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1.发明授权Nucleic acid and corresponding protein entitled 161P2F10B useful in treatment and detection of cancer 有权核酸和相应的标题为161P2F10B的蛋白质可用于治疗和检测癌症公开(公告)号：US08562989B2
公开(公告)日：2013-10-22
申请号：US13153336
申请日：2011-06-03
申请人： Aya Jakobovits , Arthur B. Raitano , Mary Faris , Rene S. Hubert , Wangmao Ge , Karen Jane Meyrick Morrison , Robert Kendall Morrison , Pia M. Challita-Eid
发明人： Aya Jakobovits , Arthur B. Raitano , Mary Faris , Rene S. Hubert , Wangmao Ge , Karen Jane Meyrick Morrison , Robert Kendall Morrison , Pia M. Challita-Eid
IPC分类号： A61K39/395
CPC分类号： C07K16/30 , A61K31/7088 , A61K39/00 , A61K51/1045 , A61K2039/505 , C07K14/47 , C07K16/18 , C07K16/3023 , C07K16/303 , C07K16/3038 , C07K16/3046 , C07K16/3061 , C07K16/3069 , C07K16/40 , C07K2317/20 , C07K2317/33 , C07K2317/34 , C07K2317/54 , C07K2317/55 , C07K2317/73 , C07K2317/76 , C07K2317/77 , C07K2319/30 , C12N9/16 , C12Q1/6886 , C12Q2600/158 , G01N33/57492 , Y02A50/466
摘要： A novel gene 0161P2F10B (also designated 161P2F10B) and its encoded protein, and variants thereof, are described wherein 161P2F10B exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 161P2F10B provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 161P2F10B gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 161P2F10B can be used in active or passive immunization.
摘要翻译： 描述了新颖的基因0161P2F10B（也称为161P2F10B）及其编码的蛋白质及其变体，其中161P2F10B在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，161P2F10B提供了诊断， 癌症的预后，预防和/或治疗靶标。 161P2F10B基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与161P2F10B反应的抗体或T细胞可用于主动或被动免疫。
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公开(公告)号：US08124741B2
公开(公告)日：2012-02-28
申请号：US12694209
申请日：2010-01-26
申请人： Arthur B. Raitano , Karen Jane Meyrick Morrison , Wangmao Ge , Pia M. Challita-Eid , Aya Jakobovits
发明人： Arthur B. Raitano , Karen Jane Meyrick Morrison , Wangmao Ge , Pia M. Challita-Eid , Aya Jakobovits
CPC分类号： C07K16/18 , A01K2217/05 , A01K2267/03 , A61K38/1709 , A61K48/00 , C07K14/705 , C12N2799/026 , C12N2799/027 , G01N33/57492
摘要： A novel gene 024P4C12 (also designated 24P4C12) and its encoded protein, and variants thereof, are described wherein 24P4C12 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 24P4C12 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 24P4C12 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 24P4C12 can be used in active or passive immunization.
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3.发明授权Nucleic acid and corresponding protein entitled 158P3D2 useful in treatment and detection of cancer 失效核酸和相应的标题为158P3D2的蛋白质可用于治疗和检测癌症公开(公告)号：US08039000B2
公开(公告)日：2011-10-18
申请号：US11483354
申请日：2006-07-06
申请人： Aya Jakobovits , Mary Faris , Karen Jane Meyrick Morrison , Robert Kendall Morrison , Rene S. Hubert , Daniel E. H. Afar , Wangmao Ge , Arthur B. Raitano , Pia M. Challita-Eid
发明人： Aya Jakobovits , Mary Faris , Karen Jane Meyrick Morrison , Robert Kendall Morrison , Rene S. Hubert , Daniel E. H. Afar , Wangmao Ge , Arthur B. Raitano , Pia M. Challita-Eid
IPC分类号： A61K39/395
CPC分类号： C07K14/4748 , A61K39/00 , Y02A50/466 , Y10T436/143333
摘要： A novel gene (designated 158P3D2) and its encoded protein, and variants thereof, are described wherein 158P3D2 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 158P3D2 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 158P3D2 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 158P3D2 can be used in active or passive immunization.
摘要翻译： 描述了一种新型基因（称为158P3D2）及其编码的蛋白质及其变体，其中158P3D2在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，158P3D2提供诊断，预后， 癌症的预防和/或治疗靶标。 158P3D2基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与158P3D2反应的抗体或T细胞可用于主动或被动免疫。
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公开(公告)号：US20110150910A1
公开(公告)日：2011-06-23
申请号：US12686939
申请日：2010-01-13
申请人： Aya Jakobovits , Pia M. Challita-Eid , Mary Faris , Wangmao Ge , Rene S. Hubert , Karen Jane Meyrick Morrison , Robert Kendall Morrison , Arthur B. Raitano , Daniel E. H. Afar
发明人： Aya Jakobovits , Pia M. Challita-Eid , Mary Faris , Wangmao Ge , Rene S. Hubert , Karen Jane Meyrick Morrison , Robert Kendall Morrison , Arthur B. Raitano , Daniel E. H. Afar
CPC分类号： C07K14/47 , A61K47/646 , A61K47/6851 , A61K47/6901 , A61K51/1045
摘要： Novel genes designated and set forth in FIG. 2 and their respective encoded proteins, and variants thereof, are described wherein a gene of the invention exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers such as those listed in Table I. Consequently, of gene products of a gene of FIG. 2 provide diagnostic, prognostic, prophylactic and/or therapeutic targets for cancer. A gene of FIG. 2 or fragment thereof, its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with a gene product of FIG. 2 can be used in active or passive immunization.
摘要翻译： 图中指定和阐述的新基因。 2及其各自编码的蛋白质及其变体，其中本发明的基因在正常成人组织中表现出组织特异性表达，并且在诸如表I所列的癌症中异常表达。因此， 基因 2提供癌症的诊断，预后，预防和/或治疗靶点。 图1的基因 2或其片段，其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与图1的基因产物反应的抗体或T细胞。 2可用于主动或被动免疫。
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公开(公告)号：US20100273174A1
公开(公告)日：2010-10-28
申请号：US12829256
申请日：2010-07-01
申请人： Arthur B. RAITANO , Karen Jane Meyrick Morrison , Wangmao Ge , Pia M. Challita-Eid , Aya Jakobovits
发明人： Arthur B. RAITANO , Karen Jane Meyrick Morrison , Wangmao Ge , Pia M. Challita-Eid , Aya Jakobovits
CPC分类号： C07K16/18 , A01K2217/05 , A01K2267/03 , A61K38/1709 , A61K48/00 , C07K14/705 , C12N2799/026 , C12N2799/027 , G01N33/57492
摘要： A novel gene 024P4C12 (also designated 24P4C12) and its encoded protein, and variants thereof, are described wherein 24P4C12 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 24P4C12 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 24P4C12 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 24P4C12 can be used in active or passive immunization.
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6.发明授权Nucleic acid and corresponding protein entitled 161P5C5 useful in treatment and detection of cancer 失效核酸和相应的标题为161P5C5的蛋白质可用于治疗和检测癌症公开(公告)号：US07642342B2
公开(公告)日：2010-01-05
申请号：US11442031
申请日：2006-05-26
申请人： Pia M. Challita-Eid , Arthur B. Raitano , Mary Faris , Rene S. Hubert , Karen Jane Meyrick Morrison , Robert Kendall Morrison , Wangmao Ge , Aya Jakobovits
发明人： Pia M. Challita-Eid , Arthur B. Raitano , Mary Faris , Rene S. Hubert , Karen Jane Meyrick Morrison , Robert Kendall Morrison , Wangmao Ge , Aya Jakobovits
IPC分类号： C07H21/02
CPC分类号： C07K14/4748 , A61K39/00 , Y02A50/466 , Y10T436/143333
摘要： A novel gene (designated 161P5C5) and its encoded protein, and variants thereof, are described wherein 161P5C5 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table 1. Consequently, 161P5C5 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 161P5C5 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 161P5C5 can be used in active or passive immunization.
摘要翻译： 描述了一种新型基因（称为161P5C5）及其编码的蛋白及其变体，其中161P5C5在正常成人组织中表现出组织特异性表达，并且在表1中列出的癌症中异常表达。因此，161P5C5提供诊断，预后， 癌症的预防和/或治疗靶标。 161P5C5基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与161P5C5反应的抗体或T细胞可用于主动或被动免疫。
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7.发明申请NUCLEIC ACID AND CORRESPONDING PROTEIN NAMED 158P1D7 USEFUL IN THE TREATMENT AND DETECTION OF BLADDER AND OTHER CANCERS 审中-公开核酸和相关蛋白158P1D7有用于治疗和检测刀片和其他癌症公开(公告)号：US20090252728A1
公开(公告)日：2009-10-08
申请号：US12050895
申请日：2008-03-18
申请人： Aya JAKOBOVITS , Robert Kendall Morrison , Arthur B. Raitano , Pia M. Challita-Eid , Juan J. Perez-Villar , Karen Jane Meyrick Morrison , Mary Faris , Wangmao Ge , Jean Gudas , Steven B. Kanner
发明人： Aya JAKOBOVITS , Robert Kendall Morrison , Arthur B. Raitano , Pia M. Challita-Eid , Juan J. Perez-Villar , Karen Jane Meyrick Morrison , Mary Faris , Wangmao Ge , Jean Gudas , Steven B. Kanner
摘要： The invention described herein relates to novel nucleic acid sequences and their encoded proteins, referred to as 158P1D7 and variants thereof, and to diagnostic and therapeutic methods and compositions useful in the management of various cancers that express 158P1D7 and variants thereof.
摘要翻译： 本文描述的本发明涉及新颖的核酸序列及其编码的蛋白质，被称为158P1D7及其变体，以及可用于治疗表达158P1D7及其变体的各种癌症的诊断和治疗方法和组合物。
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公开(公告)号：US20080167448A1
公开(公告)日：2008-07-10
申请号：US11842016
申请日：2007-08-20
申请人： Arthur B. Raitano , Karen Jane Meyrick Morrison , Wangmao Ge , Pia M. Challita-Eid , Aya Jakobovits
发明人： Arthur B. Raitano , Karen Jane Meyrick Morrison , Wangmao Ge , Pia M. Challita-Eid , Aya Jakobovits
CPC分类号： C07K16/18 , A01K2217/05 , A01K2267/03 , A61K38/1709 , A61K48/00 , C07K14/705 , C12N2799/026 , C12N2799/027 , G01N33/57492
摘要： A novel gene 024P4C12 (also designated 24P4C12) and its encoded protein, and variants thereof, are described wherein 24P4C12 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 24P4C12 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 24P4C12 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 24P4C12 can be used in active or passive immunization.
摘要翻译： 描述了一种新型基因024P4C12（也称为24P4C12）及其编码蛋白及其变体，其中24P4C12在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，24P4C12提供诊断， 癌症的预后，预防和/或治疗靶标。 24P4C12基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与24P4C12反应的抗体或T细胞可用于主动或被动免疫。
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9.发明授权Nucleic acid and corresponding protein named 158P1D7 useful in the treatment and detection of bladder and other cancers 有权核酸和相应的名为158P1D7的蛋白质可用于膀胱癌和其他癌症的治疗和检测公开(公告)号：US07358353B2
公开(公告)日：2008-04-15
申请号：US10776773
申请日：2004-02-10
申请人： Aya Jakobovits , Robert Kendall Morrison , Arthur B. Raitano , Pia M. Challita-Eid , Juan J. Perez-Villar , Karen Jane Meyrick Morrison , Mary Faris , Wangmao Ge , Jean Gudas , Steven B. Kanner
发明人： Aya Jakobovits , Robert Kendall Morrison , Arthur B. Raitano , Pia M. Challita-Eid , Juan J. Perez-Villar , Karen Jane Meyrick Morrison , Mary Faris , Wangmao Ge , Jean Gudas , Steven B. Kanner
CPC分类号： C07K16/18 , A61K38/00 , A61K47/646 , A61K47/6813 , A61K51/1093 , C07K14/47 , C07K16/30 , C07K16/3038 , C07K2317/54 , C07K2317/55 , C07K2317/622 , G01N33/57484 , Y10T436/25
摘要： A novel gene (designated 158P1D7) and its encoded protein are described. While 158P1D7 exhibits tissue specific expression in normal adult tissue, it is aberrantly expressed in multiple cancers including set forth in Table 1. Consequently, 158P1D7 provides a diagnostic and/or therapeutic target for cancers. The 158P1D7 gene or fragment thereof, or its encoded protein or a fragment thereof, can be used to elicit an immune response.
摘要翻译： 描述了一种新型基因（称为158P1D7）及其编码的蛋白质。 虽然158P1D7在正常成人组织中表现出组织特异性表达，但在多种癌症中异常表达，包括表1所示。因此，158P1D7为癌症提供诊断和/或治疗靶标。 158P1D7基因或其片段或其编码的蛋白质或其片段可用于引发免疫应答。
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10.发明授权公开(公告)号：US07244827B2
公开(公告)日：2007-07-17
申请号：US10306631
申请日：2002-11-27
申请人： Arthur B. Raitano , Karen Jane Meyrick Morrison , Wangmao Ge , Pia M. Challita-Eid , Aya Jakobovits
发明人： Arthur B. Raitano , Karen Jane Meyrick Morrison , Wangmao Ge , Pia M. Challita-Eid , Aya Jakobovits
CPC分类号： C07K16/18 , A01K2217/05 , A01K2267/03 , A61K38/1709 , A61K48/00 , C07K14/705 , C12N2799/026 , C12N2799/027 , G01N33/57492
摘要： A novel gene 024P4C12 (also designated 24P4C12) and its encoded protein, and variants thereof, are described wherein 24P4C12 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 24P4C12 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 24P4C12 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 24P4C12 can be used in active or passive immunization.
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