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![3-Pyrrolo[b]Cyclohexylene-2-Dihydroindolinone Derivatives and Uses Thereof](/abs-image/US/2010/06/24/US20100160318A1/abs.jpg.150x150.jpg)
1.发明申请3-Pyrrolo[b]Cyclohexylene-2-Dihydroindolinone Derivatives and Uses Thereof 有权3-吡咯并[b]环己基-2-二氢吲哚啉酮衍生物及其用途公开(公告)号：US20100160318A1
公开(公告)日：2010-06-24
申请号：US12517351
申请日：2007-12-03
IPC: A61K31/404 , C07D209/42 , C07D413/12 , C07D401/12 , C07D403/12 , C07D405/08 , A61K31/5377 , A61K31/496 , A61K31/454 , A61K31/4439 , C07D401/14 , C07D403/14 , A61K31/4545 , A61P35/00 , A61P17/00 , A61P9/00 , A61P9/10 , A61P3/10 , A61P19/02 , A61P37/00 , A61P29/00 , A61P27/02
CPC classification number: C07D209/42 , C07D401/14 , C07D403/14
Abstract: 3-pyrrolo[b]cyclohexylene-2-dihydro-indolinone derivatives of formula (I) or their pharmaceutically acceptable salts and uses thereof. The intermediates of formula (II) for preparing the above compounds. The bioassay shows that the above compounds and their pharmaceutically acceptable salts can modulate the activity of protein kinases (PKs), inhibit the activity of tyrosine kinases (PTKs) and inhibit many kinds of tumor cells as well as.
Abstract translation: 式（I）的3-吡咯并[b]亚环己基-2-二氢 - 二氢吲哚酮衍生物或其药学上可接受的盐和用途。 用于制备上述化合物的式（II）的中间体。 生物测定显示，上述化合物及其药学上可接受的盐可调节蛋白激酶（PK）的活性，抑制酪氨酸激酶（PTK）的活性并抑制多种肿瘤细胞。
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![3-Pyrrolo[b]cyclohexylene-2-dihydroindolinone derivatives and uses thereof](/abs-image/US/2011/12/27/US08084621B2/abs.jpg.150x150.jpg)
2.发明授权3-Pyrrolo[b]cyclohexylene-2-dihydroindolinone derivatives and uses thereof 有权3-吡咯并[b]环己基-2-二氢吲哚啉酮衍生物及其用途公开(公告)号：US08084621B2
公开(公告)日：2011-12-27
申请号：US12517351
申请日：2007-12-03
IPC: C07D209/02 , A61K31/40
CPC classification number: C07D209/42 , C07D401/14 , C07D403/14
Abstract: 3-pyrrolo[b]cyclohexylene-2-dihydro-indolinone derivatives of formula (I) or their pharmaceutically acceptable salts and uses thereof. The intermediates of formula (II) for preparing the above compounds. The bioassay shows that the above compounds and their pharmaceutically acceptable salts can modulate the activity of protein kinases (PKs), inhibit the activity of tyrosine kinases (PTKs) and inhibit many kinds of tumor cells as well as.
Abstract translation: 式（I）的3-吡咯并[b]亚环己基-2-二氢 - 二氢吲哚酮衍生物或其药学上可接受的盐和用途。 用于制备上述化合物的式（II）的中间体。 生物测定显示，上述化合物及其药学上可接受的盐可调节蛋白激酶（PK）的活性，抑制酪氨酸激酶（PTK）的活性并抑制多种肿瘤细胞。
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3.发明授权Pharmaceutical composition and its use in the preparation of a medicament for the treatment of cerebrovascular diseases 有权药物组合物及其在制备用于治疗脑血管疾病的药物中的用途公开(公告)号：US08658684B2
公开(公告)日：2014-02-25
申请号：US12920579
申请日：2009-03-03
Applicant: Xiaojin Yin , Shibao Yang , Xiaoqiang Li , Zheng Jiang , Jian He , Anyuan Zhang , Xin Huang
Inventor： Xiaojin Yin , Shibao Yang , Xiaoqiang Li , Zheng Jiang , Jian He , Anyuan Zhang , Xin Huang
IPC: A61K31/415
CPC classification number: A61K31/045 , A61K31/4152 , C07D231/22
Abstract: A pharmaceutical composition comprises 3-methyl-1-phenyl-2-pyrazolin-5-one and borneol, and can be used to prepare the medicine for treating cerebrovascular diseases.
Abstract translation: 药物组合物包含3-甲基-1-苯基-2-吡唑啉-5-酮和冰片，可用于制备治疗脑血管疾病的药物。
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4.发明申请公开(公告)号：US20110003873A1
公开(公告)日：2011-01-06
申请号：US12920579
申请日：2009-03-03
Applicant: Xiaojin Yin , Shibao Yang , Xiaoqiang Li , Zheng Jiang , Jian He , Anyuan Zhang , Xin Huang
Inventor： Xiaojin Yin , Shibao Yang , Xiaoqiang Li , Zheng Jiang , Jian He , Anyuan Zhang , Xin Huang
IPC: A61K31/4152 , A61P9/10
CPC classification number: A61K31/045 , A61K31/4152 , C07D231/22
Abstract: A pharmaceutical composition comprises 3-methyl-1-phenyl-2-pyrazolin-5-one and borneol, and can be used to prepare the medicine for treating cerebrovascular diseases.
Abstract translation: 药物组合物包含3-甲基-1-苯基-2-吡唑啉-5-酮和冰片，可用于制备治疗脑血管疾病的药物。
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