公开(公告)号：US20130096455A1

公开(公告)日：2013-04-18

申请号：US13646129

申请日：2012-10-05

申请人： Ghassan S. Kassab ,  Mark Svendsen ,  William Combs ,  Kevin Mauser ,  John Browder ,  Lynette Peters

发明人： Ghassan S. Kassab ,  Mark Svendsen ,  William Combs ,  Kevin Mauser ,  John Browder ,  Lynette Peters

IPC分类号： H01B7/04 ,  A61B5/053

CPC分类号： H01B7/048 ,  A61B5/01 ,  A61B5/0538 ,  A61B2562/222

摘要： Devices and systems for obtaining conductance data and methods of manufacturing and using the same. In at least one embodiment of a device of the present disclosure, the device is an elongated body with at least one groove defined therein, the at least one groove configured to receive one or more conductor wires therein. In another embodiment, the device is an elongated core body having a plurality of conductive elements positioned thereon and a coating to result in a device having an overall round-cross section.

摘要翻译： 用于获得电导数据的装置和系统及其制造和使用方法。 在本公开的装置的至少一个实施例中，该装置是细长主体，其中限定有至少一个凹槽，所述至少一个凹槽被配置成在其中容纳一根或多根导线。 在另一个实施例中，该装置是细长的芯体，其具有定位在其上的多个导电元件和涂层，以形成具有整体圆截面的装置。

公开(公告)号：US20070093872A1

公开(公告)日：2007-04-26

申请号：US11257715

申请日：2005-10-25

申请人： Raul Chirife ,  William Combs ,  Russell Lundstrom

发明人： Raul Chirife ,  William Combs ,  Russell Lundstrom

IPC分类号： A61N1/00

CPC分类号： A61N1/3627 ,  A61N1/365

摘要： An implantable medical device provides ventricular pacing capabilities and optimizes AV intervals for multiple purposes. In general, intrinsic conduction is promoted by determining when electromechanical systole (EMS) ends and setting an AV interval accordingly. EMS is determined utilizing various data including QT interval, sensor input, and algorithmic calculations.

公开(公告)号：US4953551A

公开(公告)日：1990-09-04

申请号：US394249

申请日：1989-08-07

申请人： Rahul Mehra ,  William Combs

发明人： Rahul Mehra ,  William Combs

IPC分类号： A61N1/39 ,  A61N1/00

CPC分类号： A61N1/3956 ,  A61N1/3906

摘要： A method of terminating ventricular fibrillation by the delivery of an asymmetric biphasic current pulse to three separate electrodes. A first catheter mounted electrode is located in the apex of the right ventricle (RV). A second electrode carried on the same catheter is located outside the atrium preferably in the superior vena cava (SV). A third plate electrode is located subcutaneously outside the chest cavity. Preferably, the SVC electrode and the subcutaneous plate electrode are electrically interconnected and an asymmetrical biphasic current pulse is applied between this electrode pair and the RV electrode to defibrillate the heart.

摘要翻译： 通过将不对称双相电流脉冲传送到三个分开的电极来终止心室颤动的方法。 第一导管安装电极位于右心室（RV）的顶点。 携带在同一导管上的第二电极位于心房外部，优选位于上腔静脉（SV）中。 第三板电极位于胸腔外皮下。 优选地，SVC电极和皮下板电极电互连，并且在该电极对和RV电极之间施加不对称的双相电流脉冲以使心脏去纤颤。

公开(公告)号：US4292892A

公开(公告)日：1981-10-06

申请号：US173466

申请日：1980-07-30

申请人： William Combs

发明人： William Combs

IPC分类号： B21D43/12 ,  B30B15/32

CPC分类号： B21D43/12 ,  Y10T83/2027

摘要： A conveyor for conveying material from a press machine. The conveyor is advanced by apparatus adapted to be connected toi the movable head of the press machine. The apparatus includes an arm having a plurality of outwardly extending fingers which is connected to the head of the press machine for movement therewith. A rachet wheel having a plurality of circumferentially spaced finger engaging members is fixably mounted to the drive rod of the conveyor. The fingers on the arm engage the finger engaging members of the rachet wheel upon movement of the head of the press in a first direction which causes the rachet wheel as well as the drive rod to rotate. The rotation of the drive rod results in an incremental advance of the conveyor which removes material deposited thereon from the press machine.

摘要翻译： 用于从压机输送材料的输送机。 输送机通过适于连接到压力机的可移动头部的设备而前进。 该装置包括具有多个向外延伸的指状物的臂，其连接到压力机的头部以与其一起运动。 具有多个周向间隔开的手指接合构件的冲击轮可固定地安装到输送机的驱动杆上。 当按压压头的头沿第一方向移动时，臂上的指状物接合旋转轮的手指接合构件，该第一方向导致冲洗轮以及驱动杆旋转。 驱动杆的旋转导致输送机的增量前进，其移除从压力机上沉积在其上的材料。

公开(公告)号：US20070250127A1

公开(公告)日：2007-10-25

申请号：US11379290

申请日：2006-04-19

申请人： Lee Stylos ,  Todd Sheldon ,  Steven Lu ,  William Combs ,  Robert Nehls

发明人： Lee Stylos ,  Todd Sheldon ,  Steven Lu ,  William Combs ,  Robert Nehls

IPC分类号： A61N1/365

CPC分类号： A61N1/3702 ,  A61N1/36514 ,  A61N1/36542 ,  A61N1/36557 ,  A61N1/37252

摘要： An implantable medical device (IMD) performs periodic testing of a patient to determine ischemia threshold information. At selected times while the patient is at rest, the IMD increases the pacing rate over time until it receives feedback either from the patient or from an ischemia sensor. The IMD determines the threshold based upon the pacing rate at the time when the feedback was received. The threshold information can be used to adjust the upper pacing rate that can be used during rate adaptive pacing, to determine the effects of drug therapy, and to provide a general indication of the state of coronary artery disease in the patient. The periodic increase of pacing rate to the ischemic zone also provides a preconditioning of the myocardium to allow the patient greater exercise benefit without angina.

摘要翻译： 可植入医疗装置（IMD）执行患者的周期性测试以确定缺血阈值信息。 在患者静止时的选定时间，IMD随着时间的推移增加起搏速率，直到其从患者或缺血传感器接收到反馈。 IMD根据接收到反馈时的起搏速率来确定阈值。 阈值信息可以用于调整速率自适应起搏期间可以使用的上起搏速率，以确定药物治疗的效果，并提供患者冠状动脉疾病状态的一般指示。 对缺血区的起搏速率的周期性增加也提供了心肌的预调节，以允许患者在没有心绞痛的情况下更大的运动益处。

公开(公告)号：US20070150123A1

公开(公告)日：2007-06-28

申请号：US11296967

申请日：2005-12-08

申请人： William Combs

发明人： William Combs

IPC分类号： G06F7/00

CPC分类号： G08G5/0052 ,  G05D1/0005

摘要： A system and method are provided for controlling the airspeed of an aircraft. A plurality of recommended airspeeds are initially determined based upon different objectives. The recommended airspeeds may be based upon various objectives including: (1) delivery of the aircraft to its destination within a predefined arrival window; (2) maximization of the fuel efficiency of the aircraft during the flight; and (3) reduction in the passenger's perceptibility of airspeed changes of the aircraft. Based upon the different objectives taken in view of the current flight conditions, a resulting airspeed is determined from the plurality of recommended airspeeds. As each objective may suggest a different recommended airspeed, the system and method may compromise between the various objectives based upon the current flight conditions so as to define the resulting airspeed. The resulting airspeed may then be applied to the auto-throttle of the aircraft.

摘要翻译： 提供了一种用于控制飞行器的空速的系统和方法。 最初根据不同的目标确定多个推荐的空速。 推荐的空速可以基于各种目标，包括：（1）在预定义的到达窗口内将飞机运送到目的地; （2）飞行期间飞机的燃油效率最大化; （3）降低乘客对飞机空速变化的敏感度。 根据目前的飞行条件考虑不同的目标，从多个推荐的空速中确定产生的空速。 由于每个目标可能表明不同的推荐空速，系统和方法可能会根据当前的飞行条件在各种目标之间进行妥协，以便定义所得到的空速。 然后，所得到的空速可以被施加到飞行器的自动节气门。

公开(公告)号：US20070016259A1

公开(公告)日：2007-01-18

申请号：US11534910

申请日：2006-09-25

申请人： Earl Bakken ,  Rebecca Bergman ,  William Combs ,  H. Markowitz

发明人： Earl Bakken ,  Rebecca Bergman ,  William Combs ,  H. Markowitz

IPC分类号： A61N1/362

CPC分类号： A61N1/365 ,  A61N1/36592

摘要： A method and apparatus for varying a parameter in an implantable medical device that includes a plurality of electrodes stimulating heart tissue and sensing cardiac signals, a timing and control device controlling the stimulation of heart tissue by the plurality of electrodes and measuring intervals between the sensed cardiac signals, a storage device storing the measured intervals, and a microprocessor. The microprocessor determines heart rate variability in response to the stored intervals, compares the determined heart rate variability to a predetermined target rate profile, adjusts the parameter from a first setting to a second setting different from the first setting in response to the comparing of the determined heart rate variability and the predetermined target rate profile, and adjusts the parameter from the second setting to a termination setting in response to a termination event or expiration of a first predetermined time period.

摘要翻译： 一种用于改变可植入医疗装置中的参数的方法和装置，其包括刺激心脏组织和感测心脏信号的多个电极，控制多个电极对心脏组织刺激的定时和控制装置，并且测量感测的心脏 信号，存储测量的间隔的存储装置和微处理器。 微处理器响应于存储的间隔来确定心率变异性，将确定的心率变异性与预定的目标速率分布进行比较，响应于所确定的心率变异性的比较，将参数从第一设置调整到与第一设置不同的第二设置 心率变异性和预定目标速率曲线，并且响应于终止事件或第一预定时间段的期满，将参数从第二设置调整到终止设置。

公开(公告)号：US20060064027A1

公开(公告)日：2006-03-23

申请号：US10945620

申请日：2004-09-21

申请人： Lynn Borowitz ,  William Combs

发明人： Lynn Borowitz ,  William Combs

IPC分类号： A61N1/362 ,  A61B5/0402

CPC分类号： A61N1/368 ,  A61N1/3682 ,  A61N1/3702

摘要： Implantable medical devices having two or more leads can utilize digital signal processing to sample and filter the acquired data. The processed data is utilized to identify electrical activity in cardiac tissue remote from the lead location. An atrial lead and a ventricular lead are used to acquire data and the data is processed to indicated electrical timing with the HIS bundle.

摘要翻译： 具有两个或多个引线的可植入医疗器械可以利用数字信号处理对所获取的数据进行采样和滤波。 处理的数据用于识别远离引导位置的心脏组织中的电活动。 使用心房引线和心室引线来获取数据，并且使用HIS束处理数据以指示电时间。

公开(公告)号：US20070093873A1

公开(公告)日：2007-04-26

申请号：US11258523

申请日：2005-10-25

申请人： Raul Chirife ,  William Combs ,  Russell Lundstrom

发明人： Raul Chirife ,  William Combs ,  Russell Lundstrom

IPC分类号： A61N1/365

CPC分类号： A61N1/3627 ,  A61N1/365

摘要： An implantable medical device provides ventricular pacing capabilities and optimizes AV intervals for multiple purposes. In general, intrinsic conduction is promoted by determining when electromechanical systole (EMS) ends and setting an AV interval accordingly. EMS is determined utilizing various data including QT interval, sensor input, and algorithmic calculations.

摘要翻译： 可植入医疗装置提供心室起搏功能并优化AV间隔用于多种目的。 通常，通过确定何时机电收缩（EMS）结束并相应地设置AV间隔来促进固有传导。 使用包括QT间隔，传感器输入和算法计算的各种数据来确定EMS。

公开(公告)号：US20050090758A1

公开(公告)日：2005-04-28

申请号：US10299397

申请日：2002-11-20

申请人： Victor Parsonnet ,  William Combs

发明人： Victor Parsonnet ,  William Combs

IPC分类号： A61B5/053

CPC分类号： A61B5/413 ,  A61B5/0537

摘要： The invention is directed to techniques for monitoring organ rejection. An implanted device monitors the impedance of the transplanted organ. When the impedance measurements indicate that the organ is being rejected, the device provides early warning of rejection.

摘要翻译： 本发明涉及用于监测器官排斥的技术。 植入装置监测移植器官的阻抗。 当阻抗测量表明器官被拒绝时，器件提供拒收的早期警告。