公开(公告)号：US06762405B1

公开(公告)日：2004-07-13

申请号：US10448631

申请日：2003-05-30

申请人： Xiaojie Zhao ,  Shane Shizhou Zhang ,  Alan Jinlin Xu ,  Yusong Yin

发明人： Xiaojie Zhao ,  Shane Shizhou Zhang ,  Alan Jinlin Xu ,  Yusong Yin

IPC分类号： H01J4904

CPC分类号： H01J49/164

摘要： A matrix assisted laser desorption and ionization system is provided. The system includes a mass spectrometer for analyzing at least one sample. The mass spectrometer includes a sample receiving chamber for receiving a sample under a vacuum. A UV laser is provided for producing a UV beam along a first beam path that does not intersect with the sample. A beam expander is provided in optical communication with the UV laser beam to expand the diameter of the beam. A focusing system is provided in optical communication with the beam expander to focus the laser beam propagating from the beam expander to a predetermined minimum spot size. The focusing system is located along the path of the beam propagating from the beam expander so that the beam strikes the approximate optical center of the focusing system. A high reflecting mirror is provided in optical communication with the focused beam propagating from the focusing system to direct the focused beam to strike the sample at a preselected strike point. Desirably, the laser, the beam expander and the focusing system, preferably a lens, are mounted to the same mounting surface or to parallel mounting surfaces that are joined together to form an integral structure.

摘要翻译： 提供了矩阵辅助激光解吸和电离系统。 该系统包括用于分析至少一个样品的质谱仪。 质谱仪包括用于在真空下接收样品的样品接收室。 提供UV激光器用于沿着不与样品相交的第一光束路径产生UV光束。 光束扩展器设置成与UV激光束光学通信以扩大光束的直径。 提供与光束扩展器光通信的聚焦系统，以将从扩束器传播的激光束聚焦到预定的最小光斑尺寸。 聚焦系统沿着从光束扩展器传播的光束的路径定位，使得光束照射到聚焦系统的近似光学中心。 提供高反射镜与从聚焦系统传播的聚焦光束进行光通信，以引导聚焦光束在预选击打点处撞击样品。 理想地，激光器，扩束器和聚焦系统（优选透镜）安装到相同的安装表面或平行的连接在一起以形成整体结构的安装表面。

公开(公告)号：US06961355B1

公开(公告)日：2005-11-01

申请号：US10339241

申请日：2003-01-09

申请人： Yusong Yin ,  Xiaojie Zhao ,  Jing Zhao ,  Samuil Karlsbrun

发明人： Yusong Yin ,  Xiaojie Zhao ,  Jing Zhao ,  Samuil Karlsbrun

IPC分类号： H01S3/10 ,  H01S3/106 ,  H01S3/107 ,  H01S3/109 ,  H01S3/11 ,  H01S3/16

CPC分类号： H01S3/117 ,  H01S3/0815 ,  H01S3/10038 ,  H01S3/107 ,  H01S3/109 ,  H01S3/115 ,  H01S3/1611

摘要： Lasers are provided to deliver a wide variety of wavelengths at variable pulse energy. A laser cavity is formed between a first and second reflective surface. A lasing medium is located within cavity which lases at a preselected fundamental frequency. One or more nonlinear crystals are provided in optical communication with the lasing crystal to produce a secondary beam having a different frequency than the fundamental beam. A modulator is provided to control the pulse energy of the secondary beam. Desirably the secondary beam is a harmonic beam for example a second, third, fourth or fifth harmonic beam or a beam provided by an optical parametric oscillator.

摘要翻译： 提供激光以在可变的脉冲能量下提供多种波长。 在第一和第二反射表面之间形成激光腔。 激光介质位于腔内，以预选的基频发光。 提供与激光晶体光学通信的一个或多个非线性晶体，以产生具有与基波束不同的频率的次波束。 提供调制器来控制次级束的脉冲能量。 期望的次级光束是例如第二，第三，第四或第五谐波光束或由光参量振荡器提供的光束的谐波束。

公开(公告)号：US06842293B1

公开(公告)日：2005-01-11

申请号：US10122060

申请日：2002-04-13

申请人： Yusong Yin ,  Xiaojie Zhao ,  Jing Zhao

发明人： Yusong Yin ,  Xiaojie Zhao ,  Jing Zhao

IPC分类号： G02B27/30

CPC分类号： G02B27/30

摘要： A laser beam includes a concave or convex mirror which is reflective for wavelength of the high intensity beam. The reflective mirror is located along a preselected path of a high intensity laser beam so that the high intensity laser beam intersects the mirror at a first position. A beam collimator is located in the path of the high intensity beam reflected by the concave or convex mirror. The concave or convex mirror is movably mounted desirably rotatably mounted in the path of the high intensity beam. Desirably the mirror is rotated about a preselected axis. Desirably, the axis is selected so that when the mirror is rotated to a new position, the high intensity beam will be reflected along the same path to the collimator as it was prior to any rotation.

摘要翻译： 激光束包括对于高强度波束的波长反射的凹面或凸面镜。 反射镜沿着高强度激光束的预选路径定位，使得高强度激光束在第一位置处与反射镜相交。 光束准直仪位于由凹凸镜反射的高强度光束的路径中。 凹凸镜可移动地安装在高强度光束的路径中可旋转地安装。 理想地，反射镜围绕预选轴线旋转。 理想地，选择轴使得当镜子旋转到新位置时，高强度光束将沿着与在任何旋转之前的准直器相同的路径被反射。