-
公开(公告)号：US20120308569A1
公开(公告)日：2012-12-06
申请号：US13491434
申请日：2012-06-07
申请人： Vivien W. CHAN , Jaime Escobedo , Pablo Dominguez Garcia , Rhonda Hansen , Joerg Kaufmann , Giulia C. Kennedy , George Lamson , Edward J. Moler , Filippo Randazzo , Christoph Reinhard , Julie Sudduth-Klinger
发明人： Vivien W. CHAN , Jaime Escobedo , Pablo Dominguez Garcia , Rhonda Hansen , Joerg Kaufmann , Giulia C. Kennedy , George Lamson , Edward J. Moler , Filippo Randazzo , Christoph Reinhard , Julie Sudduth-Klinger
IPC分类号： A61K31/713 , C40B30/04 , A61P35/00 , G01N33/574 , C12Q1/68 , A61K39/395 , C12N5/09 , G01N33/566
CPC分类号： C12Q1/6886 , A61K48/00 , C12Q2600/112 , C12Q2600/136
摘要： The present invention provides polynucleotides, as well as polypeptides encoded thereby, that are differentially expressed in cancer cells. These polynucleotides are useful in a variety of diagnostic and therapeutic methods. The present invention further provides methods of reducing growth of cancer cells. These methods are useful for treating cancer.
摘要翻译： 本发明提供在癌细胞中差异表达的多核苷酸以及由此编码的多肽。 这些多核苷酸可用于各种诊断和治疗方法。 本发明还提供减少癌细胞生长的方法。 这些方法可用于治疗癌症。
-
公开(公告)号：US08221983B2
公开(公告)日：2012-07-17
申请号：US12725341
申请日：2010-03-16
申请人： Vivien W. Chan , Jaime Escobedo , Pablo Dominguez Garcia , Rhonda Hansen , Joerg Kaufmann , Giulia C. Kennedy , George Lamson , Edward J. Moler , Filippo Randazzo , Christoph Reinhard , Julie Sudduth-Klinger
发明人： Vivien W. Chan , Jaime Escobedo , Pablo Dominguez Garcia , Rhonda Hansen , Joerg Kaufmann , Giulia C. Kennedy , George Lamson , Edward J. Moler , Filippo Randazzo , Christoph Reinhard , Julie Sudduth-Klinger
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , A61K48/00 , C12Q2600/112 , C12Q2600/136
摘要： The present invention provides polynucleotides, as well as polypeptides encoded thereby, that are differentially expressed in cancer cells. These polynucleotides are useful in a variety of diagnostic and therapeutic methods. The present invention further provides methods of reducing growth of cancer cells. These methods are useful for treating cancer.
摘要翻译： 本发明提供在癌细胞中差异表达的多核苷酸以及由此编码的多肽。 这些多核苷酸可用于各种诊断和治疗方法。 本发明还提供减少癌细胞生长的方法。 这些方法可用于治疗癌症。
-
公开(公告)号：US20100233187A1
公开(公告)日：2010-09-16
申请号：US12725341
申请日：2010-03-16
申请人： Vivien W. Chan , Jaime Escobedo , Pablo Dominguez Garcia , Rhonda Hansen , Joerg Kaufmann , Giulia C. Kennedy , George Lamson , Edward J. Moler , Filippo Randazzo , Christoph Reinhard , Julie Sudduth-Klinger
发明人： Vivien W. Chan , Jaime Escobedo , Pablo Dominguez Garcia , Rhonda Hansen , Joerg Kaufmann , Giulia C. Kennedy , George Lamson , Edward J. Moler , Filippo Randazzo , Christoph Reinhard , Julie Sudduth-Klinger
IPC分类号： A61K39/395 , C12N5/09 , C12Q1/68 , A61K31/713 , A61P35/00
CPC分类号： C12Q1/6886 , A61K48/00 , C12Q2600/112 , C12Q2600/136
摘要： The present invention provides polynucleotides, as well as polypeptides encoded thereby, that are differentially expressed in cancer cells. These polynucleotides are useful in a variety of diagnostic and therapeutic methods. The present invention further provides methods of reducing growth of cancer cells. These methods are useful for treating cancer.
摘要翻译： 本发明提供在癌细胞中差异表达的多核苷酸以及由此编码的多肽。 这些多核苷酸可用于各种诊断和治疗方法。 本发明还提供减少癌细胞生长的方法。 这些方法可用于治疗癌症。
-
公开(公告)号：US06964868B1
公开(公告)日：2005-11-15
申请号：US09297648
申请日：1999-01-28
申请人： Lewis T. Williams , Jaime Escobedo , Michael A. Innis , Pablo Dominguez Garcia , Julie Sudduth-Klinger , Christoph Reinhard , Klaus Giese , Filippo Randazzo , Giulia C. Kennedy , David Pot , Altaf Kassam , George Lamson , Radoje Drmanac , Radomir Crkvenjakov , Mark Dickson , Snezana Drmanac , Ivan Labat , Dena Leshkowitz , David Kita , Veronica Garcia , Lee William Jones , Birgit Stache-Crain
发明人： Lewis T. Williams , Jaime Escobedo , Michael A. Innis , Pablo Dominguez Garcia , Julie Sudduth-Klinger , Christoph Reinhard , Klaus Giese , Filippo Randazzo , Giulia C. Kennedy , David Pot , Altaf Kassam , George Lamson , Radoje Drmanac , Radomir Crkvenjakov , Mark Dickson , Snezana Drmanac , Ivan Labat , Dena Leshkowitz , David Kita , Veronica Garcia , Lee William Jones , Birgit Stache-Crain
CPC分类号： C07K14/4748
摘要： This invention relates to novel human polynucleotides and variants thereof, their encoded polypeptides and variants thereof, to genes corresponding to these polynucleotides and to proteins expressed by the genes. The invention also relates to diagnostic and therapeutic agents employing such novel human polynucleotides, their corresponding genes or gene products, e.g., these genes and proteins, including probes, antisense constructs, and antibodies.
摘要翻译： 本发明涉及对应于这些多核苷酸的基因和由该基因表达的蛋白质的新型人多核苷酸及其变体，其编码的多肽及其变体。 本发明还涉及使用这种新型人多核苷酸的诊断和治疗剂，其相应的基因或基因产物，例如这些基因和蛋白质，包括探针，反义构建体和抗体。
-
5.发明授权Gene products differentially expressed in cancerous cells and their methods of use II 有权在癌细胞中差异表达的基因产物及其使用方法II公开(公告)号：US08101349B2
公开(公告)日：2012-01-24
申请号：US10779543
申请日：2004-02-12
CPC分类号： A61K38/1709 , C07K14/47 , C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158 , G01N33/574
摘要： The present invention provides polynucleotides, as well as polypeptides encoded thereby, that are differentially expressed in cancer cells. These polynucleotides are useful in a variety of diagnostic and therapeutic methods. The present invention further provides methods of reducing growth of cancer cells. These methods are useful for treating cancer.
摘要翻译： 本发明提供在癌细胞中差异表达的多核苷酸以及由此编码的多肽。 这些多核苷酸可用于各种诊断和治疗方法。 本发明还提供减少癌细胞生长的方法。 这些方法可用于治疗癌症。
-
公开(公告)号：US20140249135A1
公开(公告)日：2014-09-04
申请号：US14273595
申请日：2014-05-09
申请人： Matthew Burger , Mika Lindvall , Wooseok Han , Jiong Lan , Gisele Nishiguchi , Cynthia Shafer , Cornelia Bellamacina , Kay Huh , Gordana Atallah , Christopher McBride , William Antonios-McCrea, JR. , Tatiana Zavorotinskaya , Annette Walter , Pablo Dominguez Garcia
发明人： Matthew Burger , Mika Lindvall , Wooseok Han , Jiong Lan , Gisele Nishiguchi , Cynthia Shafer , Cornelia Bellamacina , Kay Huh , Gordana Atallah , Christopher McBride , William Antonios-McCrea, JR. , Tatiana Zavorotinskaya , Annette Walter , Pablo Dominguez Garcia
IPC分类号： C07D401/12 , A61K31/55 , A61K31/497 , A61K31/4545 , A61K31/444 , C07D491/113 , C07D403/12 , A61K31/506 , C07D241/28 , C07D401/14 , C07D405/14 , C07D409/14 , C07D417/14 , C07D497/04 , C07D403/14 , A61K31/553
CPC分类号： C07D401/12 , A61K31/444 , A61K31/4545 , A61K31/497 , A61K31/506 , A61K31/55 , A61K31/553 , C07D241/24 , C07D241/28 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D417/14 , C07D491/113 , C07D497/04
摘要： New compounds, compositions and methods of inhibition of kinase activity associated with tumorigenesis in a human or animal subject are provided. In certain embodiments, the compounds and compositions are effective to inhibit the activity of at least one serine/threonine kinase or receptor tyrosine kinase. The new compounds and compositions may be used either alone or in combination with at least one additional agent for the treatment of a serine/threonine kinase- or receptor tyrosine kinase-mediated disorder, such as cancer.
摘要翻译： 提供了在人或动物受试者中抑制与肿瘤发生相关的激酶活性的新化合物，组合物和方法。 在某些实施方案中，化合物和组合物有效抑制至少一种丝氨酸/苏氨酸激酶或受体酪氨酸激酶的活性。 新化合物和组合物可以单独使用或与至少一种另外的药剂组合使用，用于治疗丝氨酸/苏氨酸激酶或受体酪氨酸激酶介导的病症，例如癌症。
-
公开(公告)号：US07700359B2
公开(公告)日：2010-04-20
申请号：US10948737
申请日：2004-09-22
申请人： Vivien W. Chan , Jaime Escobedo , Pablo Dominguez Garcia , Rhonda Hansen , Joerg Kaufmann , Giulia C. Kennedy , George Lamson , Edward J. Moler , Filippo Randazzo , Christoph Reinhard , Julie Sudduth-Klinger
发明人： Vivien W. Chan , Jaime Escobedo , Pablo Dominguez Garcia , Rhonda Hansen , Joerg Kaufmann , Giulia C. Kennedy , George Lamson , Edward J. Moler , Filippo Randazzo , Christoph Reinhard , Julie Sudduth-Klinger
CPC分类号： C12Q1/6886 , A61K48/00 , C12Q2600/112 , C12Q2600/136
摘要： The present invention provides polynucleotides, as well as polypeptides encoded thereby, that are differentially expressed in cancer cells. These polynucleotides are useful in a variety of diagnostic and therapeutic methods. The present invention further provides methods of reducing growth of cancer cells. These methods are useful for treating cancer.
摘要翻译： 本发明提供在癌细胞中差异表达的多核苷酸以及由此编码的多肽。 这些多核苷酸可用于各种诊断和治疗方法。 本发明还提供减少癌细胞生长的方法。 这些方法可用于治疗癌症。
-
公开(公告)号：US07122373B1
公开(公告)日：2006-10-17
申请号：US09313292
申请日：1999-05-13
申请人： Lewis T. Williams , Jaime Escobedo , Michael A. Innis , Pablo Dominguez Garcia , Julie Sudduth-Klinger , Christoph Reinhard , Klaus Giese , Filippo Randazzo , Giulia C. Kennedy , David Pot , Altaf Kassam , George Lamson , Radoje Drmanac , Radomir Crkvenjakov , Mark Dickson , Snezana Drmanac , Ivan Labat , Dena Leshkowitz , David Kita , Veronica Garcia , Lee William Jones , Birgit Stache-Crain
发明人： Lewis T. Williams , Jaime Escobedo , Michael A. Innis , Pablo Dominguez Garcia , Julie Sudduth-Klinger , Christoph Reinhard , Klaus Giese , Filippo Randazzo , Giulia C. Kennedy , David Pot , Altaf Kassam , George Lamson , Radoje Drmanac , Radomir Crkvenjakov , Mark Dickson , Snezana Drmanac , Ivan Labat , Dena Leshkowitz , David Kita , Veronica Garcia , Lee William Jones , Birgit Stache-Crain
CPC分类号： C07K14/47 , C12Q1/6886 , C12Q2600/106
摘要： This invention relates to novel human polynucleotides and variants thereof, their encoded polypeptides and variants thereof, to genes corresponding to these polynucleotides and to proteins expressed by the genes. The invention also relates to diagnostic and therapeutic agents employing such novel human polynucleotides, their corresponding genes or gene products, e.g., these genes and proteins, including probes, antisense constructs, and antibodies.
摘要翻译： 本发明涉及对应于这些多核苷酸的基因和由该基因表达的蛋白质的新型人多核苷酸及其变体，其编码的多肽及其变体。 本发明还涉及使用这种新型人多核苷酸的诊断和治疗剂，其相应的基因或基因产物，例如这些基因和蛋白质，包括探针，反义构建体和抗体。
-
-
-
-
-
-
-
搜索结果
8 条记录 (耗时 0.082 秒)
