公开(公告)号：US08221799B2

公开(公告)日：2012-07-17

申请号：US11671317

申请日：2007-02-05

Applicant: Kedar N. Prasad ,  Gerald M. Haase ,  William C. Cole

Inventor： Kedar N. Prasad ,  Gerald M. Haase ,  William C. Cole

IPC: A61K31/714 ,  A61K31/498 ,  A61K31/525 ,  A61K31/455 ,  A61K31/55 ,  A61K31/355 ,  A61K31/385

CPC classification number: A23L33/175 ,  A23L33/15 ,  A23L33/155 ,  A23L33/16 ,  A23V2002/00 ,  A23V2250/702 ,  A23V2250/712 ,  A23V2250/708 ,  A23V2250/71 ,  A23V2250/704 ,  A23V2250/1578 ,  A23V2250/161 ,  A23V2250/1642 ,  A23V2250/1626 ,  A23V2250/1586 ,  A23V2200/30 ,  A23V2250/0612 ,  A23V2250/314 ,  A23V2250/72 ,  A23V2250/705 ,  A23V2250/211

Abstract: The invention is directed to a method for administering antioxidant micronutrient formulations comprising multiple dietary and endogenous antioxidants, B-vitamins, vitamin D and minerals at appropriate dosages and dose schedules particularly chosen to produce long-term ‘optimal health’ effects in individuals of various age groups and occupations, with particular emphasis on reducing and/or eliminating acute and/or long term effects of environmental and physical stressors and toxic chemicals to which current Operating Forces and veterans of military service are or have been exposed.

Abstract translation: 本发明涉及一种用于在适当的剂量和剂量时间表下施用包含多种膳食和内源抗氧化剂，B族维生素，维生素D和矿物质的抗氧化微量营养素制剂的方法，其特别选择以在各种年龄的个体中产生长期的“最佳健康”作用 特别强调减少和/或消除当前工作队伍和服役退伍军人遭受暴露的环境和身体压力和有毒化学物质的急性和/或长期影响。

公开(公告)号：US4678667A

公开(公告)日：1987-07-07

申请号：US751769

申请日：1985-07-02

Applicant: Claude F. Meares ,  Sally J. DeNardo ,  William C. Cole ,  Min K. Mol

Inventor： Claude F. Meares ,  Sally J. DeNardo ,  William C. Cole ,  Min K. Mol

IPC: A61K47/48 ,  A61K49/08 ,  A61K51/04 ,  A61K51/08 ,  A61K51/10 ,  A61K39/00 ,  A61K39/42 ,  A61K43/00 ,  A61K49/00

CPC classification number: A61K51/1093 ,  A61K47/48707 ,  A61K49/085 ,  A61K49/106 ,  A61K49/16 ,  A61K51/0482 ,  A61K2121/00 ,  A61K2123/00

Abstract: A copper chelate conjugate which is stable in human serum. The conjugate includes the copper chelate of a cyclic tetraaza di-, tri-, or tetra-acetic acid, a linker attached at one linker end to a ring carbon of the chelate, and a biomolecule joined at the other end of the linker. The conjugate, or the linker-copper chelate compound used in forming the conjugate, are designed for use in diagnostic and therapeutic applications which involve Cu(II) localization via the systemic route.

Abstract translation: 在人血清中稳定的铜螯合物缀合物。 缀合物包括环状四氮杂二 - ，三 - 或四 - 乙酸的铜螯合物，在一个连接端与螯合物的环碳连接的连接体和在连接体另一端连接的生物分子。 缀合物或用于形成缀合物的接头 - 铜螯合物被设计用于通过全身途径进行Cu（II）定位的诊断和治疗应用中。

公开(公告)号：US07605145B2

公开(公告)日：2009-10-20

申请号：US11943176

申请日：2007-11-20

Applicant: Kedar N. Prasad ,  William C. Cole ,  Gerald M. Haase

Inventor： Kedar N. Prasad ,  William C. Cole ,  Gerald M. Haase

IPC: A61K31/714 ,  A61K31/59 ,  A61K31/555 ,  A61K31/525 ,  A61K31/51

CPC classification number: A61K31/19 ,  A61K31/198 ,  A61K31/355 ,  A61K31/375 ,  A61K31/385 ,  A61K31/4188 ,  A61K31/4415 ,  A61K31/455 ,  A61K31/51 ,  A61K31/525 ,  A61K31/555 ,  A61K31/714

Abstract: Formulations for minimizing damage to at least one of cells, organs and systems within the body of a subject afflicted with Diabetes Mellitus. The invention additionally encompasses methods for minimizing said damage which comprise administering to subjects in need thereof a therapeutic amount of a formulation(s) according to the invention.

Abstract translation: 用于减少受糖尿病患者体内至少一种细胞，器官和系统的损伤的制剂。 本发明另外包括用于使所述损伤最小化的方法，其包括向有需要的受试者施用治疗量的根据本发明的制剂。

公开(公告)号：US07399755B2

公开(公告)日：2008-07-15

申请号：US11357246

申请日：2006-02-17

Applicant: Kedar N. Prasad ,  William C. Cole ,  Gerald M. Haase

Inventor： Kedar N. Prasad ,  William C. Cole ,  Gerald M. Haase

IPC: A61K31/714 ,  A61K31/59 ,  A61K31/555 ,  A61K31/525 ,  A61K31/51

CPC classification number: A61K31/525 ,  A61K31/355 ,  A61K31/385 ,  A61K31/4415 ,  A61K31/455 ,  A61K31/498 ,  A61K31/51 ,  A61K31/555 ,  A61K31/714 ,  A61K2300/00

Abstract: The invention is directed to formulations comprised of multiple dietary and endogenously made antioxidants and B-vitamins and the use of these formulations in preventing and treating coronary artery disease.

Abstract translation: 本发明涉及由多种饮食和内源制造的抗氧化剂和B族维生素组成的制剂，以及这些制剂在预防和治疗冠状动脉疾病中的用途。

公开(公告)号：US09655966B2

公开(公告)日：2017-05-23

申请号：US12284841

申请日：2008-09-25

Applicant: Kedar N. Prasad ,  Gerald M. Haase ,  William C. Cole

Inventor： Kedar N. Prasad ,  Gerald M. Haase ,  William C. Cole

IPC: A61K45/06 ,  A61K31/015 ,  A61K31/714 ,  A61K31/59 ,  A61K31/555 ,  A61K31/525 ,  A61K31/4184 ,  A61K31/51

CPC classification number: A61K45/06 ,  A23V2002/00 ,  A61K31/015 ,  A61K31/4184 ,  A61K31/51 ,  A61K31/525 ,  A61K31/555 ,  A61K31/59 ,  A61K31/714 ,  A61K2300/00 ,  A23V2200/02 ,  A23V2250/1578 ,  A23V2250/1586 ,  A23V2250/1626 ,  A23V2250/1642 ,  A23V2250/211 ,  A23V2250/702 ,  A23V2250/704 ,  A23V2250/708 ,  A23V2250/7106 ,  A23V2250/026 ,  A23V2250/0616 ,  A23V2250/712

Abstract: A radioactive protection micronutrient formulation system is provided and the system comprises: a formulation consisting essentially of antioxidants, the antioxidants are selected from the group consisting essentially of vitamin C, vitamin E, N-acetyl cysteine, natural mixed carotenoids, and alpha-lipoic acid, vitamin A (palmitate), vitamin D-3 (cholecalciferol), thiamine mononitrate, riboflavin, niacinamide ascorbate, d-calcium pantothenate, pyridoxine hydrochloride, cyanocobalamin, folic acid, D-Biotin, selenium (1-seleno-methionine), chromium picolinate, zinc glycinate, calcium citrate and magnesium citrate and mixtures thereof; and plus a booster formulation selected from a group consisting essentially of vitamin C, d-alpha tocopheryl acid succinate, alpha tocopherol, N-acetyl cysteine, natural mixed carotenoids and alpha lipoic acid, the formulation is designed to reduce the risk in humans exposed to doses of ionizing radiation of becoming subjected to at least one condition selected from the group consisting essentially of radiation-induced acute leukemia, breast cancer, thyroid cancer and other somatic and heritable mutations.

公开(公告)号：US20110172179A1

公开(公告)日：2011-07-14

申请号：US12284841

申请日：2008-09-25

Applicant: Kedar N. Prasad ,  Gerald M. Haase ,  William C. Cole

Inventor： Kedar N. Prasad ,  Gerald M. Haase ,  William C. Cole

IPC: A61K31/714 ,  A61K31/375 ,  A61K31/555 ,  A61K31/525 ,  A61K31/44 ,  A61P39/06

CPC classification number: A61K45/06 ,  A23V2002/00 ,  A61K31/015 ,  A61K31/4184 ,  A61K31/51 ,  A61K31/525 ,  A61K31/555 ,  A61K31/59 ,  A61K31/714 ,  A61K2300/00 ,  A23V2200/02 ,  A23V2250/1578 ,  A23V2250/1586 ,  A23V2250/1626 ,  A23V2250/1642 ,  A23V2250/211 ,  A23V2250/702 ,  A23V2250/704 ,  A23V2250/708 ,  A23V2250/7106 ,  A23V2250/026 ,  A23V2250/0616 ,  A23V2250/712

Abstract: A radioactive protection micronutrient formulation system is provided and the system comprises: a formulation consisting essentially of antioxidants, the antioxidants are selected from the group consisting essentially of vitamin C, vitamin E, N-acetyl cysteine, natural mixed carotenoids, and alpha-lipoic acid, vitamin A (palmitate), vitamin D-3 (cholecalciferol), thiamine mononitrate, riboflavin, niacinamide ascorbate, d-calcium pantothenate, pyridoxine hydrochloride, cyanocobalamin, folic acid, D-Biotin, selenium (1-seleno-methionine), chromium picolinate, zinc glycinate, calcium citrate and magnesium citrate and mixtures thereof; and plus a booster formulation selected from a group consisting essentially of vitamin C, d-alpha tocopheryl acid succinate, alpha tocopherol, N-acetyl cysteine, natural mixed carotenoids and alpha lipoic acid, the formulation is designed to reduce the risk in humans exposed to doses of ionizing radiation of becoming subjected to at least one condition selected from the group consisting essentially of radiation-induced acute leukemia, breast cancer, thyroid cancer and other somatic and heritable mutations.

Abstract translation: 提供了一种放射性保护微量营养素配方系统，该系统包括：基本上由抗氧化剂组成的制剂，抗氧化剂选自维生素C，维生素E，N-乙酰半胱氨酸，天然混合类胡萝卜素和α-硫辛酸 ，维生素A（棕榈酸酯），维生素D-3（胆钙化醇），一硝酸硫胺素，核黄素，烟酰胺抗坏血酸盐，泛酸钙，盐酸吡哆醇，氰钴胺素，叶酸，D-生物素，硒（1-硒 - 甲硫氨酸） 吡啶甲酸盐，甘氨酸锌，柠檬酸钙和柠檬酸镁及其混合物; 并加上选自基本上由维生素C，d-α生育酚酸琥珀酸酯，α-生育酚，N-乙酰半胱氨酸，天然混合类胡萝卜素和α-硫辛酸组成的组的加强剂制剂，该制剂被设计为降低暴露于 电离辐射剂量经受至少一种选自基本上由辐射诱发的急性白血病，乳腺癌，甲状腺癌和其他体细胞和可遗传突变组成的病症。

公开(公告)号：US07628984B2

公开(公告)日：2009-12-08

申请号：US12157077

申请日：2008-06-06

Applicant: Kedar N. Prasad ,  Gerald M. Haase ,  William C. Cole

Inventor： Kedar N. Prasad ,  Gerald M. Haase ,  William C. Cole

IPC: A61K31/122 ,  A61P11/00 ,  A61P9/00

CPC classification number: A61K45/06 ,  A61K31/015 ,  A61K31/122 ,  A61K31/197 ,  A61K31/203 ,  A61K31/205 ,  A61K31/221 ,  A61K31/28 ,  A61K31/315 ,  A61K31/355 ,  A61K31/375 ,  A61K31/385 ,  A61K31/4188 ,  A61K31/51 ,  A61K31/593 ,  A61K2300/00

Abstract: A heart and pulmonry health micronutrient formulation is provided and the formulation comprises dietary antioxidants and endogenous antioxidants, and the formulation comprising dietary micronutrients and endogenous antioxidants, the dietary antioxidants are selected from a group consisting essentially of Vitamin A (Palmitate), Vitamin E, Vitamin C, Vitamin D3 (Cholecalciferol), B Vitamins, Biotin, Pantothenic Acid (as D-Calcium Pantothenate), Calcium Citrate, Magnesium Citrate, Zinc Glycinate, Selenium (Seleno-L-Methionine), Chromium (as Chromium Picolinate), Mixed Carotenoids and mixtures thereof, and the endogenous antioxidants are selected from a group consisting essentially of N-Acetyl Cysteine (NAC), Coenzyme Q10, R-alpha Lipoic Acid, Omega-3 fatty Acid, and L-Carnitine and mixtures thereof.

Abstract translation: 提供心脏和肺部健康微量营养素制剂，其制剂包含膳食抗氧化剂和内源性抗氧化剂，并且该制剂包含膳食微量营养素和内源性抗氧化剂，膳食抗氧化剂选自基本上由维生素A（棕榈酸酯），维生素E，维生素 C，维生素D3（胆钙化醇），B维生素，生物素，泛酸（作为D-泛酸钙），柠檬酸钙，柠檬酸镁，甘氨酸锌，硒（硒-L-甲硫氨酸），铬（作为吡啶甲酸铬），混合类胡萝卜素 内源性抗氧化剂选自N-乙酰半胱氨酸（NAC），辅酶Q10，R-α硫辛酸，ω-3脂肪酸和L-肉毒碱及其混合物。

公开(公告)号：US20080241119A1

公开(公告)日：2008-10-02

申请号：US12157077

申请日：2008-06-06

Applicant: Kedar N. Prasad ,  Gerald M. Haase ,  William C. Cole

Inventor： Kedar N. Prasad ,  Gerald M. Haase ,  William C. Cole

IPC: A61K31/122 ,  A61P11/00 ,  A61P9/00

CPC classification number: A61K45/06 ,  A61K31/015 ,  A61K31/122 ,  A61K31/197 ,  A61K31/203 ,  A61K31/205 ,  A61K31/221 ,  A61K31/28 ,  A61K31/315 ,  A61K31/355 ,  A61K31/375 ,  A61K31/385 ,  A61K31/4188 ,  A61K31/51 ,  A61K31/593 ,  A61K2300/00

Abstract: A heart and pulmonry health micronutrient formulation is provided and the formulation comprises dietary antioxidants and endogenous antioxidants, and the formulation comprising dietary micronutrients and endogenous antioxidants, the dietary antioxidants are selected from a group consisting essentially of Vitamin A (Palmitate), Vitamin E, Vitamin C, Vitamin D3 (Cholecalciferol), B Vitamins, Biotin, Pantothenic Acid (as D-Calcium Pantothenate), Calcium Citrate, Magnesium Citrate, Zinc Glycinate, Selenium (Seleno-L-Methionine), Chromium (as Chromium Picolinate), Mixed Carotenoids and mixtures thereof, and the endogenous antioxidants are selected from a group consisting essentially of N-Acetyl Cysteine (NAC), Coenzyme Q10, R-alpha Lipoic Acid, Omega-3 fatty Acid, and L-Carnitine and mixtures thereof.

Abstract translation: 提供心脏和肺部健康微量营养素制剂，其制剂包含膳食抗氧化剂和内源性抗氧化剂，并且该制剂包含膳食微量营养素和内源性抗氧化剂，膳食抗氧化剂选自基本上由维生素A（棕榈酸酯），维生素E，维生素 C，维生素D 3（胆钙化醇），B维生素，生物素，泛酸（作为D-泛酸钙），柠檬酸钙，柠檬酸镁，甘氨酸锌，硒（硒-L-甲硫氨酸），铬 （作为吡啶甲酸铬），混合类胡萝卜素及其混合物，内源性抗氧化剂选自基本上由N-乙酰半胱氨酸（NAC），辅酶Q 10，R-α硫辛酸，ω- -3脂肪酸和L-肉碱及其混合物。

公开(公告)号：US20080187526A1

公开(公告)日：2008-08-07

申请号：US12080189

申请日：2008-04-01

Applicant: Kedar N. Prasad ,  Gerald M. Haase ,  William C. Cole

Inventor： Kedar N. Prasad ,  Gerald M. Haase ,  William C. Cole

IPC: A61K31/122 ,  A61P27/16

CPC classification number: A61K31/7052 ,  A23L33/10 ,  A23L33/15 ,  A23L33/155 ,  A23L33/16 ,  A23L33/175 ,  A23L33/40 ,  A23V2002/00 ,  A61K31/122 ,  A61K31/355 ,  A61K33/30 ,  A61K45/06 ,  A61K2300/00 ,  A23V2250/702 ,  A23V2250/211 ,  A23V2250/708 ,  A23V2250/704 ,  A23V2250/1578 ,  A23V2250/161 ,  A23V2250/1642 ,  A23V2250/1626 ,  A23V2250/1586

Abstract: A hearing health micronutrient formulation is provided and the formulation comprises dietary antioxidants and endogenous antioxidants, and the dietary antioxidants are selected from a group consisting essentially of Vitamin A (Palmitate), Vitamin E, Vitamin C (Calcium Ascorbate), Vitamin D3 (Cholecalciferol), B Vitamins, Biotin, Pantothenic Acid (as D-Calcium Pantothenate), Calcium Citrate, Magnesium Citrate, Zinc Glycinate, Selenium (Seleno-L-Methionine), Chromium (as Chromium Picolinate), Mixed Carotenoids and mixtures thereof, and the endogenous antioxidants are selected from a group consisting essentially of N-Acetyl Cysteine (NAC), Coenzyme Q10, R-alpha Lipoic Acid, L-Carnitine and mixtures thereof,

Abstract translation: 提供了听力健康微量营养素制剂，其制剂包含膳食抗氧化剂和内源性抗氧化剂，膳食抗氧化剂选自维生素A（棕榈酸酯），维生素E，维生素C（抗坏血酸钙），维生素D 3（胆钙化醇），B维生素，生物素，泛酸（作为D-泛酸钙），柠檬酸钙，柠檬酸镁，甘氨酸锌，硒（硒-L-甲硫氨酸），铬（作为吡啶甲酸铬），混合 类胡萝卜素及其混合物和内源性抗氧化剂选自基本上由N-乙酰半胱氨酸（NAC），辅酶Q 10，R-α硫辛酸，L-肉碱及其混合物组成的组，

公开(公告)号：US20080118488A1

公开(公告)日：2008-05-22

申请号：US11943176

申请日：2007-11-20

Applicant: Kedar N. Prasad ,  William C. Cole ,  Gerald M. Haase

Inventor： Kedar N. Prasad ,  William C. Cole ,  Gerald M. Haase

IPC: A61K38/43 ,  A61K31/714 ,  A61K31/555 ,  A61K31/525 ,  A61K31/51 ,  A61K31/455 ,  A61K31/4415 ,  A61K31/4188 ,  A61K31/375 ,  A61K31/355 ,  A61K31/385 ,  A61K31/19 ,  A61K31/198

CPC classification number: A61K31/19 ,  A61K31/198 ,  A61K31/355 ,  A61K31/375 ,  A61K31/385 ,  A61K31/4188 ,  A61K31/4415 ,  A61K31/455 ,  A61K31/51 ,  A61K31/525 ,  A61K31/555 ,  A61K31/714

Abstract: Formulations for minimizing damage to at least one of cells, organs and systems within the body of a subject afflicted with Diabetes Mellitus. The invention additionally encompasses methods for minimizing said damage which comprise administering to subjects in need thereof a therapeutic amount of a formulation(s) according to the invention.

Abstract translation: 用于减少受糖尿病患者体内至少一种细胞，器官和系统的损伤的制剂。 本发明另外包括用于使所述损伤最小化的方法，其包括向有需要的受试者施用治疗量的根据本发明的制剂。