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公开(公告)号：US07829556B2
公开(公告)日：2010-11-09
申请号：US12214804
申请日：2008-06-20
申请人： Jean Bemis , Jeremy S. Disch , Michael Jirousek , Walter Joseph Lunsmann , Pui Yee Ng , Chi B. Vu
发明人： Jean Bemis , Jeremy S. Disch , Michael Jirousek , Walter Joseph Lunsmann , Pui Yee Ng , Chi B. Vu
IPC分类号： A61K31/535 , C07D413/00
CPC分类号： C07D513/04
摘要： Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.
摘要翻译： 本文提供了新的沉默调节蛋白的调节化合物及其使用方法。 沉默调节蛋白的调节化合物可用于增加细胞的寿命，以及治疗和/或预防各种各样的疾病和病症，包括例如与老化或紧张相关的疾病或病症，糖尿病，肥胖症，神经变性疾病， 心血管疾病，血液凝固障碍，炎症，癌症和/或潮红以及将受益于增加的线粒体活性的疾病或病症。 还提供了包含与另一种治疗剂组合的沉默调节蛋白的调节化合物的组合物。
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2.发明授权Stick pretreater compositions containing hydrophobically modified polar polymers 失效含有疏水改性的极性聚合物的棒状预处理组合物
公开(公告)号：US5747442A
公开(公告)日：1998-05-05
申请号：US591750
申请日：1996-01-25
申请人： Barbara Helen Bory , Walter Joseph Lunsmann , Dennis Stephen Murphy , Tamara Padron , Lucia Victoria Salas
发明人： Barbara Helen Bory , Walter Joseph Lunsmann , Dennis Stephen Murphy , Tamara Padron , Lucia Victoria Salas
CPC分类号： C11D17/00 , C11D10/045 , C11D3/3765 , C11D3/3773 , C11D3/378 , C11D3/3784 , C11D1/72
摘要： The present invention relates to pretreater or compositions in stick form which remove stains. The compositions contain 30 to 80 wt. % of a nonionic surfactant, 1 to about 20 wt. % of an anionic soap, and 0.1% to 10 wt. % of a hydrophobically modified polar polymer. A method of using the composition is also described.
摘要翻译： 本发明涉及去除污渍的预处理剂或棒形式的组合物。 组合物含有30至80wt。 ％的非离子表面活性剂，1至约20wt。 ％的阴离子皂和0.1％至10wt。 ％的疏水改性的极性聚合物。 还描述了使用该组合物的方法。
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公开(公告)号：US20110015192A1
公开(公告)日：2011-01-20
申请号：US12891667
申请日：2010-09-27
申请人： Jean Bemis , Jeremy S. Disch , Michael Jirousek , Walter Joseph Lunsmann , Pui Yee Ng , Chi B. Vu
发明人： Jean Bemis , Jeremy S. Disch , Michael Jirousek , Walter Joseph Lunsmann , Pui Yee Ng , Chi B. Vu
IPC分类号： A61K31/5377 , C07D413/14 , C07D403/14 , A61K31/498 , C07D417/14 , A61K31/4439 , A61P3/00
CPC分类号： C07D513/04
摘要： Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benfit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.
摘要翻译： 本文提供了新的沉默调节蛋白的调节化合物及其使用方法。 沉默调节蛋白的调节化合物可用于增加细胞的寿命，以及治疗和/或预防各种各样的疾病和病症，包括例如与老化或紧张相关的疾病或病症，糖尿病，肥胖症，神经变性疾病， 心血管疾病，凝血障碍，炎症，癌症和/或潮红以及由线粒体活性增加所致的疾病或病症。 还提供了包含与另一种治疗剂组合的沉默调节蛋白的调节化合物的组合物。
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公开(公告)号：US08247565B2
公开(公告)日：2012-08-21
申请号：US12891667
申请日：2010-09-27
申请人： Jean Bemis , Jeremy S. Disch , Michael Jirousek , Walter Joseph Lunsmann , Pui Yee Ng , Chi B. Vu
发明人： Jean Bemis , Jeremy S. Disch , Michael Jirousek , Walter Joseph Lunsmann , Pui Yee Ng , Chi B. Vu
IPC分类号： C07D417/00 , A61K31/44
CPC分类号： C07D513/04
摘要： Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benfit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.
摘要翻译： 本文提供了新的沉默调节蛋白的调节化合物及其使用方法。 沉默调节蛋白的调节化合物可用于增加细胞的寿命，以及治疗和/或预防各种各样的疾病和病症，包括例如与老化或紧张相关的疾病或病症，糖尿病，肥胖症，神经变性疾病， 心血管疾病，凝血障碍，炎症，癌症和/或潮红以及由线粒体活性增加所致的疾病或病症。 还提供了包含与另一种治疗剂组合的沉默调节蛋白的调节化合物的组合物。
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公开(公告)号：US20110009496A1
公开(公告)日：2011-01-13
申请号：US12812172
申请日：2009-01-07
IPC分类号： A61K31/047 , A61P39/06
摘要： Resveratrol can be used to treat or inhibit the onset of many diseases that are related to the aging process, but large doses are required. The present invention provides concentrated liquid formulations of resveratrol, typically having a resveratrol concentration of at least 10% by weight. These formulations improve patient compliance because the patient need not consume such a large volume of a resveratrol formulation.
摘要翻译： 白藜芦醇可用于治疗或抑制与衰老过程相关的许多疾病的发病，但需要大剂量。 本发明提供白藜芦醇的浓缩液体制剂，其通常具有至少10重量％的白藜芦醇浓度。 这些制剂改善了患者的依从性，因为患者不需要消耗如此大量的白藜芦醇制剂。
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6.发明授权Substantially dry cleansing product of improved latherability and wet flexibility 失效基本干燥的清洁产品具有改善的起泡性和湿润柔韧性公开(公告)号：US06638527B2
公开(公告)日：2003-10-28
申请号：US09829374
申请日：2001-04-09
申请人： Robert Edward Gott , Filomena Augusta Gomes , Craig Stephen Slavtcheff , Walter Joseph Lunsmann
发明人： Robert Edward Gott , Filomena Augusta Gomes , Craig Stephen Slavtcheff , Walter Joseph Lunsmann
IPC分类号： A61K700
CPC分类号： A61Q19/10 , A61K8/0208 , Y10T442/2525
摘要： A disposable, single-use, substantially dry cleansing article is disclosed having wet flexibility, and a lathering surfactant in one embodiment and having an apertured fabric and a specific lather volume coefficient in a second embodiment.
摘要翻译： 公开了具有湿柔性的一次性，一次性，基本上干燥的清洁制品，在一个实施方案中具有起泡表面活性剂，并且在第二实施方案中具有多孔织物和特定泡沫体积系数。
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公开(公告)号：US20090012080A1
公开(公告)日：2009-01-08
申请号：US12214804
申请日：2008-06-20
申请人： Jean Bemis , Jeremy S. Disch , Michael Jirousek , Walter Joseph Lunsmann , Pui Yee Ng , Chi B. Vu
发明人： Jean Bemis , Jeremy S. Disch , Michael Jirousek , Walter Joseph Lunsmann , Pui Yee Ng , Chi B. Vu
IPC分类号： A61K31/5377 , C07D417/14 , A61K31/4439 , A61P3/00 , C07D413/14
CPC分类号： C07D513/04
摘要： Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.
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