Process for the precipitation of cystine

    公开(公告)号:US06548700B2

    公开(公告)日:2003-04-15

    申请号:US09905359

    申请日:2001-07-13

    IPC分类号: C07C32300

    CPC分类号: C07C319/28 C07C323/58

    摘要: A process for precipitating cystine from a solution in sulfuric acid, includes forming a mixture of a solution of cystine in aqueous sulfuric acid and of an aqueous solution of a base by simultaneous metering the cystine solution and the aqueous base solution into a mixing container. The metering takes place in such a way that the mixture in the container has a pH between 1.0 and 7.0 and a temperature between 30° C. and the boiling point of the mixture.

    Method for the production of OH protected[4-(2.6-diamino-9H-purine-9-yl)-1.3-dioxolane-2-yl]methanol derivatives
    2.
    发明授权
    Method for the production of OH protected[4-(2.6-diamino-9H-purine-9-yl)-1.3-dioxolane-2-yl]methanol derivatives 失效
    制备OH保护的[4-(2,6-二氨基-9H-嘌呤-9-基)-1,3-二氧戊环-2-基]甲醇衍生物的方法

    公开(公告)号:US07560550B2

    公开(公告)日:2009-07-14

    申请号:US10595067

    申请日:2004-07-22

    IPC分类号: C07F7/18 C07D473/16

    CPC分类号: C07D473/00 C07D473/16

    摘要: Glycosylation of 2,6-diaminopurines or silyl derivatives thereof with a compound of the structure is facilitated by the presence of an optionally silylated 1,3-dicarbonyl compound during glycosylation. Byproducts are minimized, while stereoselectivity may be altered by choice of Lewis acid and other reaction condictions.

    摘要翻译: 通过在糖基化期间存在任选的甲硅烷基化的1,3-二羰基化合物,促进了具有该结构的化合物的2,6-二氨基嘌呤或其甲硅烷基衍生物的糖基化。 副产物被最小化,而立体选择性可以通过选择路易斯酸和其他反应条件而改变。

    Process for ring cleavage of thiazolidine derivatives
    4.
    发明授权
    Process for ring cleavage of thiazolidine derivatives 失效
    噻唑烷衍生物的环裂解方法

    公开(公告)号:US06372912B1

    公开(公告)日:2002-04-16

    申请号:US09543634

    申请日:2000-04-05

    IPC分类号: C07D27704

    摘要: Process for the hydrolytic ring cleavage of thiazolidine derivatives to give 2-aminomercaptan derivatives and carbonyl compounds, which comprises bringing an aqueous solution of the thiazolidine derivative into contact with an acidic cation exchanger in the H+ form, giving a solution L1 which contains the carbonyl compound and eluting the cation exchanger with a suitable eluent, giving a solution L2 which contains the 2-aminomercaptan derivative.

    摘要翻译: 用于水解环裂解噻唑烷衍生物的方法得到2-氨基哌啶衍生物和羰基化合物,其包括将噻唑烷衍生物的水溶液与H +形式的酸性阳离子交换剂接触,得到含有羰基化合物的溶液L1和 该阳离子交换剂具有合适的洗脱液,得到含有2-氨基硫醇衍生物的溶液L2。