公开(公告)号：US07175912B2

公开(公告)日：2007-02-13

申请号：US10833649

申请日：2004-04-28

申请人： Yali Cui ,  Chao Chen ,  Qiong Wang ,  Wenli Hui

发明人： Yali Cui ,  Chao Chen ,  Qiong Wang ,  Wenli Hui

IPC分类号： B32B5/16

CPC分类号： G01N33/5434 ,  Y10T428/12465 ,  Y10T428/2984 ,  Y10T428/2991

摘要： The invention relates to a super-paramagnetic composite particle with core/shell structure, preparation method and use thereof. The composite particle is consisted of a core portion and a shell portion coated on the surface of the core portion, wherein said core portion is 10–70% by weight and said shell portion is 30–90% by weight based on the total weight of the composite particle, and said core portion is consisted of magnetic particles of Fe3O4, γ-Fe2O3 or other ferric oxides, or magnetic particles of ferrites of tervalent ferrum and bivalent manganese, nickel, zinc or copper, and the said shell portion is consisted of elementary gold or silver. The particle has an average diameter of 0.05–50 μm. The preparation method comprises preparing the core portion magnetic particle by chemical co-precipitation and depositing gold or silver to coat the magnetic particle by chemical reduction. The composite particle can label biological materials or nonbiological materials selected from the group consisted of nucleic acid, antigen, antibody, enzyme, polypeptide, polysaccharide, avidin, streptavidin or cell and the like, and be used in biological test and nonbiological test.

摘要翻译： 本发明涉及具有核/壳结构的超顺磁复合颗粒，其制备方法和用途。 复合颗粒由核心部分和涂覆在芯部分表面上的壳部分组成，其中所述芯部分为10-70重量％，所述壳部分为基于总重量的30-90重量％ 复合颗粒和所述芯部分由Fe 3 O 4 O 3，γ-Fe 2 O 3 3的磁性颗粒组成， 或其它三价铁氧化物，或铁酸盐和二价锰，镍，锌或铜的铁氧体的磁性颗粒，并且所述壳部分由基本金或银组成。 颗粒的平均直径为0.05-50μm。 制备方法包括通过化学共沉淀制备核心部分磁性颗粒，并通过化学还原沉积金或银来涂覆磁性颗粒。 复合颗粒可以标记选自核酸，抗原，抗体，酶，多肽，多糖，抗生物素蛋白，链霉抗生物素蛋白或细胞等的生物材料或非生物材料，并用于生物试验和非生物试验。

公开(公告)号：US20120121717A1

公开(公告)日：2012-05-17

申请号：US13142820

申请日：2008-12-30

申请人： Xu Chao ,  Yali Cui ,  Mingli Peng ,  Chao Chen ,  Xiaofang Xin ,  Ke Li ,  Wenli Hui

发明人： Xu Chao ,  Yali Cui ,  Mingli Peng ,  Chao Chen ,  Xiaofang Xin ,  Ke Li ,  Wenli Hui

IPC分类号： A61K9/14 ,  B05D3/00 ,  A61P31/00 ,  A61K31/704 ,  A61P35/00

CPC分类号： A61K9/1652 ,  A61K9/5094 ,  A61K31/704 ,  A61K49/183 ,  B82Y25/00 ,  H01F1/0054 ,  H01F1/061

摘要： The invention relates to Polysaccharide-coated GoldMag particles (DPGPs) and the method of its synthesis, which characterized GoldMag particles as a core and natural or synthetic biodegradable polysaccharide such as dextran, cyclodextrin and derivatives as shell. DPGPs are synthesized by mixing Polysaccharide-coated GoldMag particles (DPGPs) with drug through physical bond. The preparation of the drug-loaded composite particles include: preparing the polysaccharide-coated GoldMag particles and then loading the drug on the polysaccharide-coated GoldMag particles. The drug-loading process is carried out through directly mixing the polysaccharide-coated GoldMag particles with the drug solution by the shaker. That means the polysaccharide-coated GoldMag particles load the drug through affinity adsorption.

摘要翻译： 本发明涉及多糖包被的GoldMag颗粒（DPGP）及其合成方法，其特征在于以GoldMag颗粒为核心，以天然或合成的可生物降解多糖如葡聚糖，环糊精和衍生物为壳。 DPGPs通过物理粘合剂将多糖包被的GoldMag颗粒（DPGPs）与药物混合来合成。 负载药物的复合颗粒的制备包括：制备多糖包被的GoldMag颗粒，然后将药物装载在多糖包被的GoldMag颗粒上。 药物加载过程通过将振荡器与药物溶液直接混合，将多糖包被的GoldMag颗粒直接混合来进行。 这意味着多糖包被的GoldMag颗粒通过亲和吸附装载药物。