to respond to a particular therapy, e.g., as the basis of rational therapy. In addition, the invention provides assays for identifying pharmaceuticals that modulate activity of these genes in cancers in which these genes are involved, as well as methods of inhibiting tumor growth by inhibiting activity of TTK.
Abstract translation: 本发明提供通过检测TTK的表达水平来鉴定癌细胞的方法，以及利用哺乳动物癌症中这些基因的差异表达的诊断，预后和治疗方法。 这样的方法可用于确定受试者对特定疗法的反应能力，例如作为理性治疗的基础。 此外，本发明提供了用于鉴定调节这些基因在其中涉及这些基因的癌症中这些基因的活性的药物的测定法，以及通过抑制TTK活性来抑制肿瘤生长的方法。
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公开(公告)号：US20140056912A1
公开(公告)日：2014-02-27
申请号：US14114418
申请日：2012-04-27
Applicant: Seth Alexander Ettenberg , Vivien W. Chan , Michael Patrick Morrissey , David Jenkins
Inventor： Seth Alexander Ettenberg , Vivien W. Chan , Michael Patrick Morrissey , David Jenkins
IPC: A61K39/395
CPC classification number: A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/22 , C07K16/3076 , G01N33/57407 , G01N2400/00 , G01N2800/50 , G01N2800/52
Abstract: The disclosure relates to methods for treating a sclerostin-expressing cancer, e.g., a squamous cell carcinoma (SCC), e.g., SCC of the upper aerodigestive tract, esophagus, or lung, employing a therapeutically effective amount of at least one sclerostin antagonist, e.g., an anti-sclerostin antibody, such as Antibody 1, 2, 3, 4 or 5.
Abstract translation: 本公开涉及使用治疗有效量的至少一种硬皮素拮抗剂来治疗表达硬脂蛋白的癌症例如鳞状细胞癌（SCC），例如上呼吸消化道，食管或肺的SCC的方法，例如 ，抗硬核蛋白抗体，如抗体1,2,3,4或5。
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5.发明授权Detection of colon or breast cancer by measuring TTK polypeptide expression 失效通过测量TTK多肽表达来检测结肠癌或乳腺癌公开(公告)号：US07501243B2
公开(公告)日：2009-03-10
申请号：US10951406
申请日：2004-09-27
Applicant: Christoph Reinhard , Anne B. Jefferson , Vivien W. Chan
Inventor： Christoph Reinhard , Anne B. Jefferson , Vivien W. Chan
CPC classification number: G01N33/68 , A61K38/00 , A61K2039/505 , C12N9/1205 , C12Q1/6886 , C12Q2600/106 , C12Q2600/136 , C12Q2600/142 , C12Q2600/158 , C12Y207/01037 , G01N33/5005 , G01N33/5008 , G01N33/5011 , G01N33/5044 , G01N33/57415 , G01N33/57419 , G01N33/57496 , G01N33/6842 , G01N2500/00
Abstract: The present invention provides methods for identification of cancerous cells by detection of expression levels of TTK, as well as diagnostic, prognostic and therapeutic methods that take advantage of the differential expression of these genes in mammalian cancer. Such methods can be useful in determining the ability of a subject to respond to a particular therapy, e.g., as the basis of rational therapy. In addition, the invention provides assays for identifying pharmaceuticals that modulate activity of these genes in cancers in which these genes are involved, as well as methods of inhibiting tumor growth by inhibiting activity of TTK.
Abstract translation: 本发明提供通过检测TTK的表达水平来鉴定癌细胞的方法，以及利用哺乳动物癌症中这些基因的差异表达的诊断，预后和治疗方法。 这样的方法可用于确定受试者对特定疗法的反应能力，例如作为理性治疗的基础。 此外，本发明提供了用于鉴定调节这些基因在其中涉及这些基因的癌症中这些基因的活性的药物的测定法，以及通过抑制TTK活性来抑制肿瘤生长的方法。
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Patent Agency Ranking
公开(公告)号：US20120308569A1
公开(公告)日：2012-12-06
申请号：US13491434
申请日：2012-06-07
Applicant: Vivien W. CHAN , Jaime Escobedo , Pablo Dominguez Garcia , Rhonda Hansen , Joerg Kaufmann , Giulia C. Kennedy , George Lamson , Edward J. Moler , Filippo Randazzo , Christoph Reinhard , Julie Sudduth-Klinger
Inventor： Vivien W. CHAN , Jaime Escobedo , Pablo Dominguez Garcia , Rhonda Hansen , Joerg Kaufmann , Giulia C. Kennedy , George Lamson , Edward J. Moler , Filippo Randazzo , Christoph Reinhard , Julie Sudduth-Klinger
IPC: A61K31/713 , C40B30/04 , A61P35/00 , G01N33/574 , C12Q1/68 , A61K39/395 , C12N5/09 , G01N33/566
CPC classification number: C12Q1/6886 , A61K48/00 , C12Q2600/112 , C12Q2600/136
Abstract: The present invention provides polynucleotides, as well as polypeptides encoded thereby, that are differentially expressed in cancer cells. These polynucleotides are useful in a variety of diagnostic and therapeutic methods. The present invention further provides methods of reducing growth of cancer cells. These methods are useful for treating cancer.
Abstract translation: 本发明提供在癌细胞中差异表达的多核苷酸以及由此编码的多肽。 这些多核苷酸可用于各种诊断和治疗方法。 本发明还提供减少癌细胞生长的方法。 这些方法可用于治疗癌症。
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公开(公告)号：US08299081B2
公开(公告)日：2012-10-30
申请号：US11913828
申请日：2006-05-10
Applicant: Glenn C. Michelson , Vivien W. Chan , Carla C. Heise , Marion Wiesmann , Timothy D. Dawes
Inventor： Glenn C. Michelson , Vivien W. Chan , Carla C. Heise , Marion Wiesmann , Timothy D. Dawes
IPC: A61K31/497 , A61K31/535
CPC classification number: A61K31/4425 , A61K31/4184 , A61K31/497 , A61K2300/00
Abstract: A method for treating drug-resistant cancer, includes: administering to a patient in need thereof, a compound of formula I, a tautomer of the compound, a salt of the compound, a salt of the tautomer, a mixture thereof, or a pharmaceutical composition comprising the compound, the tautomer, the salt of the compound, the salt of the tautomer, or the mixture, wherein the patient is a cancer patient with drug-resistant cancer, wherein the compound of Formula I is as defined in the application.
Abstract translation: 一种治疗耐药性癌症的方法，包括：向有需要的患者施用式I化合物，化合物的互变异构体，化合物的盐，互变异构体的盐，其混合物或药物 组合物，其包含化合物，互变异构体，化合物的盐，互变异构体的盐或混合物，其中患者是具有耐药性癌症的癌症患者，其中式I化合物如本申请中所定义。
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公开(公告)号：US08221983B2
公开(公告)日：2012-07-17
申请号：US12725341
申请日：2010-03-16
Applicant: Vivien W. Chan , Jaime Escobedo , Pablo Dominguez Garcia , Rhonda Hansen , Joerg Kaufmann , Giulia C. Kennedy , George Lamson , Edward J. Moler , Filippo Randazzo , Christoph Reinhard , Julie Sudduth-Klinger
Inventor： Vivien W. Chan , Jaime Escobedo , Pablo Dominguez Garcia , Rhonda Hansen , Joerg Kaufmann , Giulia C. Kennedy , George Lamson , Edward J. Moler , Filippo Randazzo , Christoph Reinhard , Julie Sudduth-Klinger
IPC: C12Q1/68
CPC classification number: C12Q1/6886 , A61K48/00 , C12Q2600/112 , C12Q2600/136
Abstract: The present invention provides polynucleotides, as well as polypeptides encoded thereby, that are differentially expressed in cancer cells. These polynucleotides are useful in a variety of diagnostic and therapeutic methods. The present invention further provides methods of reducing growth of cancer cells. These methods are useful for treating cancer.
Abstract translation: 本发明提供在癌细胞中差异表达的多核苷酸以及由此编码的多肽。 这些多核苷酸可用于各种诊断和治疗方法。 本发明还提供减少癌细胞生长的方法。 这些方法可用于治疗癌症。
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公开(公告)号：US20100233187A1
公开(公告)日：2010-09-16
申请号：US12725341
申请日：2010-03-16
Applicant: Vivien W. Chan , Jaime Escobedo , Pablo Dominguez Garcia , Rhonda Hansen , Joerg Kaufmann , Giulia C. Kennedy , George Lamson , Edward J. Moler , Filippo Randazzo , Christoph Reinhard , Julie Sudduth-Klinger
Inventor： Vivien W. Chan , Jaime Escobedo , Pablo Dominguez Garcia , Rhonda Hansen , Joerg Kaufmann , Giulia C. Kennedy , George Lamson , Edward J. Moler , Filippo Randazzo , Christoph Reinhard , Julie Sudduth-Klinger
IPC: A61K39/395 , C12N5/09 , C12Q1/68 , A61K31/713 , A61P35/00
CPC classification number: C12Q1/6886 , A61K48/00 , C12Q2600/112 , C12Q2600/136
Abstract: The present invention provides polynucleotides, as well as polypeptides encoded thereby, that are differentially expressed in cancer cells. These polynucleotides are useful in a variety of diagnostic and therapeutic methods. The present invention further provides methods of reducing growth of cancer cells. These methods are useful for treating cancer.
Abstract translation: 本发明提供在癌细胞中差异表达的多核苷酸以及由此编码的多肽。 这些多核苷酸可用于各种诊断和治疗方法。 本发明还提供减少癌细胞生长的方法。 这些方法可用于治疗癌症。
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公开(公告)号：US20090215793A1
公开(公告)日：2009-08-27
申请号：US11913828
申请日：2006-05-10
Applicant: Glenn C. Michelson , Vivien W. Chan , Carla C. Heise , Marion Wiesmann , Timothy D. Dawes
Inventor： Glenn C. Michelson , Vivien W. Chan , Carla C. Heise , Marion Wiesmann , Timothy D. Dawes
IPC: A61K31/496 , A61P35/00
CPC classification number: A61K31/4425 , A61K31/4184 , A61K31/497 , A61K2300/00
Abstract: A method for treating drug-resistant cancer, includes: administering to a patient in need thereof, a compound of formula I, a tautomer of the compound, a salt of the compound, a salt of the tautomer, a mixture thereof, or a pharmaceutical composition comprising the compound, the tautomer, the salt of the compound, the salt of the tautomer, or the mixture, wherein the patient is a cancer patient with drug-resistant cancer, wherein the compound of Formula I is as defined in the application.
Abstract translation: 一种治疗耐药性癌症的方法，包括：向有需要的患者施用式I化合物，化合物的互变异构体，化合物的盐，互变异构体的盐，其混合物或药物 组合物，其包含化合物，互变异构体，化合物的盐，互变异构体的盐或混合物，其中患者是具有耐药性癌症的癌症患者，其中式I化合物如本申请中所定义。
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