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    DRUG-LOADED POLYSACCHARIDE-COATED GOLDMAG PARTICLES (DPGPs) AND ITS SYNTHESIS METHOD
    1.
    发明申请
    DRUG-LOADED POLYSACCHARIDE-COATED GOLDMAG PARTICLES (DPGPs) AND ITS SYNTHESIS METHOD 审中-公开
    药物加载多糖包裹的金黄色颗粒（DPGPs）及其合成方法

    公开(公告)号：US20120121717A1

    公开(公告)日：2012-05-17

    申请号：US13142820

    申请日：2008-12-30

    申请人： Xu Chao ,  Yali Cui ,  Mingli Peng ,  Chao Chen ,  Xiaofang Xin ,  Ke Li ,  Wenli Hui

    发明人： Xu Chao ,  Yali Cui ,  Mingli Peng ,  Chao Chen ,  Xiaofang Xin ,  Ke Li ,  Wenli Hui

    IPC分类号： A61K9/14 ,  B05D3/00 ,  A61P31/00 ,  A61K31/704 ,  A61P35/00

    CPC分类号： A61K9/1652 ,  A61K9/5094 ,  A61K31/704 ,  A61K49/183 ,  B82Y25/00 ,  H01F1/0054 ,  H01F1/061

    摘要： The invention relates to Polysaccharide-coated GoldMag particles (DPGPs) and the method of its synthesis, which characterized GoldMag particles as a core and natural or synthetic biodegradable polysaccharide such as dextran, cyclodextrin and derivatives as shell. DPGPs are synthesized by mixing Polysaccharide-coated GoldMag particles (DPGPs) with drug through physical bond. The preparation of the drug-loaded composite particles include: preparing the polysaccharide-coated GoldMag particles and then loading the drug on the polysaccharide-coated GoldMag particles. The drug-loading process is carried out through directly mixing the polysaccharide-coated GoldMag particles with the drug solution by the shaker. That means the polysaccharide-coated GoldMag particles load the drug through affinity adsorption.

    摘要翻译： 本发明涉及多糖包被的GoldMag颗粒（DPGP）及其合成方法，其特征在于以GoldMag颗粒为核心，以天然或合成的可生物降解多糖如葡聚糖，环糊精和衍生物为壳。 DPGPs通过物理粘合剂将多糖包被的GoldMag颗粒（DPGPs）与药物混合来合成。 负载药物的复合颗粒的制备包括：制备多糖包被的GoldMag颗粒，然后将药物装载在多糖包被的GoldMag颗粒上。 药物加载过程通过将振荡器与药物溶液直接混合，将多糖包被的GoldMag颗粒直接混合来进行。 这意味着多糖包被的GoldMag颗粒通过亲和吸附装载药物。

    Crosslinked Dextran Composite Magnetic Microparticles and Preparation Process and Using Method Thereof
    2.
    发明申请
    Crosslinked Dextran Composite Magnetic Microparticles and Preparation Process and Using Method Thereof 审中-公开
    交联葡聚糖复合磁性微粒及其制备方法及其使用方法

    公开(公告)号：US20120003321A1

    公开(公告)日：2012-01-05

    申请号：US13142159

    申请日：2008-12-29

    申请人： Mingli Peng ,  Yanhong Liu ,  Yali Cui ,  Chao Chen ,  Ke Li

    发明人： Mingli Peng ,  Yanhong Liu ,  Yali Cui ,  Chao Chen ,  Ke Li

    IPC分类号： A61K9/14 ,  A61K31/513 ,  A61K31/337 ,  A61K31/7068 ,  A61K31/437 ,  A61K31/4375 ,  A61K31/704 ,  A61K38/14 ,  B82Y5/00

    CPC分类号： A61K9/0009 ,  A61K9/0019 ,  A61K9/1611 ,  A61K9/1652 ,  H01F1/083

    摘要： The present invention relates to crosslinked dextran magnetic composite microparticles and a preparation process and a using method thereof. The composite microparticles comprise magnetic nanoparticles and dextran with crosslinked structure, wherein the magnetic nanoparticles are dispersed in the dextran with crosslinked structure. The process for preparing the composite microparticles comprises: preparing a dextran solution; synthesizing dextran magnetic composite microparticles; and synthesizing the crosslinked dextran magnetic composite microparticles. The using method of composite microparticles comprises: preparing crosslinked dextran magnetic composite microparticles loaded with anti-cancer drug; and adding a sustained-releasing solution thereto.

    摘要翻译： 本发明涉及交联葡聚糖磁性复合微粒及其制备方法及其应用方法。 复合微粒包括具有交联结构的磁性纳米颗粒和葡聚糖，其中磁性纳米颗粒分散在具有交联结构的葡聚糖中。 制备复合微粒的方法包括：制备葡聚糖溶液; 合成葡聚糖磁复合微粒; 并合成交联的葡聚糖磁性复合微粒。 复合微粒的使用方法包括：制备负载抗癌药物的交联葡聚糖磁复合微粒; 并向其中加入缓释溶液。

    Preassembled medicine mixer
    3.
    发明授权
    Preassembled medicine mixer 有权

    公开(公告)号：US09839581B2

    公开(公告)日：2017-12-12

    申请号：US14415605

    申请日：2012-08-02

    申请人： Yu Qiu ,  Ke Li ,  Yuan Yuan ,  Hongyu Li ,  Yeli Huang

    发明人： Yu Qiu ,  Ke Li ,  Yuan Yuan ,  Hongyu Li ,  Yeli Huang

    IPC分类号： A61J1/20 ,  A61J1/10 ,  A61J1/14 ,  A61J1/16

    CPC分类号： A61J1/2089 ,  A61J1/10 ,  A61J1/1406 ,  A61J1/1462 ,  A61J1/16 ,  A61J1/201 ,  A61J1/2013 ,  A61J1/2065

    摘要： A preassembled medicine mixer comprises a rotary sleeve (4), a guide sleeve I (3), a guide sleeve II (6), a guide part, a dosing barrel (1), and a dosing double needle (2). The guide sleeve I (3) extends into the guide sleeve II (6) and is connected to the rotary sleeve (4). A guide groove (8) is provided on the side wall of the guide sleeve I (3), and two ends of the guide groove (8) are extended by a distance towards opposite directions. A guide spiral groove (7) is provided on an inner wall of the guide sleeve II (6). The guide part is disposed in the guide sleeve I (3) and has a guide block (9) at the outer side thereof. The guide block (9) penetrates through the guide groove (8) and extends into the guide spiral groove (7). In use, the rotary sleeve (4) is rotated to drive the guide part to rapidly move downwards and push a medicine container (17); an upper needle tip of the dosing double needle (2) pierces a sealing plug on the medicine container (17), and a lower needle tip pierces a diaphragm (23) in an interface (22), so that the medicine container (17) is instantly communicated with an infusion container (14), thereby implementing sterile closeness during the entire process of transportation, storage, butt joint, medicine mixing, and infusion.

    ELECTROMAGNETIC FLOW SENSOR INTERFACE ALLOWING DIFFERENTIAL DC COUPLING
    4.
    发明申请
    ELECTROMAGNETIC FLOW SENSOR INTERFACE ALLOWING DIFFERENTIAL DC COUPLING 审中-公开

    公开(公告)号：US20170153135A1

    公开(公告)日：2017-06-01

    申请号：US14975026

    申请日：2015-12-18

    申请人： Ke Li

    发明人： Ke Li

    IPC分类号： G01F1/60 ,  G01F1/58 ,  H03F3/45 ,  H03M1/12 ,  H03M1/66

    摘要： An interface circuit to an electromagnetic flow sensor is described. In an example, it can provide a DC coupled signal path from the electromagnetic flow sensor to an analog-to-digital converter (ADC) circuit. Examples with differential and pseudo-differential signal paths are described. Examples providing DC offset or low frequency noise compensation or cancellation are described. High input impedance examples are described. Coil excitation circuits are described, such as can provide on-chip inductive isolation between signal inputs and signal outputs. A switched mode power supply can be used to actively manage a bias voltage of an H-Bridge, such as to boost the current provided by the H-Bridge to the sensor coil during select time periods, such as during phase shift time periods of the coil, which can help reduce or minimize transient noise during such time periods.

    Vapor-phase decarbonylation process
    5.
    发明授权
    Vapor-phase decarbonylation process 有权
    气相脱羰工艺

    公开(公告)号：US08404871B2

    公开(公告)日：2013-03-26

    申请号：US13124574

    申请日：2009-12-08

    申请人： Ke Li ,  Ronnie Ozer

    发明人： Ke Li ,  Ronnie Ozer

    IPC分类号： C07D307/36 ,  C07D307/48

    CPC分类号： C07D307/36 ,  C07D307/46 ,  Y02P20/584

    摘要： A process is provided for the synthesis of furan and related compounds by vapor phase decarbonylation of furfural and derivatives, using a palladium/alumina catalyst that has been promoted with an alkali carbonate. Catalyst lifetime is improved. The catalyst can be regenerated in situ by feeding a mixture of air and steam, with a composition of between about 2% and about 40% air, to the catalyst bed at a temperature between about 300° C. and about 500° C.

    摘要翻译： 提供了通过使用已经用碱金属碳酸盐促进的钯/氧化铝催化剂通过糠醛和衍生物的气相脱羰来合成呋喃和相关化合物的方法。 催化剂寿命得到改善。 催化剂可以通过在约300℃至约500℃之间的温度下将空气和蒸汽的混合物与约2％至约40％空气的组合物进料到催化剂床而在原位再生。

    METHOD FOR IMPROVING FINITE ELEMENT ANALYSIS MODELING OF THREADED CONNECTIONS
    7.
    发明申请
    METHOD FOR IMPROVING FINITE ELEMENT ANALYSIS MODELING OF THREADED CONNECTIONS 审中-公开
    改进螺纹连接有限元分析建模方法

    公开(公告)号：US20110313720A1

    公开(公告)日：2011-12-22

    申请号：US13063111

    申请日：2009-09-03

    申请人： Ke Li ,  Srinand Karuppoor ,  Sepand Ossia

    发明人： Ke Li ,  Srinand Karuppoor ,  Sepand Ossia

    IPC分类号： G06F15/00

    CPC分类号： E21B17/042

    摘要： A method for improving finite element analysis of threaded connections includes selecting at least one thread parameter for a female connection and a corresponding male connection. In two dimensions a thread form is calculated for the female connection and the male connection based on the at least one parameter. In two dimensions a geometry is calculated of the female connection and the male connection based on the thread form. In two dimensions the female connection and the male connection are segmented into predefined areas. A finite element analysis mesh is calculated based on a predetermined number of nodes for each of the predefined areas and a selected number of mesh layers for each predefined area. The two dimensional female connection and male connection are assembled. The two dimensional mesh on the assembled connections is used as input to a finite element analysis of the threaded connection in three dimensions.

    摘要翻译： 用于改进螺纹连接的有限元分析的方法包括为母连接和相应的公连接选择至少一个螺纹参数。 在两个维度上，基于至少一个参数来计算母连接和公连接的螺纹形式。 在两个维度上，基于螺纹形式计算母连接和公连接的几何形状。 在两个维度上，母连接和阳连接被分割成预定区域。 基于用于每个预定义区域的预定数量的节点以及针对每个预定义区域的选定数目的网格层来计算有限元分析网格。 组装了二维阴连接和阳连接。 组装的连接上的二维网格用作三维螺纹连接的有限元分析的输入。

    Processes for synthesizing alkaline phosphatase conjugates
    9.
    发明授权
    Processes for synthesizing alkaline phosphatase conjugates 有权
    合成碱性磷酸酶缀合物的方法

    公开(公告)号：US08940512B2

    公开(公告)日：2015-01-27

    申请号：US13151876

    申请日：2011-06-02

    申请人： Chungen Qian ,  Ke Li ,  Yuping Zhang

    发明人： Chungen Qian ,  Ke Li ,  Yuping Zhang

    IPC分类号： C12N9/00 ,  C12N9/96 ,  C07K1/00 ,  G01N33/535 ,  C12Q1/42

    CPC分类号： G01N33/535 ,  C12Q1/42

    摘要： Methods for synthesizing an ALP conjugate are provided. The methods may include activating a carboxyl group of the ALP with a carbodiimide, to generate an active ester; and adding the substance to be conjugated such that a synthetic reaction occurs between the active ester and the substance to be conjugated, to generate an ALP conjugate.

    摘要翻译： 提供了合成ALP缀合物的方法。 所述方法可包括用碳二亚胺活化ALP的羧基以产生活性酯; 并加入要结合的物质，使得活性酯与待共轭物质之间发生合成反应，生成ALP缀合物。

    Automatic Explode Based on Occlusion
    10.
    发明申请
    Automatic Explode Based on Occlusion 有权
    基于闭塞的自动爆炸

    公开(公告)号：US20130124157A1

    公开(公告)日：2013-05-16

    申请号：US13734820

    申请日：2013-01-04

    申请人： Shi-Qing Xin ,  Ying-Guo Zhang ,  Ke Li

    发明人： Shi-Qing Xin ,  Ying-Guo Zhang ,  Ke Li

    IPC分类号： G06F17/50

    CPC分类号： G06F17/50 ,  G06F3/04815 ,  G06F3/04845 ,  G06F17/5086 ,  G06F2203/04802 ,  G06F2217/02 ,  G06T13/20 ,  G06T15/205 ,  G06T19/20 ,  G06T2215/08 ,  G06T2219/016 ,  G06T2219/2004 ,  G06T2219/2008

    摘要： Methods, systems, and apparatus, including computer program products feature providing a rendering of a three-dimensional assembly of components. An explosion sequence for separating first components of the assembly is determined. The explosion sequence comprises stages in which each stage represents a different spatial relationship between two or more of the first components. A first input is received from an interactive control. A first stage in the explosion sequence is selected based on the first input. The rendering of the assembly is updated, responsive to the first input, to show the first stage of the explosion sequence. A second input is received from the interactive control. A different second stage in the explosion sequence is selected based on the second input. The rendering of the assembly is updated, responsive to the second input, to show the second stage of the explosion sequence.

    摘要翻译： 包括计算机程序产品在内的方法，系统和装置提供组件的三维组装的呈现。 确定用于分离组件的第一部件的爆炸顺序。 爆炸序列包括阶段，其中每个阶段表示两个或更多个第一组件之间的不同的空间关系。 从交互式控制接收第一输入。 基于第一个输入选择爆炸序列的第一阶段。 响应于第一次输入更新组件的渲染，以显示爆炸序列的第一阶段。 从交互控制接收第二输入。 基于第二个输入选择爆炸序列中的不同的第二阶段。 响应于第二输入更新组件的呈现以显示爆炸序列的第二阶段。