公开(公告)号：US20110015192A1

公开(公告)日：2011-01-20

申请号：US12891667

申请日：2010-09-27

申请人： Jean Bemis ,  Jeremy S. Disch ,  Michael Jirousek ,  Walter Joseph Lunsmann ,  Pui Yee Ng ,  Chi B. Vu

发明人： Jean Bemis ,  Jeremy S. Disch ,  Michael Jirousek ,  Walter Joseph Lunsmann ,  Pui Yee Ng ,  Chi B. Vu

IPC分类号： A61K31/5377 ,  C07D413/14 ,  C07D403/14 ,  A61K31/498 ,  C07D417/14 ,  A61K31/4439 ,  A61P3/00

CPC分类号： C07D513/04

摘要： Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benfit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.

摘要翻译： 本文提供了新的沉默调节蛋白的调节化合物及其使用方法。 沉默调节蛋白的调节化合物可用于增加细胞的寿命，以及治疗和/或预防各种各样的疾病和病症，包括例如与老化或紧张相关的疾病或病症，糖尿病，肥胖症，神经变性疾病， 心血管疾病，凝血障碍，炎症，癌症和/或潮红以及由线粒体活性增加所致的疾病或病症。 还提供了包含与另一种治疗剂组合的沉默调节蛋白的调节化合物的组合物。

公开(公告)号：US20090012080A1

公开(公告)日：2009-01-08

申请号：US12214804

申请日：2008-06-20

申请人： Jean Bemis ,  Jeremy S. Disch ,  Michael Jirousek ,  Walter Joseph Lunsmann ,  Pui Yee Ng ,  Chi B. Vu

发明人： Jean Bemis ,  Jeremy S. Disch ,  Michael Jirousek ,  Walter Joseph Lunsmann ,  Pui Yee Ng ,  Chi B. Vu

IPC分类号： A61K31/5377 ,  C07D417/14 ,  A61K31/4439 ,  A61P3/00 ,  C07D413/14

CPC分类号： C07D513/04

摘要： Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.

公开(公告)号：US08247565B2

公开(公告)日：2012-08-21

申请号：US12891667

申请日：2010-09-27

申请人： Jean Bemis ,  Jeremy S. Disch ,  Michael Jirousek ,  Walter Joseph Lunsmann ,  Pui Yee Ng ,  Chi B. Vu

发明人： Jean Bemis ,  Jeremy S. Disch ,  Michael Jirousek ,  Walter Joseph Lunsmann ,  Pui Yee Ng ,  Chi B. Vu

IPC分类号： C07D417/00 ,  A61K31/44

CPC分类号： C07D513/04

摘要： Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benfit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.

摘要翻译： 本文提供了新的沉默调节蛋白的调节化合物及其使用方法。 沉默调节蛋白的调节化合物可用于增加细胞的寿命，以及治疗和/或预防各种各样的疾病和病症，包括例如与老化或紧张相关的疾病或病症，糖尿病，肥胖症，神经变性疾病， 心血管疾病，凝血障碍，炎症，癌症和/或潮红以及由线粒体活性增加所致的疾病或病症。 还提供了包含与另一种治疗剂组合的沉默调节蛋白的调节化合物的组合物。

公开(公告)号：US07829556B2

公开(公告)日：2010-11-09

申请号：US12214804

申请日：2008-06-20

申请人： Jean Bemis ,  Jeremy S. Disch ,  Michael Jirousek ,  Walter Joseph Lunsmann ,  Pui Yee Ng ,  Chi B. Vu

发明人： Jean Bemis ,  Jeremy S. Disch ,  Michael Jirousek ,  Walter Joseph Lunsmann ,  Pui Yee Ng ,  Chi B. Vu

IPC分类号： A61K31/535 ,  C07D413/00

CPC分类号： C07D513/04

摘要： Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.

摘要翻译： 本文提供了新的沉默调节蛋白的调节化合物及其使用方法。 沉默调节蛋白的调节化合物可用于增加细胞的寿命，以及治疗和/或预防各种各样的疾病和病症，包括例如与老化或紧张相关的疾病或病症，糖尿病，肥胖症，神经变性疾病， 心血管疾病，血液凝固障碍，炎症，癌症和/或潮红以及将受益于增加的线粒体活性的疾病或病症。 还提供了包含与另一种治疗剂组合的沉默调节蛋白的调节化合物的组合物。

公开(公告)号：US08178536B2

公开(公告)日：2012-05-15

申请号：US12955663

申请日：2010-11-29

申请人： Joseph J. Nunes ,  Jill Milne ,  Jean Bemis ,  Roger Xie ,  Chi B. Vu ,  Pui Yee Ng ,  Jeremy S. Disch ,  Thomas Salzmann ,  David Armistead

发明人： Joseph J. Nunes ,  Jill Milne ,  Jean Bemis ,  Roger Xie ,  Chi B. Vu ,  Pui Yee Ng ,  Jeremy S. Disch ,  Thomas Salzmann ,  David Armistead

IPC分类号： A61K31/50 ,  C07D237/26

CPC分类号： C07D209/80 ,  C07C233/81 ,  C07C235/56 ,  C07C237/42 ,  C07D209/14 ,  C07D213/40 ,  C07D215/12 ,  C07D231/12 ,  C07D235/18 ,  C07D241/42 ,  C07D243/08 ,  C07D249/08 ,  C07D263/57 ,  C07D265/14 ,  C07D271/107 ,  C07D277/26 ,  C07D277/28 ,  C07D277/66 ,  C07D307/68 ,  C07D333/20 ,  C07D401/12 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D417/12 ,  C07D471/04 ,  C07D487/04 ,  C07D491/04 ,  C07D513/04

摘要： Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.

公开(公告)号：US07893086B2

公开(公告)日：2011-02-22

申请号：US12214805

申请日：2008-06-20

申请人： Jean Bemis ,  Jeremy S. Disch ,  Pui Yee Ng ,  Christopher Oalmann ,  Robert B. Perni ,  Chi B. Vu

发明人： Jean Bemis ,  Jeremy S. Disch ,  Pui Yee Ng ,  Christopher Oalmann ,  Robert B. Perni ,  Chi B. Vu

IPC分类号： A01N43/42 ,  A01N43/78 ,  A01N43/26 ,  A01N43/06 ,  A61K31/44 ,  A61K31/425 ,  A61K31/385 ,  A61K31/38 ,  C07D471/02 ,  C07D491/02 ,  C07D513/02 ,  C07D515/02 ,  C07D417/00

CPC分类号： C07D513/04

摘要： Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.

公开(公告)号：US08088928B2

公开(公告)日：2012-01-03

申请号：US11499901

申请日：2006-08-04

申请人： Joseph J. Nunes ,  Jill Milne ,  Jean Bemis ,  Roger Xie ,  Chi B. Vu ,  Pui Yee Ng ,  Jeremy S. Disch ,  Thomas Salzmann ,  David Armistead

发明人： Joseph J. Nunes ,  Jill Milne ,  Jean Bemis ,  Roger Xie ,  Chi B. Vu ,  Pui Yee Ng ,  Jeremy S. Disch ,  Thomas Salzmann ,  David Armistead

IPC分类号： C07D498/02 ,  A61K31/42

CPC分类号： C07D209/80 ,  C07C233/81 ,  C07C235/56 ,  C07C237/42 ,  C07D207/327 ,  C07D215/12 ,  C07D235/18 ,  C07D241/42 ,  C07D243/08 ,  C07D249/08 ,  C07D263/57 ,  C07D265/14 ,  C07D271/107 ,  C07D277/26 ,  C07D277/28 ,  C07D277/66 ,  C07D295/155 ,  C07D307/68 ,  C07D333/38 ,  C07D401/04 ,  C07D401/12 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D417/12 ,  C07D471/04 ,  C07D487/04 ,  C07D491/04 ,  C07D513/04

摘要： Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.

公开(公告)号：US08044198B2

公开(公告)日：2011-10-25

申请号：US12070350

申请日：2008-02-15

申请人： Joseph J. Nunes ,  Jill Milne ,  Jean Bemis ,  Roger Xie ,  Chi B. Vu ,  Pui Yee Ng ,  Jeremy S. Disch

发明人： Joseph J. Nunes ,  Jill Milne ,  Jean Bemis ,  Roger Xie ,  Chi B. Vu ,  Pui Yee Ng ,  Jeremy S. Disch

IPC分类号： C07D237/26 ,  A61K31/50

CPC分类号： C07D235/18 ,  C07D401/12 ,  C07D403/12 ,  C07D513/04

摘要： Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.

摘要翻译： 本文提供了新的沉默调节蛋白的调节化合物及其使用方法。 沉默调节蛋白的调节化合物可用于增加细胞的寿命，以及治疗和/或预防各种各样的疾病和病症，包括例如与老化或紧张相关的疾病或病症，糖尿病，肥胖症，神经变性疾病， 心血管疾病，血液凝固障碍，炎症，癌症和/或潮红以及将受益于增加的线粒体活性的疾病或病症。 还提供了包含与另一种治疗剂组合的沉默调节蛋白的调节化合物的组合物。

公开(公告)号：US20090105246A1

公开(公告)日：2009-04-23

申请号：US12214805

申请日：2008-06-20

申请人： Jean Bemis ,  Jeremy S. Disch ,  Pui Yee Ng ,  Christopher Oalmann ,  Robert B. Perni ,  Chi B. Vu

发明人： Jean Bemis ,  Jeremy S. Disch ,  Pui Yee Ng ,  Christopher Oalmann ,  Robert B. Perni ,  Chi B. Vu

IPC分类号： A61K31/5377 ,  C07D513/04 ,  A61K31/4365 ,  A61K31/496

CPC分类号： C07D513/04

摘要： Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.

摘要翻译： 本文提供了新的沉默调节蛋白的调节化合物及其使用方法。 沉默调节蛋白的调节化合物可用于增加细胞的寿命，以及治疗和/或预防各种各样的疾病和病症，包括例如与老化或紧张相关的疾病或病症，糖尿病，肥胖症，神经变性疾病， 心血管疾病，血液凝固障碍，炎症，癌症和/或潮红以及将受益于增加的线粒体活性的疾病或病症。 还提供了包含与另一种治疗剂组合的沉默调节蛋白的调节化合物的组合物。

公开(公告)号：US20090099170A1

公开(公告)日：2009-04-16

申请号：US12070350

申请日：2008-02-15

申请人： Joseph J. Nunes ,  Jill Milne ,  Jean Bemis ,  Roger Xie ,  Chi B. Vu ,  Pui Yee Ng ,  Jeremy S. Disch

发明人： Joseph J. Nunes ,  Jill Milne ,  Jean Bemis ,  Roger Xie ,  Chi B. Vu ,  Pui Yee Ng ,  Jeremy S. Disch

IPC分类号： A61K31/5377 ,  C07D471/04 ,  C07D401/10 ,  C07D413/14 ,  A61K31/437 ,  A61K31/497 ,  A61P3/00

CPC分类号： C07D235/18 ,  C07D401/12 ,  C07D403/12 ,  C07D513/04

摘要： Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.