公开(公告)号：US5252692A

公开(公告)日：1993-10-12

申请号：US617177

申请日：1990-11-23

申请人： Jan Lovy ,  Vladimir A. Stoy

发明人： Jan Lovy ,  Vladimir A. Stoy

IPC分类号： C08F8/32 ,  C08F220/52

CPC分类号： C08F8/32 ,  C08F2800/10 ,  C08F2810/20

摘要： Novel amphoteric acrylic and methacrylic copolymers are described comprising cationic units of pendant N-substituted amidine and anionic units of acrylic or methacrylic acid and/or acidic groups carried by substituents of N-acrylamide, N-methacrylamide, N-acrylamidine or N-methacrylamidine. One preferred embodiment is a copolymer in which at least some types of functional groups are organized in blocks. Particularly preferred are blocks of pendant nitrile groups. Preferred compositions have the said N-substituents of the amides and/or amidines containing polar groups other than primary amines. Particularly preferred polar groups are tertiary amines, quaternary ammonium salts, hydroxyls and sulfonic acid. These copolymers may optionally be convalently or physically crosslinked and swellable rather than soluble in water. A method of preparing said amphoteric acrylic and methacrylic copolymers is described comprising the reaction of selected polymers with a multitude of pendant CN groups in mutual 1,3 positions with a primary amine in presence of water. One preferred method is the reaction of CN groups with the primary amine and water in the presence of a solvent of the said polymer and/or in the presence of a basic catalyst. The particularly preferred embodiment is a reaction of CN groups containing polymer dissolved in a mixture of the polymer solvent, a primary amine, water and an optional basic catalyst.

摘要翻译： 描述了新型两性丙烯酸和甲基丙烯酸共聚物，其包括N-取代脒侧基的阳离子单元和由N-丙烯酰胺，N-甲基丙烯酰胺，N-丙烯酰脒或N-甲基脒基的取代基所携带的丙烯酸或甲基丙烯酸和/或酸性基团的阴离子单元。 一个优选实施方案是其中至少一些类型的官能团以块形式组织的共聚物。 特别优选的是侧基腈基团。 优选的组合物具有除伯胺之外的含有极性基团的酰胺和/或脒的所述N-取代基。 特别优选的极性基团是叔胺，季铵盐，羟基和磺酸。 这些共聚物可以任选地是共价的或物理上交联的和可溶胀的而不是可溶于水。 描述制备所述两性丙烯酸和甲基丙烯酸共聚物的方法，其包括在存在水的情况下，将选定的聚合物与多个相互1,3位的侧基CN基团与伯胺反应。 一种优选的方法是在所述聚合物的溶剂存在下和/或在碱性催化剂的存在下，CN基团与伯胺和水的反应。 特别优选的实施方案是含有聚合物的CN基团溶解在聚合物溶剂，伯胺，水和任选的碱性催化剂的混合物中的反应。

公开(公告)号：US5217026A

公开(公告)日：1993-06-08

申请号：US864472

申请日：1992-04-06

申请人： George P. Stoy ,  Vladimir A. Stoy

发明人： George P. Stoy ,  Vladimir A. Stoy

IPC分类号： A61M25/00

CPC分类号： A61M25/0045 ,  A61M25/0009 ,  A61M25/09 ,  A61M2025/09083 ,  A61M2025/09091 ,  A61M2025/09108 ,  Y10S524/916

摘要： The present invention guidewire involves an elongated, non-hydrogel core element forming an inner part of the device, and an integral outside tubular layer of elastomeric hydrogel ("hydrogel sleeve"). This outer hydrogel layer has unique physical characteristics. They are (a) Gradient of chemical composition with increasing concentration of polar groups in the outward direction away from the core element; (b) Gradient of swelling in contact with water with water content increasing in the outward direction away from the core element; (c) Compressive stress in the outer hydrophilic layer causing the hydrogel in that layer to swell to a water content lower than its equilibrium value in a free-swelling state; and, optionally, (d) Inward-directed radial stress pushing the outside hydrogel layer constantly against the inner core element. The present invention also involves the methods of making these guidewires, including melt extrusion directly onto the core element, coagulation from solution, in situ hydrogel polymer formation, and tubing extrusion followed by consequent shrink-fit over the core.

摘要翻译： 本发明的导丝涉及形成装置的内部的细长的非水凝胶芯元件和弹性体水凝胶（“水凝胶套”）的整体的外部管状层。 该外部水凝胶层具有独特的物理特征。 它们是（a）化学成分的梯度随着极性基团浓度越来越远离核心元素的向外方向; （b）与水接触的膨胀梯度，水分含量沿远离核心元件的向外方向增加; （c）外层亲水层中的压缩应力使得该层中的水凝胶在游离溶胀状态下膨胀至低于其平衡值的水含量; 和（d）向内的径向应力将外部水凝胶层不断地推靠在内芯元件上。 本发明还涉及制造这些导线的方法，包括直接熔融挤出到芯元件上，从溶液凝结，原位水凝胶聚合物形成和管材挤出，随后在芯上收缩配合。

公开(公告)号：US5037178A

公开(公告)日：1991-08-06

申请号：US464187

申请日：1990-01-12

申请人： Vladimir A. Stoy ,  Francis T. Delahanty

发明人： Vladimir A. Stoy ,  Francis T. Delahanty

IPC分类号： B29C35/04 ,  B29C61/00 ,  B29C61/06 ,  C08L101/00 ,  G01B5/25 ,  G02B6/00 ,  G02B6/38

CPC分类号： B29C61/003 ,  B29C61/06 ,  G01B5/25 ,  G02B6/3803 ,  G02B6/3865 ,  B29C35/049 ,  Y10T428/1328

摘要： The present invention is directed to a device and method for precise positioning, or alignment of one or more articles with respect to the device or to each other. The device comprises one or more elements of Unistructural Mass of Inherent Memory Polymer with one or more internal cavities which have inherent shapes with at least one cross-sectional configuration which is congruent to a cross-sectional configuration shape of the said article(s) in the positioned or aligned position(s). The unistructural mass has cross-sectional configurations which are the same or smaller than those corresponding to the positions of the articles. The unistructural mass is deformed such that the articles can be readily inserted into the corresponding cavities. In one embodiment, a single unistructural mass has a single cavity for precision positioning of the article. In another embodiment, the mass has at least two cavities for article alignment. In another embodiment, a plurality of unistructural masses are aligned or connected and each contains at least one such cavity. Once the articles are inserted into their corresponding cavities, the inherent memory polymer is returned to its inherent shape by non-mechanical stimulus to force the articles into precisely defined position.

摘要翻译： 本发明涉及一种用于相对于装置或彼此精确地定位或对准一个或多个物品的装置和方法。 该装置包括具有一个或多个内部空腔的一个或多个具有一个或多个内部空腔的非结构质量的元件，所述内部空腔具有至少一个横截面构造的固有形状，其与所述制品的横截面构造形状一致， 定位或对准的位置。 非结构性物质具有与制品的位置对应的截面构造相同或更小的横截面构造。 非结构物质变形，使得制品能够容易地插入到相应的空腔中。 在一个实施例中，单一的非结构物质具有用于制品的精确定位的单个腔。 在另一个实施例中，该物质具有用于制品对准的至少两个空腔。 在另一个实施例中，多个非结构质量对齐或连接，并且每个都包含至少一个这样的空腔。 一旦物品被插入其相应的空腔中，固有的记忆聚合物通过非机械刺激返回到其固有的形状，以迫使制品进入精确限定的位置。

公开(公告)号：US4969705A

公开(公告)日：1990-11-13

申请号：US467511

申请日：1990-01-19

申请人： Vladimir A. Stoy ,  Francis T. Delahanty

发明人： Vladimir A. Stoy ,  Francis T. Delahanty

IPC分类号： G02B1/04 ,  G02B6/28 ,  G02B6/38

CPC分类号： G02B6/2804 ,  G02B1/048 ,  G02B6/3806

摘要： The present invention involves a multiple cavity optical fiber splice made of a unistructural mass of inherent shape memory polymer material. The unistructural mass has a longitudinal dimension with opposite ends which includes at least a first bore at one end and at least a second bore and a third bore at the other end wherein the bores go into the mass and at least two connect to each other. The unistructural mass has two shapes, the first shape is a unique, recoverable, predetermined inherent shape wherein each bore has a preset diameter to accommodate and tightly hold end segments of denuded optical fibers of predetermined diameter and the second shape is a deformed shape which may be caused by solvent swelling and partial shrinking of the inherent memory polymer material such that each bore has enlarged predetermined diameters greater than the diameters of the segments of the denuded optical fibers so as to freely receive the end segments of the denuded optical fibers. The mass may be initially formed in the first shape, and may be then swollen and shrunk to its second shape. It is capable of being returned to its first shape by application of a non-mechanical stimulus.

摘要翻译： 本发明涉及由固有形状记忆聚合物材料的非结构物质制成的多腔光纤接头。 该非结构物质具有相对端的纵向尺寸，该纵向尺寸至少包括一端的第一孔和至少一个第二孔，另一端包括第三孔，其中孔进入质量并且至少两个相互连接。 非结构质量具有两种形状，第一形状是独特的，可恢复的，预定的固有形状，其中每个孔具有预定直径以容纳并紧密地保持预定直径的裸露光纤的端部段，并且第二形状是变形形状， 由固有的记忆聚合物材料的溶剂膨胀和部分收缩引起，使得每个孔具有比已解开的光纤的段的直径大的预定直径的扩大，以便自由地接收裸露的光纤的端部段。 质量可以最初形成为第一形状，然后可以膨胀并收缩到其第二形状。 它能够通过应用非机械刺激而恢复到其第一形状。

公开(公告)号：US4731078A

公开(公告)日：1988-03-15

申请号：US767808

申请日：1985-08-21

申请人： Vladimir A. Stoy ,  George P. Stoy

发明人： Vladimir A. Stoy ,  George P. Stoy

IPC分类号： A61F2/16 ,  A61L27/14 ,  G02B3/08

CPC分类号： A61F2/1648 ,  A61L27/14 ,  G02B3/08 ,  A61F2002/1683 ,  A61L2430/16

摘要： An artificial intraocular lens features an optical body for refracting images onto the retina and an outer surface that encloses the optical body, is exposed to fluid within the eye, and has a refractive index no greater than 1.40. In another aspect, the optical body includes an internal refractive surface whose contour can be selectively changed to change its refractive power.

摘要翻译： 人造眼内透镜具有用于将图像折射到视网膜上的光学体，并且包围光学体的外表面暴露于眼睛内的流体，并且具有不大于1.40的折射率。 在另一方面，光学体包括内部折射表面，其轮廓可以选择性地改变以改变其屈光力。

公开(公告)号：US4369294A

公开(公告)日：1983-01-18

申请号：US323468

申请日：1981-11-20

申请人： Vladimir A. Stoy

发明人： Vladimir A. Stoy

IPC分类号： C08F8/00 ,  C08F293/00 ,  C08F220/48 ,  C08F220/52

CPC分类号： C08F293/00 ,  C08F8/00

摘要： There is disclosed block copolymers having acrylonitrile sequences and sequences of glutarimide units of a molecular weight of from about 10,000 to about 2,000,000 where the acrylonitrile sequences and sequences including glutarimide units are of a molecular weight of at least about 400 with the number of sequences being at least about 2 and preferably 5 and higher.

摘要翻译： 公开了具有丙烯腈序列和分子量为约10,000至约2,000,000的戊二酰亚胺单元序列的嵌段共聚物，其中丙烯腈序列和包含戊二酰亚胺单元的序列的分子量至少为约400，序列数为 至少约2，优选5和更高。

公开(公告)号：US4331783A

公开(公告)日：1982-05-25

申请号：US188224

申请日：1980-09-17

申请人： Vladimir A. Stoy

发明人： Vladimir A. Stoy

IPC分类号： C08F293/00 ,  C08F220/48 ,  C08F220/52

CPC分类号： C08F293/00

摘要： There is disclosed block copolymers having acrylonitrile sequences and sequences of glutarimide units of a molecular weight of form about 10,000 to about 2,000,000 where the acrylonitrile sequences and sequences including glutarimide units are of a molecular weight of at least about 400 with the number of sequences being at least about 2 and preferably 5 and higher.

摘要翻译： 公开了具有丙烯腈序列和分子量约10,000至约2,000,000的戊二酰亚胺单元序列的嵌段共聚物，其中丙烯腈序列和包含戊二酰亚胺单元的序列的分子量至少为约400，序列数为 至少约2，优选5和更高。

公开(公告)号：US5674283A

公开(公告)日：1997-10-07

申请号：US565255

申请日：1995-11-30

申请人： Vladimir A. Stoy

发明人： Vladimir A. Stoy

IPC分类号： A61F2/14 ,  A61F2/16 ,  B29D11/00

CPC分类号： A61F2/1616 ,  Y10S425/808 ,  Y10S623/901

摘要： An implantable ophthalmic lens manufactured at least partly out of soft, elastic and pliable material substantially in the shape of a saucer is described. It includes an outer optical face forming one side of the lens, and an inner optical face forming the other side of the lens. A center portion of the inner optical face of the lens as well as the lens rim each have the shape of meniscus derived from the corresponding meniscus of a liquid precursor prior to solidification, the center portion meniscus and the rim meniscus being connected by an annular ring, all surfaces of the lens except the center portion of the inner optical face and the lens rim being replicas of a solid mold from which it is formed. The inner optical face center portion and the lens rim have the shape of a liquid precursor solidified in contact with an inert fluid. The method of manufacturing an ophthalmic lens involves solidification of a liquid precursor in an at least bipartite mold with a dished base and a tubular top member which is extendable under the surface of a liquid precursor. The annular ring is preferably a conically ground face.

摘要翻译： 描述了至少部分地由基本上为碟形形状的柔软，弹性和柔韧材料制成的可植入眼科镜片。 它包括形成透镜一侧的外光学面和形成透镜另一侧的内光学面。 透镜的内部光学面的中心部分以及透镜边缘各自具有在凝固之前衍生自液体前体的相应弯液面的弯液面的形状，中心部弯月面和边缘弯液面通过环形环连接 除了内光学面的中心部分和透镜边缘之外的透镜的所有表面都是与其形成的实心模的复制品。 内部光学面中心部分和透镜边缘具有与惰性流体接触固化的液体前体的形状。 制造眼用镜片的方法包括在具有可在液体前体的表面下延伸的碟状底座和管状顶部构件的至少二分之一模具中固化液体前体。 环形环最好是圆锥形地面。

公开(公告)号：US4921323A

公开(公告)日：1990-05-01

申请号：US288629

申请日：1988-12-22

申请人： Francis T. Delahanty ,  Vladimir A. Stoy ,  Shiu-Bor Tong

发明人： Francis T. Delahanty ,  Vladimir A. Stoy ,  Shiu-Bor Tong

IPC分类号： B29C35/04 ,  B29C61/00 ,  B29C61/06 ,  G02B6/255 ,  G02B6/38

CPC分类号： B29C61/003 ,  B29C61/06 ,  G02B6/3803 ,  B29C35/049

摘要： The present invention involves an optical fiber splicer made of a unistructural mass of inherent shaped memory polymer material. The splicer has a longitudinal dimension with opposite ends having first bore at one end and a second bore at the other end wherein the bores go into the mass and to each other. Preferably, the first bore and the second bore are merely a single continuous oriface. The unistructural mass has a first shape and a second shape. The first shape is a recoverable, predetermined inherent shape wherein the first bore and second bore each have a preset diameter to accomodate and tightly hold end segments of denuded optical fibers of predetermined diameter in spliced, butted alignment with one another. The second shape is such that the first bore and second bore each have swollen predetermined diameters which are greater than the diameters of the end segments of optical fibers so as to loosely and freely receive the end segments. The unistructural mass of inherent shape memory polymer material is initially formed in the first, inherent shape, and is then swollen and partially shrunk to its second, deformed shape and is capable of being returned to its first shape by application of a non-mechanical stimulus thereto, such as heat. The invention is also directed to preparing the optical splicer as well as to using the optical splicer to obtain a butt-to-butt splicing of optical fibers.

公开(公告)号：US4563182A

公开(公告)日：1986-01-07

申请号：US667265

申请日：1984-11-01

申请人： Vladimir A. Stoy ,  George P. Stoy

发明人： Vladimir A. Stoy ,  George P. Stoy

IPC分类号： A61F5/00 ,  A61F7/02 ,  A61F7/12 ,  A61K9/02 ,  A61M31/00

CPC分类号： A61K9/02 ,  A61F5/0093 ,  A61F7/12 ,  A61F2007/0028 ,  A61F2007/0214 ,  Y10S424/15

摘要： A method of treating hemorrhoids which comprises inserting into the rectum of a subject afflicted therewith a substantially cylindrical shaped insert, comprising a water swellable polymer having a water content of at least 35% by weight, said insert having previously been frozen by being subjected to a temperature below 0.degree. C. for a sufficient amount of time to freeze the free water therein and maintaining said insert with at least a portion thereof outside the sphincter muscle, and apparatus therefore.

摘要翻译： PCT No.PCT / US83 / 00300 Sec。 371日期1984年11月1日 102（e）1984年11月1日日期PCT提交1983年3月4日PCT公布。 公开号WO84 / 03434 日本1984年9月13日。一种治疗痔疮的方法，其包括将患有基本上圆柱形的插入物的受试者的直肠插入，所述插入物包含水含量为至少35重量％的水溶胀性聚合物，所述插入物先前 通过在0℃以下的温度下冷冻足够的时间以使其中的游离水冷冻并将所述插入物至少保持在括约肌外部，并因此装置。