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1.发明授权Production of glucuronic acid using myo-inositol oxygenase from cryptococcus neoformans 有权使用来自隐球菌新生隐球菌的肌醇加氧酶生产葡萄糖醛酸公开(公告)号：US07923231B2
公开(公告)日：2011-04-12
申请号：US11015563
申请日：2004-12-17
申请人： Brian Brazeau , Jean-Claude De Troostembergh , Paula M. Hicks , Holly Jessen , Sara C. McFarlan , Willy Obyn , Fernando A. Sanchez-Riera , William A. Schroeder
发明人： Brian Brazeau , Jean-Claude De Troostembergh , Paula M. Hicks , Holly Jessen , Sara C. McFarlan , Willy Obyn , Fernando A. Sanchez-Riera , William A. Schroeder
CPC分类号： C12P7/58 , C12P17/181 , C12P19/02
摘要： A method is disclosed for increasing the specific activity of myo-inositol oxygenase. The method includes incubating a mixture including myo-inositol oxygenase and a non-sulfur containing reductant under conditions effective to increase the specific activity of the myo-inositol oxygenase. Also disclosed are methods for producing D-glucuronic acid and glucurono-γ-lactone comprising incubating a mixture including myo-inositol, myo-inositol oxygenase, and oxygen under conditions effective to form 5 grams D-glucuronic acid per liter of the mixture to 400 grams D-glucuronic acid per liter of the mixture. Glucurono-γ-lactone can be produced from the D-glucuronic acid product. Also disclosed are organisms and nucleic acids suitable for use in such methods.
摘要翻译： 公开了一种增加肌醇加氧酶比活性的方法。 该方法包括在有效提高肌醇加氧酶比活性的条件下，将包含肌醇加氧酶和不含硫的还原剂的混合物进行温育。 还公开了D-葡萄糖醛酸和葡糖苷酸-γ-内酯的制备方法，包括在有效地将每升混合物形成5克D-葡萄糖醛酸的条件下孵育包括肌醇，肌醇加氧酶和氧气的混合物至400 克D-葡萄糖醛酸每升混合物。 葡糖醛酸-γ-内酯可以由D-葡萄糖醛酸产物制备。 还公开了适用于这种方法的生物体和核酸。
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公开(公告)号：US20080187984A1
公开(公告)日：2008-08-07
申请号：US11986988
申请日：2007-11-26
CPC分类号： C12N9/0069 , C12N15/52 , C12P17/04
摘要： The invention provides methods and materials related to the production of organic products such as glucuronic acid, ascorbic acid, and glucaric acid. Specifically, the invention provides cells, methods for culturing cells, isolated nucleic acid molecules, and methods and materials for producing various organic products such as glucuronic acid, ascorbic acid, and glucaric acid.
摘要翻译： 本发明提供了与生产有机产物如葡萄糖醛酸，抗坏血酸和葡糖二酸有关的方法和材料。 具体地，本发明提供细胞，培养细胞的方法，分离的核酸分子，以及用于生产各种有机产物如葡萄糖醛酸，抗坏血酸和葡糖二酸的方法和材料。
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3.发明授权Surgical instrument having a toughened wearing surface and method of making the same 失效具有增韧磨损面的手术器具及其制造方法
公开(公告)号：US5152774A
公开(公告)日：1992-10-06
申请号：US522247
申请日：1990-05-11
申请人： William A. Schroeder
发明人： William A. Schroeder
CPC分类号： A61B17/3201 , C23C14/02 , C23C14/028 , C23C14/0641 , A61B2018/00119 , Y10T428/31678
摘要： A method for making a stainless steel or titanium surgical instrument having a high toughness wearing surface, by vapor deposition of titanium nitride thereon in a vacuum chamber having a molten evaporant in a hearth in the bottom of the chamber, and using the hollow cathode effect. A preferred method includes tempering the instrument at temperatures above 200.degree. C., then coating by physical vapor deposition at temperatures from about 175.degree. to 260.degree. C. Ring handled instruments with box lock pivots are coated before assembly. Toughened surgical instruments are also disclosed.
摘要翻译： 一种用于制造具有高韧性磨损表面的不锈钢或钛手术器械的方法，其通过在室底部的炉床中的具有熔融蒸发剂的真空室中气相沉积氮化钛，并使用中空阴极效应。 优选的方法包括在高于200℃的温度下对仪器进行回火，然后在约175°至260℃的温度下通过物理气相沉积进行涂覆。在组装之前涂覆带有盒锁枢轴的环形处理的仪器。 还公开了增韧的手术器械。
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公开(公告)号：US07326549B2
公开(公告)日：2008-02-05
申请号：US10472317
申请日：2002-03-19
CPC分类号： C12N9/0069 , C12N15/52 , C12P17/04
摘要： The invention provides methods and materials related to the production of organic products such as glucuronic acid, ascorbic acid, and glucaric acid. Specifically, the invention provides cells, methods for culturing cells, isolated nucleic acid molecules, and methods and materials for producing various organic products such as glucuronic acid, ascorbic acid, and glucaric acid.
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