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1.发明授权公开(公告)号：US09255131B2
公开(公告)日：2016-02-09
申请号：US12851980
申请日：2010-08-06
申请人： Özlem Türeci , Ugur Sahin , Sandra Schneider , Gerd Helftenbein , Volker Schlüter , Dirk Usener , Philippe Thiel , Michael Koslowski
发明人： Özlem Türeci , Ugur Sahin , Sandra Schneider , Gerd Helftenbein , Volker Schlüter , Dirk Usener , Philippe Thiel , Michael Koslowski
IPC分类号： G01N33/53 , G01N33/574 , A61K51/10 , A61K39/395 , C07K14/47 , C12Q1/68
CPC分类号： A61K39/39558 , A61K39/395 , A61K45/06 , C07K14/4748 , C07K16/28 , C07K16/30 , C12Q1/6886 , C12Q2600/106 , C12Q2600/156 , G01N33/53
摘要： An isolated truncated desmoglein 4 (DSG4) polypeptide splice variant of the invention is characterized by an amino acid sequence that lacks a region encoded before exon 9 or beyond exon 10 of the DSG4 gene having the polynucleotide sequence of SEQ ID NO: 75. Also disclosed is a method of diagnosing a cancer, or monitoring the course thereof, in a patient. The method comprises detecting in a tissue sample of a patient the expression of a tumor-associated antigen comprising the extracellular domain of a DSG4 polypeptide encoded by a DSG4 gene having the polynucleotide sequence of SEQ ID NO: 75, or a truncated DSG4 polypeptide splice variant characterized by an amino acid sequence that lacks a region encoded before exon 9 or beyond exon 10 of the DSG4 gene.
摘要翻译： 本发明的分离的截短的脱骨髓蛋白4（DSG4）多肽剪接变体的特征在于缺乏在具有SEQ ID NO：75的多核苷酸序列的DSG4基因的外显子9或超出外显子10之前编码的区域的氨基酸序列。还公开了 是在患者中诊断癌症或监测其过程的方法。 该方法包括在患者的组织样品中检测包含由具有SEQ ID NO：75的多核苷酸序列的DSG4基因或截短的DSG4多肽剪接变体编码的DSG4多肽的细胞外结构域的肿瘤相关抗原的表达 其特征在于缺乏在DSG4基因的外显子9或超出外显子10之前编码的区域的氨基酸序列。
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2.发明授权公开(公告)号：US09090940B2
公开(公告)日：2015-07-28
申请号：US11886758
申请日：2006-03-23
申请人： Ugur Sahin , Özlem Türeci , Michael Koslowski , Gerd Helftenbein , Dirk Usener , Volker Schlüter
发明人： Ugur Sahin , Özlem Türeci , Michael Koslowski , Gerd Helftenbein , Dirk Usener , Volker Schlüter
IPC分类号： C12Q1/00 , G01N33/574 , C12Q1/68
CPC分类号： G01N33/57492 , C12Q1/6886 , C12Q2600/118 , C12Q2600/158 , G06F19/22
摘要： The invention relates to identifying tumor-associated genetic products and encoding nucleic acids thereof. A therapy and diagnosis of diseases in which the tumor-associated genetic products are aberrantly expressed, proteins, polypeptides and peptides which are expressed in association with tumor and the encoding nucleic acids for said proteins, polypeptides and peptides are also disclosed.
摘要翻译： 本发明涉及鉴定肿瘤相关基因产物并编码其核酸。 还公开了与肿瘤相关表达的肿瘤相关遗传产物异常表达的疾病的治疗和诊断，以及用于所述蛋白质，多肽和肽的编码核酸的蛋白质，多肽和肽。
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公开(公告)号：US20110300144A1
公开(公告)日：2011-12-08
申请号：US13201702
申请日：2010-02-19
申请人： Ugur Sahin , Ozlem Tureci , Michael Koslowski , Gerd Helftenbein , Korden Walter , Stefan Wöll , Gabriela-Elena Oprea
发明人： Ugur Sahin , Ozlem Tureci , Michael Koslowski , Gerd Helftenbein , Korden Walter , Stefan Wöll , Gabriela-Elena Oprea
IPC分类号： A61K39/395 , C07H21/02 , C12N9/96 , C12N7/01 , C12N1/21 , C12N5/10 , C12N1/19 , C12N5/078 , C12Q1/68 , G01N33/574 , C07K16/30 , C07K14/705 , A61K39/00 , A61P35/00 , A61P35/04 , A61P37/04 , C07H21/04
CPC分类号： C12N15/113 , A61K31/7088
摘要： The present invention relates to the identification of nucleic acid and amino acid sequences that are characteristic of tumor tissues such as ovarian tumor and lung tumor tissues and which represent targets for therapy or diagnosis of tumor diseases in a subject.
摘要翻译： 本发明涉及鉴定作为肿瘤组织如卵巢肿瘤和肺肿瘤组织的特征的核酸和氨基酸序列，其代表受试者中肿瘤疾病的治疗或诊断的靶标。
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4.发明申请公开(公告)号：US20110014628A1
公开(公告)日：2011-01-20
申请号：US12851980
申请日：2010-08-06
申请人： Özlem TÜRECI , Ugur SAHIN , Sandra SCHNEIDER , Gerd HELFTENBEIN , Volker SCHLÜTER , Dirk USENER , Philippe THIEL , Michael KOSLOWSKI
发明人： Özlem TÜRECI , Ugur SAHIN , Sandra SCHNEIDER , Gerd HELFTENBEIN , Volker SCHLÜTER , Dirk USENER , Philippe THIEL , Michael KOSLOWSKI
CPC分类号： A61K39/39558 , A61K39/395 , A61K45/06 , C07K14/4748 , C07K16/28 , C07K16/30 , C12Q1/6886 , C12Q2600/106 , C12Q2600/156 , G01N33/53
摘要： An isolated truncated desmoglein 4 (DSG4) polypeptide splice variant of the invention is characterized by an amino acid sequence that lacks a region encoded before exon 9 or beyond exon 10 of the DSG4 gene having the polynucleotide sequence of SEQ ID NO: 75. Also disclosed is a method of diagnosing a cancer, or monitoring the course thereof, in a patient. The method comprises detecting in a tissue sample of a patient the expression of a tumor-associated antigen comprising the extracellular domain of a DSG4 polypeptide encoded by a DSG4 gene having the polynucleotide sequence of SEQ ID NO: 75, or a truncated DSG4 polypeptide splice variant characterized by an amino acid sequence that lacks a region encoded before exon 9 or beyond exon 10 of the DSG4 gene.
摘要翻译： 本发明的分离的截短的脱骨髓蛋白4（DSG4）多肽剪接变体的特征在于缺乏在具有SEQ ID NO：75的多核苷酸序列的DSG4基因的外显子9或超出外显子10之前编码的区域的氨基酸序列。还公开了 是在患者中诊断癌症或监测其过程的方法。 该方法包括在患者的组织样品中检测包含由具有SEQ ID NO：75的多核苷酸序列的DSG4基因或截短的DSG4多肽剪接变体编码的DSG4多肽的细胞外结构域的肿瘤相关抗原的表达 其特征在于缺乏在DSG4基因的外显子9或超出外显子10之前编码的区域的氨基酸序列。
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5.发明申请Identification of Tumour-Associated Cell Surface Antigens for Diagnosis and Therapy 有权肿瘤相关细胞表面抗原的诊断和治疗的鉴定公开(公告)号：US20080166340A1
公开(公告)日：2008-07-10
申请号：US10573229
申请日：2004-09-23
申请人： Ozlem Tureci , Ugur Sahin , Gerd Helftenbein , Volker Schluter
发明人： Ozlem Tureci , Ugur Sahin , Gerd Helftenbein , Volker Schluter
CPC分类号： G01N33/57492 , A61K2039/505 , C07K14/4748 , C07K14/705 , C07K16/30 , C07K2317/34 , C12Q1/6886 , C12Q2600/112 , C12Q2600/158 , G01N2800/56
摘要： According to the invention, tumour-associated gene products and nucleic acids coding therefor were identified. The present invention relates to the therapy and diagnosis of diseases wherein said tumour-associated gene products are expressed aberrantly. The invention also relates to proteins, polypeptides and peptides which are expressed in a tumour-associated manner and the nucleic acids coding therefor.
摘要翻译： 根据本发明，鉴定了肿瘤相关基因产物及其编码的核酸。 本发明涉及其中所述肿瘤相关基因产物异常表达的疾病的治疗和诊断。 本发明还涉及以肿瘤相关方式表达的蛋白质，多肽和肽及其编码的核酸。
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公开(公告)号：US09809815B2
公开(公告)日：2017-11-07
申请号：US13201702
申请日：2010-02-19
申请人： Ugur Sahin , Özlem Türeci , Michael Koslowski , Gerd Helftenbein , Korden Walter , Stefan Wöll , Gabriela-Elena Oprea
发明人： Ugur Sahin , Özlem Türeci , Michael Koslowski , Gerd Helftenbein , Korden Walter , Stefan Wöll , Gabriela-Elena Oprea
IPC分类号： G01N1/00 , G01N33/574 , C12N15/113 , A61K31/7088
CPC分类号： C12N15/113 , A61K31/7088
摘要： The present invention relates to the identification of nucleic acid and amino acid sequences that are characteristic of tumor tissues such as ovarian tumor and lung tumor tissues and which represent targets for therapy or diagnosis of tumor diseases in a subject.
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7.发明申请IDENTIFICATION OF TUMOUR-ASSOCIATED CELL SURFACE ANTIGENS FOR DIAGNOSIS AND THERAPY 审中-公开用于诊断和治疗的肿瘤相关细胞表面抗原的鉴定公开(公告)号：US20110135640A1
公开(公告)日：2011-06-09
申请号：US12969754
申请日：2010-12-16
申请人： ÖZLEM TÜRECI , UGUR SAHIN , GERD HELFTENBEIN , VOLKER SCHLÜTER
发明人： ÖZLEM TÜRECI , UGUR SAHIN , GERD HELFTENBEIN , VOLKER SCHLÜTER
IPC分类号： A61K39/395 , A61K31/7088 , A61K35/12 , C07H21/04 , C07K14/00 , G01N33/53 , C12Q1/68 , A61P35/00
CPC分类号： G01N33/57492 , A61K2039/505 , C07K14/4748 , C07K14/705 , C07K16/30 , C07K2317/34 , C12Q1/6886 , C12Q2600/112 , C12Q2600/158 , G01N2800/56
摘要： The present invention provides agents with tumor-inhibiting activity, and which are selective for cells expressing or abnormally expressing a tumor-associated antigen. Said tumor-associated antigen has a nucleotide sequence selected from the group consisting of: (a) a nucleotide sequence selected from the specific sequences set forth herein, or a 6-50 contiguous nucleotide residue portion thereof; (b) a nucleotide sequence of a nucleic acid which hybridizes with a nucleic acid having the nucleotide sequence of (a) under stringent conditions; (c) a nucleotide sequence which is degenerate with respect to the nucleotide sequence of (a) or (b); and (d) a nucleotide sequence which is complementary to the nucleotide sequence of (a), (b) or (c). Pharmaceutical compositions and kits comprising the agents are also provided, as well as methods treating, diagnosing or monitoring a disease characterized by expression or abnormal expression of the tumor-associated antigen.
摘要翻译： 本发明提供具有肿瘤抑制活性的药剂，并且其对表达或异常表达肿瘤相关抗原的细胞是选择性的。 所述肿瘤相关抗原具有选自以下的核苷酸序列：（a）选自本文所述的特定序列的核苷酸序列或其6-50个连续核苷酸残基部分; （b）在严格条件下与具有（a）的核苷酸序列的核酸杂交的核酸的核苷酸序列; （c）相对于（a）或（b）的核苷酸序列退化的核苷酸序列; 和（d）与（a），（b）或（c）的核苷酸序列互补的核苷酸序列。 还提供了包含这些试剂的药物组合物和试剂盒，以及治疗，诊断或监测以肿瘤相关抗原的表达或异常表达为特征的疾病的方法。
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8.发明申请公开(公告)号：US20090214550A1
公开(公告)日：2009-08-27
申请号：US11886758
申请日：2006-03-23
申请人： Ugur Sahin , Özlem Türeci , Michael Koslowski , Gerd Helftenbein , Dirk Usener , Volker Schlüter
发明人： Ugur Sahin , Özlem Türeci , Michael Koslowski , Gerd Helftenbein , Dirk Usener , Volker Schlüter
IPC分类号： A61K39/395 , A61K45/00 , C12Q1/68 , G01N33/53 , C12N15/74 , A61K38/16 , A61K31/7088 , C07K16/00 , C07H21/00 , A61P35/00
CPC分类号： G01N33/57492 , C12Q1/6886 , C12Q2600/118 , C12Q2600/158 , G06F19/22
摘要： The invention relates to identifying tumor-associated genetic products and encoding nucleic acids thereof. A therapy and diagnosis of diseases in which the tumor-associated genetic products are aberrantly expressed, proteins, polypeptides and peptides which are expressed in association with tumor and the encoding nucleic acids for said proteins, polypeptides and peptides are also disclosed.
摘要翻译： 本发明涉及鉴定肿瘤相关基因产物并编码其核酸。 还公开了与肿瘤相关表达的肿瘤相关遗传产物异常表达的疾病的治疗和诊断，以及用于所述蛋白质，多肽和肽的编码核酸的蛋白质，多肽和肽。
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9.发明申请公开(公告)号：US20080193454A1
公开(公告)日：2008-08-14
申请号：US11596106
申请日：2005-05-11
申请人： Ozlem Tureci , Ugur Sahin , Sandra Schneider , Gerd Helftenbein , Volker Schluter , Dirk Usener , Philippe Thiel
发明人： Ozlem Tureci , Ugur Sahin , Sandra Schneider , Gerd Helftenbein , Volker Schluter , Dirk Usener , Philippe Thiel
IPC分类号： A61K39/395 , C12N15/11 , C12Q1/68 , C12Q1/02 , C12N5/06 , A61K31/70 , A61P43/00 , C07K14/00 , A61K35/12 , G01N33/574 , C07K16/18
CPC分类号： A61K39/39558 , A61K39/395 , A61K45/06 , C07K14/4748 , C07K16/28 , C07K16/30 , C12Q1/6886 , C12Q2600/106 , C12Q2600/156 , G01N33/53
摘要： The invention relates to the identification of gene products that are the result of tumor-associated expression and the nucleic acids encoding the same. The invention also relates to the therapy and diagnosis of diseases wherein these gene products are the result of an aberrant tumor-associated expression. The invention also relates to the proteins, polypeptides and peptides that are the result of tumor-associated expression and to the nucleic acids encoding the same.
摘要翻译： 本发明涉及作为肿瘤相关表达的结果的基因产物的鉴定和编码其的核酸。 本发明还涉及其中这些基因产物是异常肿瘤相关表达的结果的疾病的治疗和诊断。 本发明还涉及作为肿瘤相关表达的结果的蛋白质，多肽和肽以及编码其的核酸。
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10.发明授权Identification of tumour-associated cell surface antigens for diagnosis and therapy 有权鉴定肿瘤相关细胞表面抗原进行诊断和治疗公开(公告)号：US07875424B2
公开(公告)日：2011-01-25
申请号：US10573229
申请日：2004-09-23
申请人： Özlem Türeci , Ugur Sahin , Gerd Helftenbein , Volker Schlüter
发明人： Özlem Türeci , Ugur Sahin , Gerd Helftenbein , Volker Schlüter
IPC分类号： C12Q1/68
CPC分类号： G01N33/57492 , A61K2039/505 , C07K14/4748 , C07K14/705 , C07K16/30 , C07K2317/34 , C12Q1/6886 , C12Q2600/112 , C12Q2600/158 , G01N2800/56
摘要： According to the invention, tumour-associated gene products and nucleic acids coding therefor were identified. The present invention relates to the therapy and diagnosis of diseases wherein said tumour-associated gene products are expressed aberrantly. The invention also relates to proteins, polypeptides and peptides which are expressed in a tumour-associated manner and the nucleic acids coding therefor.
摘要翻译： 根据本发明，鉴定了肿瘤相关基因产物及其编码的核酸。 本发明涉及其中所述肿瘤相关基因产物异常表达的疾病的治疗和诊断。 本发明还涉及以肿瘤相关方式表达的蛋白质，多肽和肽及其编码的核酸。
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