Nucleic acids and corresponding proteins entitled 191P4D12(b) useful in treatment and detection of cancer
    7.
    发明授权
    Nucleic acids and corresponding proteins entitled 191P4D12(b) useful in treatment and detection of cancer 有权
    题为191P4D12(b)的核酸和相应的蛋白质可用于治疗和检测癌症

    公开(公告)号:US07968090B2

    公开(公告)日:2011-06-28

    申请号:US12820279

    申请日:2010-06-22

    IPC分类号: A61K39/395

    摘要: A novel gene 191P4D12(b) and its encoded protein, and variants thereof, are described wherein 191P4D12(b) exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 191P4D12(b) provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 191P4D12(b) gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 191P4D12(b) can be used in active or passive immunization.

    摘要翻译: 描述了一种新颖的基因191P4D12(b)及其编码的蛋白及其变体,其中191P4D12(b)在正常成人组织中表现出组织特异性表达,并且在表I中列出的癌症中异常表达。因此,191P4D12(b) 提供癌症的诊断,预后,预防和/或治疗靶标。 191P4D12(b)基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与191P4D12(b)反应的抗体或T细胞可用于主动或被动免疫。