公开(公告)号：US11793763B2

公开(公告)日：2023-10-24

申请号：US17340292

申请日：2021-06-07

申请人： Honglong Li ,  Ziheng Jin ,  Xiaosong Xu ,  Linzheng Li ,  Wenjin Zhang ,  Chunfeng Yu ,  Huiting Xia

发明人： Honglong Li ,  Ziheng Jin ,  Xiaosong Xu ,  Linzheng Li ,  Wenjin Zhang ,  Chunfeng Yu ,  Huiting Xia

IPC分类号： A61K9/16 ,  A23L33/105 ,  A61K31/21 ,  A61K36/28 ,  A61K9/50

CPC分类号： A61K9/5089 ,  A61K9/5026 ,  A61K9/5063

摘要： A method of preparing water-soluble lutein ester microcapsules includes: mixing marigold flower particles with an extracting solvent, refluxing at 65-85° C.; removing the extracting solvent to obtain a crude extract; washing the crude extract with a washing solvent; removing the washing solvent to obtain a crude lutein ester; adding an oil-phase antioxidant and a vegetable oil to the crude lutein ester, mixing and heating at 90-100° C. to obtain a lutein ester oil phase; adding a wall material, an emulsifier, a water-phase antioxidant, and a water-phase filler into water, and heating to obtain a water phase; adding the lutein ester oil phase to the water phase under a high-speed shearing, mixing evenly, and homogenizing to obtain a lutein ester emulsion; drying twice to obtain semi-finished lutein ester microcapsules; and solidifying to obtain the lutein ester microcapsules. Water-soluble lutein ester microcapsules prepared by the method are also disclosed.

公开(公告)号：US20220347156A1

公开(公告)日：2022-11-03

申请号：US17473967

申请日：2021-09-13

申请人： Honglong LI ,  Xiaosong XU ,  Ziheng JIN ,  Linzheng LI ,  Congying SHI ,  Yulian GUO ,  Chunfeng YU ,  Yaqiong ZHANG

发明人： Honglong LI ,  Xiaosong XU ,  Ziheng JIN ,  Linzheng LI ,  Congying SHI ,  Yulian GUO ,  Chunfeng YU ,  Yaqiong ZHANG

IPC分类号： A61K31/375 ,  A61K31/12 ,  A61K47/22 ,  A61K9/107 ,  A23L33/105 ,  A23L33/15

摘要： A method for preparing a water-soluble curcumin liquid includes the following steps: A) dissolving curcumin, vitamin C and ascorbyl palmitate in an ethanol aqueous solution, evaporating ethanol under reduced pressure, and vacuum drying to obtain a curcumin-vitamin C-ascorbyl palmitate co-crystal; and B) high-speed emulsifying the curcumin-vitamin C-ascorbyl palmitate co-crystal and a water-soluble colloidal solution that includes an emulsifying additive under vacuum, sequentially conducting a two-stage wet grinding, a homogenization and a potential adjustment to obtain the water-soluble curcumin liquid.

公开(公告)号：US20220347107A1

公开(公告)日：2022-11-03

申请号：US17473974

申请日：2021-09-13

申请人： Honglong LI ,  Ziheng JIN ,  Linzheng LI ,  Xiaosong XU ,  Di WANG ,  Chunfeng YU ,  Wenjin ZHANG ,  Huiting XIA

发明人： Honglong LI ,  Ziheng JIN ,  Linzheng LI ,  Xiaosong XU ,  Di WANG ,  Chunfeng YU ,  Wenjin ZHANG ,  Huiting XIA

IPC分类号： A61K9/48 ,  A23L33/15 ,  A61K31/12 ,  A61K31/375

摘要： A method for preparing a water-soluble curcumin mixture with high bioavailability includes the following steps: A) dissolving curcumin, vitamin C and ascorbyl palmitate in an ethanol aqueous solution, evaporating ethanol under reduced pressure, and vacuum drying to obtain a curcumin-vitamin C-ascorbyl palmitate co-crystal; B) high-speed emulsifying the curcumin-vitamin C-ascorbyl palmitate co-crystal and a wall material colloidal solution under vacuum, sequentially conducting a two-stage wet grinding, a homogenization and a potential adjustment to obtain an emulsified body; and C) subjecting the emulsified body to microencapsulation with a wall material twice and drying to obtain the water-soluble curcumin.

公开(公告)号：US11642316B2

公开(公告)日：2023-05-09

申请号：US17473974

申请日：2021-09-13

申请人： Honglong Li ,  Ziheng Jin ,  Linzheng Li ,  Xiaosong Xu ,  Di Wang ,  Chunfeng Yu ,  Wenjin Zhang ,  Huiting Xia

发明人： Honglong Li ,  Ziheng Jin ,  Linzheng Li ,  Xiaosong Xu ,  Di Wang ,  Chunfeng Yu ,  Wenjin Zhang ,  Huiting Xia

IPC分类号： A61K9/48 ,  A23L33/15 ,  A61K31/12 ,  A61K31/375

CPC分类号： A61K9/4833 ,  A23L33/15 ,  A61K31/12 ,  A61K31/375

摘要： A method for preparing a water-soluble curcumin mixture with high bioavailability includes the following steps: A) dissolving curcumin, vitamin C and ascorbyl palmitate in an ethanol aqueous solution, evaporating ethanol under reduced pressure, and vacuum drying to obtain a curcumin-vitamin C-ascorbyl palmitate co-crystal; B) high-speed emulsifying the curcumin-vitamin C-ascorbyl palmitate co-crystal and a wall material colloidal solution under vacuum, sequentially conducting a two-stage wet grinding, a homogenization and a potential adjustment to obtain an emulsified body; and C) subjecting the emulsified body to microencapsulation with a wall material twice and drying to obtain the water-soluble curcumin.

公开(公告)号：US12121507B2

公开(公告)日：2024-10-22

申请号：US17473967

申请日：2021-09-13

申请人： Honglong Li ,  Xiaosong Xu ,  Ziheng Jin ,  Linzheng Li ,  Congying Shi ,  Yulian Guo ,  Chunfeng Yu ,  Yaqiong Zhang

发明人： Honglong Li ,  Xiaosong Xu ,  Ziheng Jin ,  Linzheng Li ,  Congying Shi ,  Yulian Guo ,  Chunfeng Yu ,  Yaqiong Zhang

IPC分类号： A61K31/375 ,  A23L2/56 ,  A23L2/58 ,  A23L27/10 ,  A23L29/10 ,  A23L33/105 ,  A23L33/15 ,  A23L35/00 ,  A61K9/107 ,  A61K31/12 ,  A61K47/22

CPC分类号： A61K31/375 ,  A23L2/56 ,  A23L2/58 ,  A23L27/10 ,  A23L29/10 ,  A23L33/105 ,  A23L33/15 ,  A23L35/10 ,  A61K9/107 ,  A61K31/12 ,  A61K47/22 ,  A23V2002/00

摘要： A method for preparing a water-soluble curcumin liquid includes the following steps: A) dissolving curcumin, vitamin C and ascorbyl palmitate in an ethanol aqueous solution, evaporating ethanol under reduced pressure, and vacuum drying to obtain a curcumin-vitamin C-ascorbyl palmitate co-crystal; and B) high-speed emulsifying the curcumin-vitamin C-ascorbyl palmitate co-crystal and a water-soluble colloidal solution that includes an emulsifying additive under vacuum, sequentially conducting a two-stage wet grinding, a homogenization and a potential adjustment to obtain the water-soluble curcumin liquid.

公开(公告)号：US20210401761A1

公开(公告)日：2021-12-30

申请号：US17340292

申请日：2021-06-07

申请人： Honglong LI ,  Ziheng JIN ,  Xiaosong XU ,  Linzheng LI ,  Wenjin ZHANG ,  Chunfeng YU ,  Huiting XIA

发明人： Honglong LI ,  Ziheng JIN ,  Xiaosong XU ,  Linzheng LI ,  Wenjin ZHANG ,  Chunfeng YU ,  Huiting XIA

IPC分类号： A61K9/50

摘要： A method of preparing water-soluble lutein ester microcapsules includes: mixing marigold flower particles with an extracting solvent, refluxing at 65-85° C.; removing the extracting solvent to obtain a crude extract; washing the crude extract with a washing solvent; removing the washing solvent to obtain a crude lutein ester; adding an oil-phase antioxidant and a vegetable oil to the crude lutein ester, mixing and heating at 90-100° C. to obtain a lutein ester oil phase; adding a wall material, an emulsifier, a water-phase antioxidant, and a water-phase filler into water, and heating to obtain a water phase; adding the lutein ester oil phase to the water phase under a high-speed shearing, mixing evenly, and homogenizing to obtain a lutein ester emulsion; drying twice to obtain semi-finished lutein ester microcapsules; and solidifying to obtain the lutein ester microcapsules. Water-soluble lutein ester microcapsules prepared by the method are also disclosed.