公开(公告)号：US20080193454A1

公开(公告)日：2008-08-14

申请号：US11596106

申请日：2005-05-11

申请人： Ozlem Tureci ,  Ugur Sahin ,  Sandra Schneider ,  Gerd Helftenbein ,  Volker Schluter ,  Dirk Usener ,  Philippe Thiel

发明人： Ozlem Tureci ,  Ugur Sahin ,  Sandra Schneider ,  Gerd Helftenbein ,  Volker Schluter ,  Dirk Usener ,  Philippe Thiel

IPC分类号： A61K39/395 ,  C12N15/11 ,  C12Q1/68 ,  C12Q1/02 ,  C12N5/06 ,  A61K31/70 ,  A61P43/00 ,  C07K14/00 ,  A61K35/12 ,  G01N33/574 ,  C07K16/18

CPC分类号： A61K39/39558 ,  A61K39/395 ,  A61K45/06 ,  C07K14/4748 ,  C07K16/28 ,  C07K16/30 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/156 ,  G01N33/53

摘要： The invention relates to the identification of gene products that are the result of tumor-associated expression and the nucleic acids encoding the same. The invention also relates to the therapy and diagnosis of diseases wherein these gene products are the result of an aberrant tumor-associated expression. The invention also relates to the proteins, polypeptides and peptides that are the result of tumor-associated expression and to the nucleic acids encoding the same.

摘要翻译： 本发明涉及作为肿瘤相关表达的结果的基因产物的鉴定和编码其的核酸。 本发明还涉及其中这些基因产物是异常肿瘤相关表达的结果的疾病的治疗和诊断。 本发明还涉及作为肿瘤相关表达的结果的蛋白质，多肽和肽以及编码其的核酸。

公开(公告)号：US20080166340A1

公开(公告)日：2008-07-10

申请号：US10573229

申请日：2004-09-23

申请人： Ozlem Tureci ,  Ugur Sahin ,  Gerd Helftenbein ,  Volker Schluter

发明人： Ozlem Tureci ,  Ugur Sahin ,  Gerd Helftenbein ,  Volker Schluter

IPC分类号： A61K39/00 ,  A61K31/70 ,  A61K38/00 ,  C12Q1/68

CPC分类号： G01N33/57492 ,  A61K2039/505 ,  C07K14/4748 ,  C07K14/705 ,  C07K16/30 ,  C07K2317/34 ,  C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/158 ,  G01N2800/56

摘要： According to the invention, tumour-associated gene products and nucleic acids coding therefor were identified. The present invention relates to the therapy and diagnosis of diseases wherein said tumour-associated gene products are expressed aberrantly. The invention also relates to proteins, polypeptides and peptides which are expressed in a tumour-associated manner and the nucleic acids coding therefor.

摘要翻译： 根据本发明，鉴定了肿瘤相关基因产物及其编码的核酸。 本发明涉及其中所述肿瘤相关基因产物异常表达的疾病的治疗和诊断。 本发明还涉及以肿瘤相关方式表达的蛋白质，多肽和肽及其编码的核酸。

公开(公告)号：US20050020527A1

公开(公告)日：2005-01-27

申请号：US10818939

申请日：2004-04-05

申请人： Thomas Peters ,  Volker Schluter ,  Johannes Grosse ,  Heike Schauerte ,  Andreas Marquardt

发明人： Thomas Peters ,  Volker Schluter ,  Johannes Grosse ,  Heike Schauerte ,  Andreas Marquardt

IPC分类号： A61K48/00 ,  C07K14/47 ,  C12N15/12

CPC分类号： A01K67/0278 ,  A01K2207/15 ,  A01K2217/00 ,  A01K2217/05 ,  A01K2217/072 ,  A01K2227/105 ,  A01K2267/0306 ,  C07K14/47

摘要： The present invention relates to a non-human vertebrate animal model displaying an alteration in fat metabolism or in the sensitivity towards leptin or insulin, which model bears a mutation in the gene encoding the spinster like 1 protein (Spinl1). The invention also relates to mutant Spinl1 proteins and nucleic acid sequences encoding these proteins. Furthermore, the invention relates to the use of the non-human vertebrate animal model for the identification of diagnostic markers, or as a model for studying the molecular and physiological mechanisms associated with an alteration in fat metabolism or an alteration in the sensitivity towards leptin or insulin, or for the identification and testing of agents useful in the prevention, amelioration, or treatment of the above conditions. Agents, pharmaceutical compositions, and methods for treating the above conditions are likewise described, as are methods for identifying said agents.

摘要翻译： 本发明涉及显示脂肪代谢改变或瘦素或胰岛素敏感性的非人脊椎动物模型，该模型在编码如1蛋白（Spin1）的纺锤体的基因中具有突变。 本发明还涉及突变Spin1蛋白和编码这些蛋白的核酸序列。 此外，本发明涉及非人类脊椎动物模型用于鉴定诊断标记物的用途，或用作研究与脂肪代谢改变相关的分子和生理机制的模型或对瘦素的敏感性的改变或 胰岛素，或用于鉴定和测试可用于预防，改善或治疗上述病症的药剂。 同样地描述了用于鉴定所述试剂的药剂，药物组合物和用于治疗上述病症的方法。