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公开(公告)号:US20140065164A1
公开(公告)日:2014-03-06
申请号:US14114652
申请日:2012-04-27
申请人: Allison Y. Luo , Wendy L. Trigona , Jinshan Shen , Li-An Xu , Yan Zhang , Bruce Stouffer , Haibin Chen , Haichun Huang , Xiaolu Tao , Catherine Brockus
发明人: Allison Y. Luo , Wendy L. Trigona , Jinshan Shen , Li-An Xu , Yan Zhang , Bruce Stouffer , Haibin Chen , Haichun Huang , Xiaolu Tao , Catherine Brockus
IPC分类号: G01N33/68 , A61K39/395
CPC分类号: G01N33/686 , A61K39/3955 , A61K2039/505 , C07K16/24 , C07K16/4208 , C07K2317/21 , C07K2317/76 , C07K2317/90
摘要: In certain embodiments, the present invention provides a method of treating an IP10-related disease in a subject, comprising: (a) administering to the subject a predetermined dosage of an anti-IPIO antibody; (b) detecting the level of the anti-IPIO antibody in a sample of the subject; and (c) if the level of the anti-IPIO antibody from step (b) is below a threshold exposure level, increasing the dosage of the anti-IPIO antibody in the subject such that the IP-10 related disease in the subject is treated.
摘要翻译: 在某些实施方案中,本发明提供了治疗受试者中IP10相关疾病的方法,其包括:(a)向受试者施用预定剂量的抗IPIO抗体; (b)检测受试者样品中抗IPIO抗体的水平; 和(c)如果来自步骤(b)的抗IPIO抗体的水平低于临界暴露水平,则增加受试者中抗IPIO抗体的剂量以使受试者中的IP-10相关疾病得到治疗 。