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    Polymorphisms in the human gene for the multidrug resistance-associated protein 1 (MRP-1) and their use in diagnostic and therapeutic applications
    7.
    发明申请
    Polymorphisms in the human gene for the multidrug resistance-associated protein 1 (MRP-1) and their use in diagnostic and therapeutic applications 有权
    多药耐药相关蛋白1（MRP-1）的人类基因多态性及其在诊断和治疗应用中的应用

    公开(公告)号：US20090144841A1

    公开(公告)日：2009-06-04

    申请号：US11901238

    申请日：2007-09-13

    申请人： Ulrich Brinkmann ,  Sven Hoffmeyer ,  Esther Mornhinweg

    发明人： Ulrich Brinkmann ,  Sven Hoffmeyer ,  Esther Mornhinweg

    IPC分类号： A01K67/027 ,  C07H21/00 ,  C12N15/74 ,  C12N5/10 ,  C12Q1/68 ,  A61K31/7088 ,  A61P35/00 ,  G01N33/567 ,  C12P21/00 ,  C12N15/02 ,  C07K16/18

    CPC分类号： C12Q1/6883 ,  C07K14/47 ,  C12Q2600/106 ,  C12Q2600/156 ,  C12Q2600/158 ,  G01N33/6893 ,  G01N2333/705 ,  G01N2500/04 ,  G01N2800/44

    摘要： The present invention relates to a polymorphic MRP-1 polynucleotide. Moreover, the invention relates to genes or vectors comprising the polynucleotides of the invention and to a host cell genetically engineered with the polynucleotide or gene of the invention. Further, the invention relates to methods for producing molecular variant polypeptides or fragments thereof, methods for producing cells capable of expressing a molecular variant polypeptide and to a polypeptide or fragment thereof encoded by the polynucleotide or the gene of the invention or which is obtainable by the method or from the cells produced by the method of the invention. Furthermore, the invention relates to an antibody which binds specifically the polypeptide of the invention. Moreover, the invention relates to a transgenic non-human animal. The invention also relates to a solid support comprising one or a plurality of the above mentioned polynucleotides, genes, vectors, polypeptides, antibodies or host cells. Furthermore, methods of identifying a polymorphism, identifying and obtaining a pro-drug or drug or an inhibitor are also encompassed by the present invention. In addition, the invention relates to methods for producing of a pharmaceutical composition and to methods of diagnosing a disease. Further, the invention relates to a method of detection of the polynucleotide of the invention. Furthermore, comprised by the present invention are a diagnostic and a pharmaceutical composition. Even more, the invention relates to uses of the polynucleotides, genes, vectors, polypeptides or antibodies of the invention. Finally, the invention relates to a diagnostic kit.

    摘要翻译： 本发明涉及多形性MRP-1多核苷酸。 此外，本发明涉及包含本发明的多核苷酸的基因或载体，并涉及用本发明的多核苷酸或基因进行遗传工程改造的宿主细胞。 此外，本发明涉及用于产生分子变体多肽或其片段的方法，用于产生能够表达分子变体多肽的细胞的方法及其由本发明的多核苷酸或基因编码的多肽或其片段，或可由 方法或由本发明方法生产的细胞。 此外，本发明涉及特异性结合本发明多肽的抗体。 此外，本发明涉及转基因非人动物。 本发明还涉及包含一种或多种上述多核苷酸，基因，载体，多肽，抗体或宿主细胞的固体支持物。 此外，鉴定多态性，鉴定和获得前药或药物或抑制剂的方法也包括在本发明中。 此外，本发明涉及制备药物组合物的方法和诊断疾病的方法。 此外，本发明涉及本发明的多核苷酸的检测方法。 此外，本发明包括诊断和药物组合物。 更进一步地，本发明涉及本发明的多核苷酸，基因，载体，多肽或抗体的用途。 最后，本发明涉及诊断试剂盒。

    Polymorphisms in the human genes for OCT1 and their use in diagnostic and therapeutic applications
    8.
    发明申请
    Polymorphisms in the human genes for OCT1 and their use in diagnostic and therapeutic applications 审中-公开
    OCT1的人类基因的多态性及其在诊断和治疗应用中的应用

    公开(公告)号：US20090018030A1

    公开(公告)日：2009-01-15

    申请号：US12221241

    申请日：2008-07-30

    申请人： Reinhold Kerb ,  Hermann Koepsell ,  Ulrich Brinkmann

    发明人： Reinhold Kerb ,  Hermann Koepsell ,  Ulrich Brinkmann

    IPC分类号： C40B30/04 ,  C12Q1/68 ,  G01N33/68 ,  G01N33/53

    CPC分类号： C07K14/4702 ,  A01K2217/05 ,  A61K38/00 ,  C12Q1/6883

    摘要： The present invention relates to a polymorphic OCT1 polynucleotide. Moreover, the invention relates to genes or vectors comprising the polynucleotides of the invention and to a host cell genetically engineered with the polynucleotide or gene of the invention. Further, the invention relates to methods for producing molecular variant polypeptides or fragments thereof, methods for producing cells capable of expressing a molecular variant polypeptide and to a polypeptide or fragment thereof encoded by the polynucleotide or the gene of the invention or which is obtainable by the method or from the cells produced by the method of the invention. Furthermore, the invention relates to an antibody which binds specifically the polypeptide of the invention. Moreover, the invention relates to a transgenic non-human animal. The invention also relates to a solid support comprising one or a plurality of the above mentioned polynucleotides, genes, vectors, polypeptides, antibodies or host cells. Furthermore, methods of identifying a polymorphism, identifying and obtaining a pro-drug or drug or an inhibitor are also encompassed by the present invention. In addition, the invention relates to methods for producing of a pharmaceutical composition and to methods of diagnosing a disease. Further, the invention relates to a method of detection of the polynucleotide of the invention. Furthermore, comprised by the present invention are a diagnostic and a pharmaceutical composition. Even more, the invention relates to uses of the polynucleotides, genes, vectors, polypeptides or antibodies of the invention. Finally, the invention relates to a diagnostic kit.

    摘要翻译： 本发明涉及多晶型OCT1多核苷酸。 此外，本发明涉及包含本发明的多核苷酸的基因或载体，并涉及用本发明的多核苷酸或基因进行遗传工程改造的宿主细胞。 此外，本发明涉及用于产生分子变体多肽或其片段的方法，用于产生能够表达分子变体多肽的细胞的方法及其由本发明的多核苷酸或基因编码的多肽或其片段，或可由 方法或由本发明方法生产的细胞。 此外，本发明涉及特异性结合本发明多肽的抗体。 此外，本发明涉及转基因非人动物。 本发明还涉及包含一种或多种上述多核苷酸，基因，载体，多肽，抗体或宿主细胞的固体支持物。 此外，鉴定多态性，鉴定和获得前药或药物或抑制剂的方法也包括在本发明中。 此外，本发明涉及制备药物组合物的方法和诊断疾病的方法。 此外，本发明涉及本发明的多核苷酸的检测方法。 此外，本发明包括诊断和药物组合物。 更进一步地，本发明涉及本发明的多核苷酸，基因，载体，多肽或抗体的用途。 最后，本发明涉及诊断试剂盒。

    T-cell receptorγ alternate reading frame protein, (TARP) and uses thereof
    9.
    发明授权
    T-cell receptorγ alternate reading frame protein, (TARP) and uses thereof 有权
    T细胞接受体交替阅读框蛋白（TARP）及其用途

    公开(公告)号：US07052703B1

    公开(公告)日：2006-05-30

    申请号：US10031158

    申请日：2000-07-12

    申请人： Ira Pastan ,  Magnus Essand ,  Byungkook Lee ,  George Vasmatzis ,  Curt Wolfgang ,  Ulrich Brinkmann

    发明人： Ira Pastan ,  Magnus Essand ,  Byungkook Lee ,  George Vasmatzis ,  Curt Wolfgang ,  Ulrich Brinkmann

    IPC分类号： A61K39/00

    CPC分类号： C07K14/47 ,  A61K38/00 ,  A61K39/00

    摘要： This invention provides nucleic acids containing sequences from a TCRγ transcript from prostate epithelial cells and many breast cancer cells and a T-cell receptor gamma Alternate Reading frame Protein (“TARP”) expressed from the translation of those sequences. Vaccines made from TARP are useful in raising immune responses to cells in which the protein is expressed, including prostate cancer cells and cells of many breast cancers. The invention also provides methods for diagnosing the presence of prostate cancer and TARP-expressing breast cancers, as well as methods of administering TARP and nucleic acids encoding TARP to subjects.

    摘要翻译： 本发明提供了含有来自前列腺上皮细胞的TCRγ转录物和许多乳腺癌细胞的序列的核酸，以及从这些序列翻译表达的T细胞受体γ替代阅读框架蛋白（“TARP”）。 由TARP制成的疫苗可用于提高蛋白质表达细胞的免疫应答，包括前列腺癌细胞和许多乳腺癌细胞。 本发明还提供了用于诊断前列腺癌和TARP表达乳腺癌的存在的方法，以及将TARP和编码TARP的核酸给予受试者的方法。