公开(公告)号：US20080206339A1

公开(公告)日：2008-08-28

申请号：US12036680

申请日：2008-02-25

申请人： Hossein Omidian ,  Cristian Gavrilas ,  Wenli Han ,  Ge Li ,  Jose G. Rocca

发明人： Hossein Omidian ,  Cristian Gavrilas ,  Wenli Han ,  Ge Li ,  Jose G. Rocca

IPC分类号： A61K9/14 ,  A61P3/04

CPC分类号： A61K47/32 ,  A61K9/0065 ,  A61K31/74 ,  C08F2/00 ,  C08F6/003 ,  C08F22/00 ,  C08L33/00

摘要： The invention relates to methods for preparing superporous hydrogels (SPH) that are very-pure and have desirable swelling properties necessary for commercial use, such as in food and pharmaceutical applications. Such methods include simultaneous use of low and high glass transition monomers to improve impurity and swelling profiles of the SPH, use of an integration means to prepare a very homogenous superporous hydrogel foam, washing the superporous hydrogel in a washing solution comprising different ratios of solvent to non-solvent (e.g., water/alcohol), use of a chemically-induced expansion/contraction process to enhance the efficiency of the multiple washing process and to fully structuralize the SPH, and employing one or more separation techniques, such as rubbing, filtration, centrifugation, compression and cutting to increase the efficiency of the purification process and to enhance the SPH swelling properties.

摘要翻译： 本发明涉及制备非常纯的具有商业应用所必需的溶胀性质的多孔水凝胶（SPH）的方法，例如在食品和药物应用中。 这样的方法包括同时使用低和高玻璃化转变单体以改善SPH的杂质和溶胀特性，使用整合方法来制备非常均匀的多孔水凝胶泡沫，在包含不同比例溶剂的洗涤溶液中洗涤多孔水凝胶 非溶剂（例如水/醇），使用化学诱导的膨胀/收缩方法来提高多次洗涤过程的效率并使SPH完全结构化，并采用一种或多种分离技术，例如摩擦，过滤 ，离心，压缩和切割以提高纯化过程的效率并增强SPH溶胀性能。

公开(公告)号：US07144505B2

公开(公告)日：2006-12-05

申请号：US10327564

申请日：2002-12-20

申请人： Wenli Han ,  Martin Ketterer ,  Jonnie Lee ,  Thanh Nguyen ,  George Washington ,  Delores Jordan ,  Dibyendu De

发明人： Wenli Han ,  Martin Ketterer ,  Jonnie Lee ,  Thanh Nguyen ,  George Washington ,  Delores Jordan ,  Dibyendu De

IPC分类号： B01D39/00 ,  B01D39/14 ,  B01D33/21

CPC分类号： B01D71/68 ,  A61M1/16 ,  B01D67/0011 ,  B01D67/002 ,  B01D67/0027 ,  B01D67/003 ,  B01D69/02 ,  B01D69/08 ,  B01D69/087 ,  B01D2325/34 ,  B01D2325/36 ,  C08J3/091 ,  C08J2381/06

摘要： The present invention provides, inter alia, a composition useful for producing a homogeneous, semipermeable membrane, the composition comprising a polysulfone semipermeable membrane, the polysulfone semipermeable membrane comprising a mixture of: an ultra-high-molecular-weight hydrophilic polymer, a polysulfone compound and a solvent for the polysulfone compound, and the polysulfone semipermeable membrane having a homogeneous structure such that the polysulfone semipermeable membrane has a substantially uniform structure. Another aspect of this invention discloses methods for fabricating semipermeable membranes by homogeneously mixing the composition, melting the composition, and melt-spinning the molten composition. Another aspect of the present invention includes homogeneous, melt-spun, semipermeable membranes useful for liquid separation processes, such as, but not limited to, microfiltration, ultrafiltration, dialysis, and reverse osmosis.

摘要翻译： 本发明尤其提供了一种用于制备均匀的半透膜的组合物，该组合物包含聚砜半透膜，聚砜半透膜包含以下混合物：超高分子量亲水聚合物，聚砜化合物 和聚砜化合物的溶剂，聚砜半透膜具有均匀的结构，使得聚砜半透膜具有基本均匀的结构。 本发明的另一方面公开了通过均匀混合组合物，熔融组合物和熔融组合物熔融纺制制造半透膜的方法。 本发明的另一方面包括用于液体分离过程的均匀的熔纺的半透膜，例如但不限于微滤，超滤，透析和反渗透。