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公开(公告)号：US20100068199A1
公开(公告)日：2010-03-18
申请号：US12558312
申请日：2009-09-11
申请人： Hong Liang , Yasmina Noubia Abdiche , Javier Fernando Chaparro Riggers , Bruce Charles Gomes , Julie Jia Li Hawkins , Jaume Pons , Xiayang Qiu , Pavel Strop , Yuli Wang
发明人： Hong Liang , Yasmina Noubia Abdiche , Javier Fernando Chaparro Riggers , Bruce Charles Gomes , Julie Jia Li Hawkins , Jaume Pons , Xiayang Qiu , Pavel Strop , Yuli Wang
IPC分类号： A61K39/395 , C07K16/00 , C12N5/10 , C07H21/04 , A61P9/00
CPC分类号： C07K16/40 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K2299/00 , C07K2317/24 , C07K2317/33 , C07K2317/76 , C07K2317/92
摘要： The present invention provides antagonizing antibodies, antigen-binding portions thereof, and aptamers that bind to proprotein convertase subtilisin kexin type 9 (PCSK9). Also provided are antibodies directed to peptides, in which the antibodies bind to PCSK9. The invention further provides a method of obtaining such antibodies and antibody-encoding nucleic acid. The invention further relates to therapeutic methods for use of these antibodies and antigen-binding portions thereof to reduce LDL-cholesterol levels and/or for the treatment and/or prevention of cardiovascular disease, including treatment of hypercholesterolemia.
摘要翻译： 本发明提供了与抗蛋白转化酶枯草杆菌蛋白酶Kexin 9型（PCSK9）结合的拮抗抗体，其抗原结合部分和适体。 还提供了针对肽的抗体，其中抗体结合PCSK9。 本发明还提供了获得这样的抗体和抗体编码核酸的方法。 本发明还涉及使用这些抗体及其抗原结合部分来降低LDL-胆固醇水平和/或用于治疗和/或预防心血管疾病（包括治疗高胆固醇血症）的治疗方法。
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公开(公告)号：US20150098957A1
公开(公告)日：2015-04-09
申请号：US14508977
申请日：2014-10-07
申请人： Brian Robert Champion , Leonard Gabriel Contillo, JR. , Michael Dale Eisenbraun , James Downey Fraser , Julie Jia Li Hawkins , James Richard Merson , Brian Gregory Pierce , Xiayang Qiu , Jakir Hussain Ullah , David Michael Wyatt
发明人： Brian Robert Champion , Leonard Gabriel Contillo, JR. , Michael Dale Eisenbraun , James Downey Fraser , Julie Jia Li Hawkins , James Richard Merson , Brian Gregory Pierce , Xiayang Qiu , Jakir Hussain Ullah , David Michael Wyatt
CPC分类号： A61K39/0005 , C12N9/6424 , C12Y304/21061
摘要： The present invention relates to the provision of novel immunogens comprising an antigenic PCSK9 peptide linked to an immunogenic carrier for the prevention, treatment or alleviation of PCSK9-mediated disorders. The invention further relates to methods for production of these medicaments, immunogenic compositions and pharmaceutical compositing thereof and their use in medicine.
摘要翻译： 本发明涉及提供包含与免疫原性载体连接的抗原性PCSK9肽以预防，治疗或缓解PCSK9介导的病症的新型免疫原。 本发明还涉及这些药物的生产方法，免疫原性组合物及其药物合成及其在药物中的用途。
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3.发明授权Proteases, compositions capable of binding to said site, and methods of use thereof 失效蛋白酶，能结合所述部位的组合物及其使用方法
公开(公告)号：US6008033A
公开(公告)日：1999-12-28
申请号：US167434
申请日：1998-10-06
申请人： Sherin Salaheldin Abdel-Meguid , Xiayang Qiu , Ward Whitlock Smith, Jr. , Cheryl Ann Janson , Susan S. Hoog , Jeffrey Culp , Christine Marie Debouck
发明人： Sherin Salaheldin Abdel-Meguid , Xiayang Qiu , Ward Whitlock Smith, Jr. , Cheryl Ann Janson , Susan S. Hoog , Jeffrey Culp , Christine Marie Debouck
IPC分类号： C12N15/09 , A61K38/00 , A61K38/46 , A61K45/00 , A61P31/12 , C12N9/50 , C12N15/00 , C12N15/57 , C12R1/19 , C12R1/92
摘要： Novel herpes viral protease crystalline structures are identified which have an active site formed by the three amino acids Ser, His and His. Also disclosed are methods of identifying inhibitors of these proteases and/or active sites.
摘要翻译： 鉴定出具有由三个氨基酸Ser，His和His形成的活性位点的新型疱疹病毒蛋白酶结晶结构。 还公开了鉴定这些蛋白酶和/或活性位点的抑制剂的方法。
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公开(公告)号：US09481875B2
公开(公告)日：2016-11-01
申请号：US14508977
申请日：2014-10-07
申请人： Brian Robert Champion , Leonard Gabriel Contillo, Jr. , Michael Dale Eisenbraun , James Downey Fraser , Julie Jia Li Hawkins , James Richard Merson , Brian Gregory Pierce , Xiayang Qiu , Jakir Hussain Ullah , David Michael Wyatt
发明人： Brian Robert Champion , Leonard Gabriel Contillo, Jr. , Michael Dale Eisenbraun , James Downey Fraser , Julie Jia Li Hawkins , James Richard Merson , Brian Gregory Pierce , Xiayang Qiu , Jakir Hussain Ullah , David Michael Wyatt
CPC分类号： A61K39/0005 , C12N9/6424 , C12Y304/21061
摘要： The present invention relates to the provision of immunogens comprising an antigenic PCSK9 peptide linked to an immunogenic carrier for the prevention, treatment or alleviation of PCSK9-mediated disorders. The invention further relates to methods for production of these medicaments, immunogenic compositions and pharmaceutical compositing thereof and their use in medicine.
摘要翻译： 本发明涉及提供免疫原，其包含与免疫原性载体连接的抗原性PCSK9肽，用于预防，治疗或缓解PCSK9介导的病症。 本发明还涉及这些药物的生产方法，免疫原性组合物及其药物合成及其在药物中的用途。
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公开(公告)号：US08889144B2
公开(公告)日：2014-11-18
申请号：US12872645
申请日：2010-08-31
申请人： Brian Robert Champion , Leonard Gabriel Contillo, Jr. , Michael Dale Eisenbraun , James Downey Fraser , Julie Jia Li Hawkins , James Richard Merson , Brian Gregory Pierce , Xiayang Qiu , Jakir Hussain Ullah , David Michael Wyatt
发明人： Brian Robert Champion , Leonard Gabriel Contillo, Jr. , Michael Dale Eisenbraun , James Downey Fraser , Julie Jia Li Hawkins , James Richard Merson , Brian Gregory Pierce , Xiayang Qiu , Jakir Hussain Ullah , David Michael Wyatt
CPC分类号： A61K39/0005 , C12N9/6424 , C12Y304/21061
摘要： The present invention relates to the provision of immunogens comprising an antigenic PCSK9 peptide linked to an immunogenic carrier for the prevention, treatment or alleviation of PCSK9-mediated disorders. The invention further relates to methods for production of these medicaments, immunogenic compositions and pharmaceutical compositing thereof and their use in medicine.
摘要翻译： 本发明涉及提供免疫原，其包含与免疫原性载体连接的抗原性PCSK9肽，用于预防，治疗或缓解PCSK9介导的病症。 本发明还涉及这些药物的生产方法，免疫原性组合物及其药物合成及其在药物中的用途。
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公开(公告)号：US20110052621A1
公开(公告)日：2011-03-03
申请号：US12872645
申请日：2010-08-31
申请人： Brian Robert Champion , Leonard Gabriel Contillo, JR. , Michael Dale Eisenbraun , James Downey Fraser , Julie Jia Li Hawkins , James Richard Merson , Brian Gregory Pierce , Xiayang Qiu , Jakir Hussain Ullah , David Michael Wyatt
发明人： Brian Robert Champion , Leonard Gabriel Contillo, JR. , Michael Dale Eisenbraun , James Downey Fraser , Julie Jia Li Hawkins , James Richard Merson , Brian Gregory Pierce , Xiayang Qiu , Jakir Hussain Ullah , David Michael Wyatt
CPC分类号： A61K39/0005 , C12N9/6424 , C12Y304/21061
摘要： The present invention relates to the provision of novel immunogens comprising an antigenic PCSK9 peptide linked to an immunogenic carrier for the prevention, treatment or alleviation of PCSK9-mediated disorders. The invention further relates to methods for production of these medicaments, immunogenic compositions and pharmaceutical compositing thereof and their use in medicine.
摘要翻译： 本发明涉及提供包含与免疫原性载体连接的抗原性PCSK9肽以预防，治疗或缓解PCSK9介导的病症的新型免疫原。 本发明还涉及这些药物的生产方法，免疫原性组合物及其药物合成及其在药物中的用途。
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公开(公告)号：US20060177871A1
公开(公告)日：2006-08-10
申请号：US10640524
申请日：2003-08-13
申请人： Cheryl Janson , Xiayang Qiu , Ward Smith
发明人： Cheryl Janson , Xiayang Qiu , Ward Smith
CPC分类号： C07K14/54 , C07K2299/00 , G01N2333/54 , G16B35/00 , G16C20/60
摘要： A novel murine IL-18 native crystalline structure is identified.
摘要翻译： 确定了一种新型的小鼠IL-18天然晶体结构。
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8.发明授权Methods using the staphylococcus aureus glycyl tRNA synthetase crystalline structure 失效方法使用金黄色葡萄球菌甘氨酰tRNA合成酶晶体结构公开(公告)号：US06197495B1
公开(公告)日：2001-03-06
申请号：US09076432
申请日：1998-05-10
IPC分类号： C12Q170
摘要： A novel Staphylococcus glycyl tRNA synthetase crystalline structure is identified. Also disclosed are methods of identifying inhibitors of these synthetases and/or active sites, and inhibitors identified by these methods.
摘要翻译： 鉴定出新型葡萄球菌糖基tRNA合成酶晶体结构。 还公开了鉴定这些合成酶和/或活性位点的抑制剂的方法，以及通过这些方法鉴定的抑制剂。
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9.发明授权Proteases compositions capable of binding to said site, and methods of use thereof 失效能够结合所述位点的蛋白酶组合物及其使用方法
公开(公告)号：US06083711A
公开(公告)日：2000-07-04
申请号：US853755
申请日：1997-05-09
申请人： Sherin Salaheldin Abdel-Meguid , Xiayang Qiu , Ward Whitlock Smith, Jr. , Cheryl Ann Janson , Susan S. Hoog , Jeffrey Culp , Christine Marie Debouck
发明人： Sherin Salaheldin Abdel-Meguid , Xiayang Qiu , Ward Whitlock Smith, Jr. , Cheryl Ann Janson , Susan S. Hoog , Jeffrey Culp , Christine Marie Debouck
IPC分类号： C12N15/09 , A61K38/00 , A61K38/46 , A61K45/00 , A61P31/12 , C12N9/50 , C12N15/00 , C12N15/57 , C12R1/19 , C12R1/92 , C12Q1/37
摘要： Novel herpes viral protease crystalline structures are identified which have an active site formed by the three amino acids Ser, His and His. Also disclosed are methods of identifying inhibitors of these proteases and/or active sites.
摘要翻译： 鉴定出具有由三个氨基酸Ser，His和His形成的活性位点的新型疱疹病毒蛋白酶结晶结构。 还公开了鉴定这些蛋白酶和/或活性位点的抑制剂的方法。
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10.发明授权Methods using the Staphylococcus aureus glycyl tRNA synthetase crystalline structure 失效方法使用金黄色葡萄球菌甘氨酰tRNA合成酶晶体结构
公开(公告)号：US06037117A
公开(公告)日：2000-03-14
申请号：US792295
申请日：1997-01-31
摘要： A novel Staphylococcus glycyl tRNA synthetase crystalline structure is identified. Also disclosed are methods of identifying inhibitors of these synthetases and/or active sites, and inhibitors identified by these methods.
摘要翻译： 鉴定出新型葡萄球菌糖基tRNA合成酶晶体结构。 还公开了鉴定这些合成酶和/或活性位点的抑制剂的方法，以及通过这些方法鉴定的抑制剂。
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