公开(公告)号：US5159360A

公开(公告)日：1992-10-27

申请号：US556329

申请日：1990-07-17

申请人： Vladimir A. Stoy ,  Jan Lovy ,  George P. Stoy

发明人： Vladimir A. Stoy ,  Jan Lovy ,  George P. Stoy

IPC分类号： G02B1/04 ,  G02C7/04

CPC分类号： G02B1/043 ,  G02C7/04

摘要： The present invention contact lens is a soft, disposable lens which, under eye wearer conditions, changes one or more characteristics essential for comfortable use, at a predetermined time to initiate disposal thereof by the user. This lens, under wear conditions, changes, for example, at least its base curve redius and its deformability as a consequence of a change in hydrophilicity of at least a portion of the contact lens material. This hydrophilicity change may be achieved by various means, e.g. degradation of crosslinking bridges or conversion of less hydrophilic groups to groups having greater hydrophilicity. In one preferred embodiment, the conversion is achieved by hydrolysis of selected functional (hydrophobic) groups into hydrophilic groups.

摘要翻译： 本发明的隐形眼镜是一种柔软的一次性透镜，其在眼睛佩戴者的条件下，在预定的时间改变用于舒适使用所必需的一个或多个特征以开始用户的处置。 这种透镜在磨损条件下，例如由于隐形眼镜材料的至少一部分的亲水性变化而至少改变其基线曲线及其变形能力。 这种亲水性变化可以通过各种方式实现，例如， 交联桥的降解或较少亲水基团转化为具有较大亲水性的基团。 在一个优选的实施方案中，通过将选择的官能（疏水）基团水解成亲水基团来实现转化。

公开(公告)号：US4943618A

公开(公告)日：1990-07-24

申请号：US135070

申请日：1987-12-18

申请人： Vladimir A. Stoy ,  George P. Stoy ,  Jan Lovy

发明人： Vladimir A. Stoy ,  George P. Stoy ,  Jan Lovy

IPC分类号： C08F8/00

CPC分类号： C08F8/00

摘要： A method is disclosed for preparing polyacrylonitrile copolymers by Heterogeneous reaction of polyacrylonitrile aquagel. Generally, the method includes the steps of preparing a solution of polyacrylonitrile by dissolving the polyacrylonitrile in a water-miscible solvent which is capable of dissolving the polyacrylonitrile but incapable of hydrolyzing the nitrile groups of the polyacrylonitrile under the dissolution conditions. Coagulating the polyacrylonitrile solution by replacing the solvent with a coagulating fluid such as water or a water-miscible fluid incapable of dissolving polyacrylonitrile at temperatures below 80.degree. C. and incapable of reacting with the nitrile groups of the polyacrylonitrile, thus obtaining the polymer in the aquagel state. Replacing the coagulating fluid with a fluid reagent capable of reacting with the nitrile groups of the polyacrylonitrile aquagel but incapable of dissolving the polyacrylonitrile aquagel at the selected reaction temperature. Allowing the fluid reagent to chemically react with the nitrile groups of the aquagel while the polyacrylonitrile aquagel is undissolved to form a copolymer product.The copolymer product is then either used in further chemical reactions involving newly formed and/or original side substituents, or isolated and utilized for molding or shaping into various articles. Various plasticizers, which when undiluted are capable of dissolving polyacrylonitrile, may be added to the copolymer product to assist in molding or shaping the material into an article.

公开(公告)号：US5252692A

公开(公告)日：1993-10-12

申请号：US617177

申请日：1990-11-23

申请人： Jan Lovy ,  Vladimir A. Stoy

发明人： Jan Lovy ,  Vladimir A. Stoy

IPC分类号： C08F8/32 ,  C08F220/52

CPC分类号： C08F8/32 ,  C08F2800/10 ,  C08F2810/20

摘要： Novel amphoteric acrylic and methacrylic copolymers are described comprising cationic units of pendant N-substituted amidine and anionic units of acrylic or methacrylic acid and/or acidic groups carried by substituents of N-acrylamide, N-methacrylamide, N-acrylamidine or N-methacrylamidine. One preferred embodiment is a copolymer in which at least some types of functional groups are organized in blocks. Particularly preferred are blocks of pendant nitrile groups. Preferred compositions have the said N-substituents of the amides and/or amidines containing polar groups other than primary amines. Particularly preferred polar groups are tertiary amines, quaternary ammonium salts, hydroxyls and sulfonic acid. These copolymers may optionally be convalently or physically crosslinked and swellable rather than soluble in water. A method of preparing said amphoteric acrylic and methacrylic copolymers is described comprising the reaction of selected polymers with a multitude of pendant CN groups in mutual 1,3 positions with a primary amine in presence of water. One preferred method is the reaction of CN groups with the primary amine and water in the presence of a solvent of the said polymer and/or in the presence of a basic catalyst. The particularly preferred embodiment is a reaction of CN groups containing polymer dissolved in a mixture of the polymer solvent, a primary amine, water and an optional basic catalyst.

摘要翻译： 描述了新型两性丙烯酸和甲基丙烯酸共聚物，其包括N-取代脒侧基的阳离子单元和由N-丙烯酰胺，N-甲基丙烯酰胺，N-丙烯酰脒或N-甲基脒基的取代基所携带的丙烯酸或甲基丙烯酸和/或酸性基团的阴离子单元。 一个优选实施方案是其中至少一些类型的官能团以块形式组织的共聚物。 特别优选的是侧基腈基团。 优选的组合物具有除伯胺之外的含有极性基团的酰胺和/或脒的所述N-取代基。 特别优选的极性基团是叔胺，季铵盐，羟基和磺酸。 这些共聚物可以任选地是共价的或物理上交联的和可溶胀的而不是可溶于水。 描述制备所述两性丙烯酸和甲基丙烯酸共聚物的方法，其包括在存在水的情况下，将选定的聚合物与多个相互1,3位的侧基CN基团与伯胺反应。 一种优选的方法是在所述聚合物的溶剂存在下和/或在碱性催化剂的存在下，CN基团与伯胺和水的反应。 特别优选的实施方案是含有聚合物的CN基团溶解在聚合物溶剂，伯胺，水和任选的碱性催化剂的混合物中的反应。

公开(公告)号：US5218039A

公开(公告)日：1993-06-08

申请号：US43327

申请日：1987-04-28

申请人： Vladimir Stoy ,  Jan Lovy

发明人： Vladimir Stoy ,  Jan Lovy

IPC分类号： A01N25/04 ,  A23C9/152 ,  A23L1/03 ,  A23L1/24 ,  A23L1/308 ,  A61K8/04 ,  A61K8/06 ,  A61K8/73 ,  A61K8/81 ,  A61K9/00 ,  A61K9/107 ,  A61K47/32 ,  A61L27/52 ,  A61Q19/00 ,  B01F17/00 ,  C08J3/02 ,  C08L33/18 ,  C09D5/02 ,  C09G1/04 ,  C09K3/00

CPC分类号： A61K8/042 ,  A23L27/60 ,  A23L33/25 ,  A61K47/32 ,  A61K8/06 ,  A61K8/73 ,  A61K8/8141 ,  A61K9/0014 ,  A61K9/107 ,  A61L27/52 ,  A61Q19/00 ,  B01F17/005 ,  C09D5/02 ,  C09G1/04

摘要： Stable emulsions and dispersions of both the water-in-oil and oil-in-water types are prepared by subjecting mixtures of the two phases to shear stress in the presence of nitrile group-containing copolymers capable of forming hydrogels containing at least 90% by weight of water at room temperature.

公开(公告)号：US20110098758A1

公开(公告)日：2011-04-28

申请号：US10541635

申请日：2003-09-12

申请人： Vladimir Stoy ,  Eugene A. Dickhudt ,  Robert Ziebol ,  Gerald Gontarz ,  Dan Baker ,  Jan Lovy

发明人： Vladimir Stoy ,  Eugene A. Dickhudt ,  Robert Ziebol ,  Gerald Gontarz ,  Dan Baker ,  Jan Lovy

IPC分类号： A61B17/56

CPC分类号： A61F2/4611 ,  A61F2/0095 ,  A61F2/442 ,  A61F2002/30075 ,  A61F2002/30113 ,  A61F2002/30563 ,  A61F2002/4622 ,  A61F2002/4627 ,  A61F2002/4635 ,  A61F2230/0006

摘要： There is disclosed a manipulation and storage tool for receiving and manipulating a partially dehydrated intervertebral disk. Manipulation and storage tool is configured to receive the disk and manipulate it into a smaller overall size and subsequently insert it into a temporary storage or sleeve device for later use. Manipulation and storage tool generally includes a manipulation assembly which is movably mounted with respect to a guide assembly. The guide assembly includes a throughbore and a slot for receiving the disk into the throughbore as well as a sleeve holder mounted at a distal end designed to retain a storage device or sleeve into which the manipulated disk is inserted. The manipulation assembly generally includes a drive member having an elongated shaft movably mounted within the bore of the guide assembly and at least one manipulation member for pin positioned adjacent the slot to manipulate the implant in response to movement of the drive member relative to the guide assembly. Preferably, the drive member and guide assembly are inter-connected by a drive rod having a chive pin which guides the motion of drive member with respect to the guide assembly in response to rotation of the drive member to manipulate the disk and insert it into the sleeve. There is also disclosed an insertion tool for receiving an assembled sleeve and disk and inserting the manipulated disk into an intervertebral disk space. Methods of use of the manipulation and storage tool and the inserter tool are also disclosed. There is also disclosed an implant folding and storage device including an implant folding device having a pair of jaws configured to fold an implant therebetween. An implant transfer device is provided to move the folded implant from within the implant folding device and into an implantation tube. There is also disclosed a novel surgical instrument assembly for receipt of a folded implant and installation of the implant into a portion of the body.

摘要翻译： 公开了用于接收和操纵部分脱水的椎间盘的操作和储存工具。 操作和存储工具被配置为接收磁盘并将其操纵成更小的总体尺寸，并且随后将其插入到临时存储或套筒装置中供以后使用。 操作和存储工具通常包括相对于引导组件可移动地安装的操纵组件。 引导组件包括通孔和用于将盘接纳到通孔中的槽，以及安装在设计成保持被操纵的盘插入其中的存储装置或套筒的远端处的套筒保持器。 操作组件通常包括驱动构件，该驱动构件具有可移动地安装在引导组件的孔内的细长轴，以及响应于驱动构件相对于引导组件的移动而相对于槽定位的销的至少一个操纵构件以操纵植入物 。 优选地，驱动构件和引导组件通过具有引导销的驱动杆相互连接，所述驱动杆响应于驱动构件的旋转而相对于引导组件引导驱动构件的运动，以操纵盘并将其插入到 袖。 还公开了用于接收组装的套筒和盘并将操纵盘插入椎间盘空间的插入工具。 还公开了使用操作和存储工具和插入器工具的方法。 还公开了一种植入物折叠和存储装置，其包括植入物折叠装置，该装置具有一对夹爪，其构造成在其间折叠植入物。 提供植入物转移装置以将折叠的植入物从植入物折叠装置内移动到注入管中。 还公开了一种新颖的外科器械组件，用于接收折叠的植入物并将植入物安装到身体的一部分中。

公开(公告)号：US20070299201A1

公开(公告)日：2007-12-27

申请号：US11821039

申请日：2007-06-21

申请人： Jan Lovy

发明人： Jan Lovy

IPC分类号： C08F8/30

CPC分类号： C08F8/12 ,  C08F8/34 ,  C08F120/44

摘要： An improved method of making a PAN copolymer is provided which includes providing a first reaction mixture including polyacrylonitrile dissolved in an aqueous solution containing a thiocyanate salt; providing a second reaction mixture including a metal catalyst dissolved in an aqueous reactive solvent; mixing the first and second reaction mixtures in a container to form a master reaction mixture; heating the master reaction mixture via a heating element to maintain a predetermined reaction temperature range for a time sufficient for completion of a predetermined level of hydrolysis of polyacrylonitrile, wherein the reaction temperature (Tr) is represented by the formula Tr=Ta+Te wherein Ta is the temperature resulting from the amount of added heat and Te is the temperature increase from the heat generated by the exothermic reaction.

摘要翻译： 提供一种制备PAN共聚物的改进方法，其包括提供溶解在含有硫氰酸盐的水溶液中的包含聚丙烯腈的第一反应混合物; 提供包括溶解在水性反应性溶剂中的金属催化剂的第二反应混合物; 将第一和第二反应混合物混合在容器中以形成主反应混合物; 通过加热元件加热母体反应混合物以保持预定的反应温度范围足以完成聚丙烯腈水解预定水平的时间，其中反应温度（T r）由 其中T a a是由加热量产生的温度，其中T a a 而且由放热反应产生的热量的温度升高。